Swap Reta for Tirz for Inflammation / Mast Cells

[Pixel-pocket]

I'm going to be switching from Reta to Tirz, as I keep seeing testimonials from others that tout superiority for inflammation. As someone with POTS, MCAS/MC, et al. I have been floored at how I've been able to eat practically all the foods I lost in the past, but suspect I may see more profound changes to the root of inflammation on Tirz.

Can anyone comment on if dosages differ between the two? I had settled out on 1.5 mg Reta after I was getting side effects when I titrated higher. I have had greatly reduced food noise from Reta, but not significant change in weight (I am just above the "normal" range, but used to be lower before I fell ill.)

Any thoughts, commentary is appreciated!

I wonder if we will see less weight measurements but higher body measurements as Reta targets fat rather than muscle?

 

[CuttingEdgeScience]

Are you tracking calories? How is your sleep? Have you started any type of exercise? Those are the most likely culprits (and also causes of inflammation).

Tracking, somewhat - I'm definitely eating less than before, and I wasn't consuming tons of calories to begin with. I rarely even snack anymore. Exercise has been increased as of late, especially since on the Tirz, I have found I can walk longer distances and have been out a lot more often. I also am just slightly overweight - so I don't know how that pans out vs how these drugs work in obesity, diabetes, etc.

 

[CuttingEdgeScience]

I never did any other GLP before Reta.

What would you be “losing out on”, by not staying with Reta? Does Reta have better fat burning advantages mechanism where Tirz has better appetite suppression? What advantages (other than inflammation management) does Tirz have over Reta?

Reta's activity at the glucagon receptor gives it greater fat burning potential as it amps up the metabolic rate and gets the body to burn more fat. However, it is also responsible for tachycardia and other side effects too. Tirz has, in my specific conditions, had a lot more testimonials for inflammation control.

I wish I could get more data on the interaction of these drugs at various receptors, it may explain some of the why - but I haven't found any studies yet.