Enclomiphene Experience (12.5mg): Higher Test, Better Recovery, Leaner Build

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Enclomiphene in three weeks Took My natural Test from 400 to 850.

Ran labs before and during this protocol and wanted to share my experience plus get feedback from others who know this space.

I’ve been running enclomiphene at 12.5 mg daily (half tab), tesamorelin 1 mg in the mornings, 1 IU HGH in the evenings, retatrutide 2 mg weekly, along with light cardio runs 5 days a week and about 20 minutes of resistance training 6 days a week. I’m also keeping protein intake high and trying to stay consistent rather than overcomplicate everything. I became interested in it after I saw HIMS offer it ((bundled with a low dose Cialis) for something around $3k a year--I found much better overseas sourcing as others do)).

The biggest measurable change so far was enclomiphene taking my total testosterone from around 400 to 850 while staying natural production based. That was a modest increase in energy. Subjectively, I’m seeing solid benefits in energy, recovery, body composition, and overall wellbeing, but nothing over-the-top or dramatic. It feels more like steady building rather than a rapid transformation, which honestly is what I was hoping for.

My goal also isn’t to get huge. I still want to be able to run and jog regularly, keep endurance, and build more of a lean swimmer-type physique. I worked hard to lose the weight, and my focus now is staying toned, athletic, and capable rather than chasing maximum size. I'll probably never lose the body dysmorphia but that's more for therapy (or dealt with during a long run).

I’ve also noticed a nice benefit from the retatrutide once the early side effects faded. At first I had some adjustment issues with sleep and heart rate, but those settled down. Since then it has been a strong addition for appetite control, staying leaner, and overall momentum.

The low-dose HGH also seems to be helping my midsection firm up. After losing around 30-40 pounds, I had some sagging through the stomach area, and that has been improving. My resistance training sessions have also noticeably improved, including better pull-up performance and overall workout quality. I was told to consider raising the IGF (via the Hgh or tesa) slightly to assist all that extra testosterone to build some lean muscle/ recovery.

One thing worth mentioning is I haven’t experienced the side effects some people talk about with these kinds of compounds. No major ongoing issues so far, and I’m guessing the lower doses may be helping there.

Another thing I like is avoiding TRT for now. No oils, no larger injections, no full replacement commitment, and no dealing with some of the downsides that can come with that route.

Just today, I also had a bottle of ostarine 25 mg and have been following the VERU / enobosarm trial discussions, so I recently added a short 2-3 week experiment at 6 mg daily, or possibly every other day after the first week depending on how I respond. From what I’ve seen, some of the VERU trial dosing discussed for endosarm/enobosarm was even lower, around 3 mg daily, which made me curious about whether lower-dose approaches can still be effective while minimizing negatives.

Overall I’m very happy with where things are heading. For anyone more experienced than me, is there anything you’d change, cycle, reduce, or add? Would you stay the course if labs and side effects remain good, or make adjustments now before long-term use?
 
I thought Tesa or any GHRH becomes useless once you start HGH, since you're shutting down endogenous production and the pituitary gland stops working. But I'm not an expert
Yep, pretty much. It's dose dependent, but certainly doesn't seem to make sense to use both tesamorelin and hgh since they antagonize each other.
 
I’m on the enclomiphene 12.5 mg/ tandalafil 8.5 mg daily from H/H for 90 month which includes quarterly testing. My T started at 200 and after 2 months I was at 500 and my online provider declined to bring my prescription up to the 25mg a day as my T was increasing quicker than expected.

I am hoping that my natural production will increase as my weight decreases and I correct my insulin resistance. My A1c has fallen significantly since I started the tirzepitide, however my fasting insulin is still higher than I’d like to see. I’m hoping that the mots-c, Ss-31, and NAD+ protocol is going to help. I am resistant to the Testosterone oil shots, as I am focusing on one aspect of my health at a time.

Insulin resistance and testosterone

1. The Direct Hit to the Testes
Research shows that insulin resistance directly impairs the Leydig cells in the testes. These are the cells responsible for churning out testosterone. When your body is resistant to insulin:
• The Leydig cells become less responsive to Luteinizing Hormone (LH)—the "start engine" signal from your brain.
• Even if your brain is screaming for more testosterone, the testes don't "hear" the signal as clearly, leading to lower output.
2. The "Belly Fat" Factor (Aromatization)
Insulin resistance is almost always tied to increased visceral (belly) fat. This fat isn't just storage; it’s metabolically active and contains an enzyme called aromatase.
• Aromatase takes the testosterone you do have and converts it into estrogen.
• Higher estrogen levels then tell your brain, "We have plenty of hormones," which causes the brain to slow down the signal to produce more testosterone.
3. SHBG Suppression
Insulin levels significantly influence Sex Hormone Binding Globulin (SHBG), a protein that carries testosterone through your blood.
• High insulin levels signal the liver to produce less SHBG.
• While this might sounds like it would leave more "free" testosterone, low SHBG is often a marker of metabolic dysfunction and is consistently linked to lower total testosterone levels over time.
4. Inflammation and the Brain
Chronic insulin resistance creates a low-grade inflammatory state. This inflammation can disrupt the Hypothalamic-Pituitary-Gonadal (HPG) axis. Essentially, the "command center" in your brain becomes less efficient at monitoring and regulating your hormone levels, leading to a drop in production.
The Silver Lining: Reversibility
The good news is that because this relationship is bidirectional, fixing one often helps the other. Improving insulin sensitivity—is one of the most effective "natural" ways to boost testosterone.
 
