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Previously, California had passed a few measures temporarily permitting people to possess needles and syringes without a prescription. Those laws were to expire on January 1, 2026. However, those have since been made permanent. Still only doctors and pharmacists, and in some cases...

Rabin (Nov. 25, 2025). Postpartum Prescription of GLP-1 Drugs Has Increased Sharply, Study Finds. By mid-2024, the weight-loss drugs were prescribed for almost 2 percent of new mothers. New York Times.

Innovent Biologics (Nov. 19, 2025). Mazdutide 9 mg Achieves Up to 20.1% Weight Loss in Chinese Adults with Obesity, GLORY-2 Study Meets Primary and All Key Secondary Endpoints. PRNewswire...

Fajkić, et al. (2025). Decoding incretin resistance - a mechanistic framework to reclassify therapeutic variability for GLP-1 receptor agonist therapy. Amino Acids 57, 55.

Bhattachar, et al. (2025). 882-P - Eloralintide, a Selective, Long-Acting Amylin Receptor Agonist for Obesity—Phase 1 Proof of Concept. Diabetes 74, Issue Supplement_1. https://diabetesjournals.org/diabetes/article/74/Supplement_1/882-P/159628. Billings, et al. (pre-publication, 2025)...

Wen (Nov. 13, 2025). Five key questions about GLP-1 weight loss medicines — What we don’t yet know about GLP-1s — and why it’s important to find out. Washington Post. Opinion Leana S. Wen Five key questions about GLP-1 weight loss medicines What we don’t yet know about GLP-1s — and why it’s...

There have been a variety of scholarly articles extolling the virtues of GLP-1 drugs for treating a variety of ailments other than just diabetes and weight loss. Here is a rare negative article on GLP-1 drugs. It concludes that while people lose weight on GLP-1 drugs, their aerobic fitness...

I've attached a paywall-free editorial from the Wall Street Journal arguing (1) the recent price cuts that Trump negotiated would likely have happened without Trump's intervention and (2) arguing that the US government is too aggressive in trying to find antitrust violations and trying to lower...

Gilbert (Nov. 7, 2025). What you need to know about Medicare coverage for weight-loss drugs - Experts call President Donald Trump’s deal with drug companies a breakthrough, but details of how it will work are still emerging. Washington Post, paywall-free link: https://wapo.st/3WGwP87

In this 48 week study, mazdutide was given in different dosages. The study lasted 48 weeks. People who took 16 milligrams of mazdutide lost slightly over twice as much weight as those taking only six milligrams. Granted the people taking six milligrams actually spent the majority of their time...

@ZippityDooDah Maybe it's time to create a new category for eloralintide. It's an amylin-based weight loss drug. Right now, most weight loss drugs are what are referred to as GLP-1 drugs, including drugs that only work on the GLP-1 system and drugs that also work on the glucagon and/or GIP...

I had never considered that something like this would help folks lose weight. Singh, et al. (2025). Duodenal Mucosal Resurfacing Stabilizes Weight Loss After Glucagon-Like Peptide 1 Receptor Agonist Withdrawal. Poster at Obesity Week 2025...

Arun, et al. (pre-publication, 2025). Survodutide- A Dual GLP-1 - Glucagon Agonist Reshaping Cardiometabolic Care. Cardiology Rev., https://doi.org/10.1097/crd.0000000000001062. Awad, et al. (2025). Evaluating the efficacy and safety of survodutide for obesity - a systematic review and...

I saw a chart repeatedly showing the supposed potencies of different weight loss drugs in humans. I assumed that the information in it was wrong, but when I checked, everything matched scholarly sources. The profiled drugs are semaglutide, tirzepatide, retatrutide, mazdutide, and survodutide...

BMI is being de-emphasized in medicine. See Rubino, et al. (2025). Definition and diagnostic criteria of clinical obesity, Lancet Diabetes & Endocrinology, 13(3), 221-262 [attached]; Fourman, et al. (2025). Implications of a New Obesity Definition Among the All of Us Cohort. JAMA Network Open...

I finally succeeded in getting ChatGPT to translate the prescribing information for Mazdutide for diabetes and for obesity. This is a translation of the information used by Chinese doctors when prescribing Mazdutide. Mazdutide prescribing instructions for diabetes Mazdutide prescribing...

This systematic review found that that tirzepatide 10-15 mg caused more weight loss than 2.4 mg of sema (the maximum dose) while resulting in fewer side effects. This is the first scientific thing that I read that confirmed what has been reported on social medial by people who have taken both...

This paywall-free articles discusses the use of GLP-1 drugs for drug addiction: Szalavitz (Oct. 14, 2025). Opinion - The Drug That Took Away More Than Her Appetite. New York Times...

Which GLP-1 drugs most strongly affect the GLP-1 system? I know between tirzepatide, retatrutide, and semaglutide, semaglutide is the strongest. My FEELZ test says that tirzepatide more strongly affects the GLP-1 system than retatrutide but that's not based on reading anything scientific...

Here are some scholarly articles on mazdutide. I included hyperlinks to the full articles for most but not all of the citations. I used bold type for the article that I believe to be most revealing. Anderson (2025). Emerging concepts in obesity managemen -: focus on glucagon receptor agonist...

https://www.fiercepharma.com/pharma/china-approval-lilly-and-innovents-mazdutide-breaks-new-class-glp-1-obesity-drugs

I sometimes hear people complain about difficulties in obtaining syringes. Sometimes those folks are from California. California laws permits, but does not require, that pharmacies sell syringes without a prescription. There is no maximum number of syringes. I purchased two one-hundred...

Has my item already passed through customs from the United Arab Emirates into the United States?

