Tirzepatide stackers: What's the ONE peptide you added that made the biggest difference (and the one you regret trying)?

[DjJoshua]

I'm trying to protect muscle and maybe accelerate things without messing up progress.

What's the single peptide you stacked with Tirz that gave you the biggest noticeable win? (E.g., faster stubborn fat melt like belly/visceral, better muscle preservation, improved recovery/energy/sleep, skin glow/recovery boost, etc.) Bonus points if you share rough dosing or how long it took to kick in!

And on the flip side what's one you added and regretted? (Sides like water retention, blunted food noise suppression, no real difference, injection overload, or just not worth the hassle/money?)
Thank you.

 

[Gr33dyOctopus]

So i may or not know a certain police seargent that is built like a greek god. He has body dysmorphia and is obsessed with his musclature. He is using reta and test, but most of his cop friends are taking steroids. He doesnt like to use those preferring peptides. Super cool, super yoked out motherfucker. Ill speak for him, heres his current stack.

Testosterone Cypianate
Sermorelin
Reta
MOT-C

He prefers natural, but he is also a genetic wonder of nature and I secretly love/hate him for it. But he has huge confidence issues most people dont see. Wild shit. Anyway, ive nothing useful to add, so just puked up all that on ya dj josh 🤪😃😅

 

[latviantower]

So i may or not know a certain police seargent that is built like a greek god. He has body dysmorphia and is obsessed with his musclature. He is using reta and test, but most of his cop friends are taking steroids. He doesnt like to use those preferring peptides. Super cool, super yoked out motherfucker. Ill speak for him, heres his current stack.

Testosterone Cypianate
Sermorelin
Reta
MOT-C

He prefers natural, but he is also a genetic wonder of nature and I secretly love/hate him for it. But he has huge confidence issues most people dont see. Wild shit. Anyway, ive nothing useful to add, so just puked up all that on ya dj josh 🤪😃😅

I get the test c / GLP stack, and I like MOTS-C - and SS-31 more. (FYI I’ve been schooled here by folks providing links dispelling the belief that reta is better than tirz at sparing muscle - there’s no difference). But I’m curious what benefit Sgt Adonis feels from the sermorelin. Thoughts?

In answer to the original question, depending on the age and gender of your rat, I would add 1-4 iu hgh daily.

 

[latviantower]

I'm trying to protect muscle and maybe accelerate things without messing up progress.

What's the single peptide you stacked with Tirz that gave you the biggest noticeable win? (E.g., faster stubborn fat melt like belly/visceral, better muscle preservation, improved recovery/energy/sleep, skin glow/recovery boost, etc.) Bonus points if you share rough dosing or how long it took to kick in!

And on the flip side what's one you added and regretted? (Sides like water retention, blunted food noise suppression, no real difference, injection overload, or just not worth the hassle/money?)
Thank you.

What worked? Tesa. 2 mg at bedtime, 5 on/2 off for six months.

Waste of time and money? AOD-9604. I should have read more. This was researched heavily by MSM/BP and abandoned. If those two leviathan entities didn’t see profit potential, I probably shouldn’t have, either.

 

[AlexSilver]

What didn't work? Vesilute. Made me pee 5-6 times a night. I recently learned that it upregulates the inflammasome NF-kB. Very bad.

 

[FarmgirlRebel]

NAD+ was the biggest game changer in my stacks I've used with Tirz.
Upped my energy, cleaned out the brain fog and generally treats me very well. Makes getting up and moving throughout the day much easier.

I haven't taken anything that was just "meh" at this point. TA-1 I guess didn't really do anything noticeable, but why would it? It's one of those "behind the scenes" things we take.

 

[ComputerElbow]

My wife is on NAD+ and echoes your statement, all of her brain fog is gone and more energy. I'm thinking of adding it in soon.

