Reta cancer data drops

TooGood76

TooGood76

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Ok I'm posting the twitter link bc the wsj article is pay walled and it summarizes it.

https://twitter.com/x/status/2057717218608099484
View: https://x.com/agingroy/status/2057717218608099484?s=46&t=zVDa3_JfTajSPzmg_nqxMg


12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%). Breast cancer: 43% cut. Colon cancer five-year mortality in a separate study: 15.5% vs 37.1%.

these effects are clearly beyond just weight loss, GLP agonists are showing more and more effects it's exciting stuff.
 
Hopefully these kinds of findings will eventually get to the bottom of what's really causing all these things (already-identified metabolic syndrome aspects; joint pain; mental health imbalance; cancer) which are mitigated by GLP-1 endruns. But clearly not root-caused by natural GLP-1 bioavailability problems, I believe.
 
lil ghost said:
I swear, everything I see on this site makes me want to get on the reta bandwagon
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You better get on the wagon now because Lilly already hiring PI's and cooperating with authorities in seizing shipments of peptides across the country. It's only going to get worse from here. Buy now, stock up and observe what happens next.
 
lil ghost said:
I swear, everything I see on this site makes me want to get on the reta bandwagon
Click to expand...
No secret that I love Reta. My avatar is even a Reta molecule. But, if the FDA caves in and they make Reta a biologic (waves magic wand), then the clampdown will get more intense than it is now, which is saying a lot.
 
TooGood76 said:
these effects are clearly beyond just weight loss, GLP agonists are showing more and more effects it's exciting stuff.
Click to expand...
Actually, the effects are probably directly driven by the weight loss process (at least thats the theory). When you deprive the body of fuel, you deprive the cancer of fuel. So not the reduction in weight, which would be likely to reduce the rate of new cancers, but the process of losing weight which is impacting existing cancer growth.
 
5byfive said:
Actually, the effects are probably directly driven by the weight loss process (at least thats the theory). When you deprive the body of fuel, you deprive the cancer of fuel. So not the reduction in weight, which would be likely to reduce the rate of new cancers, but the process of losing weight which is impacting existing cancer growth.
Click to expand...
This is my thought as well. People forget that being obese IS a health risk for many reasons, including that higher amounts of body fat are associated with an increased risk of a number of cancers.

So already getting down to a healthier body weight, has many health benefits associated to it.

Either way, interesting results from the phase 3 data, thanks for sharing.
 
5byfive said:
Actually, the effects are probably directly driven by the weight loss process (at least thats the theory). When you deprive the body of fuel, you deprive the cancer of fuel. So not the reduction in weight, which would be likely to reduce the rate of new cancers, but the process of losing weight which is impacting existing cancer growth.
Click to expand...
They are seeing results outpacing just standard weight loss. It's partially the blood sugar control, same reason metformin is used in cancer treatment but there's more going on. Inflammation drops way faster on glps than it does on equivalent calorie restriction or fasting, the elimination of liver fat on Reta is far more effective than weight loss alone etc.
 
TooGood76 said:
Ok I'm posting the twitter link bc the wsj article is pay walled and it summarizes it.

https://twitter.com/x/status/2057717218608099484
View: https://x.com/agingroy/status/2057717218608099484?s=46&t=zVDa3_JfTajSPzmg_nqxMg


12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%). Breast cancer: 43% cut. Colon cancer five-year mortality in a separate study: 15.5% vs 37.1%.

these effects are clearly beyond just weight loss, GLP agonists are showing more and more effects it's exciting stuff.
Click to expand...
Where's the data/paper?
 
I saw study a year or so ago with bowel cancer patients living a lot longer on GLP drugs than those not on GLP drugs. If this keeps getting confirmed, it might be that GLP-1 agonists are a very effective treatment for cancer, or at least surprisingly good at preventing it from spreading. This study is showing only half as many metastases ( secondary tumours ) in several different cancers if on GLPs , many cancer therapy drugs are not that good, and typically have much worse side effects. And it probably prevents a lot of cancers in the first place. Those results are easily good enough to support large scale prospective clinical trials to prove the effect is real.
 
lessthanhalf said:
I saw study a year or so ago with bowel cancer patients living a lot longer on GLP drugs than those not on GLP drugs. If this keeps getting confirmed, it might be that GLP-1 agonists are a very effective treatment for cancer, or at least surprisingly good at preventing it from spreading. This study is showing only half as many metastases ( secondary tumours ) in several different cancers if on GLPs , many cancer therapy drugs are not that good, and typically have much worse side effects. And it probably prevents a lot of cancers in the first place. Those results are easily good enough to support large scale prospective clinical trials to prove the effect is real.
Click to expand...
this is one of those situations where we are finding out more and more that these drugs do something and then retroactively figuring out exactly why and how they do that
 
lessthanhalf said:
I saw study a year or so ago with bowel cancer patients living a lot longer on GLP drugs than those not on GLP drugs. If this keeps getting confirmed, it might be that GLP-1 agonists are a very effective treatment for cancer, or at least surprisingly good at preventing it from spreading. This study is showing only half as many metastases ( secondary tumours ) in several different cancers if on GLPs , many cancer therapy drugs are not that good, and typically have much worse side effects. And it probably prevents a lot of cancers in the first place. Those results are easily good enough to support large scale prospective clinical trials to prove the effect is real.
Click to expand...
I was wondering why <50% didn't appear on this thread. Must be the time gap, eh? I can visualize you chomping down on a big fat Cuban, with a smug smirk and a nod, reading this thread. Yet, I haven't seen your take on the future of the grey zone if Reta becomes legit approved. What changes do you predict will happen for us common yeomen?
 
