BPC-157 injection site for achilles injuries?

Thadeus

Thadeus

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I have an old Achilles tendon injury, going on 5 years now. It doesn't stop me from doing active things but it's inflamed after and causes me significant pain. It's the reason I began taking a BPC-157 and TB-500 combo. I have been on 500mcg/500mcg daily dose (split morning and night) injected in the abdomen for about a month. It has helped me feel better from multiple other small injuries but my achillies is still bugging me and is still inflamed (not quite as bad as when I started but still protrudes from my heal about the size of a large marble). I've also been on a ChatGPT perscribed physical therapy regimen and have recently been resting it more than usual. The inflammation and pain is right where my tendon connects to my heal on the outside (confirmed to be soft tissue inflammation via X-ray) and there is really no fat down there to inject into. My question is would I benefit from upping my dose? Should I try injecting near the injury? I have read a lot of anecdotal evidence that BPC is more effective when dosed near the injury. Looking to get some opinions on what my best course of action would be to get it healed.
 
I've yet to see any research supporting injection near an injury site having more efficacy than anywhere else.

There are no large scale studies. No real studies at all. A few cool things with rats and wound healing.

If you want something that has quite a bit more proven results maybe take a look at PRP injections. Many actual studies on efficacy. Downsides , not covered by most insurance, hurts like a mfer.
 
Thadeus said:
I have an old Achilles tendon injury, going on 5 years now. It doesn't stop me from doing active things but it's inflamed after and causes me significant pain. It's the reason I began taking a BPC-157 and TB-500 combo. I have been on 500mcg/500mcg daily dose (split morning and night) injected in the abdomen for about a month. It has helped me feel better from multiple other small injuries but my achillies is still bugging me and is still inflamed (not quite as bad as when I started but still protrudes from my heal about the size of a large marble). I've also been on a ChatGPT perscribed physical therapy regimen and have recently been resting it more than usual. The inflammation and pain is right where my tendon connects to my heal on the outside (confirmed to be soft tissue inflammation via X-ray) and there is really no fat down there to inject into. My question is would I benefit from upping my dose? Should I try injecting near the injury? I have read a lot of anecdotal evidence that BPC is more effective when dosed near the injury. Looking to get some opinions on what my best course of action would be to get it healed.
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I hate writing long posts but I kind of know the struggle…

During a deployment I destroyed my ankle and I suffered a peroneal tendon tear. It was horrible! I had surgery to have it reattached but it still caused me serious pain. I wore that stupid boot, did the physical therapy, took pain meds, wore braces, did all the stretches, etc.

Eventually I had another surgery because the Army surgeon didn’t do the greatest job and I wasn’t a good patient during recovery because I wanted to get back into the field. I was young and really abused my body. Eventually I had a second surgery where they cut out scar tissue from the tendon and reattached it. Then I went through everything again. Nothing seemed like it helped and the pain was rough.

Eventually I had PRP therapy (Platelet-Rich Plasma). They draw blood and put it into a centrifuge to separate the plasma from everything else and then they inject it back into wherever you are injured. I had two sessions and each appointment took about an hour. It wasn’t a miracle cure where I felt immediate relief, but over time a good deal of pain subsided. It kind of took the edge off and made it more tolerable.

Recently I had a stellate ganglion block for something else, but as a happy little side effect it took away a lot of discomfort I had in my ankle and knees.

I recommend looking into PRP and a stellate ganglion block. It would take about three hours of your time but it is well worth it.
 
I was wondering about this too. I had peroneal tendinitis that was not healing. I was wondering about injecting into behind my calf when not flexed. I watched videos of people injecting right into the foot but did not feel comfortable with that. Luckily for me, the inflamed peroneal tendon actually got a lot better with time, a break from running, and PT stretching. So I never ended up using BPC-157/TB-500.
 
I don't think it really matters. The stuff we inject into ourselves works by getting into the blood stream and that goes to every part of the body that has blood in it. The reason we inject into fatty tissue is for a slightly slower absorption rate and reduced injection site pain. If you were to inject it into your foot its still probably going to go into your bloodstream first. It will still work .. but the injection will hurt more.
 
yrrdead said:
I've yet to see any research supporting injection near an injury site having more efficacy than anywhere else.

There are no large scale studies. No real studies at all. A few cool things with rats and wound healing.

