So there was a long discussion in a peptide testing discord server earlier tonight about TFA (Trifluoroacetic Acid) salts and how it's something we should avoid if possible and that acetate form is really what we should be targeting, however it's more expensive so chinese/research peptides likely don't do it.
Additionally, someone linked a Q&A with Janoshik where this topic was brought up and the answers at least to me felt inconclusive. Attached screenshot of the relevant part and the whole Q&A below (thanks B-Man). Also attached is a screenshot from a NLM article on "The Role of Counter-Ions in Peptides"
I was surprised to hear of all of this for the first time and then even more surprised to type "TFA" and "Acetate" into the search bar here and see nothing really come up about it. Wondering if folks smarter than me might be able to do more with this information and just hoping to see more discussion on this.
As an aside, I emailed my vendor (Amopure) and asked if they sell their tirz in the Acetate form or something else and their response was as follows:
"Greetings.
Thank you for your inquiry.
We don't have the acetate form of Tirz.
Thank you!"
Additionally, someone linked a Q&A with Janoshik where this topic was brought up and the answers at least to me felt inconclusive. Attached screenshot of the relevant part and the whole Q&A below (thanks B-Man). Also attached is a screenshot from a NLM article on "The Role of Counter-Ions in Peptides"
I was surprised to hear of all of this for the first time and then even more surprised to type "TFA" and "Acetate" into the search bar here and see nothing really come up about it. Wondering if folks smarter than me might be able to do more with this information and just hoping to see more discussion on this.
As an aside, I emailed my vendor (Amopure) and asked if they sell their tirz in the Acetate form or something else and their response was as follows:
"Greetings.
Thank you for your inquiry.
We don't have the acetate form of Tirz.
Thank you!"
