I have started seeing Tirzepatide (20mg) + Retatrutide (40mg) single vial combination being offered by some vendors. I am not interested in moving into that combination, but I am interested in discussion/personal experiences with this type of combination. My research suggests that mixing the two should only be done temporarily as you titrate down from one peptide (Tirz) and start titrating into a new peptide (Reta), although all of that has been anecdotal. Thoughts? Please discuss.
EDIT: I forgot to add, that I have also seen anecdotal evidence of people who "micro dose" both Tirz/Reta to one degree or another. That seems like "overkill" for a prolonged period of time as they do intersect in some areas, but what do i know?
The sustained stack of Reta and Tirz is more common than I think you realize. I am one such person who does so and I know there are many in this forum.
I don’t know how much I care for them being pre-mixed- significantly less control over dosage with zero independent flexibility.
While yes they “intersect”, they are not the same. They do not present the same effects and side effects. Food suppression is notably different, as well as how each persons handles the number of common side effects from either can easily shape what pep or peps they choose.
My path- I want the benefits of the triple agonist (Reta), but to stay at lower effective dosages as long as possible. With the lower dosage, my food suppression with Reta is minimal, so I keep the Tirz at a lower dosage as well due to the excellent suppression response I get from it. With the two, I feel fully in control of what I want to eat, when I want to eat, and how much. I have essentially zero cravings for anything I shouldn’t consume- whether it be fried/oily foods, sugars, alcohol, etc.. and even if I do partake in any of the above, I can have just one and be fine, one bite, one drink, whatever.
I also know that for me, Allodynia will keep presenting itself with the Reta, so using the Tirz to keep my progression low and slow but effective, is key.
Once I hit goal weight, I will re-evaluate enter I maintenance with both or only one, but have no aversion to maintaining both if it remains ideal for my body chemistry.
