SubQ? Intranasal? Topical?

[laansasa]

So I was curious why some peps/aminos need to be SubQ and can't be intranasal or topical. I read it is due to their molecular weight.

- If under 500 daltons, it can be absorbed well topically.
- If under 1000 daltons, it can be absorbed by the nasal mucosa (intranasal bioavailability).
- If over 1000 daltons, it has to be administered subQ.

I couldn't find a cheat sheet or chart for most peps so I created this one. I am not a scientist so this is for simple and "recreational" reference only.
Feel free to make suggestions on edits. I know I might be missing a few - I just took a vendor's price list and worked with what they had.
I hope it helps some of you who like me, like to know the reasons for things and don't want to look up a pep at a time online.

 

[Ruckus4519]

Thanks for sharing!

 

[laansasa]

Thanks for sharing!

You're welcome! 🙂

 

[CNCCurrency]

So I was curious why some peps/aminos need to be SubQ and can't be intranasal or topical. I read it is due to their molecular weight.

- If under 500 daltons, it can be absorbed well topically.
- If under 1000 daltons, it can be absorbed by the nasal mucosa (intranasal bioavailability).
- If over 1000 daltons, it has to be administered subQ.

I couldn't find a cheat sheet or chart for most peps so I created this one. I am not a scientist so this is for simple and "recreational" reference only.
Feel free to make suggestions on edits. I know I might be missing a few - I just took a vendor's price list and worked with what they had.
I hope it helps some of you who like me, like to know the reasons for things and don't want to look up a pep at a time online.

Ok who wants to be orange? 5 amino on the skin? Pass

 

[laansasa]

Ok who wants to be orange? 5 amino on the skin? Pass

LMAO!😂😂😂 Well, a lot of blue skin going on around here...but I can't fathom intranasal GHK-Cu...Ouch 😬

 

[lessthanhalf]

I would suggest not relying on that simplified set of assumptions. In general smaller lower molecular weight drugs are absorbed through surfaces like skin or nasal passages better, but it also depends a lot on how soluble it is in lipids. A polar substance with low lipid solubility is not going to make it through the skin. Glucose m.w. 180 very low skin penetration. And hardly any peptides if any are going to be absorbed through the skin, unless using fancy delivery devices like microneedles etc, and some larger proteins like insulin are absorbed intranasally m.w. 5800 daltons. Without spending ages on research my guess is none of the peptides are going to get through the skin.

 

[JourneyToPerfection]

I would suggest not relying on that simplified set of assumptions. In general smaller lower molecular weight drugs are absorbed through surfaces like skin or nasal passages better, but it also depends a lot on how soluble it is in lipids. A polar substance with low lipid solubility is not going to make it through the skin. Glucose m.w. 180 very low skin penetration. And hardly any peptides if any are going to be absorbed through the skin, unless using fancy delivery devices like microneedles etc, and some larger proteins like insulin are absorbed intranasally m.w. 5800 daltons. Without spending ages on research my guess is none of the peptides are going to get through the skin.

Ghk-cu and ahk-cu are fantastic when applied topically, but I’ve never tried any of the others.

 

[laansasa]

I would suggest not relying on that simplified set of assumptions. In general smaller lower molecular weight drugs are absorbed through surfaces like skin or nasal passages better, but it also depends a lot on how soluble it is in lipids. A polar substance with low lipid solubility is not going to make it through the skin. Glucose m.w. 180 very low skin penetration. And hardly any peptides if any are going to be absorbed through the skin, unless using fancy delivery devices like microneedles etc, and some larger proteins like insulin are absorbed intranasally m.w. 5800 daltons. Without spending ages on research my guess is none of the peptides are going to get through the skin.

I agree - i don't intend for anyone to use this as their standard for how to administer, but more for general understanding of why some peps are used one way or the other - like a general idea. I have seen many questions (elsewhere) about doing intranasal instead of subQ for peps that are too large for that. I don't mean to misinform anyone. I apologize if that is how it looks. My bad.

 

[lessthanhalf]

GHK-cu etc have actually had human clinical trials for skin effects that were positive and as far as I know is actually thought to work topically, so must be getting through the skin. I think it was also tested with microinjections. So very few peptides get through the skin rather than none. The evidence for it injected s/q is non existent.

 

[Dilbert4Life]

Topical ghk-cu works very well for my skin