New Reta Triumph 1 Results

[lessthanhalf]

Interesting , the fact that further weight loss occurred after 80 weeks with increased doses is useful to know, it suggests that the plateau in weight loss is determined by dose more so than just time.
And the vomiting rate of 25% for 9 or 12mg is not fantastic.

 

[BNLFL]

Interesting , the fact that further weight loss occurred after 80 weeks with increased doses is useful to know, it suggests that the plateau in weight loss is determined by dose more so than just time.
And the vomiting rate of 25% for 9 or 12mg is not fantastic.

My wife or I never even come close the nausea feeling. We're on 8mg Reta.

 

[TooGood76]

shout out to the 14% of the placebo group who thought themselves into diarrhea and special thanks to the 4% who talked themselves into a UTI

 

[woundcarping]

Interesting , the fact that further weight loss occurred after 80 weeks with increased doses is useful to know, it suggests that the plateau in weight loss is determined by dose more so than just time...

Nice to see actual research supporting the idea that "low and slow" may not be as detrimental as I thought, even if it doesn't make sense to me for people trying to drop substantial amounts of fat.

And the vomiting rate of 25% for 9 or 12mg is not fantastic.

For better or worse, I've had basically no nausea and zero vomiting with Reta beyond trialed levels... I wonder if all it takes to be counted as a symptom in the study is one event in the two years of the study where they vomited or had the tracked symptoms. Placebo should offset that but 🤷‍♂️.

 

[TooGood76]

Nice to see actual research supporting the idea that "low and slow" may not be as detrimental as I thought, even if it doesn't make sense to me for people trying to drop substantial amounts of fat.



For better or worse, I've had basically no nausea and zero vomiting with Reta beyond trialed levels... I wonder if all it takes to be counted as a symptom in the study is one event in the two years of the study where they vomited or had the tracked symptoms. Placebo should offset that but 🤷‍♂️.

There's a psychosomatic aspect as well if the doctor is asking you if you had bowel issues or nausea weekly and you have to fill out a survey etc you can't help but start to think about it. That's why such a big portion of the placebo had nausea.

 

[Ascojoerg]

There's a psychosomatic aspect as well if the doctor is asking you if you had bowel issues or nausea weekly and you have to fill out a survey etc you can't help but start to think about it. That's why such a big portion of the placebo had nausea.

I am sure that plays a role in the placebo results. I personally just think a much simpler answer is at play here. They had real nausea over the trial period but it was unrelated to the medication. This would also help to put the non-placebo nausea numbers into perspective, perhaps those RS would have had nausea from food or whatever else regardless of being part of the trial.

 

[TooGood76]

I am sure that plays a role in the placebo results. I personally just think a much simpler answer is at play here. They had real nausea over the trial period but it was unrelated to the medication. This would also help to put the non-placebo nausea numbers into perspective, perhaps those RS would have had nausea from food or whatever else regardless of being part of the trial.

Right I mean over 2 years having nausea a few times isn't remarkable at all.

 

[Ryanking11]

It really is incredible at what it does

 

[CallieKat]

So now I know why reta 4 made me so skinny compared with tirz 5…

 

[Bushum]

Yeah, that's hard to believe because the 4mg was on reta for 80 weeks and the placebo on nothing for those 80 weeks and then both groups titrated up to the maximum tolerated dose. That doesn't speak well for staying on lose doses for long periods of time.

Can you please explain the bolded part? This is my plan, to stay on a very low dose for years, but I am not clear on your implication. Thank you!

 

[Grogu]

I was just commenting on the fact that participants in the 4mg group lost 19% of their starting weight in 80 weeks and participants in the placebo group lost 19.2% in 24 weeks. That's a big difference in time on the medication to achieve nearly the same results. Even if we adjust out the 2.2% loss that the placebo group lost during the first 80 weeks, it's still almost the same.