If you want something that has quite a bit more proven results maybe take a look at PRP injections. Many actual studies on efficacy. Downsides , not covered by most insurance, hurts like a mfer.
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I think this is the most accurate statement. We are all working off of "Anec Data." PRP and Stem Cell therapies are the most researched items for treatment of tendinopathy/rupture. However, based on anec data and the way most of these subq peptides work, I would figure it would be fine to just inject where you normally inject any other peptide to take effect (insulin, GLP, etc.)

This is also why BPC presents as an issue for cancer/tumor growth, because no matter where you inject it seems to provide angiogenesis to other locations as well.
 
Thank you everyone for the information, it was very helpful!
 
PRP seems to be much more effective for tendon stuff than BPC/TB/etc., but also significantly more expensive.

I've used BPC/TB for more general tendon overuse injuries and they've been effective - but at higher doses than most "protocols" suggest, and I had very little luck with them at the lower doses.

My only long-standing injury is a torn meniscus and BPC/TB did nothing for it. Deca has helped with the pain for day to day/lighter weight stuff, but I still can't back squat/hack squat/safety squat with it (leg press and belt squat are OK due to being able to position my legs differently)

I suspect I'll need surgery to deal with the meniscus issue.
 
I tried site injection, abdomen subq, and glute IM and didn't notice any difference with any of these injection protocols.
 
catdog said:
I think this is the most accurate statement. We are all working off of "Anec Data." PRP and Stem Cell therapies are the most researched items for treatment of tendinopathy/rupture. However, based on anec data and the way most of these subq peptides work, I would figure it would be fine to just inject where you normally inject any other peptide to take effect (insulin, GLP, etc.)

This is also why BPC presents as an issue for cancer/tumor growth, because no matter where you inject it seems to provide angiogenesis to other locations as well.
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What research have you found demonstrating BPC presents an issue for cancer/tumor growth?
 
hexagonal said:
PRP seems to be much more effective for tendon stuff than BPC/TB/etc., but also significantly more expensive.

I've used BPC/TB for more general tendon overuse injuries and they've been effective - but at higher doses than most "protocols" suggest, and I had very little luck with them at the lower doses.

My only long-standing injury is a torn meniscus and BPC/TB did nothing for it. Deca has helped with the pain for day to day/lighter weight stuff, but I still can't back squat/hack squat/safety squat with it (leg press and belt squat are OK due to being able to position my legs differently)

I suspect I'll need surgery to deal with the meniscus issue.
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I’m using 500mcg BPC once a day for previous Achilles injury that was surgically repaired 2.5 years ago. So far nothing. Just curious what higher dose you found to be most effective?
 
I’m using .5mg 2x daily for 6-8 weeks for my rotator cuffs and tennis elbow. The shoulders were from the summer of 2024, elbow from August 2025.

I’m 3.5 weeks in and have noticed improvement. The most noticeable is with elbow; pain reduction using the tendon with grip strength and wrist extension. Before injections started, I could easily find the painful tendon anchor on bone, now I can’t find a tender spot.

Shoulders used to hurt/were tender when lifting above my shoulders, I’ve been gentle resting that as shoulder repair surgery is something I want to entirely avoid. In a small test last week with light weight, no pain presented.
 
UPresearcher said:
What research have you found demonstrating BPC presents an issue for cancer/tumor growth?
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There is none, at least that I've found. I found one article by a Dr. suggesting that this may be an issue, then other people and AI have regurgitated that one article.

Nor is there likely to be any research on this, no money in it.
 
Ragnar said:
I’m using 500mcg BPC once a day for previous Achilles injury that was surgically repaired 2.5 years ago. So far nothing. Just curious what higher dose you found to be most effective?
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I did 500mcg twice per day (first when waking, second before bed) for a knee injury from bjj. It worked great. First week I actually lost like 3 lbs from pissing out inflammation weight. Month in I was completely healed and rolling again.

Edit: forgot to add that within first week all the other little aches and pains just from life we're all gone. Big fan of bpc. Haven't had a reason to try it yet, but I got some just in case to pair with bpc if needed in future.
 
