Reta tolerance or degraded?

RamCummins6.7

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I’ve been on Reta for about 2 months, and the effects were immediate. I was at 4mg, and the food noise and cravings disappeared, and I stayed full longer. But in the last two weeks, I notice I can eat much more before feeling full, and my weight has stalled. The vial is 60mg reconstituted with 3ml bac. I’ve upped my dose to 5.5mg, but I haven't felt a difference in the last two weeks. Could it be that my vial has lost potency?
 
I had that happen on my couple of 6mg, went to 7, nothing. Just did 8mg last Friday and back to that Reta feeling and weight loss. New vial of R50. Used that 6-7mg for 6 weeks. If you mixed 3ml BAC into that 60mg and your dose is 5.5mg, are you pinning 28 units/2.8mg?
 
I had that happen on my couple of 6mg, went to 7, nothing. Just did 8mg last Friday and back to that Reta feeling and weight loss. New vial of R50. Used that 6-7mg for 6 weeks. If you mixed 3ml BAC into that 60mg and your dose is 5.5mg, are you pinning 28 units/2.8mg?
Yes, and I use PeptideCalc peptide calculator to be positive Im drawing the proper amount. The ocd gets me. Was the 8mg from the same vial or did you recon a new one and used 8mg from that?

This makes me feel better that it's maybe not just me.
 
Yes, and I use PeptideCalc peptide calculator to be positive Im drawing the proper amount. The ocd gets me. Was the 8mg from the same vial or did you recon a new one and used 8mg from that?

This makes me feel better that it's maybe not just me.
Two new vials of MLB R50. Mixed 3ml BAC, and pin 4.2 to get my 8mg shot. We used all the R40. I do two vials, up to R60. My wife is on it too.
 
I’ve been on Reta for about 2 months, and the effects were immediate. I was at 4mg, and the food noise and cravings disappeared, and I stayed full longer. But in the last two weeks, I notice I can eat much more before feeling full, and my weight has stalled. The vial is 60mg reconstituted with 3ml bac. I’ve upped my dose to 5.5mg, but I haven't felt a difference in the last two weeks. Could it be that my vial has lost potency?
Yeah I very quickly adjusted or something and reta lost effectiveness pretty quickly for me, even at 8-10 mg doses. Pretty strange, since in the beginning it was super effective even at low doses. But it was like once my body decided to not respond, dosage didn't matter much anymore.
 
Yeah I very quickly adjusted or something and reta lost effectiveness pretty quickly for me, even at 8-10 mg doses. Pretty strange, since in the beginning it was super effective even at low doses. But it was like once my body decided to not respond, dosage didn't matter much anymore.
This is exactly what happened with me too. It was very crazy, everything was working EXTREMELY well for three months and then it was like a light switch flipped off. After that switch, even bumping up to 12 mg weekly didn't help.

I'm taking a 6 week break from reta (it's been 21 days so far) to see if that "resets" things for me, and plan to report back here.
 
This is exactly what happened with me too. It was very crazy, everything was working EXTREMELY well for three months and then it was like a light switch flipped off. After that switch, even bumping up to 12 mg weekly didn't help.

I'm taking a 6 week break from reta (it's been 21 days so far) to see if that "resets" things for me, and plan to report back here.
Yeah it's so weird! Please do report back because I'd be curious to hear if that does in fact reset things for you.
 
We know that Tirzepatide is very stable reconstituted and refrigerated to about 60 days and starts dropping after that. We also think that Retatrutide likely to be less stable. I would not be shocked to starting seeing degradation around the 6o day mark. Might be worth trying a fresh vial to see if there is a difference. I'm sure everyone would be interested in the results.
 
We know that Tirzepatide is very stable reconstituted and refrigerated to about 60 days and starts dropping after that. We also think that Retatrutide likely to be less stable. I would not be shocked to starting seeing degradation around the 6o day mark. Might be worth trying a fresh vial to see if there is a difference. I'm sure everyone would be interested in the results.
It's a good point. I tried new vials and even ones from different vendors just in case. For me the result was the same - seemingly little to no effect
 
Two new vials of MLB R50. Mixed 3ml BAC, and pin 4.2 to get my 8mg shot. We used all the R40. I do two vials, up to R60. My wife is on it too.
Got it. I'm going to recon the fresh vial
Of r60 and pin that and see. My wife is just going to start reta, switching from sema. i want to start her on a fresh vial too.
Yeah I very quickly adjusted or something and reta lost effectiveness pretty quickly for me, even at 8-10 mg doses. Pretty strange, since in the beginning it was super effective even at low doses. But it was like once my body decided to not respond, dosage didn't matter much anymore.
yea, very weird. I only have one brand to compare to. I have a 10mg kit coming tomorrow that I may just recon and use right away and sheep if that’s the issue or just me
 
Got it. I'm going to recon the fresh vial
Of r60 and pin that and see. My wife is just going to start reta, switching from sema. i want to start her on a fresh vial too.
How much are you going to start her on, and what size vial are you going to mix?
 
10mg vial with 2ml BAC and .5mg-1mg. She was on sema and is still on tesa. I don’t want to start her too high and is crushes her but at the same time I’m reading since she’s already on a glp1 she may not initially get anything out of that low of a dose.
How much are you going to start her on, and what size vial are you going to mix?
 
