Should I move up to 4mg on Reta?

poundsdownstayfit

GLP-1 Apprentice
Member Since
Mar 6, 2026
Posts
35
Likes Received
21
Location
California
My dosing schedule for my first month was 0.5mg, 1mg, 1.5mg and now 2mg. Only started feeling a little appetite suppression on week 4. I my BMI is between 30-35% right now. I'm 5'7" 210lbs. Since I'm not really feeling it at 2mg, should I jump to 3mg or 4mg on week 5? I know reta hits people different. I do workout 4-5x/week and diet is alot better. Should I do 2mg for Three more weeks? And what do you really feel when you're on the right dose for reta for yourself?
 
Last edited:
BNLFL said:
Tirate up slower. Some of you don't even give the stuff time to work. No instant results.
Click to expand...
What is the benefit of slower titration of Reta, aside from avoiding sides for big’ns?

If it was Sema or Tirz, titrating to maintain effectiveness (appetite suppression) makes sense. Reta’s primary effectiveness isn’t appetite suppression, it’s GCGR, which is dose dependent.
 
poundsdownstayfit said:
My dosing schedule for my first month was 0.5mg, 1mg, 1.5mg and now 2mg. Only started feeling a little appetite suppression on week 4. I my BMI is between 30-35% right now. I'm 5'7" 210lbs. Since I'm not really feeling it at 2mg, should I jump to 3mg or 4mg on week 5? I know reta hits people different. I do workout 4-5x/week and diet is alot better. Should I do 2mg for Three more weeks? And what do you really feel when you're on the right dose for reta for yourself?
Click to expand...
I just jumped to 4mg after 4 weeks of 2mg. To be honest I wish I wouldn’t have. My heart rate was a little elevated at 2mg but at 4mg my sleeping heart rate has been 80 and 82 the last two nights. If you haven’t been tracking your resting and sleeping heart rate I would get a good couple weeks of data on it before going to 4mg.
 
BNLFL said:
Tirate up slower. Some of you don't even give the stuff time to work. No instant results.
Click to expand...
I know patience is the key. I guess when I read how people are losing 10-20lbs in a month it makes me feel like i'm doing something wrong. I'm eating right and working out. I don't want to rush it, but I also dont want to stay at a dose where its not doing anything.
 
woundcarping said:
What is the benefit of slower titration of Reta, aside from avoiding sides for big’ns?

If it was Sema or Tirz, titrating to maintain effectiveness (appetite suppression) makes sense. Reta’s primary effectiveness isn’t appetite suppression, it’s GCGR, which is dose dependent.
Click to expand...
I'm just basing it on the Lilly studies. It builds up slower to help with the side effects as you mention. I personally don't understand that .5 and 1 mg dose, but I don't know enough. Every Lilly study starts at 2mg that I've seen, but that was back in December.
 
Retarage said:
I just jumped to 4mg after 4 weeks of 2mg. To be honest I wish I wouldn’t have. My heart rate was a little elevated at 2mg but at 4mg my sleeping heart rate has been 80 and 82 the last two nights. If you haven’t been tracking your resting and sleeping heart rate I would get a good couple weeks of data on it before going to 4mg.
Click to expand...
Thanks for the advice
 
poundsdownstayfit said:
I know patience is the key. I guess when I read how people are losing 10-20lbs in a month it makes me feel like i'm doing something wrong. I'm eating right and working out. I don't want to rush it, but I also dont want to stay at a dose where its not doing anything.
Click to expand...
10lbs/month, that's 2.5lbs/week. I loose between 1-2lbs/week and I'm on 6mg. Everyone is different though. You do you and what make you comfortable.
 
Retarage said:
I just jumped to 4mg after 4 weeks of 2mg. To be honest I wish I wouldn’t have. My heart rate was a little elevated at 2mg but at 4mg my sleeping heart rate has been 80 and 82 the last two nights. If you haven’t been tracking your resting and sleeping heart rate I would get a good couple weeks of data on it before going to 4mg.
Click to expand...

BNLFL said:
10lbs/month, that's 2.5lbs/week. I loose between 1-2lbs/week and I'm on 6mg. Everyone is different though. You do you and what make you comfortable.
Click to expand...
What week/month are you at now with your 6mg dose? Did you also start in the 1mg -2mg range?
 
My 2 cents. If you are losing weight, at least .5lb a week do not increase. Slow wins the race. If you stop loosing for 4 weeks then increase 0.5-1mg. idea is to find lowest effective and tolerable dose for your self. Everyone is different. I personally know someone who lost 80lb in 9 months only on 2,5mg.
 
If I remember correctly Reta hits baseline efficacy at 5 weeks - if you jump to 4 your pumping it into your system without the initial dose being fully effective. That's typically why people stay at a dose for a month at a time, to truly see how the drug affects your system at full efficacy. Personally, if you're on 2 and only 4 weeks in, you're jumping for no reason. Do another week at 2, then a few weeks at 2.5, then jump to 3. This is a marathon, not a sprint. As far as what you feel... you'll know, I promise, you'lll know.
 
