Cloudy Reta a week after Reconstitution

Nerker

Nerker

GLP-1 Apprentice
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Hi,
I reconstituted 20mg reta with 2ml Bac water (from vendor, not Hospira) last Saturday. It was my first time. I followed protocol (powder to room temp out of freezer, alcohol wipes, bac onto side of vial) and it came out crystal clear.
A week later, I pulled out the Reta from Fridge (37F) and it was cloudy. Did some googling /AI and in about 20 minutes it was crystal clear. So I pinned my 2mg dose. No side effects.
Got a verdict of "cold-induced protein aggregation" or "cold related solubility behavior".
BTW, I contacted the vendor. New vial and Hospira en route.

So, do you guys get a cloudy that clears at room temperature?
 
Nerker said:
Hi,
I reconstituted 20mg reta with 2ml Bac water (from vendor, not Hospira) last Saturday. It was my first time. I followed protocol (powder to room temp out of freezer, alcohol wipes, bac onto side of vial) and it came out crystal clear.
A week later, I pulled out the Reta from Fridge (37F) and it was cloudy. Did some googling /AI and in about 20 minutes it was crystal clear. So I pinned my 2mg dose. No side effects.
Got a verdict of "cold-induced protein aggregation" or "cold related solubility behavior".
BTW, I contacted the vendor. New vial and Hospira en route.

So, do you guys get a cloudy that clears at room temperature?
Click to expand...
I'm on my second vial of Reta 30mg, both from different vendors, and neither of them did that.
 
I heard a story about someone who had a new vial of Reta reconstituted with factory bac all at room temperature and it was cloudy. Is that normal or safe? Another vial from the same batch was fine using hospira
 
Nerker said:
Hi,
I reconstituted 20mg reta with 2ml Bac water (from vendor, not Hospira) last Saturday. It was my first time. I followed protocol (powder to room temp out of freezer, alcohol wipes, bac onto side of vial) and it came out crystal clear.
A week later, I pulled out the Reta from Fridge (37F) and it was cloudy. Did some googling /AI and in about 20 minutes it was crystal clear. So I pinned my 2mg dose. No side effects.
Got a verdict of "cold-induced protein aggregation" or "cold related solubility behavior".
BTW, I contacted the vendor. New vial and Hospira en route.

So, do you guys get a cloudy that clears at room temperature?
Click to expand...
Last week, I turned my refrigerator temperature down and some of my peptides became "thick". Not cloudy, not frozen, just like a gel. Outside of the frig, they returned to normal.
 
Yep. A bit of a puzzler since it was my first ever. A bit discouraging, however I gotta learn.
If I made a mistake it wasn’t obvious.
Tons of successful clear reconstitutions reported here.
Vendor shipped a replacement already a threw in hospira too.

I haven’t made it to crypto and kit buying-that’s my next merit badge.
If I had ten of these 20mg, I would have gone again. As it stands, no side effects.

Definitely will toss if it doesn’t go clear after room temperature.

Related note, I read that too much powder in two little bacstatic water could create this aggregation.
I’ve heard the unit of measure being 1 MG to 1 mL.
Anyone have data on too much powder and too little water?
 
Nerker said:
Yep. A bit of a puzzler since it was my first ever. A bit discouraging, however I gotta learn.
If I made a mistake it wasn’t obvious.
Tons of successful clear reconstitutions reported here.
Vendor shipped a replacement already a threw in hospira too.

I haven’t made it to crypto and kit buying-that’s my next merit badge.
If I had ten of these 20mg, I would have gone again. As it stands, no side effects.

Definitely will toss if it doesn’t go clear after room temperature.

Related note, I read that too much powder in two little bacstatic water could create this aggregation.
I’ve heard the unit of measure being 1 MG to 1 mL.
Anyone have data on too much powder and too little water?
Click to expand...
The 1mg:1mL thing isn’t a rule — that’s just a very diluted reference point. Plenty of people run 5–10mg/mL without issues. The key is whether it
re-dissolves cleanly.

If you want to reduce the chance of that happening again, you could use 2–3mL next time to lower concentration slightly.
 
Thanks. I was going to add more Bac to my next recon.
Update, Monday is the Wife's pin day. We pulled the vial and it remained cloudy so we tossed it.
 
Most of the time these issues are due to vendor BAC.

Just some more anecdotal stories I'm on my 7th vial recon'd to 10mg/ml kept at 30*F (my lower fridge section has some weird temp ranges). I've never had a cloudy vial.
 
Some believe that Hospira isn't necessary for GLP-1s and "lesser BAC water is fine.
Vendor bac is likely culprit. Is it the quality of the BAC from the vendors that is the issue.
Like it's contaminated? Wrong PH?
I'm going to use Hospira from here on out.

Have you seen Janoshik's takes? BTW, his real name is Peter Magic!!
From interview in attachment. I just found this in Reta forum here on GLP-1
Janoshik answers these questions
Q: Is Bac water required for reconstituting peptides?
A: I've never used anything but sterile saline for injection. BAC water is not used in Europe whatsoever, at least not in my parts.
Q: Should I use Saline or Bacteriostatic water for reconstituting my peptides?
A: I strongly believe regular saline for injection is the best choice. Bacteriostatic water is basically unheard of in the EU. Saline with 0.9 NaCl. Bacteriostatic water slows down bacteriamultiplication and bacteria can digest and live off proteins/peptides.
Q: Will I ruin my precious peptides by reconstituting with sterile water vs BAC water? Or would theshelf life between the two be very different?
A: Mostly if you don't suffer local [injection site] discomfort, it doesn't matter which kind of sterilewater you use.
Q: Do you recommend using saline water for multi-use vials? How many days/weeks would youuse the vial if you are not reconstituting with BAC?
A:I think my record has been something like a month and a half back 10 years ago with MelanotanII, maybe two months.
 

Attachments

Nerker said:
Some believe that Hospira isn't necessary for GLP-1s and "lesser BAC water is fine.
Vendor bac is likely culprit. Is it the quality of the BAC from the vendors that is the issue.
Like it's contaminated? Wrong PH?
I'm going to use Hospira from here on out.

-Snip-
Click to expand...
Yeah I understand that plenty of people are just fine using vendor BAC, but spend anytime around these forums and you will see that 99% of these issues are vendor BAC related.

I don't know what the deal is and I'm assuming that people aren't testing their vendor BAC(which is understandable). The few test results we have seen have been pretty bad but that is kind of confirmation bias. My guess is its a pH issue.

Yeah most of us have seen the few Peter Magic interviews. I don't necessarily disagree with using sterile water but if you live in the U.S. with easy access to Hospira I'm not sure why you wouldn't use it. Especially if you are reconstituting peptides that you are going to poke multiple times and keep for multiple weeks. Like I don't like that last bit from him. Again why take the chance, I understand in the EU it is harder to aquire but not here.
 
Heard. And headed to Hospira. I was dead in the water b/c I didn't own a kit. (First one is on the way!) So, I couldn't toss and move on to the next.
 
I got my reconstitution solution from Amazon and I have had zero issues reconstituting Tirz or Reta it works perfect every time. Where are you getting you’re bac water?
 
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