What to add?

Delphyne

GLP-1 Apprentice
Member Since
Jan 9, 2026
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Hello,

the more I read about the individual peptides the more I think I need it, so basically I would need at least 20 different ones at the same time which is obviously not possible. I was wondering where to start adding to Tirz.

About myself. Female and in my sixties and have been obese all my life. Had a stroke 3 years ago weighing 340 pounds. I had gastric bypass just over two years ago and lost approx. 70 pounds and then it stopped. Heard about Mounjaro and took it about 11 months and lost another 44 pounds, but have been stalling for 3-4 months. Went up to 7,5 mg and have been using gray Tirz for one month now. Will titrate up to 10 next month and see if I can jump start the weight loss again.

What was your trick/additional peptide that helped you with further weight loss? I need to lose at least another 50 pounds to be in good place. Thinking of adding Reta or Cagri. Also thinking about GHK-cu as my skin is getting quite saggy - then I thing I should repair my mitochondia....a lot in my head.

Any suggestions?
 
Congratulations on your successes!

No suggestions. I am researching stacking with Tz so will be following along.

I hope you get good information.

Are you also on Peppy's or other forums/groups?
 
How are your lab results? How is your blood pressure?

Delphyne said:
Went up to 7,5 mg and have been using gray Tirz for one month now. Will titrate up to 10 next month and see if I can jump start the weight loss again.
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Sounds good to me. Upping the dose of tirz is certainly easy breezy compared to adding reta, without having to worry about reta's effect on heart rate. To me, cagri is overrated, which is why reta and tirz are mentioned way more often.

Often, when feeling more rational, my preference for dealing with a non-moving scale is to focus on labs instead or muscle gain (body recomposition). So sometimes I am very patient, taking the long way home with these non-scale victories. I have been at 200 for months now. But I can fit into smaller-sized pants/shorts, despite being the same weight.
 
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Calm Logic said:
How are your lab results? How is your blood pressure?



Sounds good to me. Upping the dose of tirz is certainly easy breezy compared to adding reta, without having to worry about reta's effect on heart rate. To me, cagri is overrated, which is why reta and tirz are mentioned way more often.

Often, when feeling more rational, my preference for dealing with a non-moving scale is to focus on labs instead or muscle gain (body recomposition). So sometimes I am very patient, taking the long way home with these non-scale victories. I have been at 200 for months now. But I can fit into smaller-sized pants/shorts, despite being the same weight.
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I just had my bloodwork done two weeks a ago and it was excellent. My A1c was at 5.3, but I was never diabetic but it reached 6.0 a few years ago. I stopped taking medication for slightly higher T3/T4 but stopped last June and my readings were perfect. Maybe I hold off on Reta and start adding Glow/Klow for my skin. Is it really that stingy? That worries my a bit.

My high blood pressure is the only one that did not go away after weight loss. Still around 140/90 with 10 mg of Lercanidipin.
 
Given you have previously had a stroke is there a reason why your blood pressure is not being treated to get it closer to 120/80? Off the top of my head I cannot think of a lot of reasons to leave it at 140/90 which is high enough to put you at increased risks of further strokes or other cardiovascular disease. Do you measure it yourself at home?, do you have lots of readings? Have you discussed this with your doctor? Undertreating high blood pressure is very common. In the longer term the tirzepatide might reduce blood pressure a bit, but given the stroke I would suggest treating it sooner rather than later, or at least talking with your doctor about it, and if it drops with further weight loss the extra treatment might be no longer needed but would be safer in the interim.
 
I've used the SLU-PP-332 and 5-Amino-1MQ, during my 2 worst stalls. The 5 Amino 1, worked the best between the 2 while changing nothing else. This is simply anecdotal on my part and I took the pill version 5-Amino at the time, but there is a shot available now which I assume would work better being more bioavailable.

Good work btw, I was damn near 600lbs and it took WLS and a GLP1 to get me where I am 179lbs. You got dis!
 
RubbaDubba1 said:
I've used the SLU-PP-332 and 5-Amino-1MQ, during my 2 worst stalls. The 5 Amino 1, worked the best between the 2 while changing nothing else. This is simply anecdotal on my part and I took the pill version 5-Amino at the time, but there is a shot available now which I assume would work better being more bioavailable.

Good work btw, I was damn near 600lbs and it took WLS and a GLP1 to get me where I am 179lbs. You got dis!
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Fantastic success!
 
