Tirza and Gerd-Reflux

[DannyGreenfire]

Guys - I am getting acid reflux at night since I have started Tirza. Is that something that might improve or is there anything I can do to lessen it.

Woke up in the night and my throat felt like it was bathing in acid.

I’ve only taken 1mg about 2 days ago.

 

[nonyabizznez]

I got my partner Omeprazole which is available OTC now and after a lifetime of antacids he's asking where it's been his whole life. I've been on Tirz for over a year without any reflux symptoms. He's been on Tirz two weeks and so far it's his only negative symptom. I figured Omeprazole must be the difference because I've been on it for years to negate potential bad gastric side effects from other necessary daily medications.

He can't believe what a difference it's making and he's a spicy food with a beer before bed kinda guy.

 

[penewbie]

I second omeprazole.

 

[GtownBrown]

I take omeprazole and a probiotic starting the day before shot day and for the first three days after. I also take ultra strength gasx those days. Finally, I added Buoy Digestion Drops.

 

[clayd]

Famotidine for me , works great

And I think eventually you won't get the reflux anymore

 

[heatherL]

I've suffered with acid reflux for the last several years. Tirz has made it so much worse ... HOWEVER ... I have learned some things.
1st - WHAT you eat/drink matters. Avoid (or at the very least; severely limit) spicy, heavily sliced foods (garlic & onion are not your friend on Tirz) and acidic foods. Alcohol makes GERD so so soooooo much worse (especially wine). Also, avoid foods that are hard to digest. Tirz drastically slows down digestion so foods that are already hard to digest make the process that much slower and because of the slower process, your stomach creates more acid to break food down the longer it sits in your stomach. If you haven't already, Google the foods you should avoid on Tirz. (Also keep in mind how big of a bite you take and how many times you chew it when you do eat. The first part of the digestion process begins with your teeth and saliva. Breaking down food as much as possible before it gets to your stomach is best.)

2nd - WHEN you eat matters. Make sure you stop eating and don't eat anything 3-4 HOURS before you go to bed. No snacks ... no little bites of something ... NOTHING! Limit water intake as well. Remember, Tirz SLOWS digestion processes so food is in your stomach for hours. While it sits in the stomach, more acid is produced. Therefore, when you lay down, that acid flows back up the esophagus. The emptier your stomach is at night, the better off you'll be.

3rd - HOW you sleep matters. Prop yourself up on a pillow or 2 at night. Let gravity become your best sleepover buddy. If you have a bed that inclines, raise both the head and feet (just a bit) so you don't slide down. DON'T sleep on your right side or back!! Sleep on your left side in the
left lateral decubitus position (Google it).

When you sleep on your left side, your stomach is below your esophagus, so gravity helps keep stomach acid down.

 

[DannyGreenfire]

Thanks all.

I have tried most of these so far - but not the omeprazole yet.

Crazy thing is I only took 1mg - first week - and for the first day or so I didn’t feel anything. But now I haven’t really had an appetite for 3 days. I have eaten bits though.

On night 2 I got really bad acid reflux like I’ve never had before but actually it was just a one night thing. I’m guessing it might get worse as and when I raise my dose though.

That aside I think it’s doing exactly what I imagined/hoped. Taking a number 2 is a little strange. I feel like I’ve lost a little weight already but I kinda feel a little backed up in the bowels - not horrendously but like I need to go to the toilet but nothing happens if I do

 

[49metal]

Guys - I am getting acid reflux at night since I have started Tirza. Is that something that might improve or is there anything I can do to lessen it.

Woke up in the night and my throat felt like it was bathing in acid.

I’ve only taken 1mg about 2 days ago.

Same experience with Tirz. Omeprazole was also the remedy for me.

 

[nonyabizznez]

Thanks all.

I have tried most of these so far - but not the omeprazole yet.

Crazy thing is I only took 1mg - first week - and for the first day or so I didn’t feel anything. But now I haven’t really had an appetite for 3 days. I have eaten bits though.

On night 2 I got really bad acid reflux like I’ve never had before but actually it was just a one night thing. I’m guessing it might get worse as and when I raise my dose though.

That aside I think it’s doing exactly what I imagined/hoped. Taking a number 2 is a little strange. I feel like I’ve lost a little weight already but I kinda feel a little backed up in the bowels - not horrendously but like I need to go to the toilet but nothing happens if I do

Also slowed gastric emptying means your food is gonna sit in your stomach for way longer than normal. Some people who've vomited are seeing food from last Tuesday. If your stomach were a sundae top it with whipped cream, not Sriracha especially if it's your last food of the day

Amazon has Omeprazole for about $10 (one/day 42 capsules) and also Hyleys Colon Cleanse Tea which works really well.

​

 

[Glp1judd]

Famotidine for me. It’s worse on tirz and a big reason i eat less. Big meals just sit there and blerg.

But separately, nighttime gerd is def a symptom of sleep apnea. Mask fixes if for me.

 

[afrayy]

Crazy cause my reaction has been the opposite - being on tirz has almost completely cleared up my GERD/acid reflux symptoms. I used to basically live on omeprazole and zantac year round, had multiple doctor and specialist visits to see what was up with me and there was never anything conclusively determined, just management.

I started tirz last year and since then I might have a reflux "attack" once a week, if at all. No more burping all day and all night, no more random stomach pains, no more laying down and feeling like im having a heart attack, no more random heart palpitations and sweating. Just gone.

I suspect that perhaps my stomach has always just been overactive, maybe a symptom (or cause?) of the constant food noise in my brain, and tirz is moderating that.

 

[BitsyRMSc]

I've suffered with acid reflux for the last several years. Tirz has made it so much worse ... HOWEVER ... I have learned some things.
1st - WHAT you eat/drink matters. Avoid (or at the very least; severely limit) spicy, heavily sliced foods (garlic & onion are not your friend on Tirz) and acidic foods. Alcohol makes GERD so so soooooo much worse (especially wine). Also, avoid foods that are hard to digest. Tirz drastically slows down digestion so foods that are already hard to digest make the process that much slower and because of the slower process, your stomach creates more acid to break food down the longer it sits in your stomach. If you haven't already, Google the foods you should avoid on Tirz. (Also keep in mind how big of a bite you take and how many times you chew it when you do eat. The first part of the digestion process begins with your teeth and saliva. Breaking down food as much as possible before it gets to your stomach is best.)

2nd - WHEN you eat matters. Make sure you stop eating and don't eat anything 3-4 HOURS before you go to bed. No snacks ... no little bites of something ... NOTHING! Limit water intake as well. Remember, Tirz SLOWS digestion processes so food is in your stomach for hours. While it sits in the stomach, more acid is produced. Therefore, when you lay down, that acid flows back up the esophagus. The emptier your stomach is at night, the better off you'll be.

3rd - HOW you sleep matters. Prop yourself up on a pillow or 2 at night. Let gravity become your best sleepover buddy. If you have a bed that inclines, raise both the head and feet (just a bit) so you don't slide down. DON'T sleep on your right side or back!! Sleep on your left side in the
left lateral decubitus position (Google it).

When you sleep on your left side, your stomach is below your esophagus, so gravity helps keep stomach acid down.

Yep. All of this.

 

[PopTart]

Crazy cause my reaction has been the opposite

Same. I’ve been on omeprazole for 10+ years to treat eosinophilia esophagitis (auto immune disease) and my acid reflux really spiked when titrating above 5mg.

I did a fair amount of research and concluded the omeprazole was making matters worse when combined with a glp1. And my EoE has been asymptomatic since then as well. Planning to get scoped and biopsies in the next couple of months so I’ll know more then.