BNLFL
GLP-1 Specialist
Appetite Suppression Ranking of the GLPs?
- Thread starter dirtyharry
- Start date
Good question, and honestly the answer is more interesting than people expect because these three compounds don't suppress appetite the same way at all, even if the end result on the scale looks similar.
My personal ratings, 1-10:
Semaglutide: 6/10. Solid, steady, kind of a "background" suppression. You notice you're just not thinking about food as much, but if food is in front of you, you'll still want it. Cravings stay mostly intact.
Tirzepatide: 8/10. This one is on another level for pure appetite shutdown. The GIP component seems to amplify the satiety signal hard. I'd get full from half a plate and the thought of eating more felt almost physically off-putting. Strongest hunger killer of the three by a clear margin in my experience.
Retatrutide: 5/10. And this is where it gets interesting, because on paper you'd expect reta to suppress the most, given it's a triple agonist. But the appetite suppression itself is actually milder than tirze for me, and a notch below sema too.
So why is reta still working so well if the hunger suppression is the weakest of the three? This is where the glucagon agonism completely changes the game, and I think a lot of people miss this when they compare compounds purely on "how much does it kill hunger."
What I notice on reta that I didn't get on the other two:
No alcohol cravings at all. Like, zero pull. Sema and tirze reduced it a bit, but with reta the desire just isn't there. There's actually emerging literature on GLP-1s and reward pathways (a lot of the addiction/alcohol use disorder trials are running on sema and tirze right now), but anecdotally reta hits this harder for me. Might be the glucagon component amplifying the dopaminergic effects, might be something else, but the effect is real.
Sweet cravings are way down. Sema and tirze killed hunger but I still wanted sweets specifically. On reta the actual desire for sugar isn't there. Big difference between "I'm not hungry" and "I genuinely don't want that donut." Reta does the second one.
Energy is noticeably higher. This is the glucagon receptor agonism doing its thing. Glucagon increases hepatic glucose output and bumps up resting energy expenditure, basically your body is running a bit hotter. You feel it. On sema and tirze in a deficit I'd get the typical lethargic, cold-hands, low-energy diet feeling. On reta I'm in a deficit and I still feel like training, still warm, still sharp. That's a huge quality-of-life difference when you're cutting.
So the way I'd frame it for anyone choosing between them:
If your problem is pure volume of food / can't stop eating, tirze is the strongest tool.
If you want steady, sustainable, mild suppression with a good safety record, sema.
If your problem is cravings (alcohol, sweets, reward-driven eating) and you want to actually feel good while losing fat, reta is in a different category.
The appetite number doesn't tell the whole story with reta. It's working on the metabolic side as much as the appetite side, and that's why people are getting these crazy recomp results even at modest doses.
My personal ratings, 1-10:
Semaglutide: 6/10. Solid, steady, kind of a "background" suppression. You notice you're just not thinking about food as much, but if food is in front of you, you'll still want it. Cravings stay mostly intact.
Tirzepatide: 8/10. This one is on another level for pure appetite shutdown. The GIP component seems to amplify the satiety signal hard. I'd get full from half a plate and the thought of eating more felt almost physically off-putting. Strongest hunger killer of the three by a clear margin in my experience.
Retatrutide: 5/10. And this is where it gets interesting, because on paper you'd expect reta to suppress the most, given it's a triple agonist. But the appetite suppression itself is actually milder than tirze for me, and a notch below sema too.
So why is reta still working so well if the hunger suppression is the weakest of the three? This is where the glucagon agonism completely changes the game, and I think a lot of people miss this when they compare compounds purely on "how much does it kill hunger."
What I notice on reta that I didn't get on the other two:
No alcohol cravings at all. Like, zero pull. Sema and tirze reduced it a bit, but with reta the desire just isn't there. There's actually emerging literature on GLP-1s and reward pathways (a lot of the addiction/alcohol use disorder trials are running on sema and tirze right now), but anecdotally reta hits this harder for me. Might be the glucagon component amplifying the dopaminergic effects, might be something else, but the effect is real.
Sweet cravings are way down. Sema and tirze killed hunger but I still wanted sweets specifically. On reta the actual desire for sugar isn't there. Big difference between "I'm not hungry" and "I genuinely don't want that donut." Reta does the second one.
Energy is noticeably higher. This is the glucagon receptor agonism doing its thing. Glucagon increases hepatic glucose output and bumps up resting energy expenditure, basically your body is running a bit hotter. You feel it. On sema and tirze in a deficit I'd get the typical lethargic, cold-hands, low-energy diet feeling. On reta I'm in a deficit and I still feel like training, still warm, still sharp. That's a huge quality-of-life difference when you're cutting.
So the way I'd frame it for anyone choosing between them:
If your problem is pure volume of food / can't stop eating, tirze is the strongest tool.
If you want steady, sustainable, mild suppression with a good safety record, sema.
If your problem is cravings (alcohol, sweets, reward-driven eating) and you want to actually feel good while losing fat, reta is in a different category.
The appetite number doesn't tell the whole story with reta. It's working on the metabolic side as much as the appetite side, and that's why people are getting these crazy recomp results even at modest doses.
Been on Reta for 10 weeks, up to 4mg. I started feeling slight appetite suppression at 2mg but never really felt much until 4mg. It still doesn’t really suppress my appetite, it just makes me feel kinda full already and makes me get fuller faster.
