Does Tirz just ghost everyone in the end?

[Mara_aa]

It seems like, for the vast majority of people, even when increasing the dose of Tirz, you eventually reach a point where after a while the effect drops off significantly or just seems to disappear.

My main concern is maintenance:
if someone already struggles with strong food noise or BED, how do you manage once Tirz stops helping?

Because realistically:
it’s not like we can just fast indefinitely if we can’t handle it…
and I can’t exactly quit my job to work out 8 hours a day (no one’s paying my bills).

So I’m wondering:

• do you switch GLP-1?
• do you add something (like an amylin receptor agonist)?
• Or do you all just accept your fate and pretend the betrayal doesn’t hurt?

I’d really like to hear real experiences, especially from people who are further along.
How did you handle the “after”? How did you survive it?

 

[latviantower]

It seems like, for the vast majority of people, even when increasing the dose of Tirz, you eventually reach a point where after a while the effect drops off significantly or just seems to disappear.

My main concern is maintenance:
if someone already struggles with strong food noise or BED, how do you manage once Tirz stops helping?

Because realistically:
it’s not like we can just fast indefinitely if we can’t handle it…
and I can’t exactly quit my job to work out 8 hours a day (no one’s paying my bills).

So I’m wondering:

• do you switch GLP-1?
• do you add something (like an amylin receptor agonist)?
• Or do you all just accept your fate and pretend the betrayal doesn’t hurt?

I’d really like to hear real experiences, especially from people who are further along.
How did you handle the “after”? How did you survive it?

I plateaued 10 pounds short of my goal on 15 mg tirz. Started pinning every six days, then five. Not much success. Then added midweek reta chaser - 2.5 mg. Boom! That did it. Am now on 10 mg tirz staggered with 5 mg reta for maintenance. Labs are even better - A1C went from 6.8 to 5.4 to 5.0.

 

[DrPEPr]

That's the risk of relying solely on medication; eventually, the body adapts. The beauty of these drugs (IMHO) is that they provide a window of opportunity to overhaul your lifestyle. Those habits are what make the difference in the long run - not an infinitely increasing dosage.

You don't necessarily need to fast, but you do need to make smarter food choices. If you eat the same foods that led to weight gain (just in smaller portions) you’re set up for a rebound the moment you stop the drug. It’s like taking aspirin daily for a headache caused by a loud noise instead of just turning down the volume.

You also don't need to work out for 8 hours a day. 3-4 (~1 hour) sessions a week is plenty. So no need to quit your job.
I have a full-time job, a family (couple of kids) and several hobbies and I even manage to lift 5 days a week (2-2.5 hour sessions).

 

[CallieKat]

I don’t think the effect disappears. I haven’t heard of anyone gaining significant weight back with consistent use. Stalling? Yes. But tirz losing effect and the user gaining back significant weight while consistently injecting every week? Not so much.

I’m thrilled I got the weight loss I wanted but I would still use it if it prevented me from gaining weight.

Success for some can be measured by just not gaining those 10 pounds every year.

 

[deluge]

It seems like, for the vast majority of people, even when increasing the dose of Tirz, you eventually reach a point where after a while the effect drops off significantly or just seems to disappear.

I've reached this point as well.

I read a good explanation on here from someone more experienced than I, who said it didn't disappear, or drop off. Think of it more like your body and the peptides have reached an equilibrium, at the new weight.

You didn't go back to your original weight, did you? This is the new weight, given the current food intake, calorie expenditure, and peptides. Make a further change, and see where that takes you.

I'm considering trying stacking Cagrilintide or Reta for my next step.

 

[chewonmysac]

I do not think it is a ghost so much as it is a shadow. When plateaus occur rather than stalls, it is because your body has fully accommodated to the given dose. Neither negative nor positive is usually seen, and we focus on the scale as the end-all be-all. As a society, we are wired to automatically increase intake for desired, speedy results. When we actually need to decrease intake to create a lower baseline for about a month. Then titrate back up. Sometimes, less is more.

 

[Jfrick11]

That's the risk of relying solely on medication; eventually, the body adapts. The beauty of these drugs (IMHO) is that they provide a window of opportunity to overhaul your lifestyle. Those habits are what make the difference in the long run - not an infinitely increasing dosage.

