Opinion/anecdote: Don't be afraid of increasing your dose

[gulangaloid]

It seems like overwhelmingly, no matter where I see GLPRA discussion, there is a great amount of advice to keep your dose as low as humanly possible and to start and stay at doses far below even the normal STARTING clinical trial values. I'm not sure how much of this is already lean and healthy bodybuilder types, but for people that the drug was actually designed for (overweight/obese/T2D) I would personally suggest (I am not a doctor) that you ignore most of that unless you find yourself being a super responder.

While the sentiment that if you are achieving healthy results that you are happy with you don't necessarily need to increase the dose on a rigid schedule I certainly agree with, I don't think being overly cautious about increasing dose (assuming side effects are tolerated) is going to help people trying to deal with obesity (the people the drug was meant for) provided that the doses and the titration are in line with the clinical trials. If you are obese and just happen to be a super responder losing all they weight they can dream of, I really am thrilled for you, and I don't want to make you change what you're doing. However, this advice is not for you.

To be clear, I don't mind that bodybuilders are taking drugs for obese people, people can do whatever they want with their bodies. Thin people can take whatever they want, but the needs of a thin, healthy person and an obese person are extremely different, and I strongly believe that the latter following the dosing examples/advice of the former can impede progress and be harmful. I would also strongly suggest not worrying about getting into stacking or changing your GLPRA before you have been on the maximum dose of your GLPRA of choice for at least a month or two without meaningful results.

This sort of stems from my anecdotal situation, where I saw little to no results from the early doses of reta. I was staying the same weight, occasionally gaining or losing a pound. I was even worried I might have gotten a bum shipment. However, when I started the maximum dose, I fairly quickly started to see strong results with manageable side effects. This has also been consistent across multiple shipments from multiple suppliers, so the quality or fill of the product does not appear to have been the issue.

 

[Labcat]

It seems like overwhelmingly, no matter where I see GLPRA discussion, there is a great amount of advice to keep your dose as low as humanly possible and to start and stay at doses far below even the normal STARTING clinical trial values. I'm not sure how much of this is already lean and healthy bodybuilder types, but for people that the drug was actually designed for (overweight/obese/T2D) I would personally suggest (I am not a doctor) that you ignore most of that unless you find yourself being a super responder.

While the sentiment that if you are achieving healthy results that you are happy with you don't necessarily need to increase the dose on a rigid schedule I certainly agree with, I don't think being overly cautious about increasing dose (assuming side effects are tolerated) is going to help people trying to deal with obesity (the people the drug was meant for) provided that the doses and the titration are in line with the clinical trials. If you are obese and just happen to be a super responder losing all they weight they can dream of, I really am thrilled for you, and I don't want to make you change what you're doing. However, this advice is not for you.

To be clear, I don't mind that bodybuilders are taking drugs for obese people, people can do whatever they want with their bodies. Thin people can take whatever they want, but the needs of a thin, healthy person and an obese person are extremely different, and I strongly believe that the latter following the dosing examples/advice of the former can impede progress and be harmful. I would also strongly suggest not worrying about getting into stacking or changing your GLPRA before you have been on the maximum dose of your GLPRA of choice for at least a month or two without meaningful results.

This sort of stems from my anecdotal situation, where I saw little to no results from the early doses of reta. I was staying the same weight, occasionally gaining or losing a pound. I was even worried I might have gotten a bum shipment. However, when I started the maximum dose, I fairly quickly started to see strong results with manageable side effects. This has also been consistent across multiple shipments from multiple suppliers, so the quality or fill of the product does not appear to have been the issue.

Very quality anecdotal data. I’ve been consdering about the things that couldl cause a vial to seem weak, this is a great reminder that sometimes a person just responds later and if you don’t with different “brands” you wouldn’t really know.

 

[Foggy-Hollow]

This sort of stems from my anecdotal situation, where I saw little to no results from the early doses of reta. I was staying the same weight, occasionally gaining or losing a pound. I was even worried I might have gotten a bum shipment. However, when I started the maximum dose, I fairly quickly started to see strong results with manageable side effects. This has also been consistent across multiple shipments from multiple suppliers, so the quality or fill of the product does not appear to have been the issue.

Your personal response is exactly that: personal. If someone is getting good response (1-2 pounds per week) on half the amount you are taking, there’s no data-driven reason to up the dose.

The advice to start low and slow is coupled with watching how the body is reacting. It’s not standalone advice.

 

[yrrdead]

I don't get posts encouraging people to send it regarding doses. Grey market, unknown fill, unknown reaction. Caution is warranted imo. Also this is a marathon not a sprint. Hard to have a longer term outlook and no instant gratification but that gets easier with age (at least for me).

It is easy to take another dose after 3 days. Or bump it next week. Quite a bit harder to uninject 12mg.

My anecdote - obese 220@5'8"M. Currently @ 185. Started Oct 1st @ .5mg e3d. But what is that worth?? Nothing.

If anyone asks me I link them the trials showing many different titration schedules. Maybe show them a shotsy chart or glp1plotter to give them an idea of buildup. But to be fair most people don't want to read or actually research. They want simple numbers and an easy schedule.

 

[Labcat]

Your personal response is exactly that: personal. If someone is getting good response (1-2 pounds per week) on half the amount you are taking, there’s no data-driven reason to up the dose.

The advice to start low and slow is coupled with watching how the body is reacting. It’s not standalone advice.

Not at allsuggesting anything happens to everyone. But it’s still very helpful to see what variations people have when they systematically vary something (like compounding source). Because there is s paucity of research, and many RS’s who communicate their experience, a kind of lore around glps has developed that include things like how a response is wildly and intensely individual, and while some say tirz is tirz (which is what the fda believes), many say that something about compounds are different. ) (I wonder if some of that is from inaccuracies in formulating, sourcing, or storage.) In this particular case it was just super interesting to see a systematic report that compounders did not differ for them, and the increased tolerance stayed with this RS, even though official conclusions from EL’s papers say that tolerance does not develop.

 

[gulangaloid]

Your personal response is exactly that: personal. If someone is getting good response (1-2 pounds per week) on half the amount you are taking, there’s no data-driven reason to up the dose.

The advice to start low and slow is coupled with watching how the body is reacting. It’s not standalone advice.

Did you not read what I wrote?