Help with sleep

Double_J

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Hello

I’ve been running retatrutide for 5 weeks now.
Dose has been conservative: 1 mg once weekly, and I haven’t increased it.
Results-wise, it’s doing exactly what the math says it should.
I’m down 5.5 lbs, which lines up almost perfectly with my balanced diet~500 calorie/day deficit. Appetite control has been excellent, cravings are muted, and adherence has been easy. From a fat-loss standpoint, reta has been fantastic.

The downside: sleep.
Over the last few weeks, my sleep has progressively worsened. I’m consistently waking up around 1–2am and struggling (or failing) to get back to sleep. It feels stimulatory, almost like my nervous system won’t fully power down. The trend is clear enough that I can’t ignore it anymore.
So while the fat loss is steady and predictable, sleep quality matters more. Poor sleep is taking a toll. If I can’t solve this, I may have to pull retatrutide despite how effective it’s been.
I’m curious if others have run into the same issue on reta and what actually helped.
 
It sounds like this is every day for you, I dose when I wake up for work so it doesn't keep me up, later in the day. But it doesn't seem to mess with my sleep, that much at all. It takes a day to kick in, but seems to give me a mild energy boost. You might try lowering your dose a bit for a few weeks or adjusting the 1mg to 0.5mg 2x a week maybe. Some people get the higher pulse rate, on the Reta that settles down after a few months. I take Taurine for that, 1-2mg a day that helps settle it back down in the mid 50's for a resting pulse rate.

I've worked night shift for over 35 years, I get the no sleep thing!!! If I get up after some sleep, I generally take a 10mg Melatonin to help me fall back a sleep. You might try Magnesium Glycinate, I take that to help stay regular on the GLP-1's and it helps with falling asleep too.
 
Double_J said:
Hello

I’ve been running retatrutide for 5 weeks now.
Dose has been conservative: 1 mg once weekly, and I haven’t increased it.
Results-wise, it’s doing exactly what the math says it should.
I’m down 5.5 lbs, which lines up almost perfectly with my balanced diet~500 calorie/day deficit. Appetite control has been excellent, cravings are muted, and adherence has been easy. From a fat-loss standpoint, reta has been fantastic.

The downside: sleep.
Over the last few weeks, my sleep has progressively worsened. I’m consistently waking up around 1–2am and struggling (or failing) to get back to sleep. It feels stimulatory, almost like my nervous system won’t fully power down. The trend is clear enough that I can’t ignore it anymore.
So while the fat loss is steady and predictable, sleep quality matters more. Poor sleep is taking a toll. If I can’t solve this, I may have to pull retatrutide despite how effective it’s been.
I’m curious if others have run into the same issue on reta and what actually helped.
Click to expand...
I've had the same experience. I'm 4 mos in now and it's gotten a little better but gets worse after a dose increase. I take cbd gummies, mag glycinate, melatonin every night just to get some sleep. But I had sleep issues before Reta too.
 
Double_J said:
Hello

I’ve been running retatrutide for 5 weeks now.
Dose has been conservative: 1 mg once weekly, and I haven’t increased it.
Results-wise, it’s doing exactly what the math says it should.
I’m down 5.5 lbs, which lines up almost perfectly with my balanced diet~500 calorie/day deficit. Appetite control has been excellent, cravings are muted, and adherence has been easy. From a fat-loss standpoint, reta has been fantastic.

The downside: sleep.
Over the last few weeks, my sleep has progressively worsened. I’m consistently waking up around 1–2am and struggling (or failing) to get back to sleep. It feels stimulatory, almost like my nervous system won’t fully power down. The trend is clear enough that I can’t ignore it anymore.
So while the fat loss is steady and predictable, sleep quality matters more. Poor sleep is taking a toll. If I can’t solve this, I may have to pull retatrutide despite how effective it’s been.
I’m curious if others have run into the same issue on reta and what actually helped.
Click to expand...

Your sugar might be dipping too low at might. I know it sounds counterintuitive, but try incorporating some sort of snack closer to bed that might keep your blood sugar more even throughout the night. On average, you will lose weight faster if you sleep through the night regularly

Also, the sleep issue might pass after a while

Sleep has been hit or miss with me on Reta. Somethings work sometimes, but not other times.

