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Heeltoeexpress

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Starting my first ever marathon training block this week and am a bit nervous. I’ve done a few half marathons, improving each time, but have not gone further than 13 in training and haven’t done much running (just a 10 miler) since starting Tirz. The Tirz has allowed me to lose 30 lbs I needed gone. As I head into this training block I’m wondering if there anything I could add to help with the bit of fatigue from Tirz or the recovery from running. Any advice or thoughts?
 
Runner here 🙋🏻‍♀️, I usually do a 6-7km run 4 days a week. I've found a week after being on Reta (2mg) my energy levels improved immensely, I did 5 consecutive daily runs, no walking breaks and no muscle soreness! Not sure if this will be an ongoing blessing or if it's a temp effect, hoping for the former!
 
lemon lady said:
Runner here 🙋🏻‍♀️, I usually do a 6-7km run 4 days a week. I've found a week after being on Reta (2mg) my energy levels improved immensely, I did 5 consecutive daily runs, no walking breaks and no muscle soreness! Not sure if this will be an ongoing blessing or if it's a temp effect, hoping for the former!
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I’ve been thinking about switching to Reta from Tirz, especially since I’ve hit maintenance but have read that Tirz is better for inflammation and that is pretty much the whole reason I want to stay on a maintenance dose. Glad you are having a good time with it!
 
Heeltoeexpress said:
Starting my first ever marathon training block this week and am a bit nervous. I’ve done a few half marathons, improving each time, but have not gone further than 13 in training and haven’t done much running (just a 10 miler) since starting Tirz. The Tirz has allowed me to lose 30 lbs I needed gone. As I head into this training block I’m wondering if there anything I could add to help with the bit of fatigue from Tirz or the recovery from running. Any advice or thoughts?
Click to expand...
I’m a long distance runner (1/2 and full marathons). Tirz helped me SO MUCH! But I did have some trouble keeping my energy up while running.
My solution is to carry squeezable containers of 100% fruit (basically, it’s baby food). They fit great into the side pockets of my running shorts and don’t leak because of the twist off cap.
If I predict I might need more calories than what’s in the pouch, before I head out I squeeze out a little of the product and replace it with jam, honey, or a little peanut butter.
It’s not a pretty process to prepare the pouches but this really gives me the giddy up I need.
Happy running! 🏃 🏃‍♀️ 🏃‍♂️
 
As an update:

I’m 12 weeks into training with a check in race (a half) coming up at the end of Oct (30 days from now). The general tirz fatigue either improved or wasn’t so bad after all. All has been going well until this past weekend when I did a 13 mile long run. It wasn’t a bad run but I had a hard time fueling correctly the day before and during the run and really paid for it after the fact and today with extreme fatigue. Shot day is typically Friday, long run is typically Saturday. The worst fatigue days (for me) are usually days 2 and 3 after the shot (Sunday/ Monday) which has been working well to keep me from being too tired at work and also not destroying my weekends. I think I may need to adjust either my dosing schedule or running schedule so that I’m able to properly fuel as the runs get longer and longer. I’m also circling back to the idea of running GLOW/ KLOW or a wolverine stack as well but need to refresh my research.
 
Not related to tirz fatigue but training in general. I run about 30-36 miles a week and boost up with TB500 and KPV, I would do BPC157 but I can’t unfortunately 🙁 I tried it and it was pretty good but can no longer take it. DSIP also helps my recovery (better rest). Happy training ❤️
 
Good luck,jist starting plan for Tokyo myself. Looking to see how ret compares to mounjaro as couldn't do more than 8 miles when I was on mounjaro
 
Training for an ultra while using Reta... I'm super low miles and lose dose right now so it wi be interesting to see what happens when the miles and MLs start ticking up.
 
Good info, I know some friends ill pass this info to. AS FOR ME .... I can run faster scared the you are mad...
 
Heeltoeexpress said:
Starting my first ever marathon training block this week and am a bit nervous. I’ve done a few half marathons, improving each time, but have not gone further than 13 in training and haven’t done much running (just a 10 miler) since starting Tirz. The Tirz has allowed me to lose 30 lbs I needed gone. As I head into this training block I’m wondering if there anything I could add to help with the bit of fatigue from Tirz or the recovery from running. Any advice or thoughts?
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How bout’ some NAD+, Glutathione and B12? NAD+ is a kick in the pants for energy for a lot of people. Also, adding in some CoQ10 at 300-600mg a day when training hard is helpful for energy production.
 
Training for my first 5k! I've dropped around 30 or so pounds and my knees don't feel like they're going to explode on a light jog anymore 🤣. Still taking it slow to avoid getting injured though. Going to be sticking to the C25k program best I can.
 
Estarossa19 said:
Training for my first 5k! I've dropped around 30 or so pounds and my knees don't feel like they're going to explode on a light jog anymore 🤣. Still taking it slow to avoid getting injured though. Going to be sticking to the C25k program best I can.
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congratulations on starting
 
MOTS-C seems to be really effective for cardio endurance and overall energy, might be worth looking into that to coincide with your training block.
 
Heeltoeexpress said:
Wanted to check back in and report that the half went exceptionally well! Last shot was two fridays before the race which was perfect for carb loading. Now for the full marathon in January.
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How did the marathon go? Did you keep taking tirz up to your marathon? did you lower the dose?

