Thought this was a cool little tidbit

[Gwenhwyfar227]

I had no idea. Pretty cool to learn..this was on a newsletter from Polaris Peptides

However, in practice, most of the TB-500 peptides available for research, including the one offered by our laboratory, are actually the full TB4 molecule rather than just the TB-500 fragment. This is typically noted on lab analysis reports as “TB-500 (TB4),” reflecting the fact that what is being sold as TB-500 is, in reality, the complete TB4 molecule. The two are often conflated in the marketplace, despite their technical differences and potentially distinct biological effects.

 

[MrsRoper_1977]

I had no idea. Pretty cool to learn..this was on a newsletter from Polaris Peptides

However, in practice, most of the TB-500 peptides available for research, including the one offered by our laboratory, are actually the full TB4 molecule rather than just the TB-500 fragment. This is typically noted on lab analysis reports as “TB-500 (TB4),” reflecting the fact that what is being sold as TB-500 is, in reality, the complete TB4 molecule. The two are often conflated in the marketplace, despite their technical differences and potentially distinct biological effects.

I learned about this a couple of months ago. I was able to join a small group buy and get the real TB500. I haven’t researched it yet, but excited to eventually.

 

[MakeItaDouble]

I learned about this a couple of months ago. I was able to join a small group buy and get the real TB500. I haven’t researched it yet, but excited to eventually.

I'm curious why you wanted TB500 over TB4. I read a whole article about it

https://www.peptidesciences.com/blog/thymosin-beta-4-vs-tb-500

TLDR: Thymosin Beta-4 vs TB-500: Summary
TB-500 and thymosin beta-4 are similar in many ways because TB-500 is a synthetic derivative of thymosin beta-4. The latter, however, is considered to be more effective because it contains an additional active domain that enhances its function. Thus, thymosin beta-4 can be thought of as evoking the same responses as TB-500, but to a much larger degree. It is for this reason that the two terms are often used interchangeably even though they don’t refer to exactly the same molecule. Many companies attempt to avoid internet search issues by simply talking about both TB-500 and thymosin beta-4 as if they were the same. For researchers looking to ensure they have one peptide over the other, it is always necessary to check the amino acid sequence. If the peptide is more than seven (7) amino acids in length, then it is probably thymosin beta-4, which is 43 amino acids long.

I'm in the process of coming up with an order for both GLOW for myself and the optimal combination for my sister, who suffers from cellulitis and has wounds that haven't healed for months despite wound care. I reached out to Anela who replied "I would do 450mcg TB and BPC both 3x a day when she is severe, 2x a day when improving and 1x a day for maintenance".

Interested in what you found that made you prefer TB500. Thx!

 

[Gwenhwyfar227]

I'm curious why you wanted TB500 over TB4. I read a whole article about it

https://www.peptidesciences.com/blog/thymosin-beta-4-vs-tb-500

TLDR: Thymosin Beta-4 vs TB-500: Summary
TB-500 and thymosin beta-4 are similar in many ways because TB-500 is a synthetic derivative of thymosin beta-4. The latter, however, is considered to be more effective because it contains an additional active domain that enhances its function. Thus, thymosin beta-4 can be thought of as evoking the same responses as TB-500, but to a much larger degree. It is for this reason that the two terms are often used interchangeably even though they don’t refer to exactly the same molecule. Many companies attempt to avoid internet search issues by simply talking about both TB-500 and thymosin beta-4 as if they were the same. For researchers looking to ensure they have one peptide over the other, it is always necessary to check the amino acid sequence. If the peptide is more than seven (7) amino acids in length, then it is probably thymosin beta-4, which is 43 amino acids long.

I'm in the process of coming up with an order for both GLOW for myself and the optimal combination for my sister, who suffers from cellulitis and has wounds that haven't healed for months despite wound care. I reached out to Anela who replied "I would do 450mcg TB and BPC both 3x a day when she is severe, 2x a day when improving and 1x a day for maintenance".

