Ok, I’m bored. And semi addicted. What’s next?

[sepehr]

I've been using Tesofensine since July with 10mg/week of tirz. Tirz was great for losing my first 50 lbs., but then my weight loss pace slowed down by half. For 7 months, I was only losing 0-5 lbs even though I still had 90 lbs to lose. Even on tirz, my metabolism is still a good bit slower than average for my height and weight.

Tesofensine supposedly speeds up your metabolism. Sure seems like it! I lost 6 lbs the first month. Added 2mg/week of reta the second month, but that was the only vial I had to experiment with. I lost 8 lbs that month. I went back to just tirz/tesofensine after that and have been losing 5 lbs/month since.

Tesofensine also adds some extra appetite suppression, but I kept my calories the same. If anything, I've had a little more flexibility in being able to have more calories or carbs sometimes without it hurting my weight loss pace.

It's technically not a peptide and it's in pill form, so I'm not sure if the Chinese peptide companies carry it. I've gotten it from various US labs. I tried it from Solution Peptides first, but then I found it a lot cheaper at Biostrategix. It's normal price at SP is $119 for 30 500mcg pills. The normal price at Biostrategix is $185 for 120 500mcg pills and they have a perpetual 10% discount code that is Rollins10 (not associated with me). I take one 500mcg pill a day, usually in the morning. Some people take 1,000mcg/day.

Now I am here on this forum looking for quality, cheaper options for both tirz and reta. I'm almost to my goal weight (yay!), but I will always need to take a GLP-1. I planning to wean myself off tirz and onto reta. My dream is to open up my diet more once I'm in maintenance and teso/reta will allow me even more calories by speeding up my metabolism. Y'all, I'm only 5'0". I wouldn't be surprised if maintenance for me is only 1100 calories/day. I need all the help I can get, lol!

Thanks for sharing your experience with Tesonfensine. I read this is serotonin/noradrenaline/dopamine reuptake inhibitor. Reads to me like multi mechanism medication like SSRIs and SNRIs (anti depressant).

Have you experienced any mood changes? Any sides?

Also, I'd be careful not to stop it suddenly, and instead reduce the dosage gradually loke it's recommended for such anti-depressants.

 

[sepehr]

You get used to it fast, even without the pen. Or at least I did.

At this point I've got quite a few injections.

TRT every other day
Reta 2x a week
SS-31 5x a week (And adding MOTS-C in next month...)
Tesa/Ipa 5x a week (Cycling off for a bit after I finish this tesa kit)


I'm going to be traveling for work quite a bit over the next few months so I'm grabbing some pens just so I'm not carrying dozens of syringes and vials around with me, but after the first week of frequent pinning, it wasn't too bad.

You should be jacked! How many cycles of Tesa+Ipa per year do you do? What protocol exactly? If you don't mind sharing.

 

[hexagonal]

You should be jacked! How many cycles of Tesa+Ipa per year do you do? What protocol exactly? If you don't mind sharing.

I started TRT about a month and a half ago and tesa+ipa about a month ago, so not jacked yet. I am lifting 5 days a week though, so hopefully that's on the way.

100mg/week on TRT
2mg tesa/300ish mcg ipa mon-fri

I'm doing bloodwork tomorrow and checking my IGF-1 levels, so I'll be making some more decisions around the GH related stuff based on those details. I've seen a lot of discussion that just doing 2IU of HGH a day produces similar results and is cheaper, so I'm contemplating that.

I've seen some people talking about their doctors prescribing anavar at 10-20mg/day to go with their GLP-1s to help with preserving muscle mass so I'm somewhat curious about that, but my ALT levels aren't great and I'd like to get my blood pressure down a bit more before I look at any sort of AAS. Supposedly doesn't really do much to your liver, lipids, or blood pressure at that low of a dosage, but I'd rather not risk it while any of those aren't already closer to optimal.

 

[zpped]

I started TRT about a month and a half ago and tesa+ipa about a month ago, so not jacked yet. I am lifting 5 days a week though, so hopefully that's on the way.

