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Angiogenesis and VEGF are well known factors for increasing tumor growth rates. There is no real debate in the science about this, to the point that anti-VEGF/angiogenesis therapies are a current hotbed of research for cancer treatment. BPC-157 and TB-500 promote angiogenesis and increased VEGF...

I'll note that the BPC-157 and TB-500 in both GLOW and KLOW are risks for cancer. Not necessarily in causing it, but for greatly increasing cancer growth rates via angiogenesis and VEGF. TB-500 also seems likely to increase risk of metastisization of existing cancers based on the TB4 research...

Tirz raised my heart rate some, reta raised it a lot. I'd be surprised if tirz increased your RHR but reta did not at therapeutic doses. It impacts the sympathetic nervous system the same way tirz does, and the glucagon receptor activation is an additional mechanism for increased RHR. But 2mg...

Down more than 80lb on the scale and up a bit more than 20lb of lean body mass per dexa in 10 months Tirz for 3 months then reta since then TRT (enough test to get me into the 700s of total T, 80mg deca for joints) for 9 months 4IU HGH for 6 months Hard lifting 5 days a week Some cardio, bad...

None of the current myostatin inhibitors work particularly well. Effect size is too small.

Pretty much every Chinese vendor also deals in steroids. SRY, SSA, etc. As for bodybuilding, the steroid-enhanced body building world is the one that is significantly more popular. (And I would also mention that I believe that basically every single competitive sport where steroids would be...

A lot of experts would disagree with you - I won't say there's universal agreement, but there's a wide variety of issues with BMI that many argue are so fundamental that it really is useless...

Well, I'm here for a reason, though I've moved out of the 'obese' category, and I'm getting closer and closer to that <20% bf category, too. GLP-1s are big in the bodybuilding community for helping with cuts, though, and for bodybuilders it really is a useless metric. The verbiage of the OP...

BMI is a pretty useless metric, particularly for people who engage in regular strength training. Since the OP is talking about lifting regularly, cutting phases, etc., they probably are more muscular than the average person and as such further skewed. All of this is pretty meaningless without...

Rodent studies did 50mg per kg, which translates to about 4mg per kg for humans. Even 20mg is a massive underdose for most of us compared to the studies, though human equivalent dosing isn't always exact. If SLU does anything in humans and is safe to use in general, I suspect 20mg is far more...

Produced in different facilities, packaged in different ways. Not something I am concerned about, personally.

DNP is very yellow and is used in much higher doses. The amount of DNP needed to be of concern in a peptide vial would make it very obvious that something is wrong

Prescribed for visceral fat in HIV patients on specific medications - they often have significantly impacted IGF-1 levels and egrifta is used to bring it back into the normal range. https://pubmed.ncbi.nlm.nih.gov/15970280/ Personally, I think anyone with normal IGF-1 levels is increasing a...

Not actually trying to be funny there - just noting that the study doesn't account for what we might be doing. And who knows what all that might change! I find it plausible that under the right conditions, say, strong nutrient partitioning effects from AAS usage, increased lipolysis and...

I don't know that there's good science here to rely on, so it's largely conjecture by bro scientists on the internet. What we do know is that in the non-chemically assisted population, fasted cardio does not result in greater fat loss than non-fasted cardio, as long as other variables are...

Plenty of people freeze HGH - it's the same concerns as with most other peptides, ice crystals, etc., can cause issue from repeated thaw/freeze cycles. If you have thermal mass insulating things, have one of the vaccine freezers, etc., it's fine. I've got no concerns about freezing mine and...

We do not have in-vivo mechanistic research on why tesa would work more on VAT than GH and even the proposed reasoning by ChatGPT in the followup post after makes no sense - exogenous HGH would also bind more to VAT if it is a matter of increased receptor density. Plenty of people inject HGH...

To the best of my (non-expert) knowledge there is no reason to believe that tesa and HGH actually function any differently in regards to visceral fat. We do not know of any mechanism on which tesa acts on VAT or body fat in general outside of increased GH production.

Why do you think GH secretagogues don't carry the same risks as exogenous HGH dosed at levels to give you the same amount of GH/IGF-1/etc.? Because a GH secretagogue increasing your natural production to the same level as you would get from exogenous HGH carries those same risks. A tesa/ipa...

None of this matters for our purposes - our vendors are not declaring our shipments as items under FDA jurisdiction. The FDA won't review them unless CBP passes it along after it's already been seized, but it would already have to have been confiscated by CBP to begin with.

Monoclonal antibodies are massively more difficult to produce than peptides or steroids. It's not impossible - China produces plenty of monoclonal antibodies in general - but they're a lot more expensive and the production capacity is more limited in general. I wouldn't expect to see these in...

You don't need to freak out and massively change your diet if there's just one or two weeks of stagnation but fundamentally yes, you need fewer calories in. You might need to adjust your macro ratio if energy is a problem, or potentially look at intentional maintenance periods, carb cycling...

That's the problem - as much as we want to praise these drugs, they actually aren't magic in the bottle. They help us with the CI by reducing appetite and CO by increased metabolism (with reta). SGLT2 inhibitors help by preventing us from absorbing some glucose and instead pissing it out, so...