RubbaDubba1 said:
I've used the SLU-PP-332 and 5-Amino-1MQ, during my 2 worst stalls. The 5 Amino 1, worked the best between the 2 while changing nothing else. This is simply anecdotal on my part and I took the pill version 5-Amino at the time, but there is a shot available now which I assume would work better being more bioavailable.

Good work btw, I was damn near 600lbs and it took WLS and a GLP1 to get me where I am 179lbs. You got dis!
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Congratulation. Sometimes it takes WLS and GLP-1 to reach goal
 
Delphyne said:
I just had my bloodwork done two weeks a ago and it was excellent. My A1c was at 5.3, but I was never diabetic but it reached 6.0 a few years ago.
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So lipids were good too?

Do they check vitamin D over there? They barely check it here, unless you ask for it. "Vitamin D deficiency is frequently linked to arterial stiffness and hypertension, and standard panels often overlook it" (Google Gemini).

My high blood pressure is the only one that did not go away after weight loss. Still around 140/90 with 10 mg of Lercanidipin.
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Yeah, I would have a "come to Jesus" over this. In other words, I would be religious about it. Have you tried the DASH diet? Lots of medical diets for blood pressure, including starch-based with the late John McDougall. He became a doctor and medical researcher after having a massive stroke at age 18, and the doctors were mostly worthless for him back then. He attributed the stroke to a Western diet, smoking, and bad genes, and he was influenced by the rice diet at Duke University by Dr. Walter Kempner.

I realize the docs now can get whatever number you want with enough meds, but the anabolic steroid users are a good example of why lab results and vitals are not enough.

I have also found intermittent fasting appealing since it is less restrictive in a way. I do eat out a few times a week at least, like at my favorite Mexican restaurant. I use Gemini to help me order, like what kind of customizations to make. It already knows what is on the menu, usually.
 
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Calm Logic said:
So lipids were good too?

Do they check vitamin D over there? They barely check it here, unless you ask for it. "Vitamin D deficiency is frequently linked to arterial stiffness and hypertension, and standard panels often overlook it" (Google Gemini).



Yeah, I would have a "come to Jesus" over this. In other words, I would be religious about it. Have you tried the DASH diet? Lots of medical diets for blood pressure, including starch-based with the late John McDougall. He became a doctor and medical researcher after having a massive stroke at age 18, and the doctors were mostly worthless for him back then. He attributed the stroke to a Western diet, smoking, and bad genes, and he was influenced by the rice diet at Duke University by Dr. Walter Kempner.

I realize the docs now can get whatever number you want with enough meds, but the anabolic steroid users are a good example of why lab results and vitals are not enough.

I have also found intermittent fasting appealing since it is less restrictive in a way. I do eat out a few times a week at least, like at my favorite Mexican restaurant. I use Gemini to help me order, like what kind of customizations to make. It already knows what is on the menu, usually.
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Yes, my lipids were good. Good HDL, LDL was a little bit elevated since I eat keto every now and then so I am not worried about that. I had a CAC scan when I had my stroke and my arteries are clear therefore I am refusing statins.

My vitamin D was a bit low so I am taking a supplement right now.

I will watch my blood pressure more regularly. An hour ago it was 135`:80 which is good enough for me.
 
Delphyne said:
An hour ago it was 135`:80 which is good enough for me.
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Okay.... Your thinking there still seems very old school, unless your doctor is the one with the old school thinking.

Some supplements can help with blood pressure too, sometimes surprisingly so.
 
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I have a similar question. I have stalled on Reta. I worked my way to 12mg, but the sleep deprivation was tearing me up. And I stalled. So, I have dropped to 8mg weekly on Sundays to improve my sleep. It has helped a little. My scores went from the 40-50s to 60-75. Still not great, but I don't have crazy night sweats every night and I don't wake up like clockwork every hour or two. Now I wake up twice at the most, but I can get back to sleep relatively quickly.

I'm thinking of getting cagri, since towards the end of the week my appetite becomes ferocious.

I tried Tesamorelin to help with the visceral fat, but after about a month I got carpal tunnel in both hands so bad the pain would keep me up at night. I'd wake up and have to shake out my arms and move my fingers to get feeling back.

Is a low dose of Cagri the best option when combined with my Reta. I don't want to starve, since I am taking test and trying to get about 200 grams of protein a day to keep the muscle gains.
 
