R60 Reconstitution

[PAPoots]

Is it safe to recon R60 with 1ml so each 10 units = 6mg? This is my wife's dose and I'm trying to keep it simple for her. Unless it is common for people to add another unit or two and that extra milligram would be way too much. Or would the dose hit the blood stream and not dilute quickly enough and cause a nauseous or other side effect.

I plan on using the R60 when my R40 runs out, so I am not worried about the efficacy of the bottle being in the fridge for an excessive amount of time. I take 8mg. So we'd be going through a bottle in less than 5 weeks.

Or should I just go 3ml. Then 30units would be 6mg. 40units would be 8mg. BAC water is relatively cheap and I have u100 syringes.

 

[FartfulCodger]

There's no concern about hitting the bloodstream too fast. You and she will be injecting into subcutaneous fat, from where the medicine will be slowly absorbed into the blood.

I personally like to add a little more BAC just to allow for more accurate dosing. A measurement of 20 units is going to be more accurate than 10. To avoid confusion, I print little tables for myself, showing the number of units that correspond to a given dose. For example:

1.5mg: 5 units
3mg: 10 units
4.5mg: 15 units
6mg: 20 units
...

I keep that little sheet taped to the inside lid of my injection kit.

 

[Smiter]

I plan on using the R60 when my R40 runs out, so I am not worried about the efficacy of the bottle being in the fridge for an excessive amount of time. I take 8mg. So we'd be going through a bottle in less than 5 weeks.

Thats your answer.. Together you will need 14mg per week. so a 60mg vial will last you 4 weeks. Hence, a 1ml Recon is best.

 

[FartfulCodger]

Hence, a 1ml Recon is best.

Why's that? Just to save BAC?

 

[Habibibi]

Is it safe to recon R60 with 1ml so each 10 units = 6mg? This is my wife's dose and I'm trying to keep it simple for her. Unless it is common for people to add another unit or two and that extra milligram would be way too much. Or would the dose hit the blood stream and not dilute quickly enough and cause a nauseous or other side effect.

I plan on using the R60 when my R40 runs out, so I am not worried about the efficacy of the bottle being in the fridge for an excessive amount of time. I take 8mg. So we'd be going through a bottle in less than 5 weeks.

Or should I just go 3ml. Then 30units would be 6mg. 40units would be 8mg. BAC water is relatively cheap and I have u100 syringes.

Max official dose is 12mg. In the trials, the pens hold 0.5ml, which makes solubility at 24mg/mL. I wouldn't go much beyond that.

 

[Smiter]

Why's that? Just to save BAC?

absolutely not... It's a 60mg vial. The dude and dudette are using 8mg and 6mg per week, respectively, so that's a 14mg per week requirement. Hence in a month, that's 56mg. Therefore, 1ml in a 60mg vial will leave only 4mg remaining with low injection volume. If they have no sides, then lower injection volume should be optimal, right?

 

[Smiter]

Max official dose is 12mg. In the trials, the pens hold 0.5ml, which makes solubility at 24mg/mL. I wouldn't go much beyond that.

Could that be due to the restriction of the pen itself or the actual solubility of the compound?

 

[BNLFL]

Do 2 vials at 3ml BAC at 3ml each. Roughly 30 units/3mg for her, 10 shots. You'll pin 40 units/4mg approx 7 shots. Check the vial volume and adjust accordingly. I just did similar with two R50.

 

[Habibibi]

Could that be due to the restriction of the pen itself or the actual solubility of the compound?

It could, but we don't know. Seems like the safe thing to do is to copy Lilly.

 

[BNLFL]

absolutely not... It's a 60mg vial. The dude and dudette are using 8mg and 6mg per week, respectively, so that's a 14mg per week requirement. Hence in a month, that's 56mg. Therefore, 1ml in a 60mg vial will leave only 4mg remaining with low injection volume. If they have no sides, then lower injection volume should be optimal, right?

The shot amount doesn't change with less/more BAC. It has do with concentrations.

 

[Bioexplorer]

I recall reading somewhere that Reta solubility is 20 mg/ml H2O. If correct, 60mg will not all dissolve in 1ml BA water. I would use 3ml for R60.

 

[Smiter]

It could, but we don't know. Seems like the safe thing to do is to copy Lilly.

Yeah, that's prudent I suppose. For me, due to the number of shots I take, low as it is, I would prefer less volume.

 

[Smiter]

I recall reading somewhere that Reta solubility is 20 mg/ml H2O. If correct, 60mg will not all dissolve in 1ml BA water. I would use 3ml for R60.

Aah, then that settles it. You will need 3ml minimum

 

[wildweasel]

I recall reading somewhere that Reta solubility is 20 mg/ml H2O. If correct, 60mg will not all dissolve in 1ml BA water. I would use 3ml for R60.

i came here to say this sort of thing. 1ml will not dissolve 60mg of any peptide that i am aware of. even with 3ml its going to take a bit of stirring and agitating to remove the floaters

 

[Gr33dyOctopus]

I use 3ml with reta and for our tirz go with 2ml, that makes the tirz concentration 30mg per ml and its a lot less to shoot.

