Tirz First Week

CornPop

CornPop

GLP-1 Apprentice
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How was everyone’s first week on tirz? Particularly at 2.5mg. Was the appetite suppression shocking or was there little difference at such a small dose. How about sides?

I’m asking because I just started at 2.5 and I barely finish my meals if I do. I don’t have any food noise and don’t have any desire to snack. No real side effects. Is this common? Does your tolerance go up and that’s why people titrate? At this point if nothing changes I don’t know if I’ll ever go above 2.5mg cause this is fine for me.
 
It started affecting me within a day or so. Not my wanting to eat so much, as how much I could eat. Over time I found I lost my desire as well. It's incredibly nice to be able to eat to live, instead of living to eat. After a while the food noise was completely gone, though I can't remember how long that took.

I've been on it now for 10 months and I have to track my calories and macros closely to make sure I actually get enough of everything, especially protein. If I didn't I'd barely eat 1200 calories a day.
 
Those were my experiences as well. My hubs and I started at the same time last July at 2.5mg and right now we’re both still only at 5mg per week. I have shortened my week to 4-5 days and found a great sweet spot but we had no desire to rush higher doses if unnecessary. Plus tirz is the only one we take by way of glp-1. Welcome to the journey!
 
CornPop said:
How was everyone’s first week on tirz? Particularly at 2.5mg. Was the appetite suppression shocking or was there little difference at such a small dose. How about sides?

I’m asking because I just started at 2.5 and I barely finish my meals if I do. I don’t have any food noise and don’t have any desire to snack. No real side effects. Is this common? Does your tolerance go up and that’s why people titrate? At this point if nothing changes I don’t know if I’ll ever go above 2.5mg cause this is fine for me.
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dont go up unless it's not working and your stalled for 3-4 weeks. my first week or two was like that, and then it faded. currently on 10. i don't respond awesome to it but im down 30 in 6 months so we keep on. it's kinda nice not wanting to smash a bag of doritos all the time
 
Sounds like you are setting up to be an excellent responder. The first month is what I like to call " The Rebirthing process." Eating clean will dramatically help avoid side effects. Drink 120 oz of water a day. Most hit the exhaustion phase around month two. Deprivation of caloric intake. Take short naps if needed. Once you get that phase managed and course-corrected, you can focus on a titration schedule. I copied the Lilly clinicals, and it worked like magic. Aggressive but not too aggressive. The best jump for me was 7.5 to 10mg.
 

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Slogger said:
Those were my experiences as well. My hubs and I started at the same time last July at 2.5mg and right now we’re both still only at 5mg per week. I have shortened my week to 4-5 days and found a great sweet spot but we had no desire to rush higher doses if unnecessary. Plus tirz is the only one we take by way of glp-1. Welcome to the journey!
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Thanks for the response. Okay that’s what I am hoping for. Just to stay at a low dose. It is interesting to do a low dose but more often. That might be helpful.

How was the jump from 2.5 to 5?
 
CornPop said:
How was everyone’s first week on tirz? Particularly at 2.5mg. Was the appetite suppression shocking or was there little difference at such a small dose. How about sides?

I’m asking because I just started at 2.5 and I barely finish my meals if I do. I don’t have any food noise and don’t have any desire to snack. No real side effects. Is this common? Does your tolerance go up and that’s why people titrate? At this point if nothing changes I don’t know if I’ll ever go above 2.5mg cause this is fine for me.
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Ya, if it aint broke don't....I was like you but at the end of the 5days all the food noise came crashing back in so I'd go up a notch and that's been the way for all dosages. I just started 10mg. YMMV...Food will power never was my strong point...
 
agussie said:
dont go up unless it's not working and your stalled for 3-4 weeks. my first week or two was like that, and then it faded. currently on 10. i don't respond awesome to it but im down 30 in 6 months so we keep on. it's kinda nice not wanting to smash a bag of doritos all the time
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Congrats on the 30 lbs. that’s awesome. I know what you mean about not wanting to snack all the time. I was constantly in the pantry
 
Given you have had strong positive effects rather than side effects from a low dose, you probably cannot rely on other peoples doses or schedules to guide your dosing. Responses to these medications is quite individual and variable. It is super early but it certainly sounds like you are quite sensitive to its effects on reducing hunger, and as you are not describing adverse effects, without nausea etc. So not extra sensitive to side effects. This means you are lucky to have that combination, and it is a promising sign. If the degree of hunger control is fine, as in you are not forcing yourself to eat less than you feel like, and you are losing weight, you do not need to increase doses. The odds are that at some point you will probably have to a bit. I do not believe there is any evidence of tolerance to their effects in causing weight loss long term, but there is definitely some tolerance or adaptation occurring in the first few months of starting treatment, so if you find yourself getting more hungry or stop losing weight up the dose then. I think most people are better off on the standard doses overall, but if it is working fine at a low dose it is working fine. But increase doses based on weight and hunger and decrease them if side effects become a problem.
This advice would be a bit different if you were older , had severe obesity ( bmi over 35 ), or obesity related health problems. In that case slowly increasing doses towards the standard 15mg is probably a better idea for long term health benefits.
 
