Administration of lower dose of Tesa if stacked with GHS (Ipamorelin)?

[MassDebater]

Regarding the dosage of Tesamorelin, the standard reference for its efficacy is the Phase III clinical trials published by Falutz et al. (2010) in the New England Journal of Medicine, which concluded that the 2mg daily dose is the threshold required for statistically significant reductions in visceral fat. However, these findings are based solely on the administration of Tesamorelin as a monotherapy. Since GHRH compounds are inherently limited by somatostatin activity, and because GHS compounds like Ipamorelin are known to significantly inhibit somatostatin, could the same statistically significant effects of a 2mg dose from tesa be achieved with only 0.5mg or 1mg if stacked with a "decent" enough dose from Ipamorelin? I primarily ask this question because much of the anecdotal evidence from users stacking 2mg of Tesamorelin with 300mcg (or other significant doses) of Ipamorelin describes the experience as 'overwhelming' in terms of side effects and intensity. From this anecdotal "suggestion", I would assume that Ipamorelin likely upregulates the body's response to Tesamorelin, potentially allowing for a lower, more efficient dose to achieve the same elevated growth hormone levels.

 

[Calm Logic]

Yes, the combination of both is assumed to be more cost effective than tesa alone.

Some general info from AI (Gemini):

Feature	Tesamorelin Alone	Tesa + Ipamorelin Stack
Typical Dose	1.4 mg – 2 mg	1 mg Tesa + 150 mcg Ipa
Water Retention Risk	Low-Moderate	Moderate-High
Schedule	5 days on / 2 days off	Strict 5 days on / 2 days off
Best For	Visceral fat loss / Minimal sides	Max fat loss / Muscle fullness

Feature	Tesamorelin Alone	Tesamorelin + Ipamorelin
Primary Goal	Targeted belly fat reduction	Max GH pulse / Muscle building
Hunger	No effect on appetite	Possible slight increase
Potency	High (for fat loss)	Very High (synergistic)
FDA Status	FDA Approved (for lipodystrophy)	Not FDA Approved
Water Retention	Moderate risk	Higher risk

Though many people on tesa alone will complain of carpal tunnel, that is mostly dose-dependent. Tesa at 1 mg may be more like placebo vs. 2 mg for carpal tunnel symptoms.

As with HGH, the water retention may be managed by 5 days on, 2 days off, along with staying hydrated and taking more taurine, potassium, and magnesium (to reduce the sodium-based water pressure pushing on the nerves):

https://thinksteroids.com/community/threads/cycle-to-get-huge.134433545/post-3648069

Take 5g of taurine a day when using GH, to prevent/lessen [carpal tunnel syndrome].

 

[deplam]

I keep my hospira back water in the fridge after it's open though. Unopened I keep it in room controlled room temperature. I'm also aware that in the summer some people turn up the air a little to about 80 -81 just to keep energy cost low at home but I think that's a little warm so I moved my supply into my office. Lol