Reta histamine reaction! Has anyone had Reta have a histamine reaction with swelling with a large red area around injection site with itching!

CraigLSU

GLP-1 Novice
🚫No Source Discussion🚫
Member Since
Apr 27, 2025
Posts
19
Likes Received
7
Location
Louisiana
United-States
Has anyone had Reta have a histamine reaction with swelling with a large red area around injection site with itching!
 
Nope, nothing happens, no bruise or itching. It felt like I used water. I use a generic, no name brand 6mm 31G noodle from the 'Zon so nothing fancy, goes in smooth like butter doesn't hurt and no issue with pulling/pushing

I've been on forums/groups for the brand stuff for ~2 yr and I'm ngl I never heard ppl having "histamine reactions" until I stumbled in the grey side of things. I get the vibe you have a bad batch or your water is bad or your noodle is bad
 
Yea he’s used 2 different suppliers but his wife uses the same with no problems. It’s very strange!
 
Localised injection site reactions are very common with semaglutide and tirzepatide, have not seen as many people online mention it for reta , but given the molecule is nearly identical, it makes sense for it to happen with reta as well. Too long since I read the studies to remember how common it was there. It is not normally the bac water, it is normally the drug that you have an immune reaction to.
The thing that concerns me a bit with your reaction is the size. Most ISR's are fairly small. Even the tiniest bit of evidence for a generalised allergic reaction should make you stop using it, and if large reactions are occurring then you might have to stop it anyway and switch to tirz instead. Cross reactions to different GLP's are rare so switching should solve the problem.
 
badsr71 said:
No histamine reaction from any of my friends/family (just over 30 of us) from Reta. MOTS, that's a different story, especially at higher doses.
Click to expand...
I didn't get it from Mots. I was blasting 10mg, 3x per week. I also didn't get much anything else from it. Guess I am already optimized. Am jealous of everyone that gets results from Mots. Lucky bastards.
 
Mr. Blonde said:
I didn't get it from Mots. I was blasting 10mg, 3x per week. I also didn't get much anything else from it. Guess I am already optimized. Am jealous of everyone that gets results from Mots. Lucky bastards.
Click to expand...
Wow. How long did you run MOTS? I'm doing a different protocol this go around, with NAD+. Started at 200mcg/day, titrating up an additional 200mcg/day every couple of weeks. So far, so good. Low and slow!
 
CraigLSU said:
Has anyone had Reta have a histamine reaction with swelling with a large red area around injection site with itching!
Click to expand...
One time, I had the same reaction. One week later pinned with same vial, waited with epipen, but no reaction. Don't know what did caused this.
 
badsr71 said:
Wow. How long did you run MOTS? I'm doing a different protocol this go around, with NAD+. Started at 200mcg/day, titrating up an additional 200mcg/day every couple of weeks. So far, so good. Low and slow!
Click to expand...
6 weeks...I think.
 
I'm on week 6 and nothing yet. The only time that I have had reactions is from pinning ghk-cu on my stomach. I switched to my glutes and no reaction so far.
 
The same thing happened to me many times but using a Mounjaro pen from EL but since I moved to the gray stuff nothing at all. Some of those red lumps used to itch like crazy
 
This happens to me with tirzepatide reconstituted with bac water. It does not happen if I reconstitute with sterile water. Doesn’t happen with any other peptides, reta+bac is fine, something about the blend of tirz and bac. You can try sterile water and see if that helps.

Before i discovered the bac water connection I would spray the area with flonase after injection and that knocked it down a bit.
 
TazaTaza said:
Nope, nothing happens, no bruise or itching. It felt like I used water. I use a generic, no name brand 6mm 31G noodle from the 'Zon so nothing fancy, goes in smooth like butter doesn't hurt and no issue with pulling/pushing

