New year review of last year’s research

jw717us

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Ok it’s the new year progress check. I figured at the start of the new year I’d pull some before and after data for my subject. In June they started Tirzepatide and a new workout routine. A few weeks later NAD and Semorelin and how was added for support. I’m also adding what I’m thinking about next. I’ve seen people asking about BPC/KLOW/etc….. so here’s the protocol I’m considering for anyone interested…

So here’s how things have gone:

THE BEFORE: May 2025 Baseline (238 lbs)

- Weight: 238 lbs | BMI: 32.8 (Class I Obese)

- Body Fat: 28.3% | Visceral Fat: 5 (high risk)

- Muscle Mass: 69.5% of body weight (166.8/238 lbs baseline-adjusted)

- Sleep: 5h49 nightly (chronic deprivation)

- Activity: 10.8k casual steps, zero structured exercise

  • Heart Rate: Awake 81bpm, asleep 71bpm (elevated)
  • Metabolic Age: 57 (6 years older than actual
Conditions:

  • Apnea: On CPAP for diagnosis of midgrade OSA ~18AHI
  • Arterial Fibrillation: Daily medicine and experiencing 12-15 events per month
Diagnosis: Classic 53yo American male trajectory — diabetes/CVD risk climbing fast.



TODAY: Jan 2026 (194 lbs)

- Weight: 194 lbs (−44 lbs, −18.5%)

- BMI: 26.9 (healthy overweight)

- Body Fat: 20.3% (−8 points, -28%)

- Visceral Fat: 3.5 (−30%)

- Muscle Mass: 76.5% of body weight (149.2/194 lbs)

- Sleep: 7h11 nightly (+1h22, 53% nights >7h)

- Activity: 8.4k steps + weights/cycling

- Heart Rate: Awake 72bpm (−9), asleep 62bpm (−9)

- Metabolic Age: 51 (−6 years reset!)

Conditions:

  • Apnea: Resolved, off CPAP and 5mins of snoring per night
  • Arterial Fibrillation: only triggered by certain food, 1 incident per month average and treated with medicine reactively
Muscle math: Withings shows lean mass preserved at 156.9 lbs despite −44 lb total loss. Muscle % rose from ~69.5% (baseline-adjusted) → 76.5% not too shabby.



RESEARCH PROTOCOL

Zepbound 10mg weekly (weight/fat loss engine)

Sermorelin 30u nightly (GH restoration)

-NAD+ 50u daily → oral transition soon (mito/energy)

Magnesium glycinate 400mg, CoQ10+Shilajit, boswellia



WHAT IS NEXT

The subject experience several knee injuries in 30s and 40. Has a meniscectomy 3-4 years ago and is developing osteoarthritis. Has developed pain and weakness in the knee. Two doctor consults both questioned the surgery. Only offered recourse is cortisone shots for a few years followed by knee replacement.

A few weeks ago started KLOW blend and have already seen huge gains in range of motion and stability. Looking to improve even further and now considering additional study.

Daily plan

  • KLOW
  • 40mg UC-II collagen supplement
  • 10g collagen powder in morning coffee
  • 250 mg hyaluronic acid supplement
  • Progressive resistance training 5x/week
Considering adding AOD injection and VIP nasal as well.
 
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