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At least dicks pills are useful, unlike gummies.

Eloranlintide has completed at least one phase 2 trial. Billings, et al. (pre-publication, 2025). Eloralintide, a selective amylin receptor agonist for the treatment of obesity - a 48-week phase 2, multicentre, double-blind, randomised, placebo-controlled trial. Lancet...

I lost 20 percent of my weight. However, I had to add a second weight loss drug to get there. I probably would have gotten to 20 percent on tirz alone if I could tolerated the maximum dose. I believe the people who are posting are on the high side of what people typically lose.

Great review.

Rabin (Nov. 25, 2025). Postpartum Prescription of GLP-1 Drugs Has Increased Sharply, Study Finds. By mid-2024, the weight-loss drugs were prescribed for almost 2 percent of new mothers. New York Times.

I looked at my hematocrit levels going back ten years. They've stayed about the same during that entire period, including the five readings taken since I started tirzepatide on August 5, 2024.

Fortunately, most of my communication about these peptides is written. That means I don't have to pronounce these words correctly. I only need to write about them. Forchunately Ime gud att speling. They're easier to spell and to pronounce if one simply sticks to the first syllable: tirz...

I don't view a vial that sends people to the emergency room as being analogous to a vial that tests at 87% percent. I'm not saying that folks should necessarily avoid HYB in the future; the unfortunate reality is that most of the folks that we buy from don't regularly test vials.

With current medications and weight loss surgeries, people generally lose more from surgery. I suspect as medications continue to improve, there will be less need for surgeries.

My endocrinologist has the lab measure my T3, T4, TSH and a variety of other things. I lack a thyroid glance. As a result, I'm dependent on levothryoxine.

If HYB says that it's a different batch, I'd believe HYB to the same extent as I trust vendors in general. You're better off testing. As to the recent incident showing that HYB is supposedly less concerned about safety than the other vendors, I'll share my assumption that vendors buy from...

You can. Just charge less. What you lack in accuracy you'll more than make up for in price.

No, every successful con man in history is both trusted and people think that the con man is trustworthy. The con man turns out to not be trustworthy,

Yura from HYB has already acknowledged that it's defective. There is no good reason for you to test an admittedly defective product. Contact a representative from HYB.

Don’t test it. Yura from HYB has advised people to contact their HYB representative and has admitted problems with their Reta.

Your comment is contradictory. If people think a person is trustworthy, then he is trusted.

That’s his actual name. Janoshik is his stage name. I heard him say so on a podcast.

Sixteen milligrams has been tested in a phase one trial and a phase two trial. The phase one trial results have been published in a peer-reviewed journal. The phase two trial results have not yet been published in a journal, however, they were presented in a poster presentation at the recent...

The whole idea of paying a lab to test is so that you can trust the lab. Go ahead and pick the cheapest lab. But if you're going do that, you might as well skip testing altogether. Just ask ChatGPT whether your peptides are safe. From the little I heard from Janoshik about Peptide Tests, he...

Then you should be able to purchase HYB reta from other users for very cheap. It reminds of the time when I had to flee an erupting volcano in Guatemala. Some people had built houses in areas that had been destroyed by a previous erupting volcano around 20 years earlier. Fortunately, the...

Equal capability to Jano? That would be ridiculously expensive. And it would be unnecessary in the US because there are plenty of substances that he handles that you would not be allowed to lawfully handle here. However, some of the largest costs will be hiring people with the skills to...

My liver numbers have gone down but are still elevated. They don't appear to be going down further. Before at least everyone assumed I had a fatty liver. But the liver doctor ruled that out with a Fibroscan. I received an elevated IGA test today, which can be a sign of liver problems, a...

HYB has acknowledged problem with some of its products and has offered a refund on them. If you belong to Meso, you can read about it here as described by Yura: https://thinksteroids.com/community/threads/hyb-best-service-and-product-international-shipping.134426680/post-3645266. I'm attaching...

I sure hope that is what it is. Wit that said, I wouldn't take a new batch of HYB reta out of the freezer to try right now.

I agree with you. It's not worth risking your job over something like this.

In contrast, retatrutide obtained a 24% weight loss at 48 weeks (Jastreboff, et al. (2023). Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial. New Eng. J. Med., 389(6), 514–526, https://www.nejm.org/doi/full/10.1056/NEJMoa2301972), 12 weeks less than the 60 weeks studied...