It’s wild how it affects everyone different. I started at 1 and stayed there 5 weeks. The first week I couldn’t look at food and lived on protein shakes. lost 20 with not much visible muscle loss. I am also on 100mg hrt. The last 2 I bumped to 1.5.
Keep in mind the half life and compounding levels each week. Even though I’m at 1.5 my current level is 2.5, that’s why they say stay at a dose 4 weeks and only increase if you are tolerating sides. Finally, I’m convinced Reta was designed to let hunger creep in for healthy refeeds to fuel glucagon and you can’t use that to measure efficacy. Finally finally you should be drinking a ton of water and water retention will fluctuate and affect the scale.
 
Last edited:
Increasing doses or not should be based on side effects, weight loss rate and hunger. If you are hungry and finding it difficult to stick to eating what you would like to eat to lose weight and do not have significant side effects, then increasing doses makes sense. If you have side effects at 2mg like some nausea, then going more slowly to 3mg or waiting makes sense. If you are losing weight at a rate you are comfortable with and not hungry all the time then staying at that dose makes sense.
Check out GLP plotter . Your current dose will not hit maximum levels for nearly 4 more weeks, so keep that in mind, as you have really only had one week at 2mg due to increasing the dose every week and starting super low. Your start BMI is 34 so you are very likely to need higher doses than 2mg in the long term, but increasing dose after only one week at 2mg does increase the odds of getting side effects. I would not recommend increasing to 4mg after only 1 week at 2mg. Maybe 3mg if you are really hungry with minimal side effects.
 
I know it's wrong, but I did the first week at 1mg, the second at 2mg, the third at 3mg, the fourth, unfortunately the vial I took ran out and I paid a lot for it, so I did 1.5mg. When the kit arrived, I did the fifth one again at 3mg. I don't know if I'm getting used to the drug, but if before I felt few effects, with the last dose I felt even less. Maybe the kit is less effective, I don't know. should I switch to 4mg this week?
 
vale113 said:
I know it's wrong, but I did the first week at 1mg, the second at 2mg, the third at 3mg, the fourth, unfortunately the vial I took ran out and I paid a lot for it, so I did 1.5mg. When the kit arrived, I did the fifth one again at 3mg. I don't know if I'm getting used to the drug, but if before I felt few effects, with the last dose I felt even less. Maybe the kit is less effective, I don't know. should I switch to 4mg this week?
Click to expand...
Could be something wrong with the vial itself. You shouldve felt something with 3mg
 
very little, I didn't have any side effects with the other one either, but it seemed to suppress my hunger more, even though I can easily manage it.
 
Side effects from GLP medications vary hugely from person to person, a dose that will make one person throw up for a week might not be noticeable to someone else, but usually once the doses get a bit higher it becomes more obvious. Even different GLP's can have unexpectedly different effects, I had horrible nausea even on tiny doses of ozempic at 0.2mg/2nd day, but next to nothing from 4.5mg of tirz/2 days. The fact that there was some appetite suppression is good evidence the GLP is OK,( not sure if reta or tirz.) and not fake. Not from the research, just from reading this forum, people who are less overweight often seem to have effects and side effects at lower doses than people who are severely overweight. The other thing to know is due to the long half life of 6-7 days, side effects that are unpleasant can last a long time, they are usually worst the day or 2 after a dose, but can last a week or more, which becomes a major problem if those effects are diarrhoea or vomiting as it can cause dehydration, which is the main way to get very unwell and need a hospital visit from taking GLPs.
In general if you have zero side effects at a given dose , bumping up a bit like from 3mg to 4mg is unlikely to cause severe side effects, but nothing is impossible. It is always worth checking out GLP plotter to see what drug levels do over time, it helps to make sense of the effects and side effects over time, as a given dose will only peak in level after the 4th weekly dose. The other method for pushing up doses with lowest risk of side effects is to just have an extra mg halfway between usual doses . As side effects relate to dose peaks, you are much less likely to have adverse effects with smaller more frequent doses than single larger ones, but you need to read up on the pharmacokinetics and understand it by using GLP plotter if you want to mess with dosing intervals.
 
I also started of with 2mg a few months ago and upped it to 4mg. I have been on 4mg ever since. It differs from person to person but my suggestion is to stay on the lowest possible dose which work for you.

If you loose weight to quickly, you might end up with loose / saggy skin.

You can consider to combine it with Tesamorelin for even better results.
 
vale113 said:
very little, I didn't have any side effects with the other one either, but it seemed to suppress my hunger more, even though I can easily manage it.
Click to expand...
What mass did the original batch test at vs. the kit you ordered?
If you were using a 10mg vial and the first tested at 12mg, and now your kit is testing at 9.5mg - of course you will feel a difference.
 
ContainHer said:
Qual era la massa del lotto originale analizzato rispetto al kit che hai ordinato?
Se prima utilizzavi una fiala da 10 mg e il primo test ha dato 12 mg, e ora il tuo kit ha dato 9,5 mg, ovviamente noterai la differenza.
Click to expand...
I don't know the mass, the first vials was 10mg, the current ones are 20mg
 
Here’s the schedule I followed. I decided to stay at 5mg.

Week: Dose: 1 0.5mg 2 1mg 3 1.5mg 4 2mg 5 2mg 6 2.5mg 7 3mg 8 3mg 9 3.5mg 10 4mg 11 4mg 12 4.5mg 13 4.5mg 14 4.5mg 15 5mg 16 5mg
 
Last edited:
You must log in or register to reply here.

Trending Topics

Latest Posts

Forum Statistics

Threads
18,069
Posts
188,221
Members
60,591
Newest
soft.corruption
Back
Top Bottom