Grey not seeming as strong for some reason?

mercuryleaf7

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Has anyone else experienced this?
So I was on Mounjaro and I tried grey for a month back in Nov and it felt good, stronger if anything so I went back to finish all my Mounjaro pens.

Then about a month ago they ran out and I went fully onto grey which tested well at the time and has been in the freezer since, then I thought I felt a lot hungrier than normal so I bumped my dose up 1mg (previously I have been fine on relatively low doses about 6mg and I started in July).
Then it still felt really underpowered so I went up to 8mg for about 3 weeks (on the third week before the 10mg it felt ridiculously low so I had another 8 later in the week fully expecting to be really unwell but I wanted some sort of reaction to prove to myself the tirz was still working like normal, if I had done that with Mounjaro I'd have been really unwell)
Suppression still felt poor went up to 10mg and it still feels underpowered.

It just all seems a bit weird.
Has anyone experienced this or have any suggestions what it could be.
 
At the end of the day it's just random shit from China that we're hoping is the right stuff. Who knows if it even is tirz lol, or if the vial is underdosed or over dosed.

I'm sure you'll have better luck with the next vendor.

Personally I'd rather inject sugar water from China than have to deal with contemptable shit the likes of doctors and pharmacies, but that's just me xD
 
mercuryleaf7 said:
Has anyone else experienced this?
So I was on Mounjaro and I tried grey for a month back in Nov and it felt good, stronger if anything so I went back to finish all my Mounjaro pens.

Then about a month ago they ran out and I went fully onto grey which tested well at the time and has been in the freezer since, then I thought I felt a lot hungrier than normal so I bumped my dose up 1mg (previously I have been fine on relatively low doses about 6mg and I started in July).
Then it still felt really underpowered so I went up to 8mg for about 3 weeks (on the third week before the 10mg it felt ridiculously low so I had another 8 later in the week fully expecting to be really unwell but I wanted some sort of reaction to prove to myself the tirz was still working like normal, if I had done that with Mounjaro I'd have been really unwell)
Suppression still felt poor went up to 10mg and it still feels underpowered.

It just all seems a bit weird.
Has anyone experienced this or have any suggestions what it could be.
Click to expand...
I haven't tried anything but grey so no can help!
 
I was on Compound Tirz( Tried them all) for about 9 months. The biggest difference I see in Grey is a bit more tiredness after shot day, but that has subsided, and I fart a lot more, I mean a lot more. Your titration schedule seems a bit slow for maximum impact, and it looks like you tried to play catch-up. 3rd party group testing is key and quite affordable.
 
That's really the one thing I check on a test sheet. That would be for overfill or underfill.
And if it doesn't seem to jibe, try another vial.
Like you (OP) I started on real Mounjaro 2.5mg. So I knew what felt correct.
Then I tried compounded. It was weak shit. When you do lyphilized tirz. you control the concentration. Which could mean you may need to double check your calculation?
 
Sasquatch said:
That's really the one thing I check on a test sheet. That would be for overfill or underfill.
And if it doesn't seem to jibe, try another vial.
Like you (OP) I started on real Mounjaro 2.5mg. So I knew what felt correct.
Then I tried compounded. It was weak shit. When you do lyphilized tirz. you control the concentration. Which could mean you may need to double check your calculation?
Click to expand...
Was about to say the same but you beat me to it.
 
I've tried brand name (zep) and grey both on low doses. I have had the same results on each with improved symptoms and weight loss. My partner has tried brand, compounded, and grey. He felt like grey and compounded were not as effective as brand.

I read something about compounded and brand use tirz in the base or raw form for their solutions and grey often uses a salt form like tirz acetate. I don't know if that makes a difference at the end of the day.
 
wheymaster1 said:
I’m still on original tirz and planning to try grey soon. Thanks for sharing. I will monitor closely how I feel as well. I’m awaiting the COA results.
Click to expand...
Definitely give it a few weeks to adjust and access. Alot of time grey is overfilled ( 10-15%) so when you reconstitute and dose calculate make adjustments accordingly.
 
Food for thought...
FDA-approved Tirzepatide (Mounjaro®, Zepbound®) is the base form, while compounded versions often use salt formulations (e.g., sodium or acetate). These salt forms are chemically different. Question is the dosage scale same? Might not be? Hope someone might have some input.
 
Last edited:
Oldguy said:
Food for thought...
FDA-approved Tirzepatide (Mounjaro®, Zepbound®) is the base form, while compounded versions often use salt formulations (e.g., sodium or acetate). These salt forms are chemically different. Question is the dosage scale same? Might not be? Hope someone might have some input.
Click to expand...
The API (the active pharmaceutical ingredient) part is the important bit that does all the stuff we want. The molecular mass difference between the various forms is not significant because the long chain amino acid mass is so large in comparison to the non active part (the salt/acetate etc) the salt form just allows it to be chemically dissolved in our case in Bac water, in Eli Lilly’s case a proprietary solution made up of buffers water and preservatives, the api remains the same.
 