Calm Logic
GLP-1 Specialist
Tirz can increase thermogenesis (energy use) using GIP-based "futile calcium cycling." But probably at least 10x less energy use than reta's glucagon-based thermogenesis. And reta does futile calcium cycling too.
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Fvck...beat me to it. I was just about to do the thermogenic effect rating. In my experience, I used sema back in 2020 and 2021. It did suppress my hunger for a day or two, but did nothing to curb the gargantuan sweet tooth possessing my body and soul. I give it a 5/10.
Reta is more like Agent 47, and its suppression is on ninja mode. It doesn't kick your ass when you see food. It's more subtle. It's like you have this dutiful, loyal friend who wears Predator-esque camouflage and when food is around, he is like, "Hey look at the ass on that chick. Now that's cake worth eating", and you dont notice the food anymore. I would rate the suppression a 6/10.
Modafinil suppression- I put at a pleasant 3/10.
But for Tesofensine, i would give a 2/10...weak sauce.
But on the Asia Black-25, I would give it a 7/10 on appetite suppression.
With Reta, Asia Black, modafinil, the trio gives me a 13/10 appetite suppression. I have to remove my glasses, roll my shirt sleeves and stuff food down my throat.
BadguyPep
Recently Joined
🚫No Source Discussion🚫
I’ve honestly had better appetite suppression on Reta than any other GLP really dialed in my defecit
longestyards
GLP-1 Apprentice
That’s insane that it doesn’t work for you! I can’t believe how depressing it must be to find out something that works awesome for everyone doesn’t work for you. How long have you been on reta now?
I don't find it depressing at all and in fact, I have found many non-responders like myself here on this forum. I take it more for insulin and longevity related issues, so it was a personal experiment more than anything else. I'm on month six, 6mg, hungrier than ever. I will be closing my reta experiment soon.
longestyards
GLP-1 Apprentice
By the way, what do you mean your reta was independently tested? Did you send to a testing lab yourself?
Yes, indeed I had it tested as I've noted in my post. It was overfilled with high purity. Also tested for endos, and I filter all of my peps.
Just shows how different we all are. Reta had me happily capable of not touching any food at all to the point where getting enough protein was a slog, with lots of protein shakes to make it doable. I also stopped wanting anything sugary and was very happy with a salad and I’m not a salad person. I’d give it a 9 out of 10 for apatite suppression.
Tirz is what I’m on now and I find it frustrating. Nausea is not the same as apatite suppression, but it has the same end effect, I guess. Electrolytes help some.
What bothers me most is that sometimes Tirz will let me eat the stupid thing that I shouldn’t eat and then make me pay for it with stomach upset afterwards. It’ll do for maintenance, but if I discount the nausea, I’d rate it a 3.
Tirz is what I’m on now and I find it frustrating. Nausea is not the same as apatite suppression, but it has the same end effect, I guess. Electrolytes help some.
What bothers me most is that sometimes Tirz will let me eat the stupid thing that I shouldn’t eat and then make me pay for it with stomach upset afterwards. It’ll do for maintenance, but if I discount the nausea, I’d rate it a 3.
I'm curious to know how long you've been on Reta? Two weeks ago the heartburn was awful but it seems to be tapering off.
Sid the SeaGull
GLP-1 Enthusiast
I'll not give a rank as I've stuck to Reta . However my plan is to switch to Tirz when I switch to maintenance. Firstly as Triz i expect has better appetite suppression, secondly triz does keep the heart running faster . When I'm on maintenance I don't feel the increased heart rate is needed . I'd think that once the Reta trials are complete this will be medical advice longer term .
dancs
GLP-1 Novice
🚫No Source Discussion🚫
At church so no time to read all these awesome comments before me, but in my personal experience this is my top ranks;
1. Tirz/Reta (took both at same time so not entirely sure which is better.)
2. Cag (took this alone when I was waiting for my re-up on the Tirz, but at 0.5mg, this hit me like a truck.)
There are others like Tesofensine (oral), semaglutide, mazdutide, orforglipron, survodutide, eloralintide, yomamatide, all the damn tides wth 😂
1. Tirz/Reta (took both at same time so not entirely sure which is better.)
2. Cag (took this alone when I was waiting for my re-up on the Tirz, but at 0.5mg, this hit me like a truck.)
There are others like Tesofensine (oral), semaglutide, mazdutide, orforglipron, survodutide, eloralintide, yomamatide, all the damn tides wth 😂
longestyards
GLP-1 Apprentice
What dose are you on reta? And for how long? I’m on 5mg and honestly I feel like when I eat I can eat how much I want. I don’t do it because I know I will feel bad after. At least I have zero cravings for sugar also. But I do have minimal cravings for chips which I am able to eat a few pieces of. Also, I will mostly eat once or twice a day because i do get hungry (no food noise just hungry in stomach) once or twice daily on 5mg.
I didn’t have much to lose. As a short middle aged woman the fat was just incredibly stubborn and made a big difference. I was on 1mg twice a week for three months.
I went from barely able to lose half a pound a week if I did all the right things (weights, cardio, and zero room for error with calories) to simply dropping 15 pounds in those three months while just continuing to work out and make sure I kept up with my protein.
