NAD+ - big doses?

tendency

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So I've been running 50mg of NAD+ daily the last 3-3.5 months. Took a couple months before I started to feel a small boost in energy and improvement in mood. It was subtle, but noticeable. Nothing dramatic.

Just for fun, I decided to really crank my dosage and last 3 days have taken 250mg daily. And wow, wow. That hits. Really nice increase in energy that's smooth, stable and lasts all day. Significant improvement in mood.

Anyone else relate to this? Anyone else have to take, or notice significant improvement, when taking a mammoth dose?
 
tendency said:
So I've been running 50mg of NAD+ daily the last 3-3.5 months. Took a couple months before I started to feel a small boost in energy and improvement in mood. It was subtle, but noticeable. Nothing dramatic.

Just for fun, I decided to really crank my dosage and last 3 days have taken 250mg daily. And wow, wow. That hits. Really nice increase in energy that's smooth, stable and lasts all day. Significant improvement in mood.

Anyone else relate to this? Anyone else have to take, or notice significant improvement, when taking a mammoth dose?
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I’ve wondered about going higher. I’m sure the bioavailability is not the same but I was taking 1000mg of TruNiagen per day for a long while prior to switching to the pep version. Right now I’m at 150mg day.

Are you going IM or SubQ? Wondering what the “whoosh” felt like at that dose.
 
tendency said:
So I've been running 50mg of NAD+ daily the last 3-3.5 months. Took a couple months before I started to feel a small boost in energy and improvement in mood. It was subtle, but noticeable. Nothing dramatic.

Just for fun, I decided to really crank my dosage and last 3 days have taken 250mg daily. And wow, wow. That hits. Really nice increase in energy that's smooth, stable and lasts all day. Significant improvement in mood.

Anyone else relate to this? Anyone else have to take, or notice significant improvement, when taking a mammoth dose?
Click to expand...
Wow, 250mg!
I thought my 100mg occasionally after 2 months was as high as I was supposed to go.
Since I love what NAD+ does to me, I'm really tempted now!

A couple of questions though: what about dilution? I have 500mg vials. If I want to fit 250mg in a 1ml syringe that means reconstituting with 2ml of BAC. Seems like the recipe for a mayor sting? If I can get it out of the vial at all🤔?

Or do you take multiple shots?
 
PinKushn said:
I’ve wondered about going higher. I’m sure the bioavailability is not the same but I was taking 1000mg of TruNiagen per day for a long while prior to switching to the pep version. Right now I’m at 150mg day.

Are you going IM or SubQ? Wondering what the “whoosh” felt like at that dose.
Click to expand...
I had been doing IM but now I'm taking it in the butt and works great 😀
 
BBA1969 said:
Wow, 250mg!
I thought my 100mg occasionally after 2 months was as high as I was supposed to go.
Since I love what NAD+ does to me, I'm really tempted now!

A couple of questions though: what about dilution? I have 500mg vials. If I want to fit 250mg in a 1ml syringe that means reconstituting with 2ml of BAC. Seems like the recipe for a mayor sting? If I can get it out of the vial at all🤔?

Or do you take multiple shots?
Click to expand...
I dilute a 500mg vial with 5ml BAC so yeah, it's a fairly large shot at 2.5ml (I just take one injection). However, as mentioned above I inject in glute and it works fine.

No sting for me.
 
tendency said:
I dilute a 500mg vial with 5ml BAC so yeah, it's a fairly large shot at 2.5ml (I just take one injection). However, as mentioned above I inject in glute and it works fine.

No sting for me.
Click to expand...

You inject 2.5ml SQ into the fat above the glute or IM into the glute?


tendency said:
I had been doing IM but now I'm taking it in the butt and works great 😀
Click to expand...

Keestering NAD+ is wild. 🤣
 
tendency said:
I dilute a 500mg vial with 5ml BAC so yeah, it's a fairly large shot at 2.5ml (I just take one injection). However, as mentioned above I inject in glute and it works fine.

No sting for me.
Click to expand...
How long is the needle?
 
I've heard of some people going as high as 500mg Sub-q in a day, for athletic competitions. I don't think it's "that" much different than getting an IV drip of 750 - 1000mg over the course of a couple hours at a med spa. Other than how quickly it's gonna hit.
 
tendency said:
I dilute a 500mg vial with 5ml BAC so yeah, it's a fairly large shot at 2.5ml (I just take one injection). However, as mentioned above I inject in glute and it works fine.

No sting for me.
Click to expand...
I'm by no means a contortionist and probably need to work on my flexibility. The only shot I can reasonably manage in the cheeks is with a pen. Right now GHK-CU. Indeed no sting.

Will start to practice with syringes behind my own back 🫣
 
BBA1969 said:
I'm by no means a contortionist and probably need to work on my flexibility. The only shot I can reasonably manage in the cheeks is with a pen. Right now GHK-CU. Indeed no sting.