I thought Tesa or any GHRH becomes useless once you start HGH, since you're shutting down endogenous production and the pituitary gland stops working. But I'm not an expert
Apparently not the case with low, therapeutic dosing. IGF labs seem to indicate this as well which is why I need to stay low (<.5iu) when the cycle runs both.
 
I thought Tesa or any GHRH becomes useless once you start HGH, since you're shutting down endogenous production and the pituitary gland stops working. But I'm not an expert
The literature supports that tesamorelin stimulates endogenous GH and that exogenous HGH can create feedback suppression. It does not clearly prove that low-dose HGH makes tesamorelin useless. The interaction is nuanced and likely dose/timing dependent. That said, it's great feedback, I'll go off the evening GH when doing the morning Tesa cycle....thanks for the advice 🙂
 
I’m on the enclomiphene 12.5 mg/ tandalafil 8.5 mg daily from H/H for 90 month which includes quarterly testing. My T started at 200 and after 2 months I was at 500 and my online provider declined to bring my prescription up to the 25mg a day as my T was increasing quicker than expected.

I am hoping that my natural production will increase as my weight decreases and I correct my insulin resistance. My A1c has fallen significantly since I started the tirzepitide, however my fasting insulin is still higher than I’d like to see. I’m hoping that the mots-c, Ss-31, and NAD+ protocol is going to help. I am resistant to the Testosterone oil shots, as I am focusing on one aspect of my health at a time.

Insulin resistance and testosterone

1. The Direct Hit to the Testes
Research shows that insulin resistance directly impairs the Leydig cells in the testes. These are the cells responsible for churning out testosterone. When your body is resistant to insulin:
• The Leydig cells become less responsive to Luteinizing Hormone (LH)—the "start engine" signal from your brain.
• Even if your brain is screaming for more testosterone, the testes don't "hear" the signal as clearly, leading to lower output.
2. The "Belly Fat" Factor (Aromatization)
Insulin resistance is almost always tied to increased visceral (belly) fat. This fat isn't just storage; it’s metabolically active and contains an enzyme called aromatase.
• Aromatase takes the testosterone you do have and converts it into estrogen.
• Higher estrogen levels then tell your brain, "We have plenty of hormones," which causes the brain to slow down the signal to produce more testosterone.
3. SHBG Suppression
Insulin levels significantly influence Sex Hormone Binding Globulin (SHBG), a protein that carries testosterone through your blood.
• High insulin levels signal the liver to produce less SHBG.
• While this might sounds like it would leave more "free" testosterone, low SHBG is often a marker of metabolic dysfunction and is consistently linked to lower total testosterone levels over time.
4. Inflammation and the Brain
Chronic insulin resistance creates a low-grade inflammatory state. This inflammation can disrupt the Hypothalamic-Pituitary-Gonadal (HPG) axis. Essentially, the "command center" in your brain becomes less efficient at monitoring and regulating your hormone levels, leading to a drop in production.
The Silver Lining: Reversibility
The good news is that because this relationship is bidirectional, fixing one often helps the other. Improving insulin sensitivity—is one of the most effective "natural" ways to boost testosterone.
This is fantastic and great research! Thanks for sharing. I've read the 6mg vs 12mg are quite similar in results so I do plan see what my levels stay at when I migrate to that approach in a few weeks. I'll loop back and let you know.
 
Curious, why are you taking Tesa in the morning ? Everything I've read say take it in the evening fasted (90 min after last meal) prior to bed to support your natural GH production which happens overnight .
 
Curious, why are you taking Tesa in the morning ? Everything I've read say take it in the evening fasted (90 min after last meal) prior to bed to support your natural GH production which happens overnight .
It actually doesnt matter when you take it, you'll still get larger pulses at night. When prescribed, there is nothing on the prescription that says you have to take it at night.
 
I've been interested in Enclo to supplement by Reta and HGH but the potential for 'eye floaters' really puts me off. Had my eyes lazered about 17 years ago and don't feel like messing round with them!
 
Just curious if anyone knows or maybe it isn't something that can be known...Couldn't find any definites with my lazy online search.

Does Enclo increase body hair by way of increased test?

I'm 39...and a half....I dont want hair to just appear on my back all of a sudden.

Basically just don't want to get sasquatch hair.

Anyone have experience or input would be appreciated.
 
I am interested in the international source of enclomiphene? I saw a message board wherein the discussants all realized they were buying racemic clomiphene which was inaccurately labeled as enclomiphene. They were purchasing from India, where enclomiphene is apparently not at all available.
 
