Reta OD

ghreid

GLP-1 Apprentice
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First reported case on reta overdose. Patient got from online med clinic and had starting dose of 10mg weekly. this was increased to 20mg. Patient forgot that he had taken his dose already and administered a second dose. within 4 hours developed intractable diarrhea (total 40mg reta). He took otc anti-diarrhea meds without response. On 7th day was admitted to hospital due to severe dehydration and early kidney failure. These were reversed with hydration and K+ replacement. Discharged after 3 days. I even get diarrhea from the 10mg dose!
 
I'm curious whether he intended to take 10mg/20mg, or made a mistake reconstituting.
 
From reading the article, it sounds like he actually started at 10mg. Decided to bump it up to 20 and then took another 20 by accident.

Reddit is full of people who do 0 research yet somehow manage to navigate their way around ordering and receiving peps.
 
ghreid said:
First reported case on reta overdose. Patient got from online med clinic and had starting dose of 10mg weekly. this was increased to 20mg. Patient forgot that he had taken his dose already and administered a second dose. within 4 hours developed intractable diarrhea (total 40mg reta). He took otc anti-diarrhea meds without response. On 7th day was admitted to hospital due to severe dehydration and early kidney failure. These were reversed with hydration and K+ replacement. Discharged after 3 days. I even get diarrhea from the 10mg dose!
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Good article - thanks!
 
I've heard of doctors mixing up sema and tirz. Started a patient using sema at 2.5 instead of .25 and the pharmacy didn't catch it . Mistakes happen but we only hear about them blasted all over the news if its grey when this can happen with any drug. Drinking too much water can harm you too.
 
toologic said:
I've heard of doctors mixing up sema and tirz. Started a patient using sema at 2.5 instead of .25 and the pharmacy didn't catch it . Mistakes happen but we only hear about them blasted all over the news if its grey when this can happen with any drug. Drinking too much water can harm you too.
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being a MD myself I know this is true. Was on call for another physician who had rx'd an antihistamine for a patient, the npatient called an said it wasn't helping his allergy so the doc told him to take 2. again said he felt worse so was told to take an additional dose in the afternoon. when I saw him he looked awful and was having a hard time getting a BP on him. He had brought his meds with him, I noticed that the pills were not antihistamines. the pharmacy had switch it to a strong blood pressure pill. I posted this to remind people to be vigilant of their doses. luckily the diarrhea was the only major side effect noted at supra-physiologic doses of the Reta. I myself have had times where I couldn't remember if I had pinned Reta that day along with my other peptides so skipped it just in case.
 
I had a bad day on 1.5mg. Highest I was able to comfortably get was 1mg twice a week. I have a friend I just started on Reta a couple of weeks ago and she’s getting a good amount of apatite suppression on 1mg twice a week so doesn’t need to go up either. Nobody should be starting at double digits with this stuff.

I read Lilly is admitting to incidents of super-responders but called it “very rare”. I call BS on that.
 
[EDIT] re: people not confirming their meds or doses.
JFC, people really need to take their own agency when it comes to their own (and only!) body. Sheesh. The amount of times I see/read about people mindlessly doing things - or taking things, in particular - without confirming they know what it is, is really beyond my ken. Like, sure, I can make a case for the very elderly or very young - ideally they should be having someone advocate for them and be their eyes and ears - but when the person is of independent age and is in charge of their own health, c'mon. SMH.
 
ghreid said:
First reported case on reta overdose. Patient got from online med clinic and had starting dose of 10mg weekly. this was increased to 20mg. Patient forgot that he had taken his dose already and administered a second dose. within 4 hours developed intractable diarrhea (total 40mg reta). He took otc anti-diarrhea meds without response. On 7th day was admitted to hospital due to severe dehydration and early kidney failure. These were reversed with hydration and K+ replacement. Discharged after 3 days. I even get diarrhea from the 10mg dose!
Click to expand...
Did you read it? It says “He started on a self-determined dose of 10 mg subcutaneously weekly for several weeks and had only just increased the dose to 20 mg”

Self determined… he didn’t get it from a clinic. A clinic would have given dosing instructions. Sounds to me like he decided a vial was a dose.
 
mainefungi said:
Did you read it? It says “He started on a self-determined dose of 10 mg subcutaneously weekly for several weeks and had only just increased the dose to 20 mg”

Self determined… he didn’t get it from a clinic. A clinic would have given dosing instructions. Sounds to me like he decided a vial was a dose.
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Oh I know, I wasn't specifically noting that post. More the follow up anecdotal ones.
 
"self-determined dose of 10 mg" I wonder if it was actually units and not mg or did they actually think starting at 10mg going to 20mg (actually 30mg) was a good idea.
 
ThatNextGril said:
Oh I know, I wasn't specifically noting that post. More the follow up anecdotal ones.
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Fair enough. My biggest concern with this market is idiotic people not doing an ounce of research before dosing and drawing unnecessary attention to people who are just trying to improve their health with at least a little affordability.
 
I have come across lots of case reports like this for tirzepatide but especially semaglutide as it has been around longer. This is exactly the biggest real world risk of grey peptides. Most people do not have a lot of background pharmaceutical knowledge and a lot of people are not that great at maths either. Doctors and nurses make dosing errors despite being very careful not to, using medication in very clearly labelled packaging, so making dosing errors when starting to use grey peptides is super easy and not rare at all. This person had the whole thing , gastrointestinal upsets leading to dehydration leading to acute kidney failure, that is exactly the worst case outcome, although his kidneys recovered, they do not always recover, and this is the main way it is possible to die from grey glp's. Do lots of research first and always double and triple check doses and dilutions.
 
Wow. I was just talking to my sponsor the other day about how rare it is for someone to OD and get into a bad situation with GLP1s. I had told him that most are folks who purposefully take huge doses hoping to get all the benefits quicker - and they don't realize that the peps need time to build up in the body to reach therapeutic levels...
 
NIGLP89user said:
Reddit is full of people who do 0 research yet somehow manage to navigate their way around ordering and receiving peps.
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I just saw somebody on there yesterday say "I'm an actual nurse and I have mis-dosed myself." I thought what if that was a patient's morphine you screwed up???
 
Usually administering injectable drugs , especially something like morphine requires 2 nurses to cross check the order and the dose, so the second person will hopefully notice a mistake if it is made. ( And hopefully notice if the doctor has made a mistake with the prescription ) It sadly does still happen despite training and systems put in place to minimise errors and maximise chances of catching them. Most medication errors are not going to cause real harm, an extra dose of antibiotics by mistake is not likely to cause problems, but sometimes serious errors do happen and sometimes people are harmed or even die. No system is ever perfect , and all people will sometimes make mistakes, and all that can be done is to design a system that will prevent as many errors as is possible.
There are no protective systems in place for peptides, and the vials have a wide range of doses , are usually not carefully labelled and each vial has enough to make you quite ill, so it is not that surprising that accidental GLP overdoses are fairly common. There are a few posts on this forum from people who were were not newbies who have done it , but thankfully there were no major issues.
 
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