100mg/week on TRT
2mg tesa/300ish mcg ipa mon-fri

I'm doing bloodwork tomorrow and checking my IGF-1 levels, so I'll be making some more decisions around the GH related stuff based on those details. I've seen a lot of discussion that just doing 2IU of HGH a day produces similar results and is cheaper, so I'm contemplating that.

I've seen some people talking about their doctors prescribing anavar at 10-20mg/day to go with their GLP-1s to help with preserving muscle mass so I'm somewhat curious about that, but my ALT levels aren't great and I'd like to get my blood pressure down a bit more before I look at any sort of AAS. Supposedly doesn't really do much to your liver, lipids, or blood pressure at that low of a dosage, but I'd rather not risk it while any of those aren't already closer to optimal.

Did you get your baseline igf1/insulin/glucose/a1c?

 

[hexagonal]

Did you get your baseline igf1/insulin/glucose/a1c?

I should have, but nah. I figure my levels will either be in line or they won't, and will go from there.

 

[hotdog!]

I didn’t care for Reta—may try it again later for maintenance

I didn't like Reta either. It made me crave sweets which I normally don't care about, but what I really couldn't handle was the skin hypersensitivity. I have sensory issues as is, and this was unbearable even though I worked up slowly from 1 mg for a couple weeks, 2mg for a month, 2.5 for a few weeks then 3mg. Never got better.

I gave up when I read that Reta does have an effect on pain receptors and amplifies the pain/sensitivity loop.

About 15 yrs ago had a very bad case of Reflex Sympathetic Dystrophy, now called Complex Regional Pain Syndrome--basically it's a continual feeling of burning pain in your limbs. Feeling like my foot was constantly on fire for months was enough to make me seriously suicidal, so I'm forever thankful that my pain management doctor successfully stopped that pain loop with a sympathetic nerve block (if I recall). Anyways, I can't risk accidentally tripping that pain loop reaction again, so Reta is a hard no for me.

 

[noggin]

It appears to me that the big issue with these extremely long half life CNS stimulants is the sleep disturbance, which is also the likely culprit of irritability many report. This is probably why dopaminergic drugs on the market today all have half lives around 6-12 hours (Adderall, Vyvanse, XR Ritalin, etc). While on the other hand serotonergic drugs like Fluoxetine exist with a 4-6 day half life (Keep in mind SSRI's are not stimulants)

I have been researching Teso for 3 days now (250mcg, then 500mcg, then another 500mcg today) and I have had extra energy and a little more jittery but overall not too bad, my mood is pretty much the exact same if not slightly worse, but my sleep is like a 4/10. I bet this kind of sleep over the long term would mess you up. Will probably stop researching and take a pill whenever I really need to spend a week sleeping less and focusing more. Probably why this drug never made it off the ground as an anti-depressant or ADHD medication and is instead being studied for weight loss, which I think will likely not succeed due to the sleep issues over the long term. Wish me luck for the next week of sleep!

 

[zpped]

It appears to me that the big issue with these extremely long half life CNS stimulants is the sleep disturbance, which is also the likely culprit of irritability many report. This is probably why dopaminergic drugs on the market today all have half lives around 6-12 hours (Adderall, Vyvanse, XR Ritalin, etc). While on the other hand serotonergic drugs like Fluoxetine exist with a 4-6 day half life (Keep in mind SSRI's are not stimulants)

I have been researching Teso for 3 days now (250mcg, then 500mcg, then another 500mcg today) and I have had extra energy and a little more jittery but overall not too bad, my mood is pretty much the exact same if not slightly worse, but my sleep is like a 4/10. I bet this kind of sleep over the long term would mess you up. Will probably stop researching and take a pill whenever I really need to spend a week sleeping less and focusing more. Probably why this drug never made it off the ground as an anti-depressant or ADHD medication and is instead being studied for weight loss, which I think will likely not succeed due to the sleep issues over the long term. Wish me luck for the next week of sleep!

Yeah, I like teso, but I can't take it for more than a couple days before it starts fucking with my sleep. So I only take it a couple times per month as an alternative to adderall.