I’d also speak to your doctor about it. Maybe they could prescribe a continuous glucose monitor to rule out the blood sugar issue
 
My sleep has been affected too, almost like I have racing thoughts brain. I will say though mine isn't as severe as yours because I already take Trazodone every night (50mg) for insomnia.
 
I could’ve wrote Double_Js post because my situation (5 weeks, 10lbs down, 1mg Reta,etc) is a carbon copy of his/hers.

I have tried adding Glycine (always took Mag Glycinate) to bedtime ritual, staying up later/going to bed earlier, warm showers, etc but I only really sleep past 1-2am when I go to bed completely exhausted from the previous 4-5 days of shitty sleep!

Tried trazadone but I just wake up at 1am feeling dopey. I’m in it for the long haul but it’s beginning to kick my butt.
 
My story is the same. A couple of months in and up to 2 of Reta. Waking up at 1-2 every night. I tried all the regular remedies to no avail. Started DSIP 3 nights ago but nothing yet. I am also wearing a cgm and there are definitely dips during the night. I’m going to try a little honey before bed and see if that helps.
 
Thinking about getting a kit of Sermorelin with my next order. Heard it’s the mildest of the GH boosters and one of the benefits is better sleep. Almost 5am here and been on Dawn Patrol since 1:11am. Gotta find something.
 
WeezinDaJuice said:
Thinking about getting a kit of Sermorelin with my next order. Heard it’s the mildest of the GH boosters and one of the benefits is better sleep. Almost 5am here and been on Dawn Patrol since 1:11am. Gotta find something.
Click to expand...
Funny you say that, I just finshed my last shot Ipamorelin yesterday. I never see any better sleep with it, even paired with CJC-1295 no dac for a while no better. Already tried Tesamorelin as well, did get the water Retention thing too. I got some Sermorelin I reconstituted and was gonna try it today. I actually got the Ipamorelin, cause it help with my Headaches.
 
RubbaDubba1 said:
Funny you say that, I just finshed my last shot Ipamorelin yesterday. I never see any better sleep with it, even paired with CJC-1295 no dac for a while no better. Already tried Tesamorelin as well, did get the water Retention thing too. I got some Sermorelin I reconstituted and was gonna try it today. I actually got the Ipamorelin, cause it help with my Headaches.
Click to expand...
Let me know your results. Probably a couple week lag with the CNY shutdown so some time before I buy.

Supposedly Sermorelin has pretty dramatic improvement for some. Hopefully we’re in that group.
 
CNCCurrency said:
I do a 10 mg vial with 3ml bac and pin 10 cc about half hour before bed
Click to expand...

Retazempic said:
I don’t think that’s right

In the protocol given, I calculate10cc as 333mcg

Could someone plz check me?
Click to expand...

cc is cubic centimeter, a unit of volume.
mL is milliliter, a unit of volume.

1cc=1mL

Thus 10cc=10mL.

I’m guessing he meant and you assumed 10 units, but that’s not what was written.
 
WeezinDaJuice said:
Let me know your results. Probably a couple week lag with the CNY shutdown so some time before I buy.

Supposedly Sermorelin has pretty dramatic improvement for some. Hopefully we’re in that group.
Click to expand...
If we're posting in this sub, chances are we're willing to try about anything. I'll see how this next week goes, I'm trying it to se if it helps with my headaches like the Ipamorelin too. I did the DSIP thing, but no improvement for me there.
 
It did get better for me. The first couple months my sleep sucked, especially a couple nights after pin day. I used Trazadone a few night then. I also did a cycle of Epitalon IN in month 3 which might have helped, but some found it didn't. I'm in month 5 at 10 mg and I'm sleeping well again, but everyone is different. I think it means my body finally adjusted to it.
 
Wish I could help, but it's the worst side effect for me. I maybe average 4hrs a night, if I'm lucky. Been taking it since 1/7/26.

I added Tesamorelin to my stack (waiting for it to arrive) as I hear that also can help with sleep.
 
Double_J said:
Hello

I’ve been running retatrutide for 5 weeks now.
Dose has been conservative: 1 mg once weekly, and I haven’t increased it.
Results-wise, it’s doing exactly what the math says it should.
I’m down 5.5 lbs, which lines up almost perfectly with my balanced diet~500 calorie/day deficit. Appetite control has been excellent, cravings are muted, and adherence has been easy. From a fat-loss standpoint, reta has been fantastic.