chewonmysac said:
Sounds like you are setting up to be an excellent responder. The first month is what I like to call " The Rebirthing process." Eating clean will dramatically help avoid side effects. Drink 120 oz of water a day. Most hit the exhaustion phase around month two. Deprivation of caloric intake. Take short naps if needed. Once you get that phase managed and course-corrected, you can focus on a titration schedule. I copied the Lilly clinicals, and it worked like magic. Aggressive but not too aggressive. The best jump for me was 7.5 to 10mg.
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Thanks for sharing. 85lbs is incredible! Is the shorts app worth paying for? On the trial right now
 
lessthanhalf said:
Given you have had strong positive effects rather than side effects from a low dose, you probably cannot rely on other peoples doses or schedules to guide your dosing. Responses to these medications is quite individual and variable. It is super early but it certainly sounds like you are quite sensitive to its effects on reducing hunger, and as you are not describing adverse effects, without nausea etc. So not extra sensitive to side effects. This means you are lucky to have that combination, and it is a promising sign. If the degree of hunger control is fine, as in you are not forcing yourself to eat less than you feel like, and you are losing weight, you do not need to increase doses. The odds are that at some point you will probably have to a bit. I do not believe there is any evidence of tolerance to their effects in causing weight loss long term, but there is definitely some tolerance or adaptation occurring in the first few months of starting treatment, so if you find yourself getting more hungry or stop losing weight up the dose then. I think most people are better off on the standard doses overall, but if it is working fine at a low dose it is working fine. But increase doses based on weight and hunger and decrease them if side effects become a problem.
This advice would be a bit different if you were older , had severe obesity ( bmi over 35 ), or obesity related health problems. In that case slowly increasing doses towards the standard 15mg is probably a better idea for long term health benefits.
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Thanks for the advice. It is helpful. I’ll go through the first month and re evaluate. It seems the consensus from everyone is no need to titrate up if the current dose is working.
 
I started with 4 weeks of 2.5mg Mounjaro pens. i could feel it within an hour.
I wish everyone could start out with real authentic stuff. That way you know what it feels like. And what it feels like to get watered down shit. (My next move was compounded shit) indeed, if it starts to fail, it's later in the week.
Coming up on a year, what I've learned: I stay true to the plan, but if I feel like I'm breaking through, I pin the overfill. (Like a booster) mind you the overfill, usually .15ml but obviously the concentration changes as one titrates up. My plan currently, is 15mg max., but with overfill, about 19.5mg. Yeah, but I'm still a big cryptid.
 
I started at 250 mcg or .25mg and the appetite suppression is real. I have been water fasting without any issues, something I had done before with a lot more effort and temptation.
 
CornPop said:
How was everyone’s first week on tirz? Particularly at 2.5mg. Was the appetite suppression shocking or was there little difference at such a small dose. How about sides?

I’m asking because I just started at 2.5 and I barely finish my meals if I do. I don’t have any food noise and don’t have any desire to snack. No real side effects. Is this common? Does your tolerance go up and that’s why people titrate? At this point if nothing changes I don’t know if I’ll ever go above 2.5mg cause this is fine for me.
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Some people don't feel anything at 2.5mg and need higher doses to get the full effects of tirzepatide. Sometimes they'll post that they don't feel anything and are still ravenous. So, consider yourself lucky that you're getting the benefits at such a low dose without the side effects.

I was also in the "camp" of low and slow when I first started reading about glp-1s. But, when I really read the clinical studies in depth, it became clear to me that people lost more weight on higher doses and more people achieved their weight loss goals on higher doses. Having a lot of weight to lose, I knew I didn't have a lot of time to screw around with 2.5mg for a long period of time, so I titrated up fairly aggressively. But all my side effects were minor and tolerable, but I didn't wait for 3 or 4 week for stalls.