 

[Chili777]

I like Reta for sure. It's been life changing, so far. As for non-GLP peptides, I'm not sure because I haven't tried them all yet. 😛 In the running would be Epitalon and NA Semax. Mots-C really kicked my ass today in a good way, but I may save that one for when I need to fight bears or jump from building to building. I thought SS-31 was a dud, feels-wise, but if it prepared me for Mots-C and the blast I got today, then it certainly did it's job. KPV is a keeper, so is TA-1 and Selank.

So I guess haven't found one that I would say never again. I do think if you are older, you feel them more because they are designed optimize aspects of your metabolism, brain signaling pathways and immune system. If you don't have that damage (yet), or deficiency, you may not feel the impact. You can't optimize an already optimal system.

 

[FarmgirlRebel]

I like Reta for sure. It's been life changing, so far. As for non-GLP peptides, I'm not sure because I haven't tried them all yet. 😛 In the running would be Epitalon and NA Semax. Mots-C really kicked my ass today in a good way, but I may save that one for when I need to fight bears or jump from building to building. I thought SS-31 was a dud, feels-wise, but if it prepared me for Mots-C and the blast I got today, then it certainly did it's job. KPV is a keeper, so is TA-1 and Selank.

So I guess haven't found one that I would say never again. I do think if you are older, you feel them more because they are designed optimize aspects of your metabolism, brain signaling pathways and immune system. If you don't have that damage (yet), or deficiency, you may not feel the impact. You can't optimize an already optimal system.

MOTS-c drained me the first few times I took it...I do think I am one of those that would have benefited more from it had I ran SS-31 first. So I backed off and I am waiting to get some SS-31 on my next order.

 

[MFGamesta]

I would say adding extra protein to my diet was the biggest improvement.

"Stacking protein"

I think CJC/Ipomorelin helped a little but protein and diet is biggest.

 

[Chili777]

MOTS-c drained me the first few times I took it...I do think I am one of those that would have benefited more from it had I ran SS-31 first. So I backed off and I am waiting to get some SS-31 on my next order.

I titrated up to 3 mg last week and started 5 mg this week. I was following the full 14-week protocol. I can't handle 5 mg. It's like rocket fuel. I hope I can sleep tonight. I was good at 3 mg, so I'm staying there.

 

[FarmgirlRebel]

I titrated up to 3 mg last week and started 5 mg this week. I was following the full 14-week protocol. I can't handle 5 mg. It's like rocket fuel. I hope I can sleep tonight. I was good at 3 mg, so I'm staying there.

Good to know...I was just using 2.5 mg 2x a week...by the time I finished up the second vial, I wasn't feeling drained at least...I'll ramp it back up after an SS-31 intro.
When you say "rocket fuel"...is this just an abundance of energy or are you feeling jittery at all? I felt that way w/my starter dose of NAD+...love it but...difficult sleeping the first night.

 

[FarmgirlRebel]

My wife is on NAD+ and echoes your statement, all of her brain fog is gone and more energy. I'm thinking of adding it in soon.

I do think the more depleted our NAD levels are, the more bang for the buck you get...of course as we age, the more depleted those get naturally.

 

[Chili777]

Good to know...I was just using 2.5 mg 2x a week...by the time I finished up the second vial, I wasn't feeling drained at least...I'll ramp it back up after an SS-31 intro.
When you say "rocket fuel"...is this just an abundance of energy or are you feeling jittery at all? I felt that way w/my starter dose of NAD+...love it but...difficult sleeping the first night.

It was an abundance of clean energy, mood lift, wanting to do SOMETHING but realizing I had to work. I wanted to go mow the grass and trim the trees, but then realized I'm in an apartment and they wouldn't appreciate that much. I did not need my coffee this morning. That kind of energy. I've also been taking NR for many years and also did the six week SS-31 precursor, so I think I was primed for it. I also did my afternoon strength training and didn't just increase by 5 or 10 reps, but increased by 20 reps.

