The case against compounded Sema

LuckyMango

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Hi,

Here's the Novo's ppt that outlines why compounded pharmacies should not be allowed to compound sema. They have a lot of reasons. :)

The first issue: Novo says compounding pharmacies use synthetic semaglutide. Whereas the FDA approved medication from Novo is "recombinantly expressed in yeast". Novo claims the compounded synthetic sema leads to impurities, immunogenicity and peptide modifications.

What I'd like to understand - is the lyophilized powder from CN for research a synthetic? Or is it the recombinant version?

And for the chemists and pharmacologists, how serious are these Novo claims?

Thx.
 

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