Am I overthinking my dosing math?

[JellyBellyBilly]

For some reason, I cannot wrap my head around this. I have been using compound tirz for my research, and been looking to find ways to save money during our trials.

Current vial from pharmacy : 5mg/0.5ml

The doctor wanted our subject to up their to the next step up. I assume the pharmacy vial will say 10mg/1ml.

The subject is taking 25 units right now.

My question is, what the subject taking 2.5mg doses, or 1.25mg doses? Or would the pharmacy really be putting 10mg/1ml into the vial, which 25 units would then be 2.5mg doses?

If we were to buy 20mg vials for our research, and the reconstitute with 1ml, then 25 units would be considered the 5mg dose?

Sorry for the confusion. I think I may have gotten myself all mixed up.

 

[clayd]

25 units from a 5mg/0.5ml vial is a 2.5mg dose.
you're right that 10mg/1ml would result in the same dose at 25 units.
the pharmacy should either increase the concentration per ml or increase the number of units if the prescriber wants you to move up to 5mg.

and yes if you bought 20mg vials and added 1ml liquid, 25 units would be 5mg dose

 

[clayd]

easy way to think about it.

Divide mg in the vial by size of your dose. for example 20mg vial / 5mg dose = 4 doses in the vial. or 30mg in the vial / 10mg dose = 3 doses in the vial.

divide the amount of liquid you added by the number of doses in the vial. for example 1ml liquid / 4 doses in the vial = 0.25ml per dose, which is the same as 25 units. 1ml liquid / 3 doses in the vial = 0.33ml or 33 units per dose.

just divide the amount of liquid by the number of doses in the vial and there's your dose volume

 

[JellyBellyBilly]

easy way to think about it.

Divide mg in the vial by size of your dose. for example 20mg vial / 5mg dose = 4 doses in the vial. or 30mg in the vial / 10mg dose = 3 doses in the vial.

divide the amount of liquid you added by the number of doses in the vial. for example 1ml liquid / 4 doses in the vial = 0.25ml per dose, which is the same as 25 units. 1ml liquid / 3 doses in the vial = 0.33ml or 33 units per dose.

just divide the amount of liquid by the number of doses in the vial and there's your dose volume

Perfect! Thank you for that! I thought I was on the right track. If we did 20mg vials, with 1ml, then 25 units is 5mg. Then when titrating up, doing 2ml would make 75 units be 7.5?
Just making sure I understand the math.

 

[TangoSix]

to your last question, 5 mg would be 25 units with 20 mg vial mixed with 1ML bac water

Peptide Dosage Calculator

The peptide dosage calculator will tell you how far you need to pull the syringe to get the dose you need.

www.omnicalculator.com

 

[clayd]

Perfect! Thank you for that! I thought I was on the right track. If we did 20mg vials, with 1ml, then 25 units is 5mg. Then when titrating up, doing 2ml would make 75 units be 7.5?
Just making sure I understand the math.

The math is correct, yes.

But you don't have to increase the liquid when titrating up if you don't want to. You could still do 1mL of water and then your 7.5mg dose is 37.5 units instead of 75. It's fine either way, some people prefer to inject less volume.