 

[CMA Pooky]

It was an abundance of clean energy, mood lift, wanting to do SOMETHING but realizing I had to work. I wanted to go mow the grass and trim the trees, but then realized I'm in an apartment and they wouldn't appreciate that much. I did not need my coffee this morning. That kind of energy. I've also been taking NR for many years and also did the six week SS-31 precursor, so I think I was primed for it. I also did my afternoon strength training and didn't just increase by 5 or 10 reps, but increased by 20 reps.

That sounds great, I'm on the 14 week Mitochondrial protocol but haven't started the Mots-C part yet. The only thing I worry a bit about is the ISRs some people mention they have with Mots-C.

 

[CNCCurrency]

I'm trying to protect muscle and maybe accelerate things without messing up progress.

What's the single peptide you stacked with Tirz that gave you the biggest noticeable win? (E.g., faster stubborn fat melt like belly/visceral, better muscle preservation, improved recovery/energy/sleep, skin glow/recovery boost, etc.) Bonus points if you share rough dosing or how long it took to kick in!

And on the flip side what's one you added and regretted? (Sides like water retention, blunted food noise suppression, no real difference, injection overload, or just not worth the hassle/money?)
Thank you.

HGH

 

[Chili777]

That sounds great, I'm on the 14 week Mitochondrial protocol but haven't started the Mots-C part yet. The only thing I worry a bit about is the ISRs some people mention they have with Mots-C.

I was worried about that, too. Some people even needed to stop, so I was concerned. Last week, titrated up from 1 mg, 2 mg, 3 mg on MWF. I had no issues. I filtered it all and didn't get even an ISR, either. I seem to be golden for it. Now I just have to figure out when to use it. I filtered and aliquoted 20 mg for the next week, thinking it might be more like SS-31. I might just spread it out over a longer period.

 

[Hichewgoddess]

That sounds great, I'm on the 14 week Mitochondrial protocol but haven't started the Mots-C part yet. The only thing I worry a bit about is the ISRs some people mention they have with Mots-C.

Honestly it’s not awful. I find it itchy and maybe a little uncomfortable for about 10 min. Well worth it though.

 

[yrrdead]

So i may or not know a certain police seargent that is built like a greek god. He has body dysmorphia and is obsessed with his musclature. He is using reta and test, but most of his cop friends are taking steroids. He doesnt like to use those preferring peptides. Super cool, super yoked out motherfucker. Ill speak for him, heres his current stack.

Testosterone Cypianate
Sermorelin
Reta
MOT-C

He prefers natural, but he is also a genetic wonder of nature and I secretly love/hate him for it. But he has huge confidence issues most people dont see. Wild shit. Anyway, ive nothing useful to add, so just puked up all that on ya dj josh 🤪😃😅

I'm not sure if you are back GO but I would feel remiss if I didn't point these things out.

TestCyp is literally a steriod, you could argue Test is the OG steroid. Definitely not "natural" (going by bro definition and I guess WADA)

 

[DjJoshua]

I'm not sure if you are back GO but I would feel remiss if I didn't point these things out.

TestCyp is literally a steriod, you could argue Test is the OG steroid. Definitely not "natural" (going by bro definition and I guess WADA)

Just to throw it out there I am also on a low amount of TRT I have been on TRT for 4 years now. My journey began from a motorcycle crash (wife and I)and got VERY banged up broken ribs etc... I gained a LOT of weight from the recovery and have been getting back in shape.

Ps. Wife was just fine. lol.

 

[gurbert]

I like Reta for sure. It's been life changing, so far. As for non-GLP peptides, I'm not sure because I haven't tried them all yet. 😛 In the running would be Epitalon and NA Semax. Mots-C really kicked my ass today in a good way, but I may save that one for when I need to fight bears or jump from building to building. I thought SS-31 was a dud, feels-wise, but if it prepared me for Mots-C and the blast I got today, then it certainly did it's job. KPV is a keeper, so is TA-1 and Selank.