The guidance from Lilly and what is happening in clincial settings has changed since the clincials. The advice now is to titrate up if you're not losing weight or experiencing food noise/hunger cues, as long as your sides effects are well managed. No need to titrate up otherwise. But what I fear for some folks, is that they get stuck on the idea that lower is "better" and after a year at 7.5mg complain that they haven't reached their weight loss goal.
 
hi c: i recently (yesterday) started tirz at 2.2mg and it's so subtle (no side effects), that i wasn't sure if it even works lol. but today i have no food noise. no voice in my brain telling me it's a good idea to eat more food because i'm bored or something. i literally had to tell myself, "yeah i guess eating is a good idea." i'm not hungry. my only side effects on the first day was the anxiety i gave myself for wondering if this is even a good idea, but i'm over it 😀
 
I lost the first thirty some pounds at 2.2. I had to start titrating to get the next 25 off. I'm six pounds from goal (20.8 BMI is goal) and was at 9 mg per week when I switched to reta last week so I can see whether it's a good fit for me and therefore I should continue hoarding it.
 
both times that i started back on tirz i always got violently sick almost exactly 36 hours after my shot, explosive exits on both ends if you catch my drift. and food volume immediately got cut in half. thats why i only take 1.25mg every 8 days right now. it does what i need it to do and i use it to the best advantage i can. i previously lost about 50ish pounds without going up past 2.5mg before insurance issue and finding this place. but i also kept off any unwanted weight for the 6 months i was off
 
sylvieon said:
hi c: i recently (yesterday) started tirz at 2.2mg and it's so subtle (no side effects), that i wasn't sure if it even works lol. but today i have no food noise. no voice in my brain telling me it's a good idea to eat more food because i'm bored or something. i literally had to tell myself, "yeah i guess eating is a good idea." i'm not hungry. my only side effects on the first day was the anxiety i gave myself for wondering if this is even a good idea, but i'm over it 😀
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Wow that’s awesome! Yeah I remember how weird it felt to not be hungry. Seems like you are responding well though.

I will say I am 5 weeks in now and I noticed that my body kind of got used to it. I started to graze food a little more and noticed food noise. I’m still eating way less though.

I also started to get very irritated after about a week and a half to three weeks. It was pretty annoying but I think it was mostly dehydration and lack of calories. So I did a fast to force my body to start using fat for fuel and submit to the calorie deficit and started taking magnesium to help with electrolytes. I feel a lot better now and am really hitting a stride.

I also only titrate up to 3 mg. Idk just didn’t feel like I needed to go higher but we’ll see.
 
bbbilly said:
both times that i started back on tirz i always got violently sick almost exactly 36 hours after my shot, explosive exits on both ends if you catch my drift. and food volume immediately got cut in half. thats why i only take 1.25mg every 8 days right now. it does what i need it to do and i use it to the best advantage i can. i previously lost about 50ish pounds without going up past 2.5mg before insurance issue and finding this place. but i also kept off any unwanted weight for the 6 months i was off
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Wow it’s crazy how our bodies respond so differently. I jut titrate up to 3 cause I felt like 5 would be too much. I’m hoping I don’t have to go too high to get my goal weight. I’m also of the mind that I’d like to put some work on myself to lose the weight.
 
It is my second week at .250mcg. I still have appetite suppression, however, I developed some acid reflux and nausea the day after pinning. I guess I am super sensitive to tirz.

I took famotidine at night to resolve the acid reflux and woke up without any issues in the morning.

Today I have eaten a bit more food that I have been able to tolerate in the previous week throughout the day without nausea. I have struggled with food allergies and gastropaeresis in the past. So far, I feel like I am digesting what I am eating and eating what I want without any psychological coercion if that makes sense.
 
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I've been on 2.5mg for 8 weeks now and the appetite suppression has slowly started to creep back in although it is still completely manageable. The first month was surreal, I had to ensure i was eating enough and struggled to get enough calories on some days. Drink far more water than you think you need, add in some calcium and magnesium supplements as well.

I'm away on holiday next week so i'm planning to move up to 3.5mg just before that as i'm sure the temptation to over indulge will be quite high. I'll probably move up to 5mg once a week soon after but hopefully I'll be able to stay on that dose for as long as possible.
 
This is my first week of tirz (2.5mg). I am coming over from wegovy 1mg pens. I wanted to start tirz at 5mg but I was nervous about side effects so i choose to begin on the starter dose.

No crazy side effects just a bit of burping but that went away in a day. I did notice that i felt appetite suppression within a few hours of injecting tirz which never happened to me on wegovy. I was pleasantly surprised.

However, i feel it wearing off by day 4. Im just now learning that the half life of tirz is 5 days not 7 like sema. I think i will go up to 5mg for my next dose and probably do every 5 days.

By the way i lost about 30lbs on wegovy in 3 months. Im looking forward to tirz i just have to find the right dose that works for me.
 
