What did you "nope" out of and why?

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randompersonrandom

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What's something you thought sounded good, got a kit, started taking, and at some point for some reason said "Oh, you know what? I'm not finishing this out, this is not a good call for me."

Maybe you rethought the potential risks of something, maybe you read one too many accounts of an adverse reaction or had one yourself, maybe you came to believe that the benefits were not as promised.

Mine is MOTS-C. I got almost all the way through the mitochondrial protocol, and then went "Uh...the hard lumps I get at my injection site under the skin do not appear to be going away. I still have the ones from week one. You know what, this one's scary, never mind." (It's been a few weeks since my last dose, and they are finally almost all the way gone, but still, no thanks.)
 
Great question! This will be a good one to follow.

1) MOTS-C - I didn’t have much ISRs with this and finished my protocol, but won’t do it again after learning about how this has such a higher risk/prevalence of anaphylaxis. (Thanks to Calm Logic for gathering and posting the info to allow me to make the decision the risk isn’t worth the reward, which for me was no noticeable positive effect.)

2) PT-141 - I only did the 1 mini pin to assess tolerability and then one regular (2 mg) pin, but I don’t like how it makes me feel at all. The flushing lasts for over an hour and it makes me nauseous. For me, the juice isn’t worth the squeeze on this one.
 
I'm in week 1 of Mots-C in the protocol and I'm up to 2 mg! We'll see what happens at 5 mg.

The peptides I am staying away from are the ones that stimulate angiogenesis like TB-500, CJC and LL-37. Among my many tribulations have been two bouts of skin cancer, one melanoma and one basal cell. They were relatively minor in the grand scheme of things, but I'm wary of that category of peptides because of that. One that is mid-to-mildly pro-angiogenic is GHK-Cu, which I will use, but with KPV and BPC-157 and I'm also using it topically. This is why I lean more towards TA-1, Epitalon and others that are either non-angiogenic peptides or even show some anti-angiogenic properties in testing. Life is short.

Edit:typo
 
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Habibibi said:
I can't bring myself to use any peptide without phase 3 clinical human data behind it. Which means I only mess with GLP1s, tesamorelin, TA1, ipamorelin.
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And sermorelin is FDA approved.

Ipamorelin stalled in phase 2, but I know what you mean.

SS-31 got accelerated approval under the brand name Forzinity (but only for a rare metabolic disorder, Barth syndrome).
 
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GHK. It was inflammation city for me! Even with KPV taken first. Each night, the last three days worth of injection sites would swell, itch, and turn bright red. It gave me a crazy chest rash, sallow skin, darrrk under-eye bags, and a bright red, vascular, alcoholic nose daily...yet I don't drink!
 
swimmer said:
5-amino 1mq. I tried it twice. Both times I suffered major migraine headaches. I was going to try a third time (just in case the migraines were happening by chance right after) but I chickened out.
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Are you prone to migraines? Does anything else trigger them? I just got 2 kits of that orange stuff.
 
Dos-Dox said:
Great question! This will be a good one to follow.

1) MOTS-C - I didn’t have much ISRs with this and finished my protocol, but won’t do it again after learning about how this has such a higher risk/prevalence of anaphylaxis. (Thanks to Calm Logic for gathering and posting the info to allow me to make the decision the risk isn’t worth the reward, which for me was no noticeable positive effect.)

2) PT-141 - I only did the 1 mini pin to assess tolerability and then one regular (2 mg) pin, but I don’t like how it makes me feel at all. The flushing lasts for over an hour and it makes me nauseous. For me, the juice isn’t worth the squeeze on this one.
Click to expand...
Out of curiosity, have you tried PT as a nasal spray? I had the same reaction to it that you did, but I way overpaid for a kit and haven't really known what to do with it. Anyway I've been researching a nasal spray made with PT and oxytocin. I think they work great together and give me the exact boost I need. PT10/oxy5/3ml was my recipe. I also tried PT by itself but I think adding the oxytocin made it more effective.
 
Chili777 said:
Are you prone to migraines? Does anything else trigger them? I just got 2 kits of that orange stuff.
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Yes I am prone to migraines it runs in my family. I think tb-500 and BPC 157 can sometimes trigger them. Also SS31 gave mild migraines 50 % of the time. The 5amino1 I took was 50 mg oral capsules. I have never pinned it.
 