So I guess haven't found one that I would say never again. I do think if you are older, you feel them more because they are designed optimize aspects of your metabolism, brain signaling pathways and immune system. If you don't have that damage (yet), or deficiency, you may not feel the impact. You can't optimize an already optimal system.

Did your lab rat try subQ selank or it prefers sprays? Is it a combo of Semax/Selank... or started one at a time.

This lab rat is currently on day 3 of Selank subq and will probably go for another ~3 weeks and then swap to nasal and check the difference.

The rats not sure if it wants to also try Semax soon.

 

[Jellybelly54]

I’ve tried 30 different peptides! Hahah! (I just did a count) . Probably the ones I’ve noticed the most were the mitochondrial peps like MOTS-C , SS-31, AICAR and 5A1MQ and of course NAD+. Out of all of those NAD+ gives the most bang for the buck. Will elevate my resting HR by 10 though! A 50 mg IM shot of NAD feels a little like what morphine feels like when being pushed IV….you feel your breath being taken away. It’s a little unnerving at first.

Probably the least noticeable in effect would be any of the Khavison bioregulators: prostamax, Cartalax , Cortagen are the ones I’ve tried . Maybe they are doing something?? I just haven’t noticed any benefits . I honestly notice nothing on BPC157 even on high doses and that’s from multiple different suppliers.

The GHRH/GHRP did nothing. I ran tesa , ipa and Kisspeptin and did pre and post testosterone levels and my testosterone actually went down! Not the effect I was hoping for. Not sure the trade off of extra GH and IGF-1 was worth it at all??

Probably the worst injection by far has been the KLOW . Painful, red , soreness for days with each shot! For something that was supposed to lower inflammation I got the opposite result. Maybe my KLOW was one of the fake ones with blue dye instead of Cu?

 

[AlexSilver]

Probably the worst injection by far has been the KLOW . Painful, red , soreness for days with each shot! For something that was supposed to lower inflammation I got the opposite result. Maybe my KLOW was one of the fake ones with blue dye instead of Cu?

Normal ISR from GLOW/KLOW. Try doubling your BAC water. Higher dilution seems to work for a lot of folks. And me.

 

[homebrew]

NAD+ was the biggest game changer in my stacks I've used with Tirz.
Upped my energy, cleaned out the brain fog and generally treats me very well. Makes getting up and moving throughout the day much easier.

I want to believe that NAD+ ups energy and cleans out brain fog, but I honestly can't tell. 50mg subQ 3x/week. 71 yrs young - Should I be feeling something?

 

[FarmgirlRebel]

I want to believe that NAD+ ups energy and cleans out brain fog, but I honestly can't tell. 50mg subQ 3x/week. 71 yrs young - Should I be feeling something?

I would think you'd be feeling something...but you are not the first person I've heard say that they didn't feel anything on NAD+. I've been running NAD+ for awhile now, and I don't really notice the effects like I did at the beginning as I think my NAD levels are better. So perhaps your NAD levels weren't as depleted as mine (I had sepsis shock back in 2023 that has lingering health issues)??

However, I did plan to go off of NAD+ for 6 weeks and run a different peptide stack that I wanted to get a clear reading on w/o NAD interference. I lasted not even a month, started feeling wilted. Brang NAD+ back on board and it was like getting a big hug from an old friend.

 

[Chili777]

Did your lab rat try subQ selank or it prefers sprays? Is it a combo of Semax/Selank... or started one at a time.

This lab rat is currently on day 3 of Selank subq and will probably go for another ~3 weeks and then swap to nasal and check the difference.

The rats not sure if it wants to also try Semax soon.

