Seems like that depends on who's manufacturing the pill. I have no doubt that the above is true if Lilly is the manufacturer. I'm less convinced this is the case for gray vendors.
Orforglipron: The next big thing?
- Thread starter Derby
- Start date
Calm Logic
GLP-1 Specialist
The third/last phase of the orfo trial used 1 mg as a starting dose. Phase two used mostly 3 mg as the starting dose, with more GI side effects.
But the smallest dose available in grey is 6 mg, and some resellers like PGB only sell 12 mg (tested at 13.7 mg). Uther has 8 mg (tested at about 9 mg) and 12 mg (tested at about 13 mg). WWB has 6 mg but no testing available.
But the smallest dose available in grey is 6 mg, and some resellers like PGB only sell 12 mg (tested at 13.7 mg). Uther has 8 mg (tested at about 9 mg) and 12 mg (tested at about 13 mg). WWB has 6 mg but no testing available.
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Jellybelly54
GLP-1 Enthusiast
Found 6mg caps . 90 capsule for $185 at The Peptique. US company in TX. Fast shipping.
Calm Logic
GLP-1 Specialist
No mass testing on their COA? I see it passed endotoxin testing though.
Though it's good they have the 6 mg, their price per mg is the same as 12 mg elsewhere. And it doesn't take long to titrate up to 12 mg, which is the sweet spot now for orfo tablets.
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Calm Logic
GLP-1 Specialist
There are people who think splitting a tablet is somehow crazy. But I would split when necessary and have before. I am too cheap to pay for 6 mg tablets.
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I researched a bit about the tablets. There should be a special coating on it. So splitting makes the medication less effective. But I dont know how they manufactor it in china.
Calm Logic
GLP-1 Specialist
My guess is that 3 mg is a safe starting dose for those who have been on GLPs before. 3 mg was mostly used as the starting dose in the second phase of the orfo trials. But only 1 mg was used as the starting dose in the third phase/study.
The Uther tablets are small but can be split into four pieces. I used a pill splitter for spitting in two. But to split again, I used my fingers instead. The smallest piece can be used for the first dose.
Another option is to take every other day or so. We will know more when more people start reporting their experiences.
I started at 8 mg of Uther, tested at 9.3 mg. GI sides were definitely moderate/strong at times, even though I was mostly on a break from tirz.
I skipped a day after day three, since the sides were getting a little tiring. Only after that did I try splitting the tablets, but I really didn't need to at that point.
Right now, I am on the 12-mg Uther tablets daily (tested at about 13 mg), along with a low dose of tirz (which I will be raising again).
The Uther tablets are small but can be split into four pieces. I used a pill splitter for spitting in two. But to split again, I used my fingers instead. The smallest piece can be used for the first dose.
Another option is to take every other day or so. We will know more when more people start reporting their experiences.
I started at 8 mg of Uther, tested at 9.3 mg. GI sides were definitely moderate/strong at times, even though I was mostly on a break from tirz.
I skipped a day after day three, since the sides were getting a little tiring. Only after that did I try splitting the tablets, but I really didn't need to at that point.
Right now, I am on the 12-mg Uther tablets daily (tested at about 13 mg), along with a low dose of tirz (which I will be raising again).
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Calm Logic
GLP-1 Specialist
Unlike the ritual of a weekly injectable, it's much easier to forget whether you've already taken a pill. So to avoid accidentally overdosing on orfo (like taking two pills in one day), I would use a weekly pill reminder case.
Personally, I am done stacking with orfo. I will just save it for a maintenance phase on its own. Had some bad GI sides, especially bloating, last night.
Personally, I am done stacking with orfo. I will just save it for a maintenance phase on its own. Had some bad GI sides, especially bloating, last night.
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jakexb
Recently Joined
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I have been using a liquid version at about 3mg. Actually has been working quite nicely for me, no GI symptoms. I like being able to titrate using the dropper. But unfortunately the vendor isn’t going to restock it so if I want to continue I’ll have to find another source.
jakexb
Recently Joined
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Hoping interest picks up again for this when this goes for final FDA approval. Seems like the gray interest has almost disappeared
RadicalCrimson
GLP-1 Apprentice
Update: the liquid drops I initially got (can’t remember if they were from Umbrella or Kimera) worked fantastically well, but the pills I got from PGB, despite having a Jano COA, seem to only make my subject super hungry, and weight goes up accordingly.
RadicalCrimson
GLP-1 Apprentice
The problem with the drops was that the taste was beyond unbearable, from what I’ve heard.
RadicalCrimson
GLP-1 Apprentice
PGB would be the last vendor I would have suspected of having ineffective stuff, but here we are
K2UGA
GLP-1 Apprentice
I would love this for maintenance, just take one pill every morning with my multivitamin and forget about it. Is that wishful thinking? Are the grey vendors going to be interested in selling these do you think?
You already can get it from uther i think.
I too want it for maintenance, but thats 25kg away...at least a year.
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Calm Logic
GLP-1 Specialist
It seems hopeless. Which is still shocking to me. We are dealing with people who love to shoot up, haha.
But Uther said the tablets could/would expire after three years or so, so there is an argument to be made for hoarding the regular GLPs instead.
Calm Logic
GLP-1 Specialist
No, it's not wishful thinking. It works well for maintaining weight. Great for traveling. The future is here.
GLP1Pharmacist
GLP-1 Enthusiast
I have heard mixed results on Uther's Orforglipron. Any updates from those who have actually tried it?
gloriavivica
Recently Joined
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I’m using 12 mg orfo pills to quiet cravings on days 5-7 with tirz. Split the pills in half, and take 6 mgs daily. They work as intended, no complaints.
K2UGA
GLP-1 Apprentice
And I'm guessing you are not having too much issues getting supplies? Are they expensive?
jakexb
Recently Joined
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The trick with the drops (if they're ever available again) is to drop them into a larger liquid. That way you're diluting the dmso and avoiding the taste (and any irritation from direct dmso contact in the mouth)
PGB (currently $205 for 12 mg x 90). There are some groups that now do group orders with Uther and PGB. They aren’t traditional GBs, just collective orders to meet minimums or make the shipping make more sense.
Calm Logic
GLP-1 Specialist
Relatively short-half life for stacking. Easier for travel or having family around during the holidays. Shits and giggles.
But there has never been a lot of interest, partly due to the effectiveness being lower than subq sema, with more GI side effects if anything.
How interesting it’s in dmso. You wouldn’t really need to put it in your mouth in that case?
Foggy-Hollow
GLP-1 Enthusiast
Not everyone can successfully take Oz or Zep.
Sema put me in a bad place with suicidal ideation. I have never had that problem, and I’m going to NOPE away from sema forever. Free sema? Nope. Pay me to take it? Still no.
Tirz wasn’t quite the same. But still not at a long term option. I’m hoping it’s tweak-able/stackable to a good enough place.
