Storing and freezing - reta and bac

[Sethe]

Did some research, however I want to make sure I'm correct + I have a few questions

1. Reta can be frozen (once per vial) If unopened, and after opening and adding bac it's stored in the fridge in a dark container, it can stay there for up to 4 weeks, but people say even up to 12 is fine, right? As long as it stays clear?

2. How do I store unopened bac (some people said in room temperature, but I'd like a second opinion) and how long can it be stored there? And after opening and being stored in the fridge how long can is stay for?

3. Should my reta and bac be the same temp when mixing? Ex. If reta is from the fridge and bac is room temperature is that fine?

4. Do I shake the vial before administering? Or is that a no-no?

 

[BNLFL]

Freezer with the Reta in powder form. In the fridge after reconstituting, and 60 days is what I usually go by. BAC stored in a dark closet, and I use mine till it's gone. I get my freezer vials out, then grab all the stuff I need to mix. No issues. They say to never shake it, but I saw Peter from Janoshik say it's OK to do. I don't.

 

[Peotidethrowaway]

Oh god here we go again

 

[BNLFL]

Oh god here we go again

Nobody reads at all anymore. The new crop of people/kids want to be spoon feed without researching on their own at all. I hate it. I use this on another site I'm on, the youngsters don't get it. Older member lol their ass off.

 

[Peotidethrowaway]

Nobody reads at all anymore. The new crop of people/kids want to be spoon feed without researching on their own at all. I hate it. I use this on another site I'm on, the youngsters don't get it. Older member lol their ass off.
View attachment 21766

It’s so damn exhausting. No one wants to have a serious discussion anymore. They just want know where can I buy right now!!!!!111 and dumb noob questions discussed repeatedly. I see it even on the sites with barriers to entry

 

[Shinobu]

Freezer with the Reta in powder form. In the fridge after reconstituting, and 60 days is what I usually go by. BAC stored in a dark closet, and I use mine till it's gone. I get my freezer vials out, then grab all the stuff I need to mix. No issues. They say to never shake it, but I saw Peter from Janoshik say it's OK to do. I don't.

Sorry this is a couple days after you made the post but i wanted to ask even after you opened bac do you still store it in a dark closet

 

[Shinobu]

It’s so damn exhausting. No one wants to have a serious discussion anymore. They just want know where can I buy right now!!!!!111 and dumb noob questions discussed repeatedly. I see it even on the sites with barriers to entry

it would be much easier if there was either a website or even a giant PDF accsesible on the site everyone could read that would veto all the dumb questions instead of having to scroll through hundreds of threads to find the answer to one question. I buy tons of other not so legal substances and they all have giant PDFs or megathreads with all the common advice you would need to know, think it would genuinely do numbers just sayin

 

[Grogu]

it would be much easier if there was either a website or even a giant PDF accsesible on the site everyone could read that would veto all the dumb questions instead of having to scroll through hundreds of threads to find the answer to one question. I buy tons of other not so legal substances and they all have giant PDFs or megathreads with all the common advice you would need to know, think it would genuinely do numbers just sayin

I think that this is the website. Most every question you can imagine has been asked.

The problem with FAQs is that the community is made up of individuals who all have different risk tolerances and opinions, and since we’re dealing with grey market products there is, at times, no definitive or absolute answer. For example, filtering, some here are grip it and rip it (no filtering), some say that they filter everything, and there are probably folks in between. What opinion do you put in the FAQ?

But as far as freezing tirzepatide and reta, that specific questions has been asked ad nauseam, and a search would see that. I think that is why some of the consternation is being expressed. Asked and answered many many times.

Freezing tirzepatide after reconstitution = YES, cockroach of peptides
Freezing retatrutide after reconstitution = NO (maybe?), more delicate of the peptides

 

[Vriende]

I think that this is the website. Most every question you can imagine has been asked. ...

... that specific questions has been asked ad nauseam, and a search would see that. I think that is why some of the consternation is being expressed. Asked and answered many many times.

Yes! This!
Use the search bar!
Read the threads!
Find the answers already here.

 

[cheesecake]

An amazing test as to how long Mot-c / Tirz / Maz keep refrigirated or at room temperature:

View: https://www.youtube.com/watch?v=lI4am0U49N4&t=2s

 

[BNLFL]

Sorry this is a couple days after you made the post but i wanted to ask even after you opened bac do you still store it in a dark closet

No problem, I do put it back in the dark cabinet after use. I just reconstituting 2 Vials of R50 this morning.

 

[Cannonball72]

Did some research, however I want to make sure I'm correct + I have a few questions

1. Reta can be frozen (once per vial) If unopened, and after opening and adding bac it's stored in the fridge in a dark container, it can stay there for up to 4 weeks, but people say even up to 12 is fine, right? As long as it stays clear?

2. How do I store unopened bac (some people said in room temperature, but I'd like a second opinion) and how long can it be stored there? And after opening and being stored in the fridge how long can is stay for?