You don't necessarily need to fast, but you do need to make smarter food choices. If you eat the same foods that led to weight gain (just in smaller portions) you’re set up for a rebound the moment you stop the drug. It’s like taking aspirin daily for a headache caused by a loud noise instead of just turning down the volume.

You also don't need to work out for 8 hours a day. 3-4 (~1 hour) sessions a week is plenty. So no need to quit your job.
I have a full-time job, a family (couple of kids) and several hobbies and I even manage to lift 5 days a week (2-2.5 hour sessions).

T.H.I.S.👆👆👆👊

 

[Sasquatch]

I go with 15mg, on Thurs. Then 4.5mg on Sat. Mainly because I have .5ml syringes. It works but I've always been able to override my signals just because we have a buffett culture here. Everyone is severely overweight. We just don't give a fuck. Doctors, God bless 'em, they try to increase your longevity and quality of life. I gotta say it worked pretty well. But you're not getting off this planet alive. Something's gonna get you. I never smoked. I figure it'll prolly be cancer, but with the weight loss a stroke is less a chance.

 

[Mara_aa]

I do not think it is a ghost so much as it is a shadow. When plateaus occur rather than stalls, it is because your body has fully accommodated to the given dose. Neither negative nor positive is usually seen, and we focus on the scale as the end-all be-all. As a society, we are wired to automatically increase intake for desired, speedy results. When we actually need to decrease intake to create a lower baseline for about a month. Then titrate back up. Sometimes, less is more.

That’s a really interesting way to look at it, I like the “shadow vs ghost” analogy.
The idea of lowering intake to reset baseline before titrating back up actually makes a lot of sense. I hadn’t thought about it that way.
Thanks for sharing, really appreciate the perspective!

 

[latviantower]

I think maybe my original post was too long, because your reply, while totally valid, feels a bit… obvious and doesn’t really address what I meant.

What you’re describing mostly applies to people who gained weight from overeating out of boredom or habit and being inactive. That’s not really the scenario I was referring to.
I was talking about long-term maintenance for people dealing with severe food noise or BED, cases where, even after years of therapy, the underlying drive to eat doesn’t just disappear. That’s a very different situation, and lifestyle changes alone don’t always “fix” it.

Also, on a lighter note… I’m genuinely impressed 😅

5 days a week, 2–2.5 hour lifting sessions? Do you sleep at all?

Because my reality looks a bit different: I work a full-time (actually more like 10–12 hour) office job as a finance manager, spend ~2 hours a day commuting, try to get at least 6–7 hours of sleep, cook most of my meals (I don’t really eat processed food), and handle all the usual life stuff.

So yeah… I don’t exactly have all that extra time for hobbies + long gym sessions. Maybe life is just more efficient in the US 😉

10-12 hours per day in the office?? You must live in Milano - in my 5 years working in Roma I never met anyone who worked like that - they seemed to be all government employees or academics and were always at lunch. 😂

 

[Mara_aa]

I plateaued 10 pounds short of my goal on 15 mg tirz. Started pinning every six days, then five. Not much success. Then added midweek reta chaser - 2.5 mg. Boom! That did it. Am now on 10 mg tirz staggered with 5 mg reta for maintenance. Labs are even better - A1C went from 6.8 to 5.4 to 5.0.

That’s awesome! Congrats, especially on your A1C, that’s a huge improvement.
Thanks for sharing your experience 🫶
Really interesting to hear how adding reta helped break the plateau and transition into maintenance.

 

[Mara_aa]

10-12 hours per day in the office?? You must live in Milano - in my 5 years working in Roma I never met anyone who worked like that - they seemed to be all government employees or academics and were always at lunch. 😂

I live near Turin, and yes, I believe you blindly. Clearly I was meant to be born in Southern Italy 😂 and, above all, to work in the public administration.

 

[Mara_aa]

I don’t think the effect disappears. I haven’t heard of anyone gaining significant weight back with consistent use. Stalling? Yes. But tirz losing effect and the user gaining back significant weight while consistently injecting every week? Not so much.

I’m thrilled I got the weight loss I wanted but I would still use it if it prevented me from gaining weight.

Success for some can be measured by just not gaining those 10 pounds every year.

