Ipamorelin + CJC 1295 experiences

[muggy]

Anyone care to share their experiences with cjc/ ipa?
I'm about to start and want to hear about your doses/ schedule/ sleep/ lean mass/ etc!

 

[hoochiscrazy]

About to start it too and would love to hear peoples experiences!

 

[Not_Your_Dad]

I'm 4 weeks in to a CJC1295 no DAC / Ipa cycle

It was supposed to be a 5/5 blend, but testing came back more like 6/5 so I'm taking a little more CJC then I was planning.

I pin 0.546 mg CJC and 0.406 mg IPA AM and PM; I try and make sure the AM pin is fasted. I take the PM pin with 2 mg of Tesamorelin as well.

I've found I have a much increased energy level and positive mindset since starting the CJC/Ipa. I'm not actively doing any strength training but have noticed slight increases in muscle mass.

Happy to answer any other questions.

 

[Hyperion]

I'm 4 weeks in to a CJC1295 no DAC / Ipa cycle

It was supposed to be a 5/5 blend, but testing came back more like 6/5 so I'm taking a little more CJC then I was planning.

I pin 0.546 mg CJC and 0.406 mg IPA AM and PM; I try and make sure the AM pin is fasted. I take the PM pin with 2 mg of Tesamorelin as well.

I've found I have a much increased energy level and positive mindset since starting the CJC/Ipa. I'm not actively doing any strength training but have noticed slight increases in muscle mass.

Happy to answer any other questions.

Can i ask your age?
I'm trying to establish if this combo has diminishing returns the older you get. For example, is a 60 year old going to get the same GH volume release as a 30 year old, and at which point are secretagogues a waste of money when compared to normal GH.

 

[joseblo]

As I understand it, the best way to know is to test your IGH-1 levels before / during / after the ipa-cjc stack. I hear about 5on/2off and 1m-on/1m-off cycles. There are standard min/max hormone levels depending on age, but people in the anti-aging sphere definitely like it. Search and you will find.

The cjc and tesa are doing pretty much the same thing secretagogue-wise.

What I want to know is, are you hungry? Are you stacking tirz or reta?
Apparently, GLP1 effects can be significantly reduced by the hormone boosters.

 

[muggy]

I'm 4 weeks in to a CJC1295 no DAC / Ipa cycle

It was supposed to be a 5/5 blend, but testing came back more like 6/5 so I'm taking a little more CJC then I was planning.

I pin 0.546 mg CJC and 0.406 mg IPA AM and PM; I try and make sure the AM pin is fasted. I take the PM pin with 2 mg of Tesamorelin as well.

I've found I have a much increased energy level and positive mindset since starting the CJC/Ipa. I'm not actively doing any strength training but have noticed slight increases in muscle mass.

Happy to answer any other questions.

Do you feel significant flushing after the pin? Any histamine responses?

 

[Main75]

As I understand it, the best way to know is to test your IGH-1 levels before / during / after the ipa-cjc stack. I hear about 5on/2off and 1m-on/1m-off cycles. There are standard min/max hormone levels depending on age, but people in the anti-aging sphere definitely like it. Search and you will find.

The cjc and tesa are doing pretty much the same thing secretagogue-wise.

What I want to know is, are you hungry? Are you stacking tirz or reta?
Apparently, GLP1 effects can be significantly reduced by the hormone boosters.

I feel like my awesome Reta experience has been flatlined for a month now and it’s either bad Reta (I changed supplier or the addition of Ipamorelin

 

[Not_Your_Dad]

I'll try and answer all the questions in one reply!

1. Age - 45. I understand that straight GH would probably be better for someone my age, but I find that level of risk unacceptable, so no GH for me.

2. Hunger - yes, more than would be expected but for the secretagogues, but not intolerable. Long time Tirz user, in the process of titrating up Reta now. Pinned maybe 3.5 mg Tirz on Monday and 6 mg Reta today.

3. Flushing - moderate with the CJC/IPA pin, significant with the Tesa pin. They're both relatively itchy and uncomfortable for me, not enough that I'm stopping the cycle early, but I wouldn't do this for fun. In contrast never had any ISR from Tirz, Reta, or my GHK-cu/KPV homebrew.

4. Mass on scale - really doesn't change. I can feel differences from the GHs, like I know my abdomen is smaller (I've been measuring), pants size decreasing, etc. I'd love to get after a DEXA scan but the closest one to me is 2.5 hours drive and $200.

5. Cycle - planning on stopping the CJC/IPA when the Tesa runs out. Should be around 55 days. Will then let it wash for at least a month before I consider any more GH secretagogues again.