Smiter said:
I was wondering why <50% didn't appear on this thread. Must be the time gap, eh? I can visualize you chomping down on a big fat Cuban, with a smug smirk and a nod, reading this thread. Yet, I haven't seen your take on the future of the grey zone if Reta becomes legit approved. What changes do you predict will happen for us common yeomen?
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Tirz and Sema became cheaper and more
Prevalent after approval. I know that there is a ton of talk about "crack downs" but I really think that is much more focused on compounders, people ordering peptides from china with crypto off of telegram is such a small part of the market compared to the mass amount of people who are getting a prescription and ordering GLP1s with their credit card.
 
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I believe people stating that these results are just a subproduct of weight loss are cutting it too short. It's not the first time I read about similar results on top of what would be expected with regular weight loss.

I also remember listening to a podcast by Dr Attia saying we don't actually know if obesity itself causes cancer, and he doesn't believe so. But things like insulin resistance could be the culprit
 
Pin&Play said:
I believe people stating that these results are just a subproduct of weight loss are cutting it too short. It's not the first time I read about similar results on top of what would be expected with regular weight loss.

I also remember listening to a podcast by Dr Attia saying we don't actually know if obesity itself causes cancer, and he doesn't believe so. But things like insulin resistance could be the culprit
Click to expand...
As stated above, Being obese IS a health risk for many reasons, including that higher amounts of body fat are associated with an increased risk of a number of cancers.
 
CNCCurrency said:
As stated above, Being obese IS a health risk for many reasons, including that higher amounts of body fat are associated with an increased risk of a number of cancers.
Click to expand...

Let's not forget obesity is determined by BMI alone, which is a silly number.

Sure, higher amounts of body fat are associated with increased cancer risks, but this does not confirm that the excess of adipose tissue causes cancer. This is a typical example of correlation =/= causality

Is it the fat or the diet? Or the blood sugar? Or the insulin resistance? Inflammation? Or some other factor we don't even know about?

Then absolutely, getting lean will almost always provide some kind of protection.

But there are people with a healthy BMI and metabolic issue that would like to know the answer
 
TooGood76 said:
Ok I'm posting the twitter link bc the wsj article is pay walled and it summarizes it.

https://twitter.com/x/status/2057717218608099484
View: https://x.com/agingroy/status/2057717218608099484?s=46&t=zVDa3_JfTajSPzmg_nqxMg


12,112 patients. Seven tumor types. GLP-1 users had half the lung cancer metastasis rate (10% vs 22%). Breast cancer: 43% cut. Colon cancer five-year mortality in a separate study: 15.5% vs 37.1%.

these effects are clearly beyond just weight loss, GLP agonists are showing more and more effects it's exciting stuff.
Click to expand...
No cause & effect, and could be part of the P.R machine, but I hope it is true because this is great news!
 
indolent said:
Hopefully these kinds of findings will eventually get to the bottom of what's really causing all these things (already-identified metabolic syndrome aspects; joint pain; mental health imbalance; cancer) which are mitigated by GLP-1 endruns. But clearly not root-caused by natural GLP-1 bioavailability problems, I believe.
Click to expand...
I would love to see the fasted insulin levels of the groups for comparison. The metabolic dysfunction is so overlooked by current mainstream healthcare.
 
Pin&Play said:
I believe people stating that these results are just a subproduct of weight loss are cutting it too short. It's not the first time I read about similar results on top of what would be expected with regular weight loss.

I also remember listening to a podcast by Dr Attia saying we don't actually know if obesity itself causes cancer, and he doesn't believe so. But things like insulin resistance could be the culprit
Click to expand...
I love listing to Ben Bikman (The Metabolic Classroom). His specialty is cell biology, with a personal interest in fat cells. He is a professor at BYU and runs research there. He really hammers on hyperinsulinemia (high blood insulin levels). Insulin is one of the body's primary anabolic hormones and promotes cellular growth, including many types of cancer cells.
 
QueenMuntha said:
I wish I could tolerate Reta. It gives me gall bladder pain that travels to back and shoulder pain. Guess I am a TirzGirl for the duration.
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If you get that feeling again, you should really consider getting it checked out by a medical professional. If it's pancreatitis. that shit can go south real quick, tissue can go necrotic etc.

Not trying to be alarmist, it could have just been a run-of-the-mill gallbladder attack, to be sure, but if it's not...
 
Spork said:
If you get that feeling again, you should really consider getting it checked out by a medical professional. If it's pancreatitis. that shit can go south real quick, tissue can go necrotic etc.

Not trying to be alarmist, it could have just been a run-of-the-mill gallbladder attack, to be sure, but if it's not...
Click to expand...
Will do. I can trigger it if I start Reta again. LOL.

The referential back pain went away 10 days after stopping 8mg weekly Reta.
 
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