Jdo414 said:
However, i feel it wearing off by day 4. Im just now learning that the half life of tirz is 5 days not 7 like sema. I think i will go up to 5mg for my next dose and probably do every 5 days.
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I'd give it some time. Interestingly, I was feeling 2.5mg of Tirz in week 3 as somewhat weaker than weeks 1-2, but then again in weeks 4, 5, and now 6 (started today), I'm feeling it on full blast, same dose, 2.5mg.
 
Jdo414 said:
This is my first week of tirz (2.5mg). I am coming over from wegovy 1mg pens. I wanted to start tirz at 5mg but I was nervous about side effects so i choose to begin on the starter dose.

No crazy side effects just a bit of burping but that went away in a day. I did notice that i felt appetite suppression within a few hours of injecting tirz which never happened to me on wegovy. I was pleasantly surprised.

However, i feel it wearing off by day 4. Im just now learning that the half life of tirz is 5 days not 7 like sema. I think i will go up to 5mg for my next dose and probably do every 5 days.

By the way i lost about 30lbs on wegovy in 3 months. Im looking forward to tirz i just have to find the right dose that works for me.
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Don't be in to big a hurry to go up in dosage. There are good reasons for not doing so and being in to big a hurry can actually set you back. Ask me how I know.... Your 1st dose partially adds to your 2nd dose and both them add to your 3rd dose and so on. It's all cumulative. Start small and go up slowly is the best medicine which many of the 'old timers' will attest to. For myself, I was doing great at 5mg, got in a hurry to speed up the process and jumped to 7.5mg and got hit with horrible sides and after playing around with split doses for a few weeks and going back down for a few more weeks and ended up starting all over at 5mg and even at that level took a few more weeks for the worst of the sides to pass. Lost all those weeks and put myself thru misery all because I had the "if a little is good lots must be better" addiction mind. The GLP's aren't the 'magic' by them selves ,there's work that has to be put in...
 
I'm nearly 4 months in now, but my original Day One I remember getting up (pinned the night before and went to bed) convinced Tirz was a dud, didnt feel anything really. Then I sat down to eat...and couldn't finish much of anything. And what little I had was ...dare I say it....enough. my prevailing thought all day long and ever since was, "My God, is this what a normal relationship with food is like?" To NOT be thinking about it all the time. To have a normal sized portion and be completely satisfied with that. Stunning. I still can't get over the surprise of that. All these people who have not had obesity to deal with, living their lives like THIS? Wow.
 
hoobz said:
I'd give it some time. Interestingly, I was feeling 2.5mg of Tirz in week 3 as somewhat weaker than weeks 1-2, but then again in weeks 4, 5, and now 6 (started today), I'm feeling it on full blast, same dose, 2.5mg.
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skeptick said:
Don't be in to big a hurry to go up in dosage. There are good reasons for not doing so and being in to big a hurry can actually set you back. Ask me how I know.... Your 1st dose partially adds to your 2nd dose and both them add to your 3rd dose and so on. It's all cumulative. Start small and go up slowly is the best medicine which many of the 'old timers' will attest to. For myself, I was doing great at 5mg, got in a hurry to speed up the process and jumped to 7.5mg and got hit with horrible sides and after playing around with split doses for a few weeks and going back down for a few more weeks and ended up starting all over at 5mg and even at that level took a few more weeks for the worst of the sides to pass. Lost all those weeks and put myself thru misery all because I had the "if a little is good lots must be better" addiction mind. The GLP's aren't the 'magic' by them selves ,there's work that has to be put in...
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I agree with going up slow. I started wegovy at 0.25 then 0.50 and i just finished up 1mg. The reason why i wanted to go up to 5mg tirz is because i found a couple of sema to tirz conversion charts and it states that 1-2.4mg sema is equivalent to 5mg tirz.

I choose to still start at 2.5mg tirz just to be on the safe side but honestly by the third day i felt the appetite suppression gone so im thinking maybe i needed to start at 5mg.

IMG_2855.webp
 
Jdo414 said:
I agree with going up slow. I started wegovy at 0.25 then 0.50 and i just finished up 1mg. The reason why i wanted to go up to 5mg tirz is because i found a couple of sema to tirz conversion charts and it states that 1-2.4mg sema is equivalent to 5mg tirz.

I choose to still start at 2.5mg tirz just to be on the safe side but honestly by the third day i felt the appetite suppression gone so im thinking maybe i needed to start at 5mg.

View attachment 21594
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ThanX, never seen that chart and never heard of a Sema/Tirz comparison but makes sense. You do you and let us know how it works out...
 
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