Same exact problem. Bumped up to 6mg last 2 weeks ago? Had some weird sides so i dropped back to 4. Been raising calories and lowering them and if anything been gaining weight every day. Usually see a 2 to 4 pound raise from morning to night. Now im swinging like 5 to 6. Drink a gallon of water a day. Under 2500c in deficit too regularly. Over 150g minimum of protein. Gym of heavy weight training 5 days a week.Nothing. no budge. At lowest 269 then keep bouncing around 270 to 275. its so bizarre
 
We know that Tirzepatide is very stable reconstituted and refrigerated to about 60 days and starts dropping after that. We also think that Retatrutide likely to be less stable. I would not be shocked to starting seeing degradation around the 6o day mark. Might be worth trying a fresh vial to see if there is a difference. I'm sure everyone would be interested in the results.
The thing is that we do see significant degradation sometimes occurring even before the 60 day mark with reta, it’s not as hardy as tirz, but there’s a difference between “purity low enough this isn’t ideally safe for human consumption” and “purity so low that it causes a loss of drug effect”. The degradation we see is generally the former, excluding big sterility failures (which shouldn’t happen in two months with good bac).
 
Same exact problem. Bumped up to 6mg last 2 weeks ago? Had some weird sides so i dropped back to 4. Been raising calories and lowering them and if anything been gaining weight every day. Usually see a 2 to 4 pound raise from morning to night. Now im swinging like 5 to 6. Drink a gallon of water a day. Under 2500c in deficit too regularly. Over 150g minimum of protein. Gym of heavy weight training 5 days a week.Nothing. no budge. At lowest 269 then keep bouncing around 270 to 275. its so bizarre
Yes, im consistently under my 2400 cal threshold while still hitting my protein and carbs. I train hard 4 days a week and hit my cardio on my active rest days, yet my weight has stalled. I just got a new kit in probably going to give it a shot and see.
 
The thing is that we do see significant degradation sometimes occurring even before the 60 day mark with reta, it’s not as hardy as tirz, but there’s a difference between “purity low enough this isn’t ideally safe for human consumption” and “purity so low that it causes a loss of drug effect”. The degradation we see is generally the former, excluding big sterility failures (which shouldn’t happen in two months with good bac).
Yea, I’ve read this too which is why I’m wondering. This vial is from a site that i ordered from before i started sourcing for myself overseas. It was also reconstituted with Hospira. Like i said above I’m going to use the new 10mg vials i got in and see if they are more potent thay the 60mg now is.
 
It's interesting to see a lot of people chiming in with similar experiences. I'm currently on 6mg and there is absolutely zero appetite suppression, and I haven't really lost any weight during this entire journey.. though there's been some recomp since I added gh. The past month has been quite difficult as reta seems to increase my appetite - if left to my own devices, I can eat an entire cake in one sitting. My vial is fresh, m/p/e tested and filtered.
 
It's interesting to see a lot of people chiming in with similar experiences. I'm currently on 6mg and there is absolutely zero appetite suppression, and I haven't really lost any weight during this entire journey.. though there's been some recomp since I added gh. The past month has been quite difficult as reta seems to increase my appetite - if left to my own devices, I can eat an entire cake in one sitting. My vial is fresh, m/p/e tested and filtered.
Yea i took 7mg this week and i still get full fast but i also get hungry fast, nothing like that first 4mg dose lol.
 
Yea i took 7mg this week and i still get full fast but i also get hungry fast, nothing like that first 4mg dose lol.
Same for me. I am always hungry. I had the strongest suppression at 1mg during the first couple of weeks, and it has never been the same.
 
Same for me. I am always hungry. I had the strongest suppression at 1mg during the first couple of weeks, and it has never been the same.
Which i wouldn’t mind so much but the fact I’m in a deficit and my weight stalled is what has me wondering if it’s just not working. At 4mg i felt like i had more energy and didn’t get crashes during the day and I’m not getting all the Reta benefits. Or it is just in my head lol
 
It's interesting to see a lot of people chiming in with similar experiences. I'm currently on 6mg and there is absolutely zero appetite suppression, and I haven't really lost any weight during this entire journey.. though there's been some recomp since I added gh. The past month has been quite difficult as reta seems to increase my appetite - if left to my own devices, I can eat an entire cake in one sitting. My vial is fresh, m/p/e tested and filtered.

Yea i took 7mg this week and i still get full fast but i also get hungry fast, nothing like that first 4mg dose lol.

Same for me. I am always hungry. I had the strongest suppression at 1mg during the first couple of weeks, and it has never been the same.
How long are you staying on your current doses? I'm a firm believer in 4 weeks on a certain dose. Wait till you hit 8mg, shit happens.
 
I havent been hungry in fifteen weeks! Lmao. Literally started tracking calories (2400) on mfp because people are tantrically chanting cico at me again like they got their matching nike cortez and tracksuits. Gee thanks marshall applewhite. Lol
 
How long are you staying on your current doses? I'm a firm believer in 4 weeks on a certain dose. Wait till you hit 8mg, shit happens.
I def jumped up this week sooner than i have been. I was doing about 2 weeks or when hunger and food noise started to return which was about 2 weeks for me at 4 mg
 
I added Cagri a few months ago and have titrated up to 1.7 along with 8mg of reta and I'm still plateaued. I guess I'm not gaining, so that's sort of a win. I don't want to raise the reta because over 8 I start getting side effects. It's tough being a non responder. I'm going the warmer weather helps the calorie burn kick in when I have more to do outside.
 
The thing is that we do see significant degradation sometimes occurring even before the 60 day mark with reta
I noticed the one vial of reta in this test that was an outlier, I assume they were from the same batch but I may be wrong.
 

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So many of you all want to rush up the dose. Let that last dose build up in your system.
I took 4 weeks between each. Once i got to 4 i spent like 6 weeks there just to make damn sure i was comfortable. Then once i went up to 6 i got some weird heartrate abnormalities and kicked back down to 4. Wasnt exactly speed racer to be fair lol
 

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