Innovent Biologics (Nov. 19, 2025). Mazdutide 9 mg Achieves Up to 20.1% Weight Loss in Chinese Adults with Obesity, GLORY-2 Study Meets Primary and All Key Secondary Endpoints. PRNewswire...

I inject myself once per day. I struggle to figure out what a medical professional would do to monitor dosing more than once per week. If you were using name brand, then there would some physical difficulty splitting the doses because the design of the pen. (I’ve split using a Zepbound pen...

It's a good question because a kit can mean all types of things. My personal pet peeve with GLP-1 terminology is the use of "unit" to refer to one hundredth of a cc (or ml). I'm used to unit meaning something more general. E.g., "Any determinate amount or quantity (as of length, time, heat...

I (a non-medical, not sciency person) interpret the article as you interpreted it other than the authors had included tons of caveats that you omitted. I believe you were just trying to be more bottom-line. They thought GIPR agonists would help people in the first catergory, but wanted the...

@JoonyO I didn't see the entire 50 shades of gray. I did watch part of the movie before becoming bored and turning it off. As a result, I figure I watched about 15-20 shades of gray.

I said "impaired enteroendocrine cell dysfunction" five times correctly (in my view). I said the phrase quite slowly. I also did not say it in front of people. I'm not going even try saying it fast five times; that would not work. That would be like me trying to jump twenty feet into the...

Not very well. Only that there are different people don't respond to GLP-1 drugs. And figuring out which reason applies may one day help turn those nonresponders into people who benefit from GLP-1 drugs.

Fajkić, et al. (2025). Decoding incretin resistance - a mechanistic framework to reclassify therapeutic variability for GLP-1 receptor agonist therapy. Amino Acids 57, 55.

Having seen the disaster of Ouisa Pharmacy in Florida, where I used to purchase my peptides until a few months before it actually was shut down, I know that at least in many states, regulation of compounding pharmacies is weak. The majority of compounding pharmacies are legally categorized such...

Bhattachar, et al. (2025). 882-P - Eloralintide, a Selective, Long-Acting Amylin Receptor Agonist for Obesity—Phase 1 Proof of Concept. Diabetes 74, Issue Supplement_1. https://diabetesjournals.org/diabetes/article/74/Supplement_1/882-P/159628. Billings, et al. (pre-publication, 2025)...

I believe the discussion was centered on whether people who lose weight on these drugs should generally be on them for life. You seem to be attacking something that no one advocated - that once a person takes these drugs that the person should necessarily be on the drugs for life. Just as a...

Wen (Nov. 13, 2025). Five key questions about GLP-1 weight loss medicines — What we don’t yet know about GLP-1s — and why it’s important to find out. Washington Post. Opinion Leana S. Wen Five key questions about GLP-1 weight loss medicines What we don’t yet know about GLP-1s — and why it’s...

I am listening to you, however, from what you describe, you have plenty of strength.

Nice to hear your aerobic fitness has been going up for the last two weeks.

I don't know the answer; I don't have diabetes myself. However, I do worry about you stopping the reta and starting a low dose (so you'll be able to tolerate it) of reta, and your diabetes being untreated. You could start at a higher dose of retatrutide, however, since it works on GCGR and...

I Google eloralintide and Janoshik. Nothing turned up. That was more for curiousity than for anything else.

Janoshik will never certify anything is safe. He doesn't have the ability to test for everything.

He recommends "sterile water" for reconstituting peptides for people to use themselves.

If Janoshik filtered peptides before conducting a sterility test, then it seems like every sterility test would result in a negative.

I did hear a podcast with Janoshik. He does prefer sterile water to BAC water. I don't recall him in the podcast I heard mention filtering. I do recall that when asked how long a person you use a peptide reconstituted with sterile water, he didn't say anything that specific. Granted we could...

That does make sense. Filtering before a sterility test would render the test useless.

Janoshik wrote: "Sterility generally is not an issue with lyophilizates. There are not too many microbes that can survive either lyophilization or months while lyophilized. Those that can are not quite likely to find their way into the vials." That's from...

I checked out whether the optimistic things you wrote squared with what I could find on Google Scholar. You're right. Sharples, et al. (2023). Skeletal Muscle Memory. J. Physiology - Cell Physiology 324(6), C1274-C1294...

Confession: I lost 15 pounds of muscle while losing 50 pounds on weight on tirz and reta. I believe some of this weight loss was pretty much inevitable; other than quitting my job, hiring a personal trainer, and completely devoting myself to fitness, I was going to lose some muscle. However...