IMHO unless you know exactly how much actual reta is in your 60mg vial you could over or underdose yourself. The fill isnt perfect on any of these and wirh a 60mg concentration... personally, lol no thanks.

 

[Smiter]

I use 3ml with reta and for our tirz go with 2ml, that makes the tirz concentration 30mg per ml and its a lot less to shoot.

IMHO unless you know exactly how much actual reta is in your 60mg vial you could over or underdose yourself. The fill isnt perfect on any of these and wirh a 60mg concentration... personally, lol no thanks.

If there is a concern of incorrect dosage, then it makes sense to reconstitute with more BAC to minimize the variance in a single pin-shot.

 

[PAPoots]

I think 3ml make the most sense. Thanks for the feedback. The volume for a 6 or 8mg shot doesn't matter much. I can see where the more concentrated it is that it might not dilute as well. Glow is the only thing that I have ever pinned that I wish I could dilute more without buying a bigger vial and transferring solutions.

I have a mouse jiggler I use to mix up my stuff. I lay the bottle on its side and it let it roll for a few minutes.

 

[woundcarping]

In general I reconstitute Reta at 30mg/ml which gets my 9mg in a .3ml syringe, which is one of my typical targets.


There can be issues with higher concentrations like precipitation, ISR, degradation, etc. At least short term, 140mg will dissolve in 1ml.

I recall reading somewhere that Reta solubility is 20 mg/ml H2O. If correct, 60mg will not all dissolve in 1ml BA water. I would use 3ml for R60.

This isn’t a thing.

 

[PAPoots]

CoPilot had an interesting response.

Does 60 mg in 3 mL (20 mg/mL) fit the known solubility envelope?​

Yes — based on:

A. GLP‑1 analog solubility ranges​

20 mg/mL is within the typical solubility range for long‑chain GLP‑1 peptides.

B. Compounding pharmacy disclosures​

Several U.S. 503A/503B pharmacies list retatrutide solubility limits between:

• 15–25 mg/mL (internal stability data)

These are not published in journals, but they are real-world compounding constraints.

C. Community reports​

Multiple independent users report:

• 1 mL cannot dissolve 60 mg
• 2 mL sometimes dissolves but is slow
• 3 mL dissolves reliably

This matches expected peptide behavior.

D. No clinical or chemical evidence contradicts 20 mg/mL​

 

[Habibibi]

CoPilot had an interesting response.

Does 60 mg in 3 mL (20 mg/mL) fit the known solubility envelope?​

Yes — based on:

A. GLP‑1 analog solubility ranges​

20 mg/mL is within the typical solubility range for long‑chain GLP‑1 peptides.

B. Compounding pharmacy disclosures​

Several U.S. 503A/503B pharmacies list retatrutide solubility limits between:

• 15–25 mg/mL (internal stability data)

These are not published in journals, but they are real-world compounding constraints.

C. Community reports​

Multiple independent users report:

• 1 mL cannot dissolve 60 mg
• 2 mL sometimes dissolves but is slow
• 3 mL dissolves reliably

This matches expected peptide behavior.

D. No clinical or chemical evidence contradicts 20 mg/mL​

🤣🤣🤣 AI hallucinations on peptides. Use at your own risk.

 

[Birdie]

Is it safe to recon R60 with 1ml so each 10 units = 6mg? This is my wife's dose and I'm trying to keep it simple for her. Unless it is common for people to add another unit or two and that extra milligram would be way too much. Or would the dose hit the blood stream and not dilute quickly enough and cause a nauseous or other side effect.

I plan on using the R60 when my R40 runs out, so I am not worried about the efficacy of the bottle being in the fridge for an excessive amount of time. I take 8mg. So we'd be going through a bottle in less than 5 weeks.

Or should I just go 3ml. Then 30units would be 6mg. 40units would be 8mg. BAC water is relatively cheap and I have u100 syringes.

I have reconstituted both Sema and Reta with 1ml and never had an issue.
Personally, I prefer to keep the SQ injection amounts small.
I may be stepping out on a ledge--Chem was a long time ago--but if you saturate a solution, you will see undissolved solute. Hasn't happened in my experience. YMMV.

 

[BNLFL]

i came here to say this sort of thing. 1ml will not dissolve 60mg of any peptide that i am aware of. even with 3ml its going to take a bit of stirring and agitating to remove the floaters

I do 3ml BAC in them and R50's no problem.

IMHO unless you know exactly how much actual reta is in your 60mg vial you could over or underdose yourself. The fill isnt perfect on any of these and wirh a 60mg concentration... personally, lol no thanks.

This is why it's important to know the vial volume. Just a example, the R50s I just did had 56mg per Jano COA.

If there is a concern of incorrect dosage, then it makes sense to reconstitute with more BAC to minimize the variance in a single pin-shot.

See above.

 

[Smiter]

Seems like the pendulum has swung the other way now. If the solubility number given above is false, then using 1ml would make the most sense IF the single shot dosage needed is high enough. 10units of a reconned 60mg/ml on a 100units 1ml syringe would be 6mg. 13 units for Eight mg.