Confusion surrounding DSIP dosing

[Researcher6076]

Aloha Pep Peeps,

My GF asked me to investigate DSIP for sleep improvements. When I did a dive into the research, I found a very confusing divergence between the doses used in the human research and the typical doses discussed on forums by FRU practitioners.

The typical range of contemporary doses I found discussed was 100 mcg – 500 mcg / night with 250 mcg / night often discussed. I found this dose sometimes associated with some pattern of cycling, sometimes 5-days-on / 2-days-off per week, and or 2-4-weeks-on / 2-4-weeks-off.

But the dose suggested by the Graf (1981) as well as the landmark human work by Schneider‑Helmert & Schoenenberger (1983) is very different. Their work suggests a subq dose more like 2.5 mg / night for just 4 nights to “normalize sleep architecture.” Graf (1981) describes the dose-response as U-shaped with larger and smaller doses reducing efficacy.

I’m absolutely not trying to tell anyone using DSIP at smaller doses they’re doing it wrong, but I am trying to learn something that would explain what’s going on.

Does anyone have any idea where the low dose protocols currently in use came from?

Has anyone tried any variations on the higher dose protocols suggested by human research?

FYI, I have attached a DRAFT of my current notes summarizing what I’ve learned about DSIP and would welcome any feedback.

 

[CNCCurrency]

Aloha Pep Peeps,

My GF asked me to investigate DSIP for sleep improvements. When I did a dive into the research, I found a very confusing divergence between the doses used in the human research and the typical doses discussed on forums by FRU practitioners.

The typical range of contemporary doses I found discussed was 100 mcg – 500 mcg / night with 250 mcg / night often discussed. I found this dose sometimes associated with some pattern of cycling, sometimes 5-days-on / 2-days-off per week, and or 2-4-weeks-on / 2-4-weeks-off.

But the dose suggested by the Graf (1981) as well as the landmark human work by Schneider‑Helmert & Schoenenberger (1983) is very different. Their work suggests a subq dose more like 2.5 mg / night for just 4 nights to “normalize sleep architecture.” Graf (1981) describes the dose-response as U-shaped with larger and smaller doses reducing efficacy.

I’m absolutely not trying to tell anyone using DSIP at smaller doses they’re doing it wrong, but I am trying to learn something that would explain what’s going on.

Does anyone have any idea where the low dose protocols currently in use came from?

Has anyone tried any variations on the higher dose protocols suggested by human research?

FYI, I have attached a DRAFT of my current notes summarizing what I’ve learned about DSIP and would welcome any feedback.

I pin 300 mcg nightly for over a year now. Puts me to sleep about 15 minutes after injection.

 

[on2jinm]

Aloha Pep Peeps,

My GF asked me to investigate DSIP for sleep improvements. When I did a dive into the research, I found a very confusing divergence between the doses used in the human research and the typical doses discussed on forums by FRU practitioners.

The typical range of contemporary doses I found discussed was 100 mcg – 500 mcg / night with 250 mcg / night often discussed. I found this dose sometimes associated with some pattern of cycling, sometimes 5-days-on / 2-days-off per week, and or 2-4-weeks-on / 2-4-weeks-off.

But the dose suggested by the Graf (1981) as well as the landmark human work by Schneider‑Helmert & Schoenenberger (1983) is very different. Their work suggests a subq dose more like 2.5 mg / night for just 4 nights to “normalize sleep architecture.” Graf (1981) describes the dose-response as U-shaped with larger and smaller doses reducing efficacy.

I’m absolutely not trying to tell anyone using DSIP at smaller doses they’re doing it wrong, but I am trying to learn something that would explain what’s going on.

Does anyone have any idea where the low dose protocols currently in use came from?

Has anyone tried any variations on the higher dose protocols suggested by human research?

FYI, I have attached a DRAFT of my current notes summarizing what I’ve learned about DSIP and would welcome any feedback.

Looks like I should try again. I was using a <1mg dose for four weeks and absolutely nothing happened for me. I'll give 2.5mg's a shot (npi)

 

[henzvwry]

I recently introduced DSIP. I am taking 100mcg every other night. So far my sleep has been much more restorative, and I feel that taking it every night would be overkill (for me personally). I tried every third day, but it seems to wear off by the third night.

I know they are not the most accurate, but I wear a sleep tracker to bed. First two nights after I take it see a huge increase in deep/rem sleep and less awake time at night. By the third day it went back to normal.