Interested in what you found that made you prefer TB500. Thx!

To be absolutely honest...because I read about TB-500 and not TB4..lol...I needed some relief for my knee that I hurt about 6 months ago..and I read up about it and BPC-157

 

[Gwenhwyfar227]

I'm curious why you wanted TB500 over TB4. I read a whole article about it

https://www.peptidesciences.com/blog/thymosin-beta-4-vs-tb-500

TLDR: Thymosin Beta-4 vs TB-500: Summary
TB-500 and thymosin beta-4 are similar in many ways because TB-500 is a synthetic derivative of thymosin beta-4. The latter, however, is considered to be more effective because it contains an additional active domain that enhances its function. Thus, thymosin beta-4 can be thought of as evoking the same responses as TB-500, but to a much larger degree. It is for this reason that the two terms are often used interchangeably even though they don’t refer to exactly the same molecule. Many companies attempt to avoid internet search issues by simply talking about both TB-500 and thymosin beta-4 as if they were the same. For researchers looking to ensure they have one peptide over the other, it is always necessary to check the amino acid sequence. If the peptide is more than seven (7) amino acids in length, then it is probably thymosin beta-4, which is 43 amino acids long.

I'm in the process of coming up with an order for both GLOW for myself and the optimal combination for my sister, who suffers from cellulitis and has wounds that haven't healed for months despite wound care. I reached out to Anela who replied "I would do 450mcg TB and BPC both 3x a day when she is severe, 2x a day when improving and 1x a day for maintenance".

Interested in what you found that made you prefer TB500. Thx!

I would say...listen to Anela!!!.. she really is a fountain of knowledge

 

[MakeItaDouble]

I would say...listen to Anela!!!.. she really is a fountain of knowledge

I just DM'd her to ask if it made a difference. Then on to sourcing... Leaning toward Skye

 

[MakeItaDouble]

Her response:
There is zero TB500 on the market. It doesn't exist. Many years ago tb500 was synthesized as long-acting TB4. TB500 is the synthetic form of TB4. Everything on the market right now is TB4, even if it says TB500. TB4 works just as well except because it is in its natural state it is not long acting and is dosed the same as BPC.
Good companies will call it TB4 or TB500/TB4 or TB500 (TB4). I combine TB4 and BPC in one vial. I prefer dosing it this way. I'm not a fan of premixed combo vials. I prefer buying the vials separately and reconstituting it together.

 

[zpped]

I'm curious why you wanted TB500 over TB4. I read a whole article about it

TB500 doesn't do everything that TB4 does (theoretically). That could be preferrable based on what you want. But of course, finding out what you actually are buying isn't simple.

 

[Gwenhwyfar227]

How would you go about finding that out?
And now that I have a rabbithole to fall down to look into TB4 and see if that is preferable to my needs.

 

[Broken Chef]

I just DM'd her to ask if it made a difference. Then on to sourcing... Leaning toward Skye

AR is back up and running. They are adding more items to the menu each week and will be coming out with custom blends. I think they are a bit cheaper than Sky, and generally post 3 tests per batch.

At least they were cheaper on sema back when I bought from them, before I felt comfortable with CN options.

EDIT: They have TB4 currently

Looking at the test for it, I guess they just triple test the glp1's

 

[MakeItaDouble]

AR is back up and running. They are adding more items to the menu each week and will be coming out with custom blends. I think they are a bit cheaper than Sky, and generally post 3 tests per batch.

At least they were cheaper on sema back when I bought from them, before I felt comfortable with CN options.

EDIT: They have TB4 currently

Looking at the test for it, I guess they just triple test the glp1's

Thanks for pointing me to AR but Skye has them beaten, in the case of TB4 by a lot. The BP-157 they beat by a little for 1 but quite a bit with a qty discount. The TB4 is 2 1/2 times more. Interestingly, ASC is 1 1/2 times more on the TB4 as well. All are for 10mg.

