Tirzepatide stackers: What's the ONE peptide you added that made the biggest difference (and the one you regret trying)?

[latviantower]

I don’t enjoy the ISR from typical GLOW or KLOW, and I never thought the proportions were all that great. Most recommendations I’ve seen vary for all 3 (4 for KLOW) component peps. TB500, for example, is only supposed to be twice a week whereas BPC can be 2-3x per day. My solution was to buy kits of all 3 and draw them up into the same syringe just prior to pinning. The big win is that by pulling the GHK first followed by the others, they buffer the copper and all but eliminate the sting. My GHK and TB500 kits last a lot longer too!

 

[DjJoshua]

I recently purchased some buffered phosphate solution for my ARA290 which works wonderfully by the way at getting the ARA to go into solution. This last KLOW that I mixed up, I added about a half a milliliter of buffered phosphate solution in with the BAC water and then added two more milliliters of BAC water to dilute it even more. So far no ISR or pain so I’m hopeful that fixes it because that KLOW isn’t cheap!

you've probably nailed the reconstitution hack. How's the KLOW feeling otherwise, any noticeable recovery or anti-inflammatory benefits kicking in?

 

[DjJoshua]

I don’t enjoy the ISR from typical GLOW or KLOW, and I never thought the proportions were all that great. Most recommendations I’ve seen vary for all 3 (4 for KLOW) component peps. TB500, for example, is only supposed to be twice a week whereas BPC can be 2-3x per day. My solution was to buy kits of all 3 and draw them up into the same syringe just prior to pinning. The big win is that by pulling the GHK first followed by the others, they buffer the copper and all but eliminate the sting. My GHK and TB500 kits last a lot longer too!

No ISR and better tolerability, that's the real win!!

 

[Jellybelly54]

you've probably nailed the reconstitution hack. How's the KLOW feeling otherwise, any noticeable recovery or anti-inflammatory benefits kicking in?

Not noticing anything to be honest but I’ve only taken a couple of shots since coming up with the new reconstitution solution. ? I have my wife doing a 20 day run of it to see if that will improve her energy and stop some hair loss she has been having while on the TIRZ and TRT. Honestly, I think her hair loss was from the TRT. Her dumbass provider has majorly overdosed her on the testosterone! On Her last labs her total testosterone was almost 200! I don’t understand these idiots and their damn pellets! I’m pretty sure a woman shouldn’t have a testosterone at 200! I’m thinking that her hair loss is likely from the DHT effect of the testosterone. I figured getting her on some of the KLOW with the copper will likely be beneficial.

 

[swimmer]

This is the protocol I followed except for 1 week I took off when I was out of the country and the 1 time I injected 250 mg of NAD+ so I would not have to bring remaining vial through customs on a different international trip.

 

[DjJoshua]

This is the protocol I followed except for 1 week I took off when I was out of the country and the 1 time I injected 250 mg of NAD+ so I would not have to bring remaining vial through customs on a different international trip.

Wow, that is a interesting read, I'm going to have to spend some time on this pdf.

 

[MsGizmo]

I'm trying to protect muscle and maybe accelerate things without messing up progress.

What's the single peptide you stacked with Tirz that gave you the biggest noticeable win? (E.g., faster stubborn fat melt like belly/visceral, better muscle preservation, improved recovery/energy/sleep, skin glow/recovery boost, etc.) Bonus points if you share rough dosing or how long it took to kick in!

And on the flip side what's one you added and regretted? (Sides like water retention, blunted food noise suppression, no real difference, injection overload, or just not worth the hassle/money?)
Thank you.

KLOW.

I started taking it in hopes of reducing the amount of sagging skin I end up having, but it has done so much more for me.

Less joint pain
Eliminated back pain
Less inflammation

When I took a break from taking it my weight loss stalled out. Now that I am taking it everyday again the stall is broken. Maybe a coincidence perhaps .. but inflammation is tied to weight gain and that could be something I've had a problem with all along and just didn't know it.

The other stuff that I've purchased

NAD+ - Seems to have improved my sleep
SS-31 - No noticeable effect
MOTS-c - I haven't started this yet (on schedule for a few weeks from now)
Epitalon - I haven't started this yet (on schedule for 2 months from now)

Ipamorlin - I haven't taken this, didn't know about the CJC DAC/no DAC thing. I regret this purchase, but perhaps might buy some CJC and try it at a later date. I might also try taking it on its own. Dunno.

 

[randompersonrandom]

My only "regret" one currently is MOTS-C. My last dose of that was more than thirty days ago, and I still have two injection site lumps. I really do believe they're fading and will eventually be gone, but the fact that I can still locate both of them if I poke around is kinda upsetting.

 

[Jellybelly54]

This is the protocol I followed except for 1 week I took off when I was out of the country and the 1 time I injected 250 mg of NAD+ so I would not have to bring remaining vial through customs on a different international trip.

That’s a Pretty popular protocol floating around here and other places on the Net. You have to be a patient bugger on that protocol! 14 weeks is a long time! The 100mg NAD dosages are up there. Anyone doing this I would be interested to see their HR changes over the 14 weeks. I would expect the resting HR to go up.