I don't know about you, but if I had the choice to lose 50 pounds in 6 months versus 50 pounds in 1.5 years, I'd take the former rather than the later.

We have a lot of people in the forum asking for advice about what to do when they stall or plateau on these medications and less so people begging to slow down weight loss.

But, low and slow definitely works. Probably better for those in a less diseased state when they start treatment. I have a family member lose 50lbs on less then 2mg of tirzepatide over 9 months. But she didn't spend her entire life obese, and wouldn't have meet the clinical requirements to be on the meds in the first place.

Since you only have 10lbs to lose, my comments were definitely not directed towards you. Being on TRT, reta, and add in some tesa and your abs will be showing before you know it.

 

[yeddie]

Some comments from a blogger who participated in the trial.

He has a new post up about the TRIUMPH 1 and Transcend T2D-1A Phase 3 results announced at the ADA conference.

ADA 2026: Retatrutide Revolution

 

[cujet]

I was just commenting on the fact that participants in the 4mg group lost 19% of their starting weight in 80 weeks and participants in the placebo group lost 19.2% in 24 weeks.

Pretty sure that group was titrated up to the max dose they could tolerate. In other words, from what I understand the dose was not 4mg at 80 weeks.

 

[Grogu]

Pretty sure that group was titrated up to the max dose they could tolerate. In other words, from what I understand the dose was not 4mg at 80 weeks.

Nope, that's not what happened.

 

[lastresort]

Interesting , the fact that further weight loss occurred after 80 weeks with increased doses is useful to know, it suggests that the plateau in weight loss is determined by dose more so than just time.
And the vomiting rate of 25% for 9 or 12mg is not fantastic.

Good thing I stashed reta then! I have 20 vials of 60mg.

 

[cujet]

Nope, that's not what happened.

View attachment 26994

That's not how I read it. The 4mg group lost 19% which does not match the 28% weight loss of 12mg. Another aspect of the 4mg group titrated up to the maximum tolerated dose lost the same 28% as the 12mg group over 80 weeks. The placebo group titrated up to maximum tolerated dose lost 19% body weight.

The placebo group prob had less time on Reta.

What am I missing?

 

[Grogu]

What am I missing?

The 4mg dose arm of the study was on 4mg at week 80. What you said in regards to the 4mg group was:

In other words, from what I understand the dose was not 4mg at 80 weeks.

But the 4mg group was on 4mg at week 80. It went up after that.

 

[woundcarping]

…And it's not the same 28%. The 12mg group lost 30.3% and the 4mg group lost 27.9% at 104 weeks. That's a difference of 2.4% or about 12 pounds difference in loss. That's not the same.

The exposure over time curve for the 4mg group and the 12mg group is widely different. A direct comparison of their likely maximum loss at 12mg isn’t fair 24 weeks vs 104 weeks.

 

[Grogu]

The exposure over time curve for the 4mg group and the 12mg group is widely different. A direct comparison of their likely maximum loss at 12mg isn’t fair 24 weeks vs 104 weeks.

But it replicates actual human behavior. Someone hears on social media that low doses are best and decides to stay on a low dose, after 80 weeks they realize that their not doing well as they should and start to titrate up to higher doses. To late.... 27.9% isn't the same as 30.3%. Same 104 weeks.

 

[woundcarping]

But it replicates actual human behavior. Someone hears on social media that low doses are best and decides to stay on a low dose, after 80 weeks they realize that their not doing well as they should and start to titrate up to higher doses. To late.... 27.9% isn't the same as 30.3%. Same 104 weeks.

Absolutely not the same number of weeks under the same curve.

One spent 24 weeks moving from 4mg to 12mg, the other spent 104 weeks at 12mg.

Compare results on the moving up group at 184 weeks for an accurate comparison of endpoints, imo.

 

[bockscar]

if ive gone from 262 to 226 in a couple months running .3mg/2x weekly.......will i look like Kelly Osbourne in a month if I take the clinical trial doses?