3. Should my reta and bac be the same temp when mixing? Ex. If reta is from the fridge and bac is room temperature is that fine?

4. Do I shake the vial before administering? Or is that a no-no?

I had this exact question this AM.

https://www.prohibited-data-mining-site.com/blog/articles/how-to-store-retatrutide

A nice summary of the article in the link as provided by Gemini.

Refrigerated reconstituted retatrutide typically lasts 2–4 weeks, but some sources suggest up to 60 days under optimal conditions. Proper storage and handling are crucial to prevent degradation.

 

[UpDownLeftRightAS*]

Did some research, however I want to make sure I'm correct + I have a few questions

1. Reta can be frozen (once per vial) If unopened, and after opening and adding bac it's stored in the fridge in a dark container, it can stay there for up to 4 weeks, but people say even up to 12 is fine, right? As long as it stays clear?

2. How do I store unopened bac (some people said in room temperature, but I'd like a second opinion) and how long can it be stored there? And after opening and being stored in the fridge how long can is stay for?

3. Should my reta and bac be the same temp when mixing? Ex. If reta is from the fridge and bac is room temperature is that fine?

4. Do I shake the vial before administering? Or is that a no-no?

For dry lyophilized material:

There is little or no free water present, so the classic freeze-thaw stress mechanisms are dramatically reduced. That said, not all peptides are equally stable. Some highly delicate or modified peptides can still slowly degrade over time even while lyophilized. But for most research peptides commonly discussed online, freezer storage of the dry powder is considered standard practice.

 

[casprow]

I have 10 vials of powdered Reta in my shelf at room temperature same thing with bac water (unopened) the entire time. Is that wrong ??

 

[Estarossa19]

I have 10 vials of powdered Reta in my shelf at room temperature same thing with bac water (unopened) the entire time. Is that wrong ??

Nah, it'll be good there for a long time.

 

[Thighknee]

I'm considering buying a few years worth of reta and tirz in one go to keep in the freezer, would they last years in there or only months? What would be the maximum amount of time you would all generally freeze them for?

 

[V6R3W]

I'm considering buying a few years worth of reta and tirz in one go to keep in the freezer, would they last years in there or only months? What would be the maximum amount of time you would all generally freeze them for?

Decades

 

[GimmePep]

Freezer with the Reta in powder form. In the fridge after reconstituting, and 60 days is what I usually go by. BAC stored in a dark closet, and I use mine till it's gone. I get my freezer vials out, then grab all the stuff I need to mix. No issues. They say to never shake it, but I saw Peter from Janoshik say it's OK to do. I don't.

For the record, Peter Magic said it was ok to shake and throw lyophilized (powder form) not reconstituted vials. I’m not neurotic about slow dripping to recon. I just slow down the vacuum force a bit.

I think it’s like having a new born baby. At first you want to keep it in bubble wrap, terrified of everything. By your third child, you understand their resilience.

 

[GimmePep]

I'm considering buying a few years worth of reta and tirz in one go to keep in the freezer, would they last years in there or only months? What would be the maximum amount of time you would all generally freeze them for?

According to Peter Magic at Jano, stored in a regular freezer will be good for decades.

 

[eidos]

Do whatever you like with this research paper, but personally, I don't refreeze my vials.

The Detrimental Effects of Crystalline Excipients: How They Jeopardize the Long-Term Stability of Freeze-Dried Polypeptide Formulations

2025 Nov

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Background: Despite the growing importance of polypeptide-based drugs in clinical therapy, studies investigating the stability of their freeze-dried formulations remain scarce. Crystalline excipients, such as mannitol, are commonly used in freeze-dried formulations of chemically synthesized drugs, but they often negatively impact the long-term stability of biological macromolecules like monoclonal antibodies (mAbs). This study bridges this knowledge gap by evaluating the effects of crystalline and amorphous excipients, surfactants, and amino acid-based stabilizers on the long-term stability of freeze-dried formulations using model polypeptides, glucagon and insulin.

Methods: The freeze-dried formulations were prepared with crystalline and amorphous excipients, surfactants, and amino acid-based stabilizers. The crystallization behavior of the excipients and the thermal stability of the formulations were thoroughly characterized using X-ray powder diffraction (XRPD) and differential scanning calorimetry (DSC).

Results: The crystallization of mannitol was directly correlated with a significant reduction in the long-term stability of both model polypeptides. This detrimental effect mirrors the instability observed in mAbs formulations, indicating a common mechanism of protein destabilization induced by crystalline excipients, independent of molecular size.

Conclusions: This study provides the first direct evidence that crystalline excipients pose a significant risk to the stability of freeze-dried polypeptides. These findings offer critical insights for the rational design of stable freeze-dried formulations, guiding industrial development strategies for polypeptide-based therapeutics.

 

[Thighknee]

Decades

According to Peter Magic at Jano, stored in a regular freezer will be good for decades.

That's awesome, thanks folks. I feel a new addiction/super focused hoarding episode coming already haha 😆