I agree with you, building sustainable habits is definitely key in the long run, and these meds can really help create that window.
At the same time, I think for some people (especially those dealing with strong food noise or BED) it can be a bit more complex than just habits, which is why I’m trying to hear different experiences.
Really appreciate you sharing your perspective! 🫶

 

[Mara_aa]

That's the risk of relying solely on medication; eventually, the body adapts. The beauty of these drugs (IMHO) is that they provide a window of opportunity to overhaul your lifestyle. Those habits are what make the difference in the long run - not an infinitely increasing dosage.

You don't necessarily need to fast, but you do need to make smarter food choices. If you eat the same foods that led to weight gain (just in smaller portions) you’re set up for a rebound the moment you stop the drug. It’s like taking aspirin daily for a headache caused by a loud noise instead of just turning down the volume.

You also don't need to work out for 8 hours a day. 3-4 (~1 hour) sessions a week is plenty. So no need to quit your job.
I have a full-time job, a family (couple of kids) and several hobbies and I even manage to lift 5 days a week (2-2.5 hour sessions).

I think maybe my original post was too long, because your reply, while totally valid, feels a bit… obvious and doesn’t really address what I meant.

What you’re describing mostly applies to people who gained weight from overeating out of boredom or habit and being inactive. That’s not really the scenario I was referring to.
I was talking about long-term maintenance for people dealing with severe food noise or BED, cases where, even after years of therapy, the underlying drive to eat doesn’t just disappear. That’s a very different situation, and lifestyle changes alone don’t always “fix” it.

Also, on a lighter note… I’m genuinely impressed 😅

5 days a week, 2–2.5 hour lifting sessions? Do you sleep at all?

Because my reality looks a bit different: I work a full-time (actually more like 10–12 hour) office job as a finance manager, spend ~2 hours a day commuting, try to get at least 6–7 hours of sleep, cook most of my meals (I don’t really eat processed food), and handle all the usual life stuff.

So yeah… I don’t exactly have all that extra time for hobbies + long gym sessions. Maybe life is just more efficient in the US 😉

 

[Mara_aa]

I've reached this point as well.

I read a good explanation on here from someone more experienced than I, who said it didn't disappear, or drop off. Think of it more like your body and the peptides have reached an equilibrium, at the new weight.

You didn't go back to your original weight, did you? This is the new weight, given the current food intake, calorie expenditure, and peptides. Make a further change, and see where that takes you.

I'm considering trying stacking Cagrilintide or Reta for my next step.

That’s a really helpful way to frame it, thinking of it as a new equilibrium rather than something “failing” actually makes a lot of sense.
And you’re right, maintaining a lower weight is already a big shift compared to where we started.
Curious to see how stacking works for you if you try it, would be great to hear an update. Thanks!

 

[CallieKat]

I plateaued 10 pounds short of my goal on 15 mg tirz. Started pinning every six days, then five. Not much success. Then added midweek reta chaser - 2.5 mg. Boom! That did it. Am now on 10 mg tirz staggered with 5 mg reta for maintenance. Labs are even better - A1C went from 6.8 to 5.4 to 5.0.

I get ya. Too much skim reading on my part. If you haven’t tried everything then yes…try them all. Combine. Max them out. You can’t say it doesn’t work if you haven’t tried everything.

I like choosing a base med that you plan on maxing out if you have to like tirz or Reta. I like combining microdosing with sema or cagri along the way while you slowly max out on your base. Tirz with micro reta is pretty cool too. I’m sure folks do Reta with micro tirz.

But there isn’t a right or wrong way imo. Technically it’s all the wrong way because none of what we are doing here is “recommended”. Those that tell you that there is a right or wrong way are usually trying to make money off giving you advice….

Good luck!

 

[Airborne Daddy]

I go with 15mg, on Thurs. Then 4.5mg on Sat. Mainly because I have .5ml syringes. It works but I've always been able to override my signals just because we have a buffett culture here. Everyone is severely overweight. We just don't give a fuck. Doctors, God bless 'em, they try to increase your longevity and quality of life. I gotta say it worked pretty well. But you're not getting off this planet alive. Something's gonna get you. I never smoked. I figure it'll prolly be cancer, but with the weight loss a stroke is less a chance.

