BPC-157 injection site for achilles injuries?

[Calm Logic]

It looks like a .246% vs .378% risk, a ~52% increase.

Definitely another reason to "test the test" more frequently, as well as test E2 level (sensitive or otherwise).

Per Gemini, the risk is still low and estrogen can be protective at high-normal (which also reminds me of HCG):

The jump from 0.246% to 0.378% is indeed a 53.6% relative increase. Even with the increase, 99.6% of men on TRT did not experience an Achilles injury during the study period.

Most of these studies don't account for E2 levels. By keeping yours high-normal, you are actively fighting the "tendon stiffness" that likely caused the increased risk in the study cohorts (many of whom may have been using AI or had "dry" joints).

 

[Thadeus]

BTW, conflicting info on TRT and Achillies issues ---

"Significant association between Achilles tendon injury and prescription TRT":

Testosterone replacement therapy is associated with increased odds of Achilles tendon injury and subsequent surgery: a matched retrospective analysis - Journal of Foot and Ankle Research

Background Prescription of testosterone replacement therapy (TRT) has increased in the United States in recent years, and though anabolic steroids have been associated with tendon rupture, there is a paucity of literature evaluating the risk of Achilles tendon injury with TRT. This study aims to...

link.springer.com

"Low hormone levels maybe associated with the risk of Achilles tendon rupture":

https://journals.sagepub.com/doi/abs/10.1177/2325967113S00085

Gemini's take is to aim for a consistent, mid-normal range of total testosterone (500 to 799):

Interesting, thanks, I've actually been on TRT for about a year and half on a once weekly injection protocol. My tendon issue predates that switch for me but this is good food for thought.

 

[Thadeus]

Also just to update, I've finished up the couple vials of BPC/TB I had and switched to KLOW for the last few weeks. The issue hasn't resolved but I'm definitely seeing some improvements. I'm able to jog again even on concrete without significant flare-ups or pain. I've traditionally always used jogging as a way to regulate my weight and it's working for me. Trying to delicately balance the benefits of some weight loss putting less pressure on my achilles and not over doing it and causing more inflammation. So far so good, down about 25lbs since early December and still trending less and less localized pain.

 

[RubbaDubba1]

For my Achilles, I use GH peptides (abdominal subq), as well as oral supplements (like collagen, cissus quadrangularis, curcumin, and taurine, with hyaluronic acid on the way). No miracles so far, but most of the time I feel perfectly fine anyway.

I know BPC is touted the most (at least for mice with tendon issues), along with TB-500 and the other ingredients of KLOW (KPV and GHK). So I will finally recon/inject those soon, in addition to ARA-290 for shits and giggles. But I have been taking my time since I am skeptical.

So far, what helps me the most (in addition to stretching and heel raises) is buying new shoes every three months and never going barefoot. I love the Sketchers walking/running shoes with the rocker bottoms (as with the Hoka brand). Driving makes it worse, so the ergonomics of the pedals and using cruise control helps.

I had a triple Ankle fusion many moon ago and the Arthritis, along with some other mentioned (Achilles) is back. I really like the Asics Keyano Gel 31. I walked around in a pair at the local shoe place and was sold pretty quick. I work on concrete all day, I'd tell ya to go give these a try if you're out lookin again.

 

[Calm Logic]

I had a triple Ankle fusion many moon ago and the Arthritis, along with some other mentioned (Achilles) is back. I really like the Asics Keyano Gel 31. I walked around in a pair at the local shoe place and was sold pretty quick. I work on concrete all day, I'd tell ya to go give these a try if you're out lookin again.

Cool:

Cut in half: ASICS Gel Kayano 31 Review

ASICS Gel Kayano 31 review: The Gel Kayano has been around us since 1993 and is more alive than ever. After surviving a risky update last year, we found that ASICS has built on its solid foundations by adding subtle improvements to the upper, stability, weight, and fit. It's still a big and...

runrepeat.com

 

[Flexon]

Regarding the place of injection, I didn't inject BPC, but used it sublingually. The problem BPC resolved for me 95% was prostatitis (very painful prostate region flare-ups). The thing is, the prostate should be a problem for many drugs to penetrate. Or, to make things simpler, the journey from under my tongue to my prostate wasn't a problem for BPC to get there and do it's wanders! So, to my experience, once it's in the bloodstream, the efficacy is more dependent on the right dosage.

 

[Chris Thomas]

I haven’t seen 20mg/week.

I’m taking BPC .5mg 2x daily, for 6-8 weeks. This coming Wednesday makes the 6th week. I’ll probably finish the vial I’m on and stop, although I’ll decide later.

