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I’d stick with tirz and slowly add Reta while leaving the tirz dose the same. I’m trying to avoid having you regain wait during a transition from tirz to Reta.

There have been a variety of scholarly articles extolling the virtues of GLP-1 drugs for treating a variety of ailments other than just diabetes and weight loss. Here is a rare negative article on GLP-1 drugs. It concludes that while people lose weight on GLP-1 drugs, their aerobic fitness...

I don't listen to Taylor Swift. I wouldn't know.

The US military didn't design the epipen. Nor did the US military design the ComboPen, a predecessor to the epipen that permitted administration of another drug. Survival Technology Inc. (STI) invented both. Although a team invented them, the name most frequently associated with the invention...

By the way, what's great about eloralintide is that it works by different means than most GLP-1+ drugs. That means it's ideal for stacking.

Should I have avoided posting the article? The rationale for not posting the article, at least as I see in retrospect, is not because of what the article says about free market economy, but because it directly criticizes Trump. Criticizing Trump or any Democrat who looks like they might run...

Agreed. And I'm not good at enduring suffering. I don't want to be.

Some folks view overeating as a sign of a lack of self-discipline. I look at myself and how I manage to control my appetite through medication as an example of me exercising self-discipline to achieve a goal than I otherwise couldn't achieve. I am proud of myself for losing weight. But I...

I've attached a paywall-free editorial from the Wall Street Journal arguing (1) the recent price cuts that Trump negotiated would likely have happened without Trump's intervention and (2) arguing that the US government is too aggressive in trying to find antitrust violations and trying to lower...

I did have elevated levels of ALT. They were 10 times the upper limit of normal. I wasn't willing to try anything for my liver without the approval of the hepatologist. I'm not saying that something would or would not have worked; I'm just explaining what I thought. Neither the hepatologist...

Weight loss drugs in general will tend to reduce liver fat. However weight loss drugs that agonize (activate) the glucagon receptors (GCGR) result in a greater reduction in liver fat. Liver fat is bad. You want the level of liver fat to be low. Mazdutide and survodutide are, in part, GCGR...

I later spent hours looking up the sources. The above chart provides correct data. I hadfolks who seemed like they understood biology and pharmacology far better than I do caution me against relying much on the data in the chart as a user of peptides to decide what will work best for me. There...

Getting result that are close to those provided by reta requires using doses of 10-16 mg of mazduride. I’m going by the mazduride studies, which did not directly compare reta to maz. There was recently a 48 week trial conducted using maz at 10 and 16 mg doses.

No side effects? That's great!

All your fault? You did get scammed. But it's easy to see how you were scammed. I ended up making a bad purchase too. It's quite common. Be very careful. Hopefully what you wrote will encourage folks to be more cautious. (Considering that we don't know where the people who scammed you are...

These medicines are not tested using once per day dosing. That's a good reason not to the newer GLP-1 medicines once per day. I take them once per day to give my body a chance to adapt. This also avoids the peaks and valleys. I believe the once per week dosing is based upon most people not...

I won't ignore you: I also take tirzepatide. I take 1.1 mg per day. I don't exceed that dose for tirzepatide because it tends to make me tired and causes GI problems when I exceed that.

The article is not paywalled, but it's close: When I opened it in my incognito tab, it required that I set up a free Washington Post account where they'd send me spam to encourage me to join. Try this: Gilbert2.pdf. I printed out a .pdf of the same article.

The approaches used in the trials are not set in stone. Nor is the advice given by the FDA approved instructions as to dose to be applied religiously. I'm not sure that our actual approach is that different.

I use a quite unconventional dosing schedule. For most folks, it's overly complicated. I use an Excel sheet I found on Peppys that calculates how much mazdutide I have in the body. That figure is on the right. The figure on the left is how much I inject each day. As you can see, I ignore the...

If you read jellybelly54's post, he (or she) suggests that he followed the links from Alice's official vendor page. "So I thought this would be a good place to order my first order of peptides. Clicked on the links underneath the vendor. Took me to the discord page. Started a communication with...

Gilbert is the last name of the author.

Reta is fine but it creates problems with some people. Both semaglutide and tirzepatide created problems for some folks too. I personally use mazdutide. I'm not going to tell you whether it works for me or not because I started just a few weeks ago.

I am definitely not a fan of Donald Trump. However, this looks quite good so far, with the government pressuring two big drug companies to lower prices with assurances, I suspect, that far more people will be using the drugs. The drug companies still make large amounts of money -- as they...

Gilbert (Nov. 7, 2025). What you need to know about Medicare coverage for weight-loss drugs - Experts call President Donald Trump’s deal with drug companies a breakthrough, but details of how it will work are still emerging. Washington Post, paywall-free link: https://wapo.st/3WGwP87

Considering my success I also see little reason to stop. I was unable to lose much weight without these drugs and even the weight I lost I was unable to keep off.