Gained 2lbs this week and have been 232 for 6 weeks even after adding cardio and cutting more sugar. 10mg reta and 2mg sema every 6 days....like my body just said after 15 months "were not fallin for your bullshit" frickin glucose running over 100.... im disgusted. My supply is good as the wife lost 11lbs in her first month at a ridiculously low dose. Sqwatch, im shit responder, nice to meet you.

 

[YoYoFat]

I believe it’s the SURMOUNT study that showed Tirz stops weight loss around the a year to 72 weeks.

 

[Mara_aa]

I go with 15mg, on Thurs. Then 4.5mg on Sat. Mainly because I have .5ml syringes. It works but I've always been able to override my signals just because we have a buffett culture here. Everyone is severely overweight. We just don't give a fuck. Doctors, God bless 'em, they try to increase your longevity and quality of life. I gotta say it worked pretty well. But you're not getting off this planet alive. Something's gonna get you. I never smoked. I figure it'll prolly be cancer, but with the weight loss a stroke is less a chance.

Sounds like you’ve found a setup that works well for you, that’s what really matters.
I get what you’re saying about being able to override signals, that part can be tough regardless of the meds.
And yeah… none of us are getting out of here alive 😎 but improving quality of life along the way is still a pretty big win.

 

[Mara_aa]

I believe it’s the SURMOUNT study that showed Tirz stops weight loss around the a year to 72 weeks.

That’s really interesting, I’ve heard similar things about weight loss slowing or plateauing around that timeframe, sometimes even before the person reaches their goal… something to think about.

 

[JoonyO]

Gained 2lbs this week and have been 232 for 6 weeks even after adding cardio and cutting more sugar. 10mg reta and 2mg sema every 6 days....like my body just said after 15 months "were not fallin for your bullshit" frickin glucose running over 100.... im disgusted. My supply is good as the wife lost 11lbs in her first month at a ridiculously low dose. Sqwatch, im shit responder, nice to meet you.

You sound disheartened or at least frustrated. 🙁

IMO, like latviantower said, switching things up got him back on track for his goal.

We're all just RS, trying to better ourselves as we've discovered it's up to us, no one else.
Hang in there.🫡

 

[Mara_aa]

Gained 2lbs this week and have been 232 for 6 weeks even after adding cardio and cutting more sugar. 10mg reta and 2mg sema every 6 days....like my body just said after 15 months "were not fallin for your bullshit" frickin glucose running over 100.... im disgusted. My supply is good as the wife lost 11lbs in her first month at a ridiculously low dose. Sqwatch, im shit responder, nice to meet you.

I get why you’re frustrated, it really does feel like your body just slammed the brakes.
You’ve been consistent for 15 months, and that matters way more than one stubborn stretch, it’s a hard plateau.
After this long, stalls are pretty normal. A couple of pounds can easily be water, stress, or glucose fluctuations, not fat gain. Just hang in there, it passes. Some folks stay stuck for months before things finally shift again.

 

[randompersonrandom]

I believe it’s the SURMOUNT study that showed Tirz stops weight loss around the a year to 72 weeks.

this is something that's spooking me a little bit. I started on tirz at late June of last year. I'm dragging through the last two months at six pounds from goal on a stack of 8 mg tirz and 1.6 mg Survo. I don't want to titrate up because I'm not in the mood for the fatigue that happens for a few weeks every time I do. I switched to a single vials of reta (37 mg) a week or two ago and am titrating up a little fast just so I don't have a lapse as the tirz washes out, but the only reason I'm screwing around with the reta is to check and make sure it's not something that would be awful for me so I can keep on slow hoarding it, not because I think it's the answer to finish this.

Meanwhile...did I stop the clock on the 72 weeks when I started messing around with reta? Or is the clock still running and I'm eating up my time when I should be taking advantage of still being within the time period? There's no way to know the answer because nobody tested "but what if they stop and start and switch to something that's also a glp-1 but different" and the billion variables of "randompersonrandom is fucking around."

 

[Mara_aa]

this is something that's spooking me a little bit. I started on tirz at late June of last year. I'm dragging through the last two months at six pounds from goal on a stack of 8 mg tirz and 1.6 mg Survo. I don't want to titrate up because I'm not in the mood for the fatigue that happens for a few weeks every time I do. I switched to a single vials of reta (37 mg) a week or two ago and am titrating up a little fast just so I don't have a lapse as the tirz washes out, but the only reason I'm screwing around with the reta is to check and make sure it's not something that would be awful for me so I can keep on slow hoarding it, not because I think it's the answer to finish this.