My rotator cuffs and ECRB tendon (tennis elbow) were my main complaints… both were acute injuries from July 2024 and August 2025. Two orthos said I had good range of motion in the shoulders, avoid pain, live with it (good advice) as surgery would be recovery intensive. The shoulders I avoided doing much lifting higher than my shoulders, and normally they didn’t bother me very much. The ECRB, a steroid shot to treat the symptoms was a choice, surgery would be another choice for me, but the doctor suggested waiting to see. The wait and see period ended at Christmas, it was better, but still not well.

I started lifting last week, after 4 weeks on BPC. I did 5 sets of 10 reps of shoulder presses with no localized discomfort, just typical overall muscle soreness. My ECRB has improved in terms of pain relief as well as load bearing.


While not a “miracle”, and decidedly not scientific, I appear better off than when I started to a measure that is beyond expected healing during that relatively short time.

Pain relief in the elbow was early, perhaps a week. Research suggested that was inflammation reduction, not actual healing. That’s why I waited a month to start lifting.

Oh boy, good to hear someone is improving.

I tore something in my shoulder while lifting weights. It was clear I needed to back off and let it heal, but it just never seemed to improve. After several months, I finally went to the doctor. He diagnosed a minor tear with an MRI and recommended a PRP injection.

When I mentioned this to a friend of mine, he suggested adding BPC-157. I was skeptical since I was completely new to peptides, I was also concerned the doctor might hesitate to move forward if he knew I was using a non-approved substance, so I waited until after the injection to start BPC.

It’s been exactly 20-days since the PRP injection, but who is counting. I still feel like I’ve been run over by a truck. I have gotten somewhat better since the ijection, but I still can't even look at weights, I can't imagine benchpressing at 4 weeks. I am currently taking the same dosage as you Mr. Woundcarping.

I am crossing my fingers, there is nothing more that I would like than to be healthy!

Best to all, maybe I will check back in a couple weeks.

 

[Calm Logic]

Anyone who took 1 mg twice a day (2 mg/day)?

 

[woundcarping]

Anyone who took 1 mg twice a day (2 mg/day)?

I may have taken my first 10mg at that rate…

 

[woundcarping]

Anyone who took 1 mg twice a day (2 mg/day)?

Were you going somewhere with that?

I’m curious where the limiting factor comes in on single dose. Half life is very short, I also wonder about max single dose vs more than twice a day.

Best I recall, there isn’t a practical max dose in terms of toxicology.

 

[Calm Logic]

I’m curious where the limiting factor comes in on single dose. Half life is very short, I also wonder about max single dose vs more than twice a day.

Yeah, right now considering doing 500 mcg three times a day.

Incidentally, some crazy (extremely non-scientific) reverse engineering:

Considering some vials of BPC are 20 mg, which is often/usually taken twice a day, and 20 punctures is my ideal upper limit, that gives 10 days of 1 mg BID.

 

[LabRatts]

First experience with researching was Wolverine (bpc/tb500).
We did .5 mg daily then .75 and finished off 6 10/10 vials at 1.25 daily.
Both of us rats are 60ish, lots of chronic pain and some acute, on injection day one we were anyway.
About 4 weeks in (doing .75 daily) we both noticed acute was regulated, and chronic aches drastically. That 8 week cycle, in the end, has reduced my pain to near nil, like nada, and the wife's (rat) corrected some Achilles issues, but not so severe as the OP indicated theirs is\was.
I'll always keep a kit of Wolverine on hand for the hard knocks we al!encounter during active lifestyles.
Prayers for effective treatment for your ailments, regardless of which form they arrive in.

 

[Matvic81]

I've yet to see any research supporting injection near an injury site having more efficacy than anywhere else.

There are no large scale studies. No real studies at all. A few cool things with rats and wound healing.

If you want something that has quite a bit more proven results maybe take a look at PRP injections. Many actual studies on efficacy. Downsides , not covered by most insurance, hurts like a mfer.

I’ve had PRP injections for my spine…what a ride!

 

[Zol1th]

I haven’t seen 20mg/week.

I’m taking BPC .5mg 2x daily, for 6-8 weeks. This coming Wednesday makes the 6th week. I’ll probably finish the vial I’m on and stop, although I’ll decide later.

My rotator cuffs and ECRB tendon (tennis elbow) were my main complaints… both were acute injuries from July 2024 and August 2025. Two orthos said I had good range of motion in the shoulders, avoid pain, live with it (good advice) as surgery would be recovery intensive. The shoulders I avoided doing much lifting higher than my shoulders, and normally they didn’t bother me very much. The ECRB, a steroid shot to treat the symptoms was a choice, surgery would be another choice for me, but the doctor suggested waiting to see. The wait and see period ended at Christmas, it was better, but still not well.