I am interested in the international source of enclomiphene? I saw a message board wherein the discussants all realized they were buying racemic clomiphene which was inaccurately labeled as enclomiphene. They were purchasing from India, where enclomiphene is apparently not at all available.
Yep, the enclo from India was actually clomiphene. Not sure about the Chinese sources. The best bet might actually be some online clinic in the states or something like modern aminos or umbrella labs, etc.
 
I’m on the enclomiphene 12.5 mg/ tandalafil 8.5 mg daily from H/H for 90 month which includes quarterly testing. My T started at 200 and after 2 months I was at 500 and my online provider declined to bring my prescription up to the 25mg a day as my T was increasing quicker than expected.

I am hoping that my natural production will increase as my weight decreases and I correct my insulin resistance. My A1c has fallen significantly since I started the tirzepitide, however my fasting insulin is still higher than I’d like to see. I’m hoping that the mots-c, Ss-31, and NAD+ protocol is going to help. I am resistant to the Testosterone oil shots, as I am focusing on one aspect of my health at a time.

Insulin resistance and testosterone

1. The Direct Hit to the Testes
Research shows that insulin resistance directly impairs the Leydig cells in the testes. These are the cells responsible for churning out testosterone. When your body is resistant to insulin:
• The Leydig cells become less responsive to Luteinizing Hormone (LH)—the "start engine" signal from your brain.
• Even if your brain is screaming for more testosterone, the testes don't "hear" the signal as clearly, leading to lower output.
2. The "Belly Fat" Factor (Aromatization)
Insulin resistance is almost always tied to increased visceral (belly) fat. This fat isn't just storage; it’s metabolically active and contains an enzyme called aromatase.
• Aromatase takes the testosterone you do have and converts it into estrogen.
• Higher estrogen levels then tell your brain, "We have plenty of hormones," which causes the brain to slow down the signal to produce more testosterone.
3. SHBG Suppression
Insulin levels significantly influence Sex Hormone Binding Globulin (SHBG), a protein that carries testosterone through your blood.
• High insulin levels signal the liver to produce less SHBG.
• While this might sounds like it would leave more "free" testosterone, low SHBG is often a marker of metabolic dysfunction and is consistently linked to lower total testosterone levels over time.
4. Inflammation and the Brain
Chronic insulin resistance creates a low-grade inflammatory state. This inflammation can disrupt the Hypothalamic-Pituitary-Gonadal (HPG) axis. Essentially, the "command center" in your brain becomes less efficient at monitoring and regulating your hormone levels, leading to a drop in production.
The Silver Lining: Reversibility
The good news is that because this relationship is bidirectional, fixing one often helps the other. Improving insulin sensitivity—is one of the most effective "natural" ways to boost testosterone.
I was running 108-10 fasting glucose.... mots c i did 5mg, three times a week, got me down to high 90's.
 
Just curious if anyone knows or maybe it isn't something that can be known...Couldn't find any definites with my lazy online search.

Does Enclo increase body hair by way of increased test?

I'm 39...and a half....I dont want hair to just appear on my back all of a sudden.

Basically just don't want to get sasquatch hair.

Anyone have experience or input would be appreciated.
I tested 15 mg of Enclo daily for 4 months. I did not see any change in hair growth. No hair growth anywhere new and no new balding on my head. I did notice a little increased aggression but nothing I couldn't handle.
 
I tested 15 mg of Enclo daily for 4 months. I did not see any change in hair growth. No hair growth anywhere new and no new balding on my head. I did notice a little increased aggression but nothing I couldn't handle.
What about your swimmers?
 
Clomid gave me the Clomid Crazies. I am researching Enclomiphene as I am struggling on TRT Test Cyp/Enan with Erythrocytosis. Curious to what you hematocrit is and escpecially if your test levels continue to rise. My hematocrit did not raise nearly as much on Clomid, but I was losing my mind and also concerned about floaters since I was experiencing sides.
 
I tested 15 mg of Enclo daily for 4 months. I did not see any change in hair growth. No hair growth anywhere new and no new balding on my head. I did notice a little increased aggression but nothing I couldn't handle.
Nice, thanks.
 
I don't know if there were more but the drive to let them go definitely increased.
Now that's the shit I'm talking about. What were you on about hair, aggression and other unmanly things when you should have led with this? Atleast consider your own name here.
 
Yep, the enclo from India was actually clomiphene. Not sure about the Chinese sources. The best bet might actually be some online clinic in the states or something like modern aminos or umbrella labs, etc.
I was taking the mislabeled Indian clomid. Messed my hormones all up. I then switched to actual enclomiphene from MA Research but never could quite get to feeling good. My SHBG shot up and tanked my e2. My total test went up a bit but free test dropped. Everything was just messed up and I couldn't dial it in. Felt worse than I did with my natural low t. Threw in the towel and jumped on trt and am annoyed I spent so much money and energy trying to avoid it. I feel AMAZING and will never go back! One of the best decisions I've made for my health and wellbeing.
 
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Now that's the shit I'm talking about. What were you on about hair, aggression and other unmanly things when you should have led with this? Atleast consider your own name here.
I don't know if this is normal or not but this is what they looked like under the microscope!! You think I should see a doctor?
 

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