Meanwhile...did I stop the clock on the 72 weeks when I started messing around with reta? Or is the clock still running and I'm eating up my time when I should be taking advantage of still being within the time period? There's no way to know the answer because nobody tested "but what if they stop and start and switch to something that's also a glp-1 but different" and the billion variables of "randompersonrandom is fucking around."

I think “randompersonrandom is fucking around” might be the most scientifically accurate variable ever documented 😅
At this point I’m not sure there even is a clock anymore… feels more like we all quietly left the study protocol months ago and are just freelancing it.
Jokes aside, you’re handling a pretty chaotic mix of variables and still only 6 lbs from goal, that’s honestly impressive.
Hope you find a way to close it out without triggering the fatigue boss fight again 🫶

 

[lessthanhalf]

The most common reason for feeling like the GLP drugs are no longer working is that they have caused weight loss , and you are at the new normal weight for that dose. As you lose weight metabolic rate goes down and hunger increases, so it feels like it is not working, but if weight is stable at a lower level it is working and if continued will maintain that weight loss.
I think the research on GLP drugs for BED is in its infancy, it is not really a recognised and accepted treatment yet but early research is strongly suggestive they work.
My solution was to treat high calorie / highly rewarding foods as something I just could not eat in reasonable amounts and had to totally avoid, and along with a high protein low calorific density diet got from 145kg to 75 kg and stayed there for a year, but I was still hungry most of the time, not uncontrollably so , but enough to make life a lot less pleasant. Thankfully I discovered cheap chinese GLP drugs and maintaining that weight loss is much easier with 15mg of tirz plus 5 of reta , plus more recently 0.5 of cagri as well.

 

[bbbilly]

im POSITIVE i will get hate for this. but this is my own personal experience with tirz and BED.

i lost a little over 100lbs about 11 years ago in my 20s by shear willpower and dedication. then started slowly putting the weight back on in false attempt to bulk and put muscle on. then covid shut everything down and i got laidoff several times and put back on most of it.
restarting the journey i lost somewhere around 60lbs in about 10 months and decided "why not, i qualify and i have pre diabetes, sounds like it could be easier" and it was. dropped the next 50ish pounds effortlessly by doing the same thing i did to lose the first 60, and the 100 before that.. just ignore my hunger and eat my premade meals, but this time with alot less mental pressure. when my weight slowed and stalled ill remake my meals to be a little lighter, or add more bulk (pro tip add some pre shredded coleslaw mix to stuff for a nice crunch and like 3 calories)
once i got into the normal bmi range my PCP had me stop losing as to maintain the total weight and to just get use to what i eat and how much etc for about 6 months. then the worst happened.. i lost my day job that had the health insurance that was paying for my brand name zepbound. i again went into this with the mindset of "well ill do a bulk and try to put on some muscle and enjoy the holidays" and put on 35lbs in like 4 months, then had to cut it back off... i cut 25lbs without the zep in about 3 months. then found this forum and got back on the sauce.

all that brings me to present. i take 1.25mg tirz every 7-8 days. as apposed to the 2.5mg i took to lose the 50 before. i only increased to 5 for about a month the first time i got on before the job thing happened so i didnt see anything from that. but this time im purposely spacing it a little more and using a little less specifically to feel the hunger and the food noise start coming back as a reference before i erase them. i know what to eat because i just eat what all the calorie calculators tell me to eat, and if they are a little off i adjust the last couple hundred calories but i always leave a little room for a those BED episodes i only catch when im allready in it by having the routine and have the opportunity to think "i haven't eaten something over the sink in my underwear in a while.. why am i doing it now?"
because i wasnt hungry while on tirz i had that apophony of "why am i eating when i feel so full already?" because for me its not about hunger, i just want to EAT. so when i lost access for a while i just said to myself "im not actually hungry right now, my stomach is lying to me". and would just ignore it. i eat what im supposed to eat and maybe a couple bite my wife leaves over and just go about my day.

TL😀R i used my time on tirz to learn my stomach is a liar and just ignore it, stick to my calories and move on, but also how to spot a BED episode when im in it and to avoid falling into one to begin with.

