Just wondering if anyone has frozen reconstituted tirzepatide in pen cartridges. Theoretically, I'm thinking that there really should be no difference between freezing a pen cart versus a vial, but not sure. It probably wouldn't be a great idea to extact all the air from the cart prior to freezing as to leave space for expansion. Although with a pen cart the stopper isn't crimped in like a vial, so maybe it's not a good idea as a freezing container. I could reconsitute, then freeze in a regular vial, defrost when I need it and then put the thawed tirz into the pen cart. It's just another step I was hoping to avoid.
Freezing pen carts filled with reconstituted tirzepatide
- Thread starter Grogu
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CJsMom
GLP-1 Apprentice
There is a whole thread on this here: https://glp1forum.com/threads/tirz-freezing-defrosting.3850/
Thank you. I appreciate the link and the effort to assist, that was really nice. I was actually was asking about whether it’s okay to freeze reconstituted tirzepatide in a pen cartridge versus a vial as that would save me a step, but I think a vial is ultimately going to be safer. I’m aware that tirzepatide can be frozen.
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joseblo
GLP-1 Enthusiast
Yeah, it will expand. As long as the cart isn't too full (and won't pop out the stopper) you should be fine. However, I generally would only do this with Tirz, and limit the number of cycles to 1. Probably, only worth it if you're holding it for 90 days or more.
Thanks! I figured that there could be some expansion and that the stopper might move, which is why I asked. I was only planning on doing this with tirz for 1 freeze/thaw cycle. Maybe I'll just leave it in the fridge and call it a day. I wasn't planning on keeping it frozen too long.
I've been wondering the same! I had a cart I filled & didn't need it for a while, but ended up giving it to someone else since I didn't know & didn't want to waste it.
I would love to recon all at once & freeze the carts, but I don't want them all to blow out & lose them all either. I was thinking of leaving the air space for expansion, but was also thinking if that could possibly let anything creep in there
randompersonrandom
GLP-1 Specialist
I freeze carts. I just make sure they're only 2/3 full (I could probably get away with more), and I get all the air out before I freeze so that if the expansion pushes the stopper back, it won't blow out. I've also frozen WITHOUT doing that, and not lost a stopper.
You have actually done it so that is great news that it hasn't happened to any of them. Do you think 1.5ml is enough since that's only 1/2 full? My Tirz 30 (34mg tested) I want to lower the volume (this time I did 2ml but want to go down to 1.5 in case I keep needing to go up) 🙂
randompersonrandom
GLP-1 Specialist
Yeah, here, look. I just went and looked in my freezer. Got a full cart of klow that I froze and forgot about til just now, and a half cart of survo cause I'm temporarily switched to reta and don't need it right now. Stopper didn't move on either that I can see.
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Yay!! Thank you!! That is such great news!! My next recon I'm doing kits in carts. That way I dont have to waste the rest of my Hospira, (especially since I started low & will take a bit to get through each cart). I appreciate the pic too!! Thank you for taking the time!! 🙂
Thanks so much! This is very encouraging.
Dilbert4Life
GLP-1 Apprentice
Thanks. Your comments were very helpful.
Dilbert4Life
GLP-1 Apprentice
BTW, can this be done for other peps like tesa or ghk-cu too?
SITHRE
GLP-1 Apprentice
I'm curious as well. Have a blend of BPC / TB / KPV that I make for a family member, would be nice to be able to prep them ahead of time and remove from freezer as needed...