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I am only a few days into my protocol but am considering increasing to twice a day based on experiences from @woundcarping and @Mr. Blonde
Appreciate the feedback and am optimistic that my Achilles will improve with time.
I might also add TB500 in future I just get cautious and apprehensive to add too many things at once.
 
don't matter where you do it I do in leg or belly and my shoulder is so much better
 
Phatmax said:
i take 1mg of bp157 and 1mg of tb500 daily
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Late to the party, but I have a relevant comment andquestion.
Question first:
Is there such a thing as "too much" BPC-157, and if "yes", where is that threshold and how would I know if I have approached it? I ask because I have seen these as recommended dosages:
1) 250-500 mcg per day
2) 5000 mcg – 20000 mg per week (recommendation did not say if this should be split into daily)
3) @Phatmax is using 1000 mcg/daily
Comment:
My orthopedic surgeon recommended PRP for an old ankle injury. An old, old ankle injury. I sprained it over 45 years ago. In turns out the sprain was an undiagnosed ligament tear. PRP, combined with (very painful) physical therapy, was close to a miracle for me. My ankle is measurably more stable and less painful than it was.
I am hoping BPC-157/TB-500 well help with the ankle, and more importantly, help with recovery from a cervical fusion (C6/C7) from last summer that hasn't been going well. I have rather suddenly (last two months) lost a great deal of arm strength and stamina since the surgery. Thanks in advance.
 
lostlakebear said:
Late to the party, but I have a relevant comment andquestion.
Question first:
Is there such a thing as "too much" BPC-157, and if "yes", where is that threshold and how would I know if I have approached it? I ask because I have seen these as recommended dosages:
1) 250-500 mcg per day
2) 5000 mcg – 20000 mg per week (recommendation did not say if this should be split into daily)
3) @Phatmax is using 1000 mcg/daily
Comment:
My orthopedic surgeon recommended PRP for an old ankle injury. An old, old ankle injury. I sprained it over 45 years ago. In turns out the sprain was an undiagnosed ligament tear. PRP, combined with (very painful) physical therapy, was close to a miracle for me. My ankle is measurably more stable and less painful than it was.
I am hoping BPC-157/TB-500 well help with the ankle, and more importantly, help with recovery from a cervical fusion (C6/C7) from last summer that hasn't been going well. I have rather suddenly (last two months) lost a great deal of arm strength and stamina since the surgery. Thanks in advance.
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Who knows, by that I mean there is almost no data/studies. I say this a lot in these threads but its not any less true. Just understand in the case of BPC we really are doing the research.

Though I haven't even seen anecdotal posts about adverse reactions to taking "too much". Not that I would recommend it, just relaying that it appears pretty well tolerated with a good safety profile.

Lastly I would say that compared to PRP these peptides are a significant step down for most people in regards to efficacy. Sure there are going to be some amazing stories but plenty more discussing almost zero effect.
 
lostlakebear said:
Late to the party, but I have a relevant comment andquestion.
Question first:
Is there such a thing as "too much" BPC-157, and if "yes", where is that threshold and how would I know if I have approached it? I ask because I have seen these as recommended dosages:
1) 250-500 mcg per day
2) 5000 mcg – 20000 mg per week (recommendation did not say if this should be split into daily)
3) @Phatmax is using 1000 mcg/daily
Comment:
My orthopedic surgeon recommended PRP for an old ankle injury. An old, old ankle injury. I sprained it over 45 years ago. In turns out the sprain was an undiagnosed ligament tear. PRP, combined with (very painful) physical therapy, was close to a miracle for me. My ankle is measurably more stable and less painful than it was.
I am hoping BPC-157/TB-500 well help with the ankle, and more importantly, help with recovery from a cervical fusion (C6/C7) from last summer that hasn't been going well. I have rather suddenly (last two months) lost a great deal of arm strength and stamina since the surgery. Thanks in advance.
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I haven’t seen 20mg/week.

I’m taking BPC .5mg 2x daily, for 6-8 weeks. This coming Wednesday makes the 6th week. I’ll probably finish the vial I’m on and stop, although I’ll decide later.

My rotator cuffs and ECRB tendon (tennis elbow) were my main complaints… both were acute injuries from July 2024 and August 2025. Two orthos said I had good range of motion in the shoulders, avoid pain, live with it (good advice) as surgery would be recovery intensive. The shoulders I avoided doing much lifting higher than my shoulders, and normally they didn’t bother me very much. The ECRB, a steroid shot to treat the symptoms was a choice, surgery would be another choice for me, but the doctor suggested waiting to see. The wait and see period ended at Christmas, it was better, but still not well.

I started lifting last week, after 4 weeks on BPC. I did 5 sets of 10 reps of shoulder presses with no localized discomfort, just typical overall muscle soreness. My ECRB has improved in terms of pain relief as well as load bearing.


While not a “miracle”, and decidedly not scientific, I appear better off than when I started to a measure that is beyond expected healing during that relatively short time.