 

[Mara_aa]

The most common reason for feeling like the GLP drugs are no longer working is that they have caused weight loss , and you are at the new normal weight for that dose. As you lose weight metabolic rate goes down and hunger increases, so it feels like it is not working, but if weight is stable at a lower level it is working and if continued will maintain that weight loss.
I think the research on GLP drugs for BED is in its infancy, it is not really a recognised and accepted treatment yet but early research is strongly suggestive they work.
My solution was to treat high calorie / highly rewarding foods as something I just could not eat in reasonable amounts and had to totally avoid, and along with a high protein low calorific density diet got from 145kg to 75 kg and stayed there for a year, but I was still hungry most of the time, not uncontrollably so , but enough to make life a lot less pleasant. Thankfully I discovered cheap chinese GLP drugs and maintaining that weight loss is much easier with 15mg of tirz plus 5 of reta , plus more recently 0.5 of cagri as well.

That’s a really thoughtful perspective, and it makes a sense, especially the part about a “new normal” for a given dose.
Also huge respect for the weight loss and maintaining it, that’s an incredible result.
What you said about still being hungry even after doing everything “right” is exactly the part that I think many people underestimate. That’s where it feels like it goes beyond just habits.
Really appreciate you sharing all of that. 🫶

 

[Mara_aa]

im POSITIVE i will get hate for this. but this is my own personal experience with tirz and BED.

i lost a little over 100lbs about 11 years ago in my 20s by shear willpower and dedication. then started slowly putting the weight back on in false attempt to bulk and put muscle on. then covid shut everything down and i got laidoff several times and put back on most of it.
restarting the journey i lost somewhere around 60lbs in about 10 months and decided "why not, i qualify and i have pre diabetes, sounds like it could be easier" and it was. dropped the next 50ish pounds effortlessly by doing the same thing i did to lose the first 60, and the 100 before that.. just ignore my hunger and eat my premade meals, but this time with alot less mental pressure. when my weight slowed and stalled ill remake my meals to be a little lighter, or add more bulk (pro tip add some pre shredded coleslaw mix to stuff for a nice crunch and like 3 calories)
once i got into the normal bmi range my PCP had me stop losing as to maintain the total weight and to just get use to what i eat and how much etc for about 6 months. then the worst happened.. i lost my day job that had the health insurance that was paying for my brand name zepbound. i again went into this with the mindset of "well ill do a bulk and try to put on some muscle and enjoy the holidays" and put on 35lbs in like 4 months, then had to cut it back off... i cut 25lbs without the zep in about 3 months. then found this forum and got back on the sauce.

all that brings me to present. i take 1.25mg tirz every 7-8 days. as apposed to the 2.5mg i took to lose the 50 before. i only increased to 5 for about a month the first time i got on before the job thing happened so i didnt see anything from that. but this time im purposely spacing it a little more and using a little less specifically to feel the hunger and the food noise start coming back as a reference before i erase them. i know what to eat because i just eat what all the calorie calculators tell me to eat, and if they are a little off i adjust the last couple hundred calories but i always leave a little room for a those BED episodes i only catch when im allready in it by having the routine and have the opportunity to think "i haven't eaten something over the sink in my underwear in a while.. why am i doing it now?"
because i wasnt hungry while on tirz i had that apophony of "why am i eating when i feel so full already?" because for me its not about hunger, i just want to EAT. so when i lost access for a while i just said to myself "im not actually hungry right now, my stomach is lying to me". and would just ignore it. i eat what im supposed to eat and maybe a couple bite my wife leaves over and just go about my day.

TL😀R i used my time on tirz to learn my stomach is a liar and just ignore it, stick to my calories and move on, but also how to spot a BED episode when im in it and to avoid falling into one to begin with.

Huge respect for the level of discipline and self-awareness you’ve built.
Using tirz as a tool to understand your patterns and create that kind of structure is not something everyone manages to do.

At the same time, I think cases like yours also highlight how different BED can be from person to person. In more severe cases, it’s often tied to underlying issues that aren’t always fully resolved, so it’s not just about overriding hunger or sticking to a plan, even when you know exactly what’s happening.
Your approach is genuinely impressive and really valuable, maybe not something everyone can easily replicate?
I really appreciate you sharing your experience 🤗