I started lifting last week, after 4 weeks on BPC. I did 5 sets of 10 reps of shoulder presses with no localized discomfort, just typical overall muscle soreness. My ECRB has improved in terms of pain relief as well as load bearing.


While not a “miracle”, and decidedly not scientific, I appear better off than when I started to a measure that is beyond expected healing during that relatively short time.

Pain relief in the elbow was early, perhaps a week. Research suggested that was inflammation reduction, not actual healing. That’s why I waited a month to start lifting.

Did you ever take TB500?

 

[woundcarping]

Did you ever take TB500?

Nope

 

[CycleSloth]

Regarding the place of injection, I didn't inject BPC, but used it sublingually. The problem BPC resolved for me 95% was prostatitis (very painful prostate region flare-ups). The thing is, the prostate should be a problem for many drugs to penetrate. Or, to make things simpler, the journey from under my tongue to my prostate wasn't a problem for BPC to get there and do it's wanders! So, to my experience, once it's in the bloodstream, the efficacy is more dependent on the right dosage.

What's the process for administering BPC sublingually?

 

[marraqy]

I’m currently running 1mg each of BPC and TB-500 for a disc herniation and a right wrist injury. I’ve noticed some relief with the disc, though I’m not calling it a win just yet to avoid a false positive. My wrist hasn't seen much change yet, though.

Since you’re already seeing systemic benefits for your other injuries, trying a more localized approach near the heel might be worth a shot for the Achilles, given how little blood flow that area gets.

 

[Calm Logic]

Since you’re already seeing systemic benefits for your other injuries, trying a more localized approach near the heel might be worth a shot for the Achilles, given how little blood flow that area gets.

Punny.

For me, sitting a lot makes it worse, I guess due to the attached calf and hamstring muscles getting tight.

I would also consider a new pair of shoes (new pair of rocker sneakers or at least inserts for me every 3 months, such as heel lifts).

One sneaker mentioned before:

I had a triple Ankle fusion many moon ago and the Arthritis, along with some other mentioned (Achilles) is back. I really like the Asics Keyano Gel 31. I walked around in a pair at the local shoe place and was sold pretty quick. I work on concrete all day, I'd tell ya to go give these a try if you're out lookin again.

Cut in half: ASICS Gel Kayano 31 Review

ASICS Gel Kayano 31 review: The Gel Kayano has been around us since 1993 and is more alive than ever. After surviving a risky update last year, we found that ASICS has built on its solid foundations by adding subtle improvements to the upper, stability, weight, and fit. It's still a big and...

runrepeat.com

And isometric/loading exercises and heavy slow resistance (HSR):

The modern "gold standard" for Achilles issues usually follows this progression:

1. Phase 1: Isometrics. If your heel hurts just walking around or during your first few sets of calf raises, start here. Doing 5 sets of 45-second holds can actually "numb" the tendon for several hours, allowing you to get through the rest of your workout.
   
   
2. Phase 2: HSR. Once the sharp pain subsides into a dull ache, you move to HSR. This involves very slow (3 seconds up, 3 seconds down) weighted calf raises. This "slow-cooks" the tendon, forcing the collagen fibers to realign and get stronger.

It's a very slow healing process no matter what. Lots of Youtube videos on Achilles, including how to massage near the tendon.

Some videos by licensed practitioners (Bob & Brad series):

View: https://www.youtube.com/watch?v=qvfm3Lb3Ojs

View: https://www.youtube.com/watch?v=2ke5BXW-ujo

View: https://www.youtube.com/watch?v=xx9rokOgJVA

 

[RubbaDubba1]

Part of my Kitchen Sink Protocol, is I take Tadalafil 5mg 2X a day to help increase blood flow and help get the peps to where they can do there job. I just had shoulder surgery, I got the jacked ankle and a few other things. I'm not just coming out of left field: watch 2 minutes from here

View: https://youtu.be/RgA4Hyr1Hbk?t=2730

 

[Flexon]

What's the process for administering BPC sublingually?

Reconstitute as you would for injection then squirt it gently, drop by drop into mouth under your tongue. Hold it there for 90-120 seconds, then swallow.

 

[CycleSloth]

Thanks - that’s interesting. What does it taste like?

I was asking as I understand for BPC it is recommended to inject daily and I am not sure whether I want to do that. So I might try sublingually, I will research some more to understand this better or are there good resources already available which I haven’t found yet?