 

[Broken Chef]

Thanks for pointing me to AR but Skye has them beaten, in the case of TB4 by a lot. The BP-157 they beat by a little for 1 but quite a bit with a qty discount. The TB4 is 2 1/2 times more. Interestingly, ASC is 1 1/2 times more on the TB4 as well. All are for 10mg.

Interesting. When I was buying Sema - Skye was $150 for 10mg and AR was $120 for 14mg - I bought 8 vials during the 50% off sale, so I paid $60 for 14mg x8.... pretty good deal for triple tested domestic option. Got a kit of T30 for $372 also. Shame that was a one time deal!

Is there maybe a price difference between actual TB4 and TB-500? I was not aware there were 2 versions of this until I read it here.

AR calls it TB4 (TB-500) and Sky calls it TB-500 (TB4), lol I'm clueless

EDIT: NM, Just saw your other post saying they are the same

 

[Broken Chef]

I'm interested in trying the TB-500/BPC-157 combo, but not sure where to start and trying to get gpl1's secured and dialed in first. Just ordered half a kit of Cagri.

I'm interested in several of the purported benefits of that stack - Pain, Focus, Healing, Anti-inflammatory, GI health... But I do take an antidepressant... I thought I read somewhere it can interfere with that - "Discontinue if causes depression or anxiety" - this scares me a bit, so I'd probably want to start with 1 vial rather than kits, lol

Is there a domestic option for a stack of this, or would I need to get a vial of each?

 

[zpped]

Her response:
There is zero TB500 on the market. It doesn't exist. Many years ago tb500 was synthesized as long-acting TB4. TB500 is the synthetic form of TB4. Everything on the market right now is TB4, even if it says TB500. TB4 works just as well except because it is in its natural state it is not long acting and is dosed the same as BPC.
Good companies will call it TB4 or TB500/TB4 or TB500 (TB4). I combine TB4 and BPC in one vial. I prefer dosing it this way. I'm not a fan of premixed combo vials. I prefer buying the vials separately and reconstituting it together.

I did some more digging and this is almost correct. TB500 is a specific fragment of TB4 (Fragment 17-23). Most (maybe all) TB500 is TB4, so it appears most have taken to calling them TB500-frag and TB500. Which is also dumb because 17-23 is not the only fragment.

But they are definitely different, not exactly the same effect and different half-lifes.

 

[MakeItaDouble]

Is there a domestic option for a stack of this, or would I need to get a vial of each?

I did some more digging and this is almost correct. TB500 is a specific fragment of TB4 (Fragment 17-23). Most (maybe all) TB500 is TB4, so it appears most have taken to calling them TB500-frag and TB500. Which is also dumb because 17-23 is not the only fragment.

But they are definitely different, not exactly the same effect and different half-lifes.

They are definitely different. I did find a source for TB-500 (Artic).

Chef, your new serving of rabbit for the day is attached. It's a compilation of research from a user on reddit with lots and lots of references to research docs on a few peptides. There are lots more sites to read, too. I have not seen BPC-157 and TB-500 combined other than with GHK-Cu (otherwise known as GLOW) but that doesn't mean it doesn't exist.

Edit: It is not TB-500. From Anela:
I can tell you without a shadow of a doubt there is no tb5 on the market right now. Tb4 is fine it works the same you just dose it more often. In fact I'm currently running TB4 and BPC together. I reconstitute them both in one vial. I just dose it like BPC. Just FYI, TB500 is not superior to TB4. You identify a peptide by its CAS. It's identified on their lab reports.CAS 77591-33-4 which is TB4

 

[Sackett]

They are definitely different. I did find a source for TB-500 (Artic).

Chef, your new serving of rabbit for the day is attached. It's a compilation of research from a user on reddit with lots and lots of references to research docs on a few peptides. There are lots more sites to read, too. I have not seen BPC-157 and TB-500 combined other than with GHK-Cu (otherwise known as GLOW) but that doesn't mean it doesn't exist.

Thank you for the paper