We’ve all heard “tirz is tirz”, yet our lore is very much that everyone responds differently and even compounders formulations behave differently. Which really goes against the basic concepts behind pharmacology (generics) and chemistry itself.
Other than being shorted on mgs due to errors or decomposition, what’s the science idea behind our belief? Please explain like I’m 5, but a very demanding 5 🙂.
I’ve seen a number of semi technical yet still ambiguous posts on different forums hinting that even the same API could somehow be different, and it’s never been clear to me what is meant by that chemically.
Maybe HPLC can’t separate very similar molecules? But if so could someone in the know explain please how that suffices to be used to confirm identity in analytical chemistry?
I’d like if y’all could share explanations in chemistry rather than analogy, using the basics like “electrons” or “orbitals” or “conformation”, perhaps with a specific example (which could be theoretical )… rather than be more general. General can be true but I don’t know enough to have it seem other than handwavy
Other than being shorted on mgs due to errors or decomposition, what’s the science idea behind our belief? Please explain like I’m 5, but a very demanding 5 🙂.
I’ve seen a number of semi technical yet still ambiguous posts on different forums hinting that even the same API could somehow be different, and it’s never been clear to me what is meant by that chemically.
Maybe HPLC can’t separate very similar molecules? But if so could someone in the know explain please how that suffices to be used to confirm identity in analytical chemistry?
I’d like if y’all could share explanations in chemistry rather than analogy, using the basics like “electrons” or “orbitals” or “conformation”, perhaps with a specific example (which could be theoretical )… rather than be more general. General can be true but I don’t know enough to have it seem other than handwavy