Will start to practice with syringes behind my own back 🫣
Click to expand...
Ask a friend if he wants to give it to you in the butt. 🤣
 
Anything with the gluteus concerns me about hitting something like the sciatic nerve or the superior gluteal artery.

At least for TRT and glutathione, I was happy with deep subq or IM in the thigh (vastus lateralis) muscle. Like the instructions on Youtube by Nurse Scott.
 
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At least with the higher or more frequent doses, I would take daily oral TMG, as mentioned by @Skidude since last year:

how to NAD+

So I got a kit of NAD+ but don't really know how to use it. I honestly don't even know if it's buffered or not, or what buffered means. I watched some videos and feel like I'll recon with 5ml but not sure on dosing or timing and a lot of conflicting info on dr.google. Help, please.
glp1forum.com glp1forum.com

I got mine on Amazon for like $10, Nutricost brand:

 
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BBA1969 said:
A couple of questions though: what about dilution? I have 500mg vials. If I want to fit 250mg in a 1ml syringe that means reconstituting with 2ml of BAC.
Click to expand...
That’s crazy that this topic came up because I just had a case of the fuck it’s today and did the same thing. 500mg w/2ML bac and injected 95 unit which is like 220mg or something and wow 😮 that was definitely a kick start.
 
I also upped today for no particular reason, not quite to the same level tho lol. I've been taking 100mg 3x/week for about 2 weeks and went to 150mg today. Definitely started flushing and had to sit down haha. Rest of the day no issues tho, going forward I think I'll stick to 100mg and just increase frequency as necessary tho lol. Fwiw I reconstitute 1000mg with 2mL bac water so my 150mg was still just 30 unit shot, and my 100mg has been 20 units, I haven't had any significant issues with stinging or anything else when pinning, maybe a small brief one but nothing bad or very noticeable.
 
LabRatBarbie said:
That’s crazy that this topic came up because I just had a case of the fuck it’s today and did the same thing. 500mg w/2ML bac and injected 95 unit which is like 220mg or something and wow 😮 that was definitely a kick start.
Click to expand...
How did the pin itself go? Any irritation or lump? And where did you put it?
 
BBA1969 said:
How did the pin itself go? Any irritation or lump? And where did you put it?
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I do my pin very slow. It’s not supposed to burn if it does you’re in muscle not fat or the ph is off ( meaning not buffered ). But I did in the abdominal.

If you have ph test check it, it shouldn’t be any higher then 6. Let your nads get to room temp (in the pin not the vial) and push plunger in slower. I tend to pinch really hard so I feel less poke.

With the Mots c I feel kinda itchy at pin site for a little while. Just started on that so not 💯 if that’s normal. But I have great energy I definitely would recommend increasing but don’t go over board. That kinda feeling could freak some people out if they are more sensitive to the amped feeling.
 
Dam, I reduced down from 50mg to 25mg because if the sting. I couldn’t imagine 100mg or 250mg!!
 
So I am wondering if NAD+ is even doing anything. Is there any blood test or anything that someone could take to tell if the NAD+ is doing anything?
 
Either you guys are using non-buffered NAD+ or I've gotten used to it. I mix 500mg with 1mL bac, take 0.20mL sub-q, and I feel no sting.
 
Commander said:
So I am wondering if NAD+ is even doing anything. Is there any blood test or anything that someone could take to tell if the NAD+ is doing anything?
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It seems like 50-75% of the posts i've come across are of the same mind set. Is this doing anything... My research is more into wrinkles and aging than energy. You have any before and after of yourself maybe it's working? lol
 
I tried doing a higher dose and had some not so fun gastric side effects a few hours later. Not sure I’ve seen many benefits either.
 
Commander said:
So I am wondering if NAD+ is even doing anything. Is there any blood test or anything that someone could take to tell if the NAD+ is doing anything?
Click to expand...
No. I heard Dr. Paul Jones talk about the difficulty measuring. Unstable in blood and blood does not represent qty in organs and tissues. Similar probs measuring Glutathione.

The science says NAD is definitely doing it's job. Whether the cellular environment is ready to use it is why we geek out on the MOTS/SS31 Mito health path. I'm convinced it's working behind the scenes for me, catch a flush at 100mg, but am not banking on the energy rise. That said, you bet I wanna blast 500mg to see what it's like. Common IV dose is 750ml. The other research rat and I both get some gastro going on pin day.
I'm messing with 100mg 3x weekly. Clinics (Konniver and Jones) use a "loading dose" --100mg for week then come back for the IV big bag. Patients then return 1x monthly or once weekly depending.
 
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I keep thinking about trying NAD+ subQ, but keep hearing so much wildly varying opinions on it. I've been taking NMN for 2 years now.
 
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