Start dose Reta

[skaylife]

Hi friends,

A good friend of mine weighs 146kg (322lbs) and have been using Ozempic couple of years at highest dosage. He could ever lose 20kgs. But gained back and at the moment it doesn't help anymore. He wants to try Reta and asked me advice about dosage. But I am not a Reta user. Sometime ago tried Reta for a few weeks. But did not work for me. Stopped after getting 3 days long heavy diarrhea.

I know how Reta protocol is. But I didn't ever reach such a high weight and don't have any idea what should be his start dose? Good advice will be much appreciated.
Almost forgotten! He has also diabetes II.

 

[eidos]

It should be noted that the effect of retatrutide on the glucagon receptor is really felt from 8mg/week in clinical studies (7.5 significantly lowered my blood sugar). This is what is really important for diabetes.

I started at 2.5mg to test my reaction and then gradually increased the dose up to 10mg/week. My blood sugar level is below 100 mg/dl, even though it's after dinner. I have a CGM and it projects an HbA1c of 6.5% whereas I was at 10.5 in February, under Tirz and before switching to Reta. BMI from 31-32 to 27-28.

 

[skaylife]

It should be noted that the effect of retatrutide on the glucagon receptor is really felt from 8mg/week in clinical studies (7.5 significantly lowered my blood sugar). This is what is really important for diabetes.

I started at 2.5mg to test my reaction and then gradually increased the dose up to 10mg/week. My blood sugar level is below 100 mg/dl, even though it's after dinner. I have a CGM and it projects an HbA1c of 6.5% whereas I was at 10.5 in February, under Tirz and before switching to Reta. BMI from 31-32 to 27-28.

Thanks for your advice. I was also thinking that start doses like 0.5~1mg like most people do, should be too low for him. Thought may be start at 2mg and after a month titrate to 4 and so on unltil we find the good response dosage. But could not dare to give any advice without asking opinion of researchers with Reta experience.

At first he was also sceptisch about Reta and had concerns about long term unexpexted consequences which are not known yet. Asked, what if he after 10 years get some other health issues because of Reta use. He is already 61 years old and has a passive office job. Walking 2 steps takes 2 seconds. I had to ask him if he was expecting to live 10 more years at that weight, age and condition? It was not easy to say that to him. But as a friend I had to confront him with truth. I hope he can live healthier and longer thanks to Reta. In Belgium insurance pays only semaglutide. He has to pay full price for Mounjaro and 10mg costs €400/month which he can't afford. Grey market is the only good solution for him at the moment. I can even pay it for him, if he accepts. But I don't think he will.