Ultra runner here, on reta, body feels improved energy levels (we'll see how the long runs go) but when running anaerobic or steep hill climbing having acidic burps / little nausea. Training block starts April, think I'll reduce or cycle off reta till after the race.
 
Not a serious runner but I found after starting GLP-1 agonists I was able to run further without getting tired. I can now do 5k very easily while it used to be a challenge before.
 
I’m on tirz and for me the first couple of months were the hardest. I started late 2024 and that was the time I started running again as well. (After injuries and lots of other reasons) I managed to improve slowly and up my mileage. My heart rate was elevated and it took a while to settle down. But I did improve. From the moment I started tirz maintenance things got a lot easier. Eating carbs and enough carbs to fuel training is really important. Now I run 50-70km a week with no problem. When eating is difficult try to eat more frequently. And for a race I stop the medication one or two weeks. But all in all the longer I use tirz the less it interferes with everything.
 
VVoices said:
Ultra runner here, on reta, body feels improved energy levels (we'll see how the long runs go) but when running anaerobic or steep hill climbing having acidic burps / little nausea. Training block starts April, think I'll reduce or cycle off reta till after the race.
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Update, after that post increased my dosage then got cold/virus 🤧, so took the week off. Was experiencing extreme fatigue but tried to force myself back running earlier this week. Unfortunately was getting sharp/cramping in low abs that I could only run for a few mins then had to bring it down to a jog/hiking 😡. Hydration/electrolytes were good.

With April around the corner & I've reached my weight loss goal long time ago, yesterday I've dropped my dosage to 2mg.
 
Running on reta (2mg) for me made it a lot harder to stay in zone 2 and I have not had any resting heart rate increases so it can't be that.
 
Plus one for NAD+. I think it really helps me workouts by giving me a boost on a cellular level giving me way more reps in the tank. Cleaner and more powerful than any caffeine based pre-workout.
 
Definitely following this 🙂 I am recovering from a hip injury but I want to get back into running. I think running can make one too lean if you are dieting strictly, which has happened to me before. Maybe not an issue for me now, because of the meds I'm on. Glad it seems your runs have mostly improved. 🙂
 
Also following this as intermittent runner training for half marathon (run 29th march) about to start my first reta but read a couple reviews saying they has awful lethargy and tiredness in general and not much enthusiasm to train. Ill be back in gym for a while then got a trail half marathon in sept.

Not looking to lose lots (few kilos) so concerned it would impact my training. Seems line this thread has had opposite experience with most improving after reta.
 
richtyke said:
Also following this as intermittent runner training for half marathon (run 29th march) about to start my first reta but read a couple reviews saying they has awful lethargy and tiredness in general and not much enthusiasm to train. Ill be back in gym for a while then got a trail half marathon in sept.

Not looking to lose lots (few kilos) so concerned it would impact my training. Seems line this thread has had opposite experience with most improving after reta.
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Everyone's different. I had to go off reta (2mg) because I could not ingest enough calories to fuel my runs. I noticed even the gels took longer to absorb.
 
I run every morning in order to spite my Dr. I was in really bad shape when I first met her and she said I couldn't reverse my Type 2 on my own, A1C to high.

So that day I started running every day, not very far at first, but longer and longer every morning.

When I started I was close to 300lbs, with diet and exercise I was able to lower my a1c and BP. I was stuck though and I couldn't get my weight down below 265, so I started the trizepatide. It made my recovery easier.

Recently I started on the SS-31, Mots-c, NAD+ protocol, after the 3rd day of Ss-31 I found an extra gear where I was able to go faster than I was before and didn't run out of breath.
.
 
I lost about 15 pounds on Tirz at the start of my training for my last half, but then stayed just steady during the peak months for some reason. I had 2 100 mile months in there but weight just seemed to lucite between 5-6 pounds. I never titrated past 5 mg though.
 
BinaryPinecone said:
Running on reta (2mg) for me made it a lot harder to stay in zone 2 and I have not had any resting heart rate increases so it can't be that.
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How much is it popping over compared RPE?

Reta gave me a universal +10 bpm which 5-10 is pretty common. Maybe yours just shows up during exercise? I have zero basis outside of wild guesses as to why it would show up that way.
 
Heeltoeexpress said:
Starting my first ever marathon training block this week and am a bit nervous. I’ve done a few half marathons, improving each time, but have not gone further than 13 in training and haven’t done much running (just a 10 miler) since starting Tirz. The Tirz has allowed me to lose 30 lbs I needed gone. As I head into this training block I’m wondering if there anything I could add to help with the bit of fatigue from Tirz or the recovery from running. Any advice or thoughts?
Click to expand...
Hey bro!

I used to do a few 10K's a week, havent done it in some time now due to work and other things, but im going to get back into it again soon.

I was lifting weights post injury 4-5 x a week as well... that combo made me feel amazing.
 
I like to sprint 100 yards, lol.

A fun (or not-so-fun) question:

Does running on GLPs increase runner's diarrhea? If GLPs give you constipation (instead of diarrhea or no side effects), I guess they could actually help prevent runner's diarrhea.
 
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