Tirzepatide tolerance

lurchy123

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Jun 18, 2025
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Morning all, I have seen a few posts elsewhere where people are saying that they've just gone up a dose and all the appetite suppression went away and I thought that can't be right and largely ignored these kind of posts but.. here I am with one of them posts! I'm only on 5mg just gone up and just like the posts I disregarded all of a sudden I feel like I want to eat everything in the house!

Is this tolerance based do you think or is this the body saying I've been on 1400 calories for over a month I want more food? I'm a 42 year old 6ft 5in guy, I started at 19st 8lbs or 274lbs if you're in the US and in 5 weeks I've dropped 2 stone or 28lbs.

What do you think causes this?
 
Welcome 👋 Being a person of your stature, you might have to increase your dose and possibly increase a few extra calories in protein. Protein and water is key. I must congratulate you. 👏 👏 👏 You're doing great!
 
I didn't see much benefit at 5mg and hunger from time to time can happen regardless. If you look at the clinical trials best dose for many is the 12-15mg per week. That said low and slow imho is best. I lost at sema 0.5 but flat lined with Tirzepatide until 10mg.

I would slowly titrate up dose some and when hungry try for something health - chicken, salad, fruit, etc. Just my 2 cents.
 
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