Retatrutide and mood changes

[dandam]

I’m planning to start retatrutide right after the holidays and I’d really like to hear about your experiences with mood. I’ve read that it can cause anhedonia or emotional flattening. Based on your experience, is this side effect usually temporary or persistent? Is it generally manageable, or can it become too difficult to tolerate?


I’m worried about feeling depressed and unmotivated. Is there anything that can help mitigate this side effect? I’ll be starting at 0.5 mg per week, does this issue tend to appear at that dose?

Thank you to anyone who shares their experience. I truly need to start retatrutide, but I’m very concerned about this potenti al side effect.

Thanks,
Larissa 🥰

 

[Mastodon]

0.5 is tiny dose

Answering your question, I don't know. I take other meds that might cause low mood so can't really tell if it's reta specifically

 

[aquis]

I’m planning to start retatrutide right after the holidays and I’d really like to hear about your experiences with mood. I’ve read that it can cause anhedonia or emotional flattening. Based on your experience, is this side effect usually temporary or persistent? Is it generally manageable, or can it become too difficult to tolerate?


I’m worried about feeling depressed and unmotivated. Is there anything that can help mitigate this side effect? I’ll be starting at 0.5 mg per week, does this issue tend to appear at that dose?

Thank you to anyone who shares their experience. I truly need to start retatrutide, but I’m very concerned about this potenti al side effect.

Thanks,
Larissa 🥰

I've been on Reta for 7 months and have not experienced any mood changes. I haven't even heard this side effect mentioned before, but I'm sure if you look hard enough you can find all sorts of side effects.

.5mg is pretty low and 1.0mg is a more common starting dose. It's good to be cautious, but you should feel very comfortable starting at that dose. Like most people, I am sure you will be pleased. Keep us posted!

 

[miss-sanne]

Oh, man anhedonia is a real thing and quite a bitch. But I felt it very strong on tirz, high dose 11 mg, but not on Reta, now I'm on 8 mg
It's difficult to say, how it will be for you, you just have to try it out.

 

[ambot88]

I can only offer anecdotal experience but I didn't notice anything negative moodwise. I think I'm in a better mood because I feel better in almost all measures, My body is smaller and my joints don't hurt and my skin is better and it cured my reflux. Big fan, do it. I started at 2mg and am now at 5, 4 months later. (43/f)

 

[Chili777]

Oh, man anhedonia is a real thing and quite a bitch. But I felt it very strong on tirz, high dose 11 mg, but not on Reta, now I'm on 8 mg
It's difficult to say, how it will be for you, you just have to try it out.

I've have that to some degree. It's not a feeling of being depressed, but more a feeling of, " Nah, I don't feel like doing that right now.", even though I probably should. I've resorted to putting a list together and not stopping until I knock everything out. But, it's a small price to pay for all the other benefits I've received on Reta.

 

[GeraltRedhammer]

In the opinion of a large number of doctors, GLP-1 analogues have a slight mood-altering effect.

Anhedonia is also a frequently reported side effect. I wonder, however, whether this must necessarily be associated with a lower mood? I tend to experience it as a reduction in impulsiveness and the need to prove anything to anyone. A very unpleasant consequence of this may be a lack of motivation to act...