 

[swimmer]

That’s a Pretty popular protocol floating around here and other places on the Net. You have to be a patient bugger on that protocol! 14 weeks is a long time! The 100mg NAD dosages are up there. Anyone doing this I would be interested to see their HR changes over the 14 weeks. I would expect the resting HR to go up.

I am not sure if this protocol bumped up my heart rate or not but the Tessamorelin/Ipmorelin definitely does. At 2 mg/300mcg it bumped up more than 15 bpm. That freaked me out so I dropped it to 1mg/300mcg which bumps it up about 10 bpm. Mazdutide bumps it up a little too. The Mots-c gave me big lumps the first couple of shots. I started diluting each shot more. I am doing 1ml with the 5mg mots-c and I don't get any ISR anymore.

 

[MsGizmo]

I am not sure if this protocol bumped up my heart rate or not but the Tessamorelin/Ipmorelin definitely does. At 2 mg/150mcg it bumped up more than 15 bpm. That freaked me out so I dropped it to 1mg/150mcg which bumps it up about 10 bpm. Mazdutide bumps it up a little too. The Mots-c gave me big lumps the first couple of shots. I started diluting each shot more. I am doing 1ml with the 5mg mots-c and I don't get any ISR anymore.

Eww ... the mots-c part is coming up soon for me. So I guess I need to dilute it more than I planned. MK, good to know.

 

[Chili777]

Eww ... the mots-c part is coming up soon for me. So I guess I need to dilute it more than I planned. MK, good to know.

I filtered and didn't get any of that. Maybe I'm just lucky. Since I've been filtering the last few weeks, my stomach and love handles have calmed down a lot.

 

[MNSunshine]

KLOW.

I started taking it in hopes of reducing the amount of sagging skin I end up having, but it has done so much more for me.

Less joint pain
Eliminated back pain
Less inflammation

When I took a break from taking it my weight loss stalled out. Now that I am taking it everyday again the stall is broken. Maybe a coincidence perhaps .. but inflammation is tied to weight gain and that could be something I've had a problem with all along and just didn't know it.

The other stuff that I've purchased

NAD+ - Seems to have improved my sleep
SS-31 - No noticeable effect
MOTS-c - I haven't started this yet (on schedule for a few weeks from now)
Epitalon - I haven't started this yet (on schedule for 2 months from now)

Ipamorlin - I haven't taken this, didn't know about the CJC DAC/no DAC thing. I regret this purchase, but perhaps might buy some CJC and try it at a later date. I might also try taking it on its own. Dun

Good morning. I am thinking of starting KLOW. I love that it has provided you more benefits than expected.

I am curious......has it helped with your sagging skin? What changes have you noticed?

 

[MsGizmo]

Good morning. I am thinking of starting KLOW. I love that it has provided you more benefits than expected.

I am curious......has it helped with your sagging skin? What changes have you noticed?

Well ... there is a problem with deciding if it helps with prevention of sagging skin or not. How can you tell? I mean .. I started off weighing in at 334 pounds and 54 years old. I don't think its possible to avoid sagging and its already happening a bit as I expected. But .. could it have been worse without the KLOW or not? Will I get some rebound to my skin as I continue to take KLOW over time?

I still have more than 100 pounds to lose. I am just going to do the best that I can do and just accept the results. Who knows maybe there is a skin removal surgery in my future. Maybe there isn't.

 

[DjJoshua]

My only "regret" one currently is MOTS-C. My last dose of that was more than thirty days ago, and I still have two injection site lumps. I really do believe they're fading and will eventually be gone, but the fact that I can still locate both of them if I poke around is kinda upsetting.

That is crazy, is this one side affect from Mots-c that could happen?

 

[randompersonrandom]

That is crazy, is this one side affect from Mots-c that could happen?

Yeah, hard lumps under the skin at the injection site is a reported thing with MOTS-C. And I've heard people bitching that they took awhile to go away, but the fact that mine are lasting a month is enough to spook me. It's only two, though, and the rest are gone, so I think these two will also fade eventually.

 

[DjJoshua]

Yeah, hard lumps under the skin at the injection site is a reported thing with MOTS-C. And I've heard people bitching that they took awhile to go away, but the fact that mine are lasting a month is enough to spook me. It's only two, though, and the rest are gone, so I think these two will also fade eventually.

I'm sure you have but have you had your kit tested?

 

[randompersonrandom]

I'm sure you have but have you had your kit tested?

Not personally, but I trust the results of the group buy-ish source I got it from. I'm not concerned about infection or it not being what it says it is, I think this one just isn't for me, and it really brought home "What are you doing, randompersonrandom, just shooting up stuff that's not ever been tested in humans just because you're bored? Knock this off and go get an ACTUAL hobby."

 

[DunningKruger]

I didn't stack with Tirz, only with Reta, but Tesamorelin every night before bed (1 month at 1mg because I'm still paying Canadian resale prices of $150 per 20mg vial.) I recently upped it to 2mg nightly because I thought I was plateauing, but a recent scan shows favourable results, so I might drop it back down to 1mg.