 

[Laxfinity]

It appears to me that the big issue with these extremely long half life CNS stimulants is the sleep disturbance, which is also the likely culprit of irritability many report. This is probably why dopaminergic drugs on the market today all have half lives around 6-12 hours (Adderall, Vyvanse, XR Ritalin, etc). While on the other hand serotonergic drugs like Fluoxetine exist with a 4-6 day half life (Keep in mind SSRI's are not stimulants)

I have been researching Teso for 3 days now (250mcg, then 500mcg, then another 500mcg today) and I have had extra energy and a little more jittery but overall not too bad, my mood is pretty much the exact same if not slightly worse, but my sleep is like a 4/10. I bet this kind of sleep over the long term would mess you up. Will probably stop researching and take a pill whenever I really need to spend a week sleeping less and focusing more. Probably why this drug never made it off the ground as an anti-depressant or ADHD medication and is instead being studied for weight loss, which I think will likely not succeed due to the sleep issues over the long term. Wish me luck for the next week of sleep!

Thanks for this. It looks like the pills will stay in the bottle for a bit. I am already an insomniac and cannot afford to get any worse than I am now...

 

[Nikki nik]

Yeah, I like teso, but I can't take it for more than a couple days before it starts fucking with my sleep. So I only take it a couple times per month as an alternative to adderall.

Does tesofensine help with anxiety. How does Adderall help you?

 

[zpped]

Does tesofensine help with anxiety. How does Adderall help you?

I don't have anxiety. I have attention control issues. I get distracted by anything other than the thing I should be doing.

I guess technically the procrastination eventually leads to anxiety.

 

[Nikki nik]

I don't have anxiety. I have attention control issues. I get distracted by anything other than the thing I should be doing.

I guess technically the procrastination eventually leads to anxiety.

Ok thanks.

 

[noggin]

Thanks for this. It looks like the pills will stay in the bottle for a bit. I am already an insomniac and cannot afford to get any worse than I am now...

Oh boy it messes with your sleep. On day one of 250mcg I slept a-ok. Next day on 500mcg (~700mcg blood levels) and I slept okayish, definitely slightly noticed sleep disturbance. Day 3 I took another 500mcg (~1200mcg blood levels) and I slept at 6:30am last night 😵‍💫. Terrible experience. I'm probably gonna deal with this for the next week since I'll still be at 800mcg blood levels by Friday. Hooooo boy at least I have more focus and can push myself more in the gym. Not pushing my levels past 800mcg again.

 

[zpped]

Oh boy it messes with your sleep. On day one of 250mcg I slept a-ok. Next day on 500mcg (~700mcg blood levels) and I slept okayish, definitely slightly noticed sleep disturbance. Day 3 I took another 500mcg (~1200mcg blood levels) and I slept at 6:30am last night 😵‍💫. Terrible experience. I'm probably gonna deal with this for the next week since I'll still be at 800mcg blood levels by Friday. Hooooo boy at least I have more focus and can push myself more in the gym. Not pushing my levels past 800mcg again.

I took 500mcg for 5 days the first time. Sleep time just kept getting shorter. Now I never use more than a couple days in a row. Started getting better immediately. Very obvious in this graph.

 

[Valerie]

Ok, I’ve got enough tirz for 4-5 years, and should not even be shopping but now I’m addicted and bored.

What’s next?

Teso?
AOD?
NAD?

(Not cagri, I’m not messing around with that goopy ooze)

It's a new year ... what did you decide to try ?

 

[Awesome82]

Ok, I’ve got enough tirz for 4-5 years, and should not even be shopping but now I’m addicted and bored.

What’s next?

Teso?
AOD?
NAD?

(Not cagri, I’m not messing around with that goopy ooze)

What goopy ooze? I've tried to look up the research and can't see anything on it.

 

[Glp1judd]

It's a new year ... what did you decide to try ?

Nothing yet. Waiting to see how Nikki’s spicy research goes. 😜

 

[Sunflower]

Funny enough, I felt nothing my whole Teso cycle a few months back. Today is my first day of Mots-C and I actually probably feel something. Like natural, clean energy. Interesting!!

