Start dose Reta

[skaylife]

Hi friends,

A good friend of mine weighs 146kg (322lbs) and have been using Ozempic couple of years at highest dosage. He could ever lose 20kgs. But gained back and at the moment it doesn't help anymore. He wants to try Reta and asked me advice about dosage. But I am not a Reta user. Sometime ago tried Reta for a few weeks. But did not work for me. Stopped after getting 3 days long heavy diarrhea.

I know how Reta protocol is. But I didn't ever reach such a high weight and don't have any idea what should be his start dose? Good advice will be much appreciated.
Almost forgotten! He has also diabetes II.

 

[eidos]

It should be noted that the effect of retatrutide on the glucagon receptor is really felt from 8mg/week in clinical studies (7.5 significantly lowered my blood sugar). This is what is really important for diabetes.

I started at 2.5mg to test my reaction and then gradually increased the dose up to 10mg/week. My blood sugar level is below 100 mg/dl, even though it's after dinner. I have a CGM and it projects an HbA1c of 6.5% whereas I was at 10.5 in February, under Tirz and before switching to Reta. BMI from 31-32 to 27-28.