The downside: sleep.
Over the last few weeks, my sleep has progressively worsened. I’m consistently waking up around 1–2am and struggling (or failing) to get back to sleep. It feels stimulatory, almost like my nervous system won’t fully power down. The trend is clear enough that I can’t ignore it anymore.
So while the fat loss is steady and predictable, sleep quality matters more. Poor sleep is taking a toll. If I can’t solve this, I may have to pull retatrutide despite how effective it’s been.
I’m curious if others have run into the same issue on reta and what actually helped.
Click to expand...
In case your sleep issue is low-glucose related, try a cup of greek yogurt just before you go to bed. That may help keep glucose more stable. Another option may be to try one of the extended release carb bars, like Extend, that some diabetics use to keep from going hypo. Both suggestions might buy you time. You may not make it to 6 or 7 am, but if you can sleep till 5, instead of waking up at 2, that is something.
 
Double_J said:
Hello

I’ve been running retatrutide for 5 weeks now.
Dose has been conservative: 1 mg once weekly, and I haven’t increased it.
Results-wise, it’s doing exactly what the math says it should.
I’m down 5.5 lbs, which lines up almost perfectly with my balanced diet~500 calorie/day deficit. Appetite control has been excellent, cravings are muted, and adherence has been easy. From a fat-loss standpoint, reta has been fantastic.

The downside: sleep.
Over the last few weeks, my sleep has progressively worsened. I’m consistently waking up around 1–2am and struggling (or failing) to get back to sleep. It feels stimulatory, almost like my nervous system won’t fully power down. The trend is clear enough that I can’t ignore it anymore.
So while the fat loss is steady and predictable, sleep quality matters more. Poor sleep is taking a toll. If I can’t solve this, I may have to pull retatrutide despite how effective it’s been.
I’m curious if others have run into the same issue on reta and what actually helped.
Click to expand...
Maybe try NAD+ its improved my sleep by quite a bit.
 
RubbaDubba1 said:
Funny you say that, I just finshed my last shot Ipamorelin yesterday. I never see any better sleep with it, even paired with CJC-1295 no dac for a while no better. Already tried Tesamorelin as well, did get the water Retention thing too. I got some Sermorelin I reconstituted and was gonna try it today. I actually got the Ipamorelin, cause it help with my Headaches.
Click to expand...
Have you had a chance to try Sermorelin and did it have any impact on your sleep? 🤞
 
Just want to add that anyone considering adding a GH secretagogue should ideally have an IGF-1 level tested before starting. Insulin resistance and IGF-1 levels are U-shaped curves and you can stall/undo weight loss if you spike your IGF too high from GH,

I'd suggest taking some time to learn about the IGF-1/GH axis. I wish I did before I ran my first cycle of secretagogues.

But, I do sincerely hope you can find something to help with you sleep issues!
 
WeezinDaJuice said:
Have you had a chance to try Sermorelin and did it have any impact on your sleep? 🤞
Click to expand...

I’m going to second this. Serm/Ipa has helped a friend who is on Tirz tremendously, but he needs both. He’s about to switch to Ipa/CJC, so it’ll be interesting to see what that adjustment does.

For myself, Reta destroyed my sleep as well. Four hours a night was top of what I can get on 1mg of Reta a week. I was going to add Tesa and Ipa starting this coming weekend but decided to start the Ipa last night at 250mcg because I just couldn’t take the sleep dep anymore. For me, the Ipa was enough. Deep wonderful sleep and wild vivid dreams all night and my alarm woke me up this morning.
 
WeezinDaJuice said:
Have you had a chance to try Sermorelin and did it have any impact on your sleep? 🤞
Click to expand...
WeezinDaJuice said:
Have you had a chance to try Sermorelin and did it have any impact on your sleep? 🤞
Click to expand...
I knew Sermorelin was the Step child of the bunch, but damn. When I 1st tried Ipamorelin, day 1 noticed, Tesamorelin noticed day 2, Sermorelin Day 5 still buffering. Already at 500mcg's last 2 days, bout ready to switch to CJC-1295 no dac with Ipamorelin.
 
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