PAPoots said:
I'm thinking of getting cagri, since towards the end of the week my appetite becomes ferocious.
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Have you tried splitting the dose of reta to twice a week? That can also help with side effects, to some degree.

The biggest problem with cagri, to me, is waiting around for the miracle to happen (getting the dose right). And then sooner or later, it is known to not work as well (based on reports here by veteran members). So a stall buster, at best. OTOH, still some FOMO out there with cagri. So why deny yourself, haha.

It seems a lot easier to me to just up the GLP (which is safer with split dosing) than to add cagri, or even to make dietary optimizations for the long-term. Personally, I have been cutting back on coffee creamer, doing more intermittent fasting (which is easier with my H/GH fasting ritual), having more pickled veggies, rarely using butter, etc. I am motivated largely because of side effects with higher doses of GLPs.
 
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Calm Logic said:
Have you tried splitting the dose of reta to twice a week? That can also help with side effects, to some degree.

The biggest problem with cagri, to me, is waiting around for the miracle to happen (getting the dose right). And then sooner or later, it is known to not work as well (based on reports here by veteran members). So a stall buster, at best. OTOH, still some FOMO out there with cagri. So why deny yourself, haha.

It seems a lot easier to me to just up the GLP (which is safer with split dosing) than to add cagri, or even to make dietary optimizations for the long-term. Personally, I have been cutting back on coffee creamer, doing more intermittent fasting (which is easier with my H/GH fasting ritual), having more pickled veggies, rarely using butter, etc. I am motivated largely because of side effects with higher doses of GLPs.
Click to expand...
I tried split dosing and for some reason it did not work much better than taking once a week. Plus my sleep was worse. I took my 8mg dose yesterday and it is a struggle to not go down and eat. Yet I have to occasionally to get my protein in. If I IF during the day, I miss my protein goal. I probably need some hypnosis. ;-)

I guess I'll order more salads and fight through the struggle of wanting more.
 
To get an idea of cagri's effectiveness (or lack thereof):

www.novonordisk.com

News Details

www.novonordisk.com www.novonordisk.com

People treated with CagriSema achieved a superior weight loss of 22.7% after 68 weeks compared to a reduction of 11.8% with cagrilintide 2.4 mg, 16.1% with semaglutide 2.4 mg and 2.3% with placebo alone.

In addition, 40.4% of patients who received CagriSema reached a weight loss of 25% or more after 68 weeks, compared to 6.0% with cagrilintide 2.4 mg, 16.2% with semaglutide 2.4 mg, and 0.9% with placebo.
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designing677 said:
What led you to that decision? Rather than upping your tirz dose?
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Shiny object envy probably. I have years of tirz stocked at my current dose but already know I need to titrate up soon. Reta being the new up and coming hotness seems like an interesting add to perhaps glean some of its unique qualities?
 
Statins do not just reduce risks of heart attacks, they quite significantly reduce the risks of stroke and vascular dementia and even more so if one has occurred already. Statins combined with more aggressive blood pressure control could drop your risks of a second stoke by about half, That is a pretty big difference and might be worth reconsidering.
 
lessthanhalf said:
Statins do not just reduce risks of heart attacks, they quite significantly reduce the risks of stroke and vascular dementia and even more so if one has occurred already. Statins combined with more aggressive blood pressure control could drop your risks of a second stoke by about half, That is a pretty big difference and might be worth reconsidering.
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I started taking Lipitor almost 25 years ago. I am on the generic now. It was my first med and I felt a little bad about being on it but when I saw all the side effects benefits and doctors were taking it just for the long term side effects I was glad I did. And now that I am in my 50's its probably been the best thing for me. And taking CoQ10 with it from the beginning.
 
MeedzMoar said:
Congratulations on your successes!

No suggestions. I am researching stacking with Tz so will be following along.

I hope you get good information.

Are you also on Peppy's or other forums/groups?
Click to expand...
Peppy's just joined. Slightly overwhelming ! Do we know exactly the difference between peppys and this glp1 ? Looks more research based certainly more private. trying to figure it all out !
 
AcadiaPeptides said:
Shiny object envy probably. I have years of tirz stocked at my current dose but already know I need to titrate up soon. Reta being the new up and coming hotness seems like an interesting add to perhaps glean some of its unique qualities?
Click to expand...
Fair enough, thanks for the answer.
 
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