This is a lot of words that say absolutely nothing to dispel the facts of CICO. It basically just says that CO isn't a static number and is impacted by a lot of factors, including medication, hormones, etc. Which, well, yeah, of course. No one here is arguing otherwise. My experience is that...

About 1g per lb of lean body mass. As a newbie, pretty much any new stimulus to a muscle will work, but in the medium to long term, you have to take the muscle close to failure to provide it the level of stimulus needed to signal to your body to either preserve or grow it. I personally think a...

There have been a variety of people saying that that is explicitly their reason for using a CC on the forums over the time that I've been here. Also people that have opened paypal/alibaba disputes, etc. And vendors give chargebacks and disputes as explicit reasons as to why they don't accept them.

As someone who has been unfortunate enough to be hearing about crypto since you could get multiple bitcoin for a penny: Porn was not the primary use case for it. Just as it is with us, it was buying drugs. Silk Road was a big name, but drug buying sites on TOR predate crypto and they all...

Another +1 for acecosm. I grab my glutathione there, arrives quickly and in good condition. No real desire for the DIY botox that a lot of people use them for, though.

Doctors in America seem to really not know too much about it, somehow. My PCP didn't even realize it existed before I mentioned it to him the first time, said he'd read up on it. Next time I saw him he told me he was now presenting it as an option for patients where they're catching the...

Glad you were able to get on it and get a doctor willing to work with you. Sucks when they just ignore things that are important like the fact you're taking the same active ingredient in unknown quantities, purities, etc. as actual pharmaceuticals... I've actually swapped from rosuvastatin to...

There are thousands of factors that can impact your CO even if you are perfectly counting your CI. You're literally taking drugs that manipulate the CO. Again: This is governed by the laws of reality. Arguing against this is arguing against basic physics, and it's silly. Your body obeys the...

Yes

Sure - not saying they are. Just replying to the certain things getting triggered at certain peak concentrations - at that point, once the split dosing hits that trigger point, does split dosing become viable? Yeah. I'm definitely biased towards split dosing - just worked better for me on both...

Yeah, I've read the anecdotes. Personally, I've tried both when I was at lower dosages and seen no difference besides my RHR spiking more. Which raises the metabolism a bit, but... not much, and has other health concerns. (It spikes it too much now for me to even want to move from 5mg twice a...

Some peptides don't like it. Reta has a poor reaction, apparently.

Citation?

I do Wednesday and Saturday. Too lazy to perfectly do e3.5d or whatever I started at 2 and titrated a little faster than I did on tirz, but still mostly in the 3-4 week per range. The glucagon receptor activation is going to be a virgin response regardless of what dose you were on with tirz...

Because of how you were using handcuffs in private? Must have been some wild parties.

Yes. Human equivalent dosing compared to the rat studies is like 4mg/kg, but people swear it changed everything on the 250mcg doses. I'm pretty sure it's all placebo.

Most of the CN vendors here also offer HGH. Amount you need to do is highly variable. Most people will see replacement IGF-1 levels at 2-3IU and performance similar to secretagogues at 3-4IU. 4IU puts me significantly higher than the secretagogues did - about 150 more.

They certainly help with balance, but progressive overload resistance training is about the only form of exercise that gains muscle. Other stuff can do it with extremely high volume/repetitions over time (e.g. the muscles you build with physical labor) but vibration plates are not a method for...

SGLT2 inhibitors are interesting for a myriad of reasons, including looking to be quite cardio and renal protective even in non-diabetics, but the amount of weight loss they help with is pretty dependent on how carb heavy your diet is, and even on the high side, it's not anywhere near the realm...

Ultraprocessed foods are bad news for weight loss because they are extremely palatable and calorie dense. They also tend to have bad macros, so bad for your health for other reasons, but you can still lose weight with bad macros. But people fail to lose weight even when eating whole foods with...

Yup. Not really much for me to add here - well said. There's a huge variety of factors that make both halves of the equation very different for different people and someone can be doing the exact same thing as a skinny person and have basically no results. It sucks. And anyone that acts like...

Sure. I'm here too - on retatrutide as well. As I have noted multiple times, none of this is an indictment on her. I am not saying that the fact that CICO must work means there has been any sort of moral failing on anyone's part when they fail to lose weight when attempting to count calories...

I am explaining why it is physically impossible. You are making a fallacious argument from authority and insulting me. Can you explain how it is physically possible for something to come from nothing and you to be storing excess energy when you are in an energy deficit? Can you explain why you...

I'm not calling you a liar. I am saying you are misunderstanding what calories in, calories out means, or misunderstanding how physics works. I don't have to know your body because you are claiming that the laws of physics do not apply to you. If you are expending more calories than you are...

Except this article just says that calories out gets reduced for a variety of reasons. Which no one is debating. It doesn't mean that calories in, calories out is wrong. Because calories in calories out being wrong is physically impossible.

I don't mean to be rude and I don't want to discount your struggles, because it sounds like the CO is likely just not what it should be due to other issues, but it is impossible for CICO to not work. In a local frame of reference, energy is always conserved. This is one of the laws governing...

I think the fundamental problem is that while of course businesses in general can always change over time, in this space, those changes happen rapidly and often very decisively. The inertia from prior positive reviews would take time to overcome, or administration would have to step in and...