Melanotan 1 gave me migraines. I'm fair skinned and I was curious if it would help with sun sensitivity, plus I am starting to get a lot of gray hair so I thought I would try. Instant nausea and huge headache that lasted about 12 hours, both times I injected. Was just a 250 mcg dose, too. Not for me, I guess!
 
swimmer said:
Yes I am prone to migraines it runs in my family. I think tb-500 and BPC 157 can sometimes trigger them. Also SS31 gave mild migraines 50 % of the time. The 5amino1 I took was 50 mg oral capsules. I have never pinned it.
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Ok. Yeah, my daughter gets them chronically and gets Botox treatments twice a year. I got the lysophilized version. We'll see what happens.
 
Of the things I’ve tried, I’m done with 5 Amino, NAD and Lipo C - the 5 Amino didn’t do anything noticeable and I got tired of daily pins. The NAD I would try again buffered instead, because the sting was gross, it did seem to give me a calm energy so I thought I’d try those liposomal caps. The lipo c I would do again but the amount of liquid I was injecting started to gross me out.
I feel like I’m settling in with all this now and will probably lean more toward only trying stuff with human trials. I’m trying Sermorelin sometime in the near future.
 
cheaperseeker said:
NAD+ made my legs itch SO much. I know it would have passed in time but I just couldn't handle it, especially when I was trying to sleep.
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I was just watching Chicago Med last night where the psychiatrist said itching was one of the most distressing sensations a human can have.....the patient itched a hole in her head. That's a show, of course.

However, due to nerve pain (per the dr.), I've itched a hole in a favorite pair jeans (granted skinny jeans, so not a pair of Wranglers or anything like that 😅) and caused thickened, discolored skin on my thigh where the itch was. Luckily my itch was intermittent, though still super annoying and after about 3 yrs it disappeared as mysteriously as it showed up.

I've been thinking about the NAD+ but it'll be a no-go for sure if it makes me itch!
 
Almost nothing works on me. But I had a bit Respekt with motsc. 5mg Made my histamine reaction tonreta massive...and motsc itself did nothing.
 
DjJoshua said:
I personally did not like SEMAX nasal spray. after a 20 day cycle all i got out of it was a foggy mindset.
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To add to this,
The foggy mind was not all day. Plus Stack/interaction factors I am on tirzepatide can subtly influence energy/mood via metabolic changes. These could interact oddly with Semax's neurotrophic effects e.g., tirz sometimes causes transient brain fog in some users during dose adjustments, and layering peptides might amplify that. I have never lacked this but I just never got that whole sharpening focus feeling on semax
 

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For me it was KLOW. I definitely felt the anti-inflammatory benefit and I genuinely believe it cut my healing time significantly post surgery (reverse total shoulder replacement). I completed a 12 week course but I dealt with itchy, angry lumps at the injection sites for days after each injection. I constantly had two or three welts on my flank (rotating injection sites) for 3 months. I tried diluting the doses with more BAC, topical and oral antihistamines, lidocaine - nothing really helped. I'll return to BPC/TB and forego the KPV and GHk-Cu for my next foray.
 
Dos-Dox said:
Great question! This will be a good one to follow.

1) MOTS-C - I didn’t have much ISRs with this and finished my protocol, but won’t do it again after learning about how this has such a higher risk/prevalence of anaphylaxis. (Thanks to Calm Logic for gathering and posting the info to allow me to make the decision the risk isn’t worth the reward, which for me was no noticeable positive effect.)

2) PT-141 - I only did the 1 mini pin to assess tolerability and then one regular (2 mg) pin, but I don’t like how it makes me feel at all. The flushing lasts for over an hour and it makes me nauseous. For me, the juice isn’t worth the squeeze on this one.
Click to expand...
Do you have links to the mots-c anaphylaxis risk study?
 
Blindman said:
Do you have links to the mots-c anaphylaxis risk study?
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Someone I knew almost went to the ER after injecting 5 mg of MOTS-c by IM.

Other anecdotal reports, at least of IM use of MOTS-c:

What is MOTS-c like?

I've been reading up on MOTS-c and it seems quite promising, although some of the claims seem to be really out there. Does it affect gym performance in a noticeable way? Can it help with losing fat while maintaining (or even gaining) muscle? Animal and human clinical trials often use...
glp1forum.com glp1forum.com

More generally:

Epi Pen resources?

Has anyone managed to buy some Epi Pens as a hedge against potential anaphylaxis? If so, what was your process? Is there a go-to telehealth that can issue a scrip?
glp1forum.com glp1forum.com
 
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