WSJ, This Hated Stock Siddenly Looks Like An Obesity Bargain: Pfizer’s latest deal could make it the budget entry-point to the weight loss bonanza. https://www.wsj.com/health/pharma/pfizer-stock-obesity-investment-bargain-7cdb6ca2?st=Samwmz

FDA Demurs on GLP-1 Compounding Fight, Debuts Consumer ‘Green List’ Instead This article argues that the FDA's green list of approved API providers is bad for Eli Lilly and Novo.

I wanted to warn folks about a low probability event: an adverse liver reaction to a GLP-1 drug. For background, my doctor said that I most likely experienced a drug-induced-liver injury (DILI). I have no noticeable symptoms but do have ALT levels 10 times the upper limits or normal and also...

I saw at least two vendors who posted stuff today. Those who are low on peptides and worried may choose to look in the vendor forum and contact those. I'm sure there are other vendors who are still active.

The Indian online pharmacy, PCT 24X7, recently informed me that they could ship to the US but that I'd have to pay the 20% tariff. I wonder if us paying tariffs is the way of the future for Chinese research peptides.

Where would be able to buy Tazorac (tazarotene) without a prescription? Is now just a bad time to buy overseas pharmaceuticals?

During the last two weeks, I've had far more gas and bloating than before. Feeling uncomfortable has made it hard for me to sleep at times. While GLP-1 do cause me to experience gas and bloating, I didn't understand why it was much worse during the last two weeks. Then I finally figured it...

I have a link in my signature to the Peptide Group Buys user guide. The only problem is that when I clicked on it most recently, it didn't work. Does anyone have the current link?

What happened to vendor forums? It looks like most posts have been deleted.

My understanding is that folks on Medicare have to pay a much higher cash price for tirzepatide and semaglutide than other folks whose insurance doesn't cover these drugs. Is that an intentional decision on the part of the manufacturers? Or is that mandated by U.S. law?

The New York Times published an article entitled "Pill Causes Major Weight Loss in Eli Lilly Trial’s Results - The company said it planned to seek Food and Drug Administration approval for the drug, orforglipron, before the end of the year." The link does not contained a paywall...

Pill Causes Major Weight Loss in Eli Lilly Trial’s Results: The company said it planned to seek Food and Drug Administration approval for the drug, orforglipron, before the end of the year. Here is a link to a New York Times article on the subject. There is no paywall...

My 34" waist pants are beginning to be a little loose. I bought some 32" waist pants and they fit. Yet when I measured my waist at the thinnest place between the hips and the ribs, I measured 36 1/2." Why is there a discrepancy?

SRY has posted some COAs from Janoshik and some from Chromate. Does anyone have any opinion as to Chromate itself? (I'm not asking whether a vendor sends only good stuff to the lab; a vendor can do that when it arranges testings regardless of the quality of the lab.)

Does anyone know what my ultrasound from today shows? I don't see the endocrinologist until Friday of next week. This is what the radiologist wrote: US Abdomen Complete REASON FOR EXAM: Metabolic dysfunction-associated steatotic liver disease (MASLD) COMPARISON: None TECHNIQUE...

Washington Post, Americans spent $71 billion on GLP-1 drugs in 2023 - 
Spending on Ozempic, Wegovy and similar prescriptions soared 500 percent in five years, according to a research letter (Apr. 21, 2025), unlocked article. https://wapo.st/3RN38jj

Wall Street Journal, Americans Are Obsessed With Protein and It’s Driving Nutrition Experts Nuts - Food companies pack the nutrient into candy, coffee and even water; ‘How about a chicken breast, people?’

WSJ, Lilly’s First Pill for Diabetes, Weight Loss Shows Positive Study Results: The drug helped lower blood sugar and cut an average of 16 pounds, unlocked article...

Wall Street Journal, Trump Administration Rejects Expanding Medicare, Medicaid Coverage of Obesity Drugs - Biden administration had proposed late last year coverage of the popular medicines for obesity (Apr. 4, 2025), no paywall article.

Today Trump signed an order ending the de minimis rule. The de minimis rule was a tariff loophole on low cost items sent in small amount. Earlier this year, Trump signed an executive order to end the de minimis rule. However, a few days later, Trump backed off that rule. Members of this forum...

Young folks tend to lose more weight when they take GLP-1 drugs. Guo, et al. (2025) Comparative efficacy and safety of GLP-1 receptor agonists for weight reduction - A model-based meta-analysis of placebo-controlled trials. Obesity Pillars 13, 100162...

Women Get All The Breaks? Not really. However, according to the linked article, women do lose more than men when taking GLP-1 drugs. Yang, et al. (2025). Sex Differences in the Efficacy of Glucagon-Like Peptide-1 Receptor Agonists for Weight Reduction - A Systematic Review and Meta-Analysis...

New York Times, Why Ultrathin Is In - When it comes to fashion models, the body diversity revolution appears to be at an end (March 20, 2025), unlocked article, https://www.nytimes.com/2025/03/20/style/ultra-thin-models.html?unlocked_article_code=1.5k4.sSDm.uApVijucjoER&smid=url-share I was...

New York Times, How Much Should Weight Loss Drugs Cost? A new study found that fair prices for medications like Wegovy and Zepbound would be hundreds less per month than they are now (March 14, 2025), unlocked...

Does anyone have any opinions as whether retatrutide or tirzepatide causes greater gastrointestinal symptoms (e.g., bloated stomach, gas, burps, stomach ache, constipation, diarrhea, )? If so, please share.

The new name for Amolist is Bfflist. I guess that they ran out of suffixes to add to Amo. The new website, https://bfflist.com, is still under construction although you can see a little bit of the site.

What does "sterile" mean? Specifically, when a healthcare worker uses the term "sterile," what does a healthcare worker mean? When I looked up "sterile" in two dictionaries, I saw two definitions, both of which were better than the others, but which seem to have problems. Definition one...