I've been on forums/groups for the brand stuff for ~2 yr and I'm ngl I never heard ppl having "histamine reactions" until I stumbled in the grey side of things. I get the vibe you have a bad batch or your water is bad or your noodle is bad
Click to expand...
Noodle? Pretty sure you meant needle, unless that's some new hip term to use. 😁
 
lessthanhalf said:
Localised injection site reactions are very common with semaglutide and tirzepatide, have not seen as many people online mention it for reta , but given the molecule is nearly identical, it makes sense for it to happen with reta as well. Too long since I read the studies to remember how common it was there. It is not normally the bac water, it is normally the drug that you have an immune reaction to.
The thing that concerns me a bit with your reaction is the size. Most ISR's are fairly small. Even the tiniest bit of evidence for a generalised allergic reaction should make you stop using it, and if large reactions are occurring then you might have to stop it anyway and switch to tirz instead. Cross reactions to different GLP's are rare so switching should solve the problem.
Click to expand...
Yea I agree! They were fairly large and looked bad!
 
a friend of mine has been getting giant red welts from the reta, same batch as me - she's tried all the tricks I could think of but every week it was worse so she has to discontinue use.
 
Mr. Blonde said:
I didn't get it from Mots. I was blasting 10mg, 3x per week. I also didn't get much anything else from it. Guess I am already optimized. Am jealous of everyone that gets results from Mots. Lucky bastards.
Click to expand...
Mots wiped me out. I stopped after 3 weeks and my diet, supplements & exercise is always locked in. I’m going to try SS31 then mots to see if there’s better results!
 
ambot88 said:
a friend of mine has been getting giant red welts from the reta, same batch as me - she's tried all the tricks I could think of but every week it was worse so she has to discontinue use.
Click to expand...
Yea he’s about to call it quits!
 
I haven't with Reta, but I sure did with Tirz! To the point that I had to stop using it. I can not confirm that this is why I haven't had a reaction with Reta, but I also do a 500mcg injection of KPV about two inches away from where I inject the Reta on injection day. I find it also helps me with the skin-sensitivity-death-itching between my shoulder blades I get the day after injecting Reta.
 
Hambocommando said:
I haven't with Reta, but I sure did with Tirz! To the point that I had to stop using it. I can not confirm that this is why I haven't had a reaction with Reta, but I also do a 500mcg injection of KPV about two inches away from where I inject the Reta on injection day. I find it also helps me with the skin-sensitivity-death-itching between my shoulder blades I get the day after injecting Reta.
Click to expand...
Interesting about the KPV... wonder if it will help with my skin sensitivity/allodynia from the Reta. I have a kit on the way so we shall see.
 
Summer48 said:
The same thing happened to me many times but using a Mounjaro pen from EL but since I moved to the gray stuff nothing at all. Some of those red lumps used to itch like crazy
Click to expand...
That's odd you don't get it from the gray! Is the food noise reduction about the same?
 
CraigLSU said:
Has anyone had Reta have a histamine reaction with swelling with a large red area around injection site with itching!
Click to expand...
Every single time. Lasts about a week and a half. Flares even worse at night when cortisol drops and histamine rises. Sometimes comes with this red outline. KPV doesn't help. Hell, my KPV injections swell and flare too. Fun times!

IMG_8887 2.webp
 
I have had histamine reactions with 5 different batches: 3 products (sema, tirz and reta), 2 suppliers for sema and tirz. The itch would last 5 to 7 days. I tried just the BAC water (2 suppliers) and had no reaction whatsoever.

I found a lotion at my local drugstore that is a mix of calamine and antihistamine. Helps keeping me sane through the worst of the itching. The workaround I have found works the best is to inject the peptides deeper. It does not work ever time, but I get a histamine reaction maybe 20% of the time now.

Injecting deeper hurts a bit, though. And I am worried that it may increase some risks (as it seems to bypass the immune system) and/or reduce the efficiency of the GLP-1s. I saw some stories of people saying their histamine reactions eventually went away. I am hoping I get there at some point.
 
Friendly reminder that peps are not sterile and you should make decisions around this. These are some recent pics of R30 and T60 as reminders:

IMG_6624.webp
IMG_6626.webp


IMG_6623.webp
IMG_6625.webp

The most common reason for ISR’s (injection site reactions) is moldy/unsterile peps. Do not forget that this stuff isn’t pharmacy grade.

Fortunately, with PES filters, these can be made completely sterile and safe. I have no qualms using these vials because they’ve been filtered
 
You must log in or register to reply here.

Trending Topics

Latest Posts

Forum Statistics

Threads
18,064
Posts
188,129
Members
60,571
Newest
Hhgofantioch
Back
Top Bottom