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DMs from two different people I've received in the last hour:

Do you lie about people on other platforms too or just this one? In response to @nccane on that other platform, someone had this to say: That's how I conduct myself on other platforms. But when people completely ignore the science and just talk shit like you've done? Don't play innocent and...

No, I'm here to talk science. Are you?

I am "in my feelings" because I said the following to you? After which you cried about me being condescending? Textbook case of projection. You were so butthurt that you had to go whine about me being "condescending" on another platform. 🤣

You conveniently omitted the part about vendors now offering pH-buffered cagrilintide, in response to demand from customers. You were the first to make a market argument (that cagri promos are selling out). I responded with a market argument. Both show demand, except mine demonstrates a...

Let me get this straight. You reply several times to my post, never addressing any of the actual science in it, but instead repeatedly launching ad hominems, personal insults, conspiracy theories about my "true" identity, and lies of omission to misrepresent me. But I'm the "giant asshole"...

Here's exactly what happened. I said the tide has been turning of late about this cagrilintide topic. You denied it. I suggested maybe you're just not up to date, and I pointed to evidence: multiple people within the chat including the server owner who said they had finally been persuaded by...

My concerns are in my original post. Read that, and your question is already answered. 🙄

You are very confused...

Once again, I'm not concerned in the slightest about fibrils.

You cited the same article that I already cited first. It's literally the first link on my list of citations. Except it proves my point, not yours. 🙃

I already linked to this article in my original post and heavily quoted from it, as well as several other sister reports from Novo. Clearly you never read my post to begin with if you think your post somehow counters it. 🙃

Maybe you should stop defaulting to sharing misinformation? 🤔

I literally just shared direct quotes from Novo Nordisk about their own drug. Which of their statements do you consider 💩?

Yeah, a handful of people still can't tell we have entirely different personalities, but most people have it figured out.

Here's something I wrote. Does it answer your question? Cagrilintide retains the three proline substitutions that pramlintide made to human amylin to make it resistant to fibrillation, but it has four more improvements: While pramlintide has a short half-life and must be dosed multiple times...

What's the point in sharing this? Novo themselves literally said Cagrilintide forms fibrils.

that was funny the other 10 times you said it in Discord.

I sure thought that was strange. I took myself out of the equation by making it all about direct Novo quotes and people still want to shoot the messenger.

Not at 100 yet, but I'm working on it. Posts like this are the fruits of my epic stack.

Fibrils are of secondary importance in this discussion. You could almost leave them out of it. The real toxic species are oligomers. Oligomers eventually become fibrils, but they raise a lot of hell on the way. And yes, they subjected many different amylin analogues to mechanical stress to...

The other significant omission you made was the "based on a test" part, referring to anyone pushing a test result conducted without using SEC at a bare minimum. This is not just about the opinions held by randos.

i don't believe i've used any lofty language...? can you point out what you think the big words are?

This is my only name. I just now tried to tag you on PTDS but it looks like you were kicked out?

I plead ignorance.

what kind of answer are you looking for? Someone shared to Discord a link to the recent fibril post here. I reviewed it, and thought, these guys might appreciate a thorough examination of everything that Novo had to say about the topic.

you wouldn't be the first to make that mistake, but stick around and you'll figure out our personalities couldn't be more different

Why, when I offered two possibilities there, did you pretend like I offered only one?

Which ones would you like to see?

Did I say anywhere that people who disagree with my assessment have ulterior motives?

Citations [1] https://pubs.acs.org/doi/10.1021/acs.jmedchem.1c00565 [2] https://www.jbc.org/article/S0021-9258(20)88558-5/fulltext [3] https://onlinelibrary.wiley.com/doi/10.1002/oby.23329 [4] https://pubs.acs.org/doi/10.1021/acs.jmedchem.4c00022 [5] https://pubmed.ncbi.nlm.nih.gov/33544470/ [6]...

“Some of these toxic oligomeric species are associated with beta-cell death and the progression of type 2 diabetes (16−18)” Here, they cite research showing that not fibrils, but toxic oligomers are what cause the death of the insulin-producing beta cells in the pancreas. This is from the first...

In Novo’s Own Words: Degradation of Amylin Analogs Such as Cagrilintide (and How to Test For It) “A hallmark of the pancreatic hormone amylin is its high propensity toward the formation of amyloid fibrils, which makes it a challenging drug design effort.” So begins Novo Nordisk’s excellent...