It's magical! I've slacked on my training this month yet still look jacked; the definition is visible, and there's zero fluid retention, even with my 10g creatine and 2 LMNT packets daily. A recent DEXA reveals I'm up 6.6% in muscle mass, and down 6.9% in fat mass since starting Jan 7. I am eating 1 to 1.5 grams of protein per lb of body weight though, so that definitely plays a role.

Other faves so far have been Reta, SS-31, & Epitalon.

My meh? Copper. My body does not do the blue.

 

[DjJoshua]

I didn't stack with Tirz, only with Reta, but Tesamorelin every night before bed (1 month at 1mg because I'm still paying Canadian resale prices of $150 per 20mg vial.) I recently upped it to 2mg nightly because I thought I was plateauing, but a recent scan shows favourable results, so I might drop it back down to 1mg.

It's magical! I've slacked on my training this month yet still look jacked; the definition is visible, and there's zero fluid retention, even with my 10g creatine and 2 LMNT packets daily. A recent DEXA reveals I'm up 6.6% in muscle mass, and down 6.9% in fat mass since starting Jan 7. I am eating 1 to 1.5 grams of protein per lb of body weight though, so that definitely plays a role.

Other faves so far have been Reta, SS-31, & Epitalon.

My meh? Copper. My body does not do the blue.

That's seriously impressive DEXA progress +6.6% muscle and -6.9% fat while dialing back on training is straight fire! Tesamorelin at night is clearly doing its GH magic perfectly (great call on the timing). Dropping back to 1mg if the scan still looks strong makes total sense keep fine-tuning what your body loves most. SS-31 and Epitalon too Epitalon is one of my personal favorites; the dreams on that stuff are next-level wild. I've got two kits incoming that should keep me set for years. Copper peptides / GHK-Cu? Yeah, not everyone's skin plays nice with the blue. Totally fair to pass on what doesn't vibe, I'm honestly about ready to drop it myself; it feels like an ex who just keeps coming back to sting my ass Keep killing it, gains like yours are straight-up motivating!

 

[Ruckus4519]

Yeah, hard lumps under the skin at the injection site is a reported thing with MOTS-C. And I've heard people bitching that they took awhile to go away, but the fact that mine are lasting a month is enough to spook me. It's only two, though, and the rest are gone, so I think these two will also fade eventually.

out of curiosity how close were those two from the others?

 

[DunningKruger]

SS-31 and Epitalon too Epitalon is one of my personal favorites; the dreams on that stuff are next-level wild.

OH heck yes! The clarity and retention of them too! OMG. Without sounding too ✨woo-woo,✨ it's like, ~Pineal open, messages from Universe downloaded and integrated.~ 🤣

IYKYK, and YOU KNOW!

 

[Wallydog]

HGH

For which question? Or is it both a plus and a minus?

 

[Wallydog]

That’s a Pretty popular protocol floating around here and other places on the Net. You have to be a patient bugger on that protocol! 14 weeks is a long time! The 100mg NAD dosages are up there. Anyone doing this I would be interested to see their HR changes over the 14 weeks. I would expect the resting HR to go up.

Any evidence of increased BP along with increased HR?

 

[swimmer]

Any evidence of increased BP along with increased HR?

When I got near my target weight my blood pressure decreased. I promptly stoped the beta blocker and losartan. My bp averages is 110/70. I have not seen nad+ or any other peptide increase it. Even the ones that raised my heart rate. The only thing that raises it is when I have to talk to my ex.

 

[DjJoshua]

OH heck yes! The clarity and retention of them too! OMG. Without sounding too ✨woo-woo,✨ it's like, ~Pineal open, messages from Universe downloaded and integrated.~ 🤣

IYKYK, and YOU KNOW!

I did a funny post on what my dreams gave me and WOW.... it's in a post somewhere in this forum ..... funny shit !!!

 

[FlowerFairy]

Well ... there is a problem with deciding if it helps with prevention of sagging skin or not. How can you tell? I mean .. I started off weighing in at 334 pounds and 54 years old. I don't think its possible to avoid sagging and its already happening a bit as I expected. But .. could it have been worse without the KLOW or not? Will I get some rebound to my skin as I continue to take KLOW over time?

I still have more than 100 pounds to lose. I am just going to do the best that I can do and just accept the results. Who knows maybe there is a skin removal surgery in my future. Maybe there isn't.

Hang in there- I’m 20 lbs from my first goal.. I’ve lost 100 lbs and haven’t decided if I’m going to set another goal, since I wasn’t too sure I’d make the first one almost 2 years ago.

 

[Mand61]

Nad+ is my number 1 pro! Absolutely love it!

 

[DjJoshua]

Nad+ is my number 1 pro! Absolutely love it!

I have not tried NAD+ yet. This is on my order wish list to get along with stacking 5-Amino-1MQ. have you tried 5-Amino-1MQ yet?

 

[randompersonrandom]

out of curiosity how close were those two from the others?

I spread them all over my lower abdomen. The two left (I think there's only one left now, I just poked around looking for them and could only find one, and it's definitely smaller than it was last time.) are on the right lower area of my stomach.