 

[ThePepPlanner]

I've had no complaints and literally melted away from tirz over 6 months, but I have to admit I've been doing a ton of research into reta for the past few weeks for these last 20-30ish pounds and im thinking about pulling the trigger soon.

main issue im running into is it seems like reta doesnt have the same anti-inflammatory effects as tirz (completely cured my sleep apena in 3 weeks of 2.5mg) which I want to keep on for life honestly, but stacking the two seems counter-productive even though it seems to be a popular choice

Did you switch?

I stocked up on reta for the last push on my final 10-15lbs which I heard were the hardest to drop.

Reta made is so easy to reach goal. I'm using Tirz for maintenance because I'm a Tirz-gal but will absolutely use Reta in the future to switch things up.

 

[Nikki nik]

Did you switch?

I stocked up on reta for the last push on my final 10-15lbs which I heard were the hardest to drop.

Reta made is so easy to reach goal. I'm using Tirz for maintenance because I'm a Tirz-gal but will absolutely use Reta in the future to switch things up.

I have 1 vial of reta I haven't touched. Do you think that 1 can break my tirz stall? 🤷🏽‍♀️

 

[zpped]

I have 1 vial of reta I haven't touched. Do you think that 1 can break my tirz stall? 🤷🏽‍♀️

No, it takes time to switch over properly and mixing them is just less effective.

 

[normal]

Did you switch?

I stocked up on reta for the last push on my final 10-15lbs which I heard were the hardest to drop.

Reta made is so easy to reach goal. I'm using Tirz for maintenance because I'm a Tirz-gal but will absolutely use Reta in the future to switch things up.

No, ended up staying with tirz. Currently like 7.5lbs from initial goal weight at this point, probably aiming for another ~20 total though at this point.

As interested and tempted as I was by reta, I've responded so well to tirz it didn't seem worth it in the end to switch.

Might still give it a go for maintenance, we'll see in a couple of months

 

[diceman]

There is nothing to it if you use an injection pen. I used to think daily sounded bananas, and now i have a morning and evening shot plus two staggered weeklies, it’s all just part of the routine and not a big deal

Interesting.. any specific brand or model you can recommend?

 

[zpped]

Interesting.. any specific brand or model you can recommend?

You can get them from aliexpress for a bit cheaper. or buy them from here https://allthingspeptides.com/ for more convenience.

 

[chmuse]

You can get them from aliexpress for a bit cheaper. or buy them from here https://allthingspeptides.com/ for more convenience.

Bundle Kit V1 Vitality Pen, V1 Bezel Pen, V1 Phantom Pen, and 10 Sterilized Carts — EZP Supply

This is a discounted V1 metal pen bundle. This bundle includes 1x V1 Vitality Pen, 1x V1 Phantom Pen, 1x V1 Bezel Pen, and 10 empty sterilized carts. V1 Pens are 80u Please note this bundle does not come with cases.

www.ezpsupply.com

I personally took the leap with this three pack (no longer Nexa affiliated, don't call me a shill!)

Ordered 1/1 shipped today a bit after noon.

 

[Laxfinity]

Bundle Kit V1 Vitality Pen, V1 Bezel Pen, V1 Phantom Pen, and 10 Sterilized Carts — EZP Supply

This is a discounted V1 metal pen bundle. This bundle includes 1x V1 Vitality Pen, 1x V1 Phantom Pen, 1x V1 Bezel Pen, and 10 empty sterilized carts. V1 Pens are 80u Please note this bundle does not come with cases.

www.ezpsupply.com

I personally took the leap with this three pack (no longer Nexa affiliated, don't call me a shill!)

Ordered 1/1 shipped today a bit after noon.

What is the difference in the pens? Do you know?

 

[chmuse]

What is the difference in the pens? Do you know?

Absolutely zero idea! 😇🤣

I just assumed it was three different colors.

 

[Laxfinity]

I am gearing up to try a pen tonight for KLOW. Wish me luck. 😉

 

[Valerie]

@chmuse The whole loading into cartridges and sucking extra air out looks like a lot on "YouTube " ... does it become quick and easy to get that down to a science ?

 

[Valerie]

Nothing yet. Waiting to see how Nikki’s spicy research goes. 😜

Chicken