Mine liked them both via IN. The sprays were almost immediate onset and lastest 3-4 hours and it's easy to just take a couple more for added support. I am going to try Sq next cycle and compare, but I'll always have the sprays in my rat toolkit

 

[swimmer]

When I was losing my last 10 lbs, I was on 20 mg tirz every 5 days. I wanted to stop losing muscle. I added Tesa/Ipamorelin 1mg/150 mcg right after workouts. 5 days on 2 off. It was a game changer. I actually started gaining muscle and continued to lose weight. I still cycle it : 12 weeks on 8 weeks off.

I am currently finishing the 14 week NAD, ss31, mots-c protocol. I did not notice anything for the first 6 weeks. Around week 7, I started to notice definite memory and reaction time improvment. It was crazy! When something would fall off the table, my hand would shoot out and catch it like I was 20 again. I recently started timing the nad+ shot in the early morning before a very physical work day and I notice definite improvement. Way less fatigue on a 15 hour day! The changes from the protocol were very gradual but very pronounced. I hope the changes last after I stop next week.

 

[DjJoshua]

I’ve tried 30 different peptides! Hahah! (I just did a count) . Probably the ones I’ve noticed the most were the mitochondrial peps like MOTS-C , SS-31, AICAR and 5A1MQ and of course NAD+. Out of all of those NAD+ gives the most bang for the buck. Will elevate my resting HR by 10 though! A 50 mg IM shot of NAD feels a little like what morphine feels like when being pushed IV….you feel your breath being taken away. It’s a little unnerving at first.

Probably the least noticeable in effect would be any of the Khavison bioregulators: prostamax, Cartalax , Cortagen are the ones I’ve tried . Maybe they are doing something?? I just haven’t noticed any benefits . I honestly notice nothing on BPC157 even on high doses and that’s from multiple different suppliers.

The GHRH/GHRP did nothing. I ran tesa , ipa and Kisspeptin and did pre and post testosterone levels and my testosterone actually went down! Not the effect I was hoping for. Not sure the trade off of extra GH and IGF-1 was worth it at all??

Probably the worst injection by far has been the KLOW . Painful, red , soreness for days with each shot! For something that was supposed to lower inflammation I got the opposite result. Maybe my KLOW was one of the fake ones with blue dye instead of Cu?

I have not tried NAD+ It's on my China wish list of things to get. I'm in the same boat, GHK-cu does burn a bit but that trick with adding BAC water I posted does work for me. Thank you for your info.

 

[Jellybelly54]

I recently purchased some buffered phosphate solution for my ARA290 which works wonderfully by the way at getting the ARA to go into solution. This last KLOW that I mixed up, I added about a half a milliliter of buffered phosphate solution in with the BAC water and then added two more milliliters of BAC water to dilute it even more. (one vial of KLOW with 4.5 ML‘s BAC and 0.5 ML‘s of PBS for a total volume of 5 ML‘s). So far no ISR or pain so I’m hopeful that fixes it because that KLOW isn’t cheap!

 

[DjJoshua]

When I was losing my last 10 lbs, I was on 20 mg tirz every 5 days. I wanted to stop losing muscle. I added Tesa/Ipamorelin 1mg/150 mcg right after workouts. 5 days on 2 off. It was a game changer. I actually started gaining muscle and continued to lose weight. I still cycle it : 12 weeks on 8 weeks off.

I am currently finishing the 14 week NAD, ss31, mots-c protocol. I did not notice anything for the first 6 weeks. Around week 7, I started to notice definite memory and reaction time improvment. It was crazy! When something would fall off the table, my hand would shoot out and catch it like I was 20 again. I recently started timing the nad+ shot in the early morning before a very physical work day and I notice definite improvement. Way less fatigue on a 15 hour day! The changes from the protocol were very gradual but very pronounced. I hope the changes last after I stop next week.

This is some good info. I ran a cycle of MOTS-c and SS-31 for about a month, I'm giving it a break then I was going to start it back up. How long did you run it ie all 7 days or did you take a break on the weekends? I'm on a cycle of CJC no DAC and just got some Ipamorelin showing up today.