 

[muggy]

I'll try and answer all the questions in one reply!

1. Age - 45. I understand that straight GH would probably be better for someone my age, but I find that level of risk unacceptable, so no GH for me.

2. Hunger - yes, more than would be expected but for the secretagogues, but not intolerable. Long time Tirz user, in the process of titrating up Reta now. Pinned maybe 3.5 mg Tirz on Monday and 6 mg Reta today.

3. Flushing - moderate with the CJC/IPA pin, significant with the Tesa pin. They're both relatively itchy and uncomfortable for me, not enough that I'm stopping the cycle early, but I wouldn't do this for fun. In contrast never had any ISR from Tirz, Reta, or my GHK-cu/KPV homebrew.

4. Mass on scale - really doesn't change. I can feel differences from the GHs, like I know my abdomen is smaller (I've been measuring), pants size decreasing, etc. I'd love to get after a DEXA scan but the closest one to me is 2.5 hours drive and $200.

5. Cycle - planning on stopping the CJC/IPA when the Tesa runs out. Should be around 55 days. Will then let it wash for at least a month before I consider any more GH secretagogues again.

I think its interesting that the cjc/ipa is moderate and tesa is strong flushing. Have you tried Zyrtec for the histamine response?

A university near me offers dexa scans for $50. Maybe theres a university near you that would do something similar.

 

[Jfrick11]

If you’re going to take something like ipamorelin it really matters to check a baseline IGF-1 first.

General Optimal IGF-1 Ranges (ng/mL):

• Ages 20–30: 200–350
• Ages 31–50: 175–300
• Ages 51–65: 150–250
• Ages 66+: 125–200

If it's higher than that. and you push that pathway anyway, you can very easily end up worsening your metabolic state, by increasing insulin resistance.

And for further info....tesa is even more aggressive at worsening insulin resistance if your IGF1 is already above optimal ranges

This is one of those ones where it's pretty important to understand why you’re taking something, not just follow a trend or a protocol.

 

[Main75]

I feel like my awesome Reta experience has been flatlined for a month now and it’s either bad Reta (I changed supplier or the addition of Ipamorelin

Just Reta and hunger was great until …
New batch Reta
And
Started ipa
Popped up 9 lbs and have really have not budged even with upping Reta from 6 to 8 last week

 

[tallclarknhandsome]

I feel like it doesn't do much for me. Maybe slightly better sleep. Started in November. I'm 47. If I could go back I would have just gone to hgh. I don't feel much hunger from it like mk 677. I get flushing, but I enjoy the flush

 

[Not_Your_Dad]

If you’re going to take something like ipamorelin it really matters to check a baseline IGF-1 first.

General Optimal IGF-1 Ranges (ng/mL):

• Ages 20–30: 200–350
• Ages 31–50: 175–300
• Ages 51–65: 150–250
• Ages 66+: 125–200

If it's higher than that. and you push that pathway anyway, you can very easily end up worsening your metabolic state, by increasing insulin resistance.

And for further info....tesa is even more aggressive at worsening insulin resistance if your IGF1 is already above optimal ranges

This is one of those ones where it's pretty important to understand why you’re taking something, not just follow a trend or a protocol.

Can you point me towards the data that supports this? I'm not arguing with you, but genuinely curious.

 

[Not_Your_Dad]

I think its interesting that the cjc/ipa is moderate and tesa is strong flushing. Have you tried Zyrtec for the histamine response?

A university near me offers dexa scans for $50. Maybe theres a university near you that would do something similar.

Nope - the flush never bothered me.

I did discontinue the Tesa rather abruptly: I had three nights of waking up with migraine of increasing intensity (almost sought emergency care on night 3); realized that I was having continuing ISRs from Tesa pins 5+ days ago. Assumed something was going haywire and abandoned the Tesa. It's been about a week an no migraine since.

 

[Jfrick11]

Can you point me towards the data that supports this? I'm not arguing with you, but genuinely curious.

Totally fair to ask and I think I can easily point you in the right direction.... . Good news is, this isn’t obscure or controversial data, it’s very well established endocrinology. If you want to dig in, some good search terms are:
• growth hormone insulin resistance
• GH antagonizes insulin action
• IGF-1 age-adjusted reference ranges
• acromegaly glucose intolerance diabetes
• tesamorelin fasting glucose HbA1c clinical trials
• GH secretagogues glucose metabolism
These pathways, the normal lab ranges, and the human trial data have been around for decades and are easy to find in review papers and clinical guidelines.