Got online tonight to post this. Started reta from a compound pharmacy prescribed by my NP cousin. So many things I've read on here about reta were the exact opposite of what I was feeling. Appetite DESTROYED on 1mg. Others saying they are taking 5mg and still want to eat. Before I found grey I found "off white" lol the websites that sell something with their label and freedom diagnostics coas. Pinned my first dose of 4mg yesterday. Previous dose had been 3mg for 4 weeks. I know it's there but sure doesn't feel as strong as the compounded version. Now I have a kit of reta 30 in the freezer. Almost considering trying it before running out of the "off white" brand.
 
mercuryleaf7 said:
Has anyone else experienced this?
So I was on Mounjaro and I tried grey for a month back in Nov and it felt good, stronger if anything so I went back to finish all my Mounjaro pens.

Then about a month ago they ran out and I went fully onto grey which tested well at the time and has been in the freezer since, then I thought I felt a lot hungrier than normal so I bumped my dose up 1mg (previously I have been fine on relatively low doses about 6mg and I started in July).
Then it still felt really underpowered so I went up to 8mg for about 3 weeks (on the third week before the 10mg it felt ridiculously low so I had another 8 later in the week fully expecting to be really unwell but I wanted some sort of reaction to prove to myself the tirz was still working like normal, if I had done that with Mounjaro I'd have been really unwell)
Suppression still felt poor went up to 10mg and it still feels underpowered.

It just all seems a bit weird.
Has anyone experienced this or have any suggestions what it could be.
Click to expand...
There really should be no difference. The formulation differences and optimisation of the legit one is more about maintaining stability of the peptide dissolved in water over a few years so it can be sold that way, really should make zero difference to bioavailability. Did you buy it from a well known vendor with a good reputation? With published test results? or even better any third party test results? Have you double and triple checked your calculations for diluting it with bac and for the dose? it is super easy to make errors on this.

Is this the same batch you previously took or a new one? If it is the original batch was it stored frozen, fridge, room temp? It could have degraded if not frozen over months.
Trying to determine dose from effects on hunger is hard, but from side effects is often easier, and you say you would previously have felt sick if you used 10mg, and you were only on 6mg of the legit version, it does sound like what you are using might actually be weaker, but unless you send a vial off for testing it is impossible to know for certain.

If you have any of the legit stuff left you could try a dose of 6mg of that to confirm it really is different.
Over time, it can seem like the effect is weaker once a fair bit of weight has been lost, but this should be a fairly gradual thing not all of a sudden. ( due to drop in energy expenditure from weight loss and compensatory increase in appetite as your body starts trying to hang on to fat reserves )
The simplest solution might just be to buy another batch and see if it is the same, from a well known vendor.
I thankfully had a weird side effect from tirz , louder tinnitus, which is an odd drug side effect, but the grey version had exactly the same effect as the legit one so I could tell immediately it was the same drug.
 
mercuryleaf7 said:
which tested well at the time
Click to expand...
When you say it tested well at the time do you mean you sent a vial of yours to be tested? Some of the same batch was 3P tested by a group? Or you were relying on a vendor COA? There is a significant different in confidence between all three.
 
sfkid said:
There is a detailed post about this on Twitter that goes deep in explaining why...
https://twitter.com/x/status/2046307300869345284
View: https://x.com/i/status/2046307300869345284
Click to expand...
Excellent points, we can only control our end of the chain wrt storage recon etc. but I guess my view is that the huge saving I make going grey means I can afford to slightly increase my dose to compensate and indeed highly tailor my dose as I don’t follow the 2.5mg increase, I only increase by 1mg at a time split between my two weekly doses (minimising sides). The actual wanted action of the available molecule can be compensated for by slight dosing increases but the action of those bioavailable molecules is identical to the original due to the high specificity of the receptor. I split dose so can use a ‘smaller’ test doses to see the effect. Most people on larger doses probably won’t notice difference as over time the noticeable sides can decrease and vary weekly anyway due to body acclimating, hormones etc. but the biological action remains. Even Eli Lilly have a BUD which means they expect the activity to degrade over time, also, it just depends what level is tolerated by QA and the various regulatory authorities.
 
My thoughts, are yes, the grey works and it might require a bit larger dose than the name brand to get the job done. I’m no expert in this field, just an old rat. Happy to be on the dark side, the grey works just fine for me.
 
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