Pain relief in the elbow was early, perhaps a week. Research suggested that was inflammation reduction, not actual healing. That’s why I waited a month to start lifting.
 
yrrdead said:
Who knows, by that I mean there is almost no data/studies. I say this a lot in these threads but its not any less true. Just understand in the case of BPC we really are doing the research.

Though I haven't even seen anecdotal posts about adverse reactions to taking "too much". Not that I would recommend it, just relaying that it appears pretty well tolerated with a good safety profile.

Lastly I would say that compared to PRP these peptides are a significant step down for most people in regards to efficacy. Sure there are going to be some amazing stories but plenty more discussing almost zero effect.
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Good to know. Thank you.
 
I gotta say, I started BPC at the same time I switched Reta vendors and I was sure the 2 week long explosive bowel was because of the Reta, then I saw an influencer blame bpc and I stopped the bpc that day and everything went back to normal. Go figure. I thought bpc was supposed to help your gut. Was pushing .5-1mg
 
The only urgency I’ve had was once when I started magnesium glycinate while still taking 21g of PHGG (fiber). I dialed back the fiber and no urgency since while on BPC, tirz, and/or Reta.
 
Thadeus said:
The inflammation and pain is right where my tendon connects to my heal on the outside (confirmed to be soft tissue inflammation via X-ray) and there is really no fat down there to inject into.
Click to expand...

For my Achilles, I use GH peptides (abdominal subq), as well as oral supplements (like collagen, cissus quadrangularis, curcumin, and taurine, with hyaluronic acid on the way). No miracles so far, but most of the time I feel perfectly fine anyway.

I know BPC is touted the most (at least for mice with tendon issues), along with TB-500 and the other ingredients of KLOW (KPV and GHK). So I will finally recon/inject those soon, in addition to ARA-290 for shits and giggles. But I have been taking my time since I am skeptical.

So far, what helps me the most (in addition to stretching and heel raises) is buying new shoes every three months and never going barefoot. I love the Sketchers walking/running shoes with the rocker bottoms (as with the Hoka brand). Driving makes it worse, so the ergonomics of the pedals and using cruise control helps.
 
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While YouTube is far from medical research, I believe a content creator, Dr. Jones, stated that he used 2mg a day for a shoulder injury. I have a friend who used the same protocol for plantar fasciitis without issue. That would still be less than 20mg a week though.
 
BTW, conflicting info on TRT and Achillies issues ---

"Significant association between Achilles tendon injury and prescription TRT":

link.springer.com

Testosterone replacement therapy is associated with increased odds of Achilles tendon injury and subsequent surgery: a matched retrospective analysis - Journal of Foot and Ankle Research

Background Prescription of testosterone replacement therapy (TRT) has increased in the United States in recent years, and though anabolic steroids have been associated with tendon rupture, there is a paucity of literature evaluating the risk of Achilles tendon injury with TRT. This study aims to...
link.springer.com link.springer.com

"Low hormone levels maybe associated with the risk of Achilles tendon rupture":


Gemini's take is to aim for a consistent, mid-normal range of total testosterone (500 to 799):

Rapid fluctuations in androgen levels are often more taxing on connective tissue than a steady, moderate dose.

The "sweet spot" is likely balancing the two:

Avoid the "Dip": Low levels (from an inconsistent protocol) will hinder repair.

Control the "Peak": Avoid supra-physiological spikes that encourage the muscle to outpace the tendon.

Leverage BPC-157: This is where BPC-157 becomes relevant. In the studies you were asking about, BPC-157 specifically targets the tendon-to-bone healing junction and fibroblast growth. It essentially acts as a "bridge" to help the tendon catch up to the increased mechanical load provided by the TRT.

Level TypeTotal T RangeImpact on Achilles Tendon
Hypogonadal<300 ng/dLHigh Risk: Brittle, thin tendons; poor fibroblast activity and repair capacity.
Low-Normal300–499 ng/dLModerate Risk: Slow collagen synthesis; tendon may struggle to recover from chronic "micro-tears."
Mid-Normal500–799 ng/dLLowest Risk: Balanced remodeling; muscle strength and tendon thickness usually develop in sync.
High-Normal800–1,100 ng/dLModerate Risk: Muscle-tendon "lag"; rapid strength gains can put excessive mechanical strain on the tendon.
Supraphysiological1,200+ ng/dLHigh Risk: Potential for disorganized collagen fibers and "stiffening," increasing sudden rupture risk.
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