Daisbuys
GLP-1 Novice
🚫No Source Discussion🚫
I’m seeing contradictory answers to how to store Tesamorelin after reconstituting.
I was led to believe that once mixed with Bac to store it for up to a week in a fridge between 4-8 degrees. But reading the FDA approved paper from EGRIFTA it states that it should be stored at room temperature in a dark place?
And I’m wondering if this is the reason why there’s a lot of gelling up of vials after being stored in a fridge?
The below is a post I seen on Facebook which explains why.
You're Storing Tesamorelin Wrong
If you're treating your tesamorelin like every other peptide in your protocol, you're probably wasting it.
Tesamorelin is structurally different from the other peptides you're used to working with, and those differences change how you have to handle it.
So let me teach you why this one behaves differently.
Peptides are just chains of amino acids bound together.
Tesamorelin is a 44 amino acid chain.
And for context, CJC-1295 no DAC is 29 amino acids, ipamorelin is five, and BPC-157 is 15.
And that length matters for a couple reasons.
First, the longer the chain, the more sites where chemical degradation can occur when it's in solution.
Tesamorelin retains the native amino acids from the original GHRH molecule, and some of those are actually vulnerable to processes called deamidation and oxidation.
Deamidation is when an amino acid loses part of its structure and changes shape and oxidation is when oxygen damages certain amino acids in the chain.
Both of these compromise the peptide's function and both of them start the moment you add water.
Second, longer chains are more likely to fold back on themselves when they're in solution.
And when you have more folding, you have more opportunities for the molecules to bind to each other and aggregate, which basically means they clump together into larger and larger clusters.
Now, here's where things get different from your other peptides.
Unlike CJC or ipamorelin, tesamorelin has temperature dependent solubility that actually inverts at cold temperatures.
So when you put it in the refrigerator like you do with everything else, it exceeds its saturation point and those folded chains start aggregating into a gel.
And once that happens, the vial is done.
And this is exactly why the FDA approved version requires room temperature storage after reconstitution.
And it's also why tesamorelin comes in smaller vials than you might expect.
The vial sizes are designed around a seven day window, because that's how long you have before the degradation makes it ineffective.
So here's what you should actually do with your tesamorelin.
You can keep it frozen before you reconstitute it.
That's fine, but once you mix it, store it in a dark place at room temperature and use it within a week.
The bottom line is tesamorelin requires handling that goes against everything you've learned with other peptides, and now you understand why.
Most people lose potency without realizing it because they're storing it refrigerated like every other peptide.
The gel formation isn't always obvious, and even if you don't see visible clumping, the aggregation is still happening at the molecular level.
That means you're injecting degraded peptide that can't bind to the receptor properly.
You're going through the motions, but you're not getting the growth hormone pulse you're paying for.
If you've been running tesamorelin and not seeing the results you expected, this is probably why.
Check your storage method, reconstitute smaller amounts more frequently, and keep it at room temperature once it's mixed.
And here’s the FDA link:
Interested to hear if anyone stores theirs at room temperature or not?
I was led to believe that once mixed with Bac to store it for up to a week in a fridge between 4-8 degrees. But reading the FDA approved paper from EGRIFTA it states that it should be stored at room temperature in a dark place?
And I’m wondering if this is the reason why there’s a lot of gelling up of vials after being stored in a fridge?
The below is a post I seen on Facebook which explains why.
You're Storing Tesamorelin Wrong
If you're treating your tesamorelin like every other peptide in your protocol, you're probably wasting it.
Tesamorelin is structurally different from the other peptides you're used to working with, and those differences change how you have to handle it.
So let me teach you why this one behaves differently.
Peptides are just chains of amino acids bound together.
Tesamorelin is a 44 amino acid chain.
And for context, CJC-1295 no DAC is 29 amino acids, ipamorelin is five, and BPC-157 is 15.
And that length matters for a couple reasons.
First, the longer the chain, the more sites where chemical degradation can occur when it's in solution.
Tesamorelin retains the native amino acids from the original GHRH molecule, and some of those are actually vulnerable to processes called deamidation and oxidation.
Deamidation is when an amino acid loses part of its structure and changes shape and oxidation is when oxygen damages certain amino acids in the chain.
Both of these compromise the peptide's function and both of them start the moment you add water.
Second, longer chains are more likely to fold back on themselves when they're in solution.
And when you have more folding, you have more opportunities for the molecules to bind to each other and aggregate, which basically means they clump together into larger and larger clusters.
Now, here's where things get different from your other peptides.
Unlike CJC or ipamorelin, tesamorelin has temperature dependent solubility that actually inverts at cold temperatures.
So when you put it in the refrigerator like you do with everything else, it exceeds its saturation point and those folded chains start aggregating into a gel.
And once that happens, the vial is done.
And this is exactly why the FDA approved version requires room temperature storage after reconstitution.
And it's also why tesamorelin comes in smaller vials than you might expect.
The vial sizes are designed around a seven day window, because that's how long you have before the degradation makes it ineffective.
So here's what you should actually do with your tesamorelin.
You can keep it frozen before you reconstitute it.
That's fine, but once you mix it, store it in a dark place at room temperature and use it within a week.
The bottom line is tesamorelin requires handling that goes against everything you've learned with other peptides, and now you understand why.
Most people lose potency without realizing it because they're storing it refrigerated like every other peptide.
The gel formation isn't always obvious, and even if you don't see visible clumping, the aggregation is still happening at the molecular level.
That means you're injecting degraded peptide that can't bind to the receptor properly.
You're going through the motions, but you're not getting the growth hormone pulse you're paying for.
If you've been running tesamorelin and not seeing the results you expected, this is probably why.
Check your storage method, reconstitute smaller amounts more frequently, and keep it at room temperature once it's mixed.
And here’s the FDA link:
Interested to hear if anyone stores theirs at room temperature or not?