See also Hsia, et al (poster presentation, Obesity Week 2025). Eloralintide Phase 2 Study in Adult Participants With Overweight or Obesity - Design and Study Population...

In this 48 week study, mazdutide was given in different dosages. The study lasted 48 weeks. People who took 16 milligrams of mazdutide lost slightly over twice as much weight as those taking only six milligrams. Granted the people taking six milligrams actually spent the majority of their time...

She is a legitimate vendor. By that, I mean she has fulfilled purchases before. I do note that she promises to reship stuff if you have customs problems. I don't actually understand her message. Ask for clarification. But I wouldn't send any additional money to her other than for a new order...

@ZippityDooDah Maybe it's time to create a new category for eloralintide. It's an amylin-based weight loss drug. Right now, most weight loss drugs are what are referred to as GLP-1 drugs, including drugs that only work on the GLP-1 system and drugs that also work on the glucagon and/or GIP...

I had never considered that something like this would help folks lose weight. Singh, et al. (2025). Duodenal Mucosal Resurfacing Stabilizes Weight Loss After Glucagon-Like Peptide 1 Receptor Agonist Withdrawal. Poster at Obesity Week 2025...

The farther one deviates from the conditions in a study, the less likely the results in the study will apply to that person. I agree that individual outcomes different from group outcomes. So are group outcomes irrelevant? Not at all. If a drug was tested in a large group and in general...

I actually don't remember. I remember when I looked up what to do, it looked quite complicated.

I'd also be willing to use my Hospira water past 2036. As a practical matter, although I have over a case of Hospira water right now, it won't be around then. I'll either have used up my BAC water reconstituting peptides within a few years of now or I'll have thrown away the BAC water. I'm...

The official answer is that once a vial of BAC water has been punctured, it should be used with 28 days. After that, it should be discarded. However, that advice is given for hospital settings, where there are often multiple patients and tons of germs around. Most folks who use BAC water for...

The Chinese manufacturers also believe in having high standards. Just state what standard that you want them to meet and they'll assure you that they're complying with it.

Here is an updated list, part II: List of Reta Sources Tewari, et al. (2025). Efficacy and safety of triple hormone receptor agonist retatrutide for the management of obesity - a systematic review and meta-analysis. Expert Rev. Clin. Pharmacology, 1–16, doi.org/10.1080/17512433.2025.2450254...

Here is an updated list, part III: List of Reta Sources Martins, et al. (2024). Glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide agonists for the treatment of obesity and diabetes mellitus. Exploration Drug Sci., 2, 126-143, doi.org/10.37349/eds.2024.00039. Melson, et...

Here is an updated list, part II: List of Reta Sources Hong & Choi (2024). Gut Hormones and appetite regulation. Curr. Opn. Endocrinology Diabetes & Obesity 31(3), 115-121. Jastreboff, A. M., Kaplan, L. M., Frías, J. P., Wu, Q., Du, Y., Gurbuz, S., Coskun, T., Haupt, A., Milicevic, Z., &...

Here is an updated list, part I: List of Reta Sources Abouelmagd, et al. (2025). Efficacy and safety of retatrutide, a novel GLP-1, GIP, and glucagon receptor agonist for obesity treatment - a systematic review and meta-analysis of randomized controlled trials. Baylor Univ. Med. Ctr...

You wrote the best, in my opinion, that appears in the thread. However, based upon the screenshot posted by @frankpeptid, it appears one has request the additional names on the CA when placing the order with Janoshik. https://glp1forum.com/attachments/unnamed-png.9520/

Only 99%. Where does the other 1% come from?

You can find the US manufacturers right next to the unicorns.

At best, Nexaph lyophilizes the peptides here. But Cain has a history of lies. I'm not criticizing Nexaph product or customer service.

I haven't taken survodutide. I'd be reluctant to take it because it is less well studied than the FDA approved drugs and reta. Also it seems to carry more side effects than the other weight loss drugs. It seems like it will turn out to be reasonably effectively, probably stronger than...

I'm glad that you'll use them. I know that most folks, certainly including me, it is hard to read and understand the scientific articles. I'm much better and finding and getting copies, when necessary, of the studies than at being able to interpret them. It was easier compiling something on...

Arun, et al. (pre-publication, 2025). Survodutide- A Dual GLP-1 - Glucagon Agonist Reshaping Cardiometabolic Care. Cardiology Rev., https://doi.org/10.1097/crd.0000000000001062. Awad, et al. (2025). Evaluating the efficacy and safety of survodutide for obesity - a systematic review and...

I can imagine the report to the FDA: "I bought GLP-1 from a vendor called Homopeptide and ever since I purchased that vial, I've been having gay sex twice a day. But I'm not gay. Really. I'm not that type of person."

I don't worry about situations like that since I know that my farts smell great.

Is there